General Information
Gene ID | 1906 |
---|---|
Gene Symbol | EDN1 |
Gene Name | endothelin 1 |
Gene Type | protein-coding |
Cytoband | 6p24.1 |
Ensembl ID | ENSG00000078401 |
#miR regulators | 8 |
Omim ID | 131240 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0001516: prostaglandin biosynthetic process GO:0016049: cell growth GO:0001569: patterning of blood vessels GO:0001666: response to hypoxia GO:0001701: in utero embryonic development GO:0001821: histamine secretion GO:0035815: positive regulation of renal sodium excretion GO:0003100: regulation of systemic arterial blood pressure by endothelin GO:0035810: positive regulation of urine volume GO:0006885: regulation of pH GO:0007166: cell surface receptor signaling pathway GO:0007186: G-protein coupled receptor signaling pathway GO:0007204: elevation of cytosolic calcium ion concentration GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway GO:0019722: calcium-mediated signaling GO:0007243: intracellular protein kinase cascade GO:0007267: cell-cell signaling GO:0007507: heart development GO:0007585: respiratory gaseous exchange GO:0007589: body fluid secretion GO:0008284: positive regulation of cell proliferation GO:0045987: positive regulation of smooth muscle contraction GO:0009953: dorsal/ventral pattern formation GO:0010259: multicellular organismal aging GO:0010460: positive regulation of heart rate GO:0010595: positive regulation of endothelial cell migration GO:0010613: positive regulation of cardiac muscle hypertrophy GO:0010870: positive regulation of receptor biosynthetic process GO:0014032: neural crest cell development GO:0014065: phosphatidylinositol 3-kinase cascade GO:0014824: artery smooth muscle contraction GO:0014826: vein smooth muscle contraction GO:0015758: glucose transport GO:0046887: positive regulation of hormone secretion GO:0019229: regulation of vasoconstriction GO:0019233: sensory perception of pain GO:0048016: inositol phosphate-mediated signaling GO:0030072: peptide hormone secretion GO:0030185: nitric oxide transport GO:0030195: negative regulation of blood coagulation GO:0030335: positive regulation of cell migration GO:0030818: negative regulation of cAMP biosynthetic process GO:0031583: phospholipase D-activating G-protein coupled receptor signaling pathway GO:0032269: negative regulation of cellular protein metabolic process GO:0032496: response to lipopolysaccharide GO:0033574: response to testosterone stimulus GO:0034392: negative regulation of smooth muscle cell apoptotic process GO:0035094: response to nicotine GO:0042045: epithelial fluid transport GO:0042310: vasoconstriction GO:0042313: protein kinase C deactivation GO:0042474: middle ear morphogenesis GO:0042482: positive regulation of odontogenesis GO:0042554: superoxide anion generation GO:0043179: rhythmic excitation GO:0043200: response to amino acid stimulus GO:0043406: positive regulation of MAP kinase activity GO:0043507: positive regulation of JUN kinase activity GO:0045321: leukocyte activation GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0045793: positive regulation of cell size GO:0045840: positive regulation of mitosis GO:0046888: negative regulation of hormone secretion GO:0048661: positive regulation of smooth muscle cell proliferation GO:0051216: cartilage development GO:0051482: elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051771: negative regulation of nitric-oxide synthase biosynthetic process GO:0051899: membrane depolarization GO:0051930: regulation of sensory perception of pain GO:0060137: maternal process involved in parturition GO:0060298: positive regulation of sarcomere organization GO:0060585: positive regulation of prostaglandin-endoperoxide synthase activity GO:0070101: positive regulation of chemokine-mediated signaling pathway GO:0071347: cellular response to interleukin-1 GO:0071356: cellular response to tumor necrosis factor GO:0090023: positive regulation of neutrophil chemotaxis GO:0005576: extracellular region GO:0005615: extracellular space GO:0005737: cytoplasm GO:0005515: protein binding GO:0005125: cytokine activity GO:0005179: hormone activity GO:0031707: endothelin A receptor binding GO:0031708: endothelin B receptor binding |
KEGG pathways |
4916: Melanogenesis |
PMID | Title | Tumor | Value |
---|---|---|---|
16417466 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. | no | no |
21656314 | Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. | no | no |
21681744 | Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. | yes | no |
title | all | all |