Results for EDN1

General Information

Gene ID 1906
Gene Symbol EDN1
Gene Name endothelin 1
Gene Type protein-coding
Cytoband 6p24.1
Ensembl ID ENSG00000078401
#miR regulators 8
Omim ID 131240
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0001516: prostaglandin biosynthetic process
GO:0016049: cell growth
GO:0001569: patterning of blood vessels
GO:0001666: response to hypoxia
GO:0001701: in utero embryonic development
GO:0001821: histamine secretion
GO:0035815: positive regulation of renal sodium excretion
GO:0003100: regulation of systemic arterial blood pressure by endothelin
GO:0035810: positive regulation of urine volume
GO:0006885: regulation of pH
GO:0007166: cell surface receptor signaling pathway
GO:0007186: G-protein coupled receptor signaling pathway
GO:0007204: elevation of cytosolic calcium ion concentration
GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0019722: calcium-mediated signaling
GO:0007243: intracellular protein kinase cascade
GO:0007267: cell-cell signaling
GO:0007507: heart development
GO:0007585: respiratory gaseous exchange
GO:0007589: body fluid secretion
GO:0008284: positive regulation of cell proliferation
GO:0045987: positive regulation of smooth muscle contraction
GO:0009953: dorsal/ventral pattern formation
GO:0010259: multicellular organismal aging
GO:0010460: positive regulation of heart rate
GO:0010595: positive regulation of endothelial cell migration
GO:0010613: positive regulation of cardiac muscle hypertrophy
GO:0010870: positive regulation of receptor biosynthetic process
GO:0014032: neural crest cell development
GO:0014065: phosphatidylinositol 3-kinase cascade
GO:0014824: artery smooth muscle contraction
GO:0014826: vein smooth muscle contraction
GO:0015758: glucose transport
GO:0046887: positive regulation of hormone secretion
GO:0019229: regulation of vasoconstriction
GO:0019233: sensory perception of pain
GO:0048016: inositol phosphate-mediated signaling
GO:0030072: peptide hormone secretion
GO:0030185: nitric oxide transport
GO:0030195: negative regulation of blood coagulation
GO:0030335: positive regulation of cell migration
GO:0030818: negative regulation of cAMP biosynthetic process
GO:0031583: phospholipase D-activating G-protein coupled receptor signaling pathway
GO:0032269: negative regulation of cellular protein metabolic process
GO:0032496: response to lipopolysaccharide
GO:0033574: response to testosterone stimulus
GO:0034392: negative regulation of smooth muscle cell apoptotic process
GO:0035094: response to nicotine
GO:0042045: epithelial fluid transport
GO:0042310: vasoconstriction
GO:0042313: protein kinase C deactivation
GO:0042474: middle ear morphogenesis
GO:0042482: positive regulation of odontogenesis
GO:0042554: superoxide anion generation
GO:0043179: rhythmic excitation
GO:0043200: response to amino acid stimulus
GO:0043406: positive regulation of MAP kinase activity
GO:0043507: positive regulation of JUN kinase activity
GO:0045321: leukocyte activation
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045793: positive regulation of cell size
GO:0045840: positive regulation of mitosis
GO:0046888: negative regulation of hormone secretion
GO:0048661: positive regulation of smooth muscle cell proliferation
GO:0051216: cartilage development
GO:0051482: elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051771: negative regulation of nitric-oxide synthase biosynthetic process
GO:0051899: membrane depolarization
GO:0051930: regulation of sensory perception of pain
GO:0060137: maternal process involved in parturition
GO:0060298: positive regulation of sarcomere organization
GO:0060585: positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070101: positive regulation of chemokine-mediated signaling pathway
GO:0071347: cellular response to interleukin-1
GO:0071356: cellular response to tumor necrosis factor
GO:0090023: positive regulation of neutrophil chemotaxis
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005737: cytoplasm
GO:0005515: protein binding
GO:0005125: cytokine activity
GO:0005179: hormone activity
GO:0031707: endothelin A receptor binding
GO:0031708: endothelin B receptor binding
KEGG pathways 4916: Melanogenesis

PubMed abstracts associated with EDN1

PMID Title Tumor Value
16417466 Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. no no
21656314 Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. no no
21681744 Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. yes no
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