General Information
Gene ID | 1909 |
---|---|
Gene Symbol | EDNRA |
Gene Name | endothelin receptor type A |
Gene Type | protein-coding |
Cytoband | 4q31.22 |
Ensembl ID | ENSG00000151617 |
#miR regulators | 8 |
Omim ID | 131243 |
Gene ontology |
GO:0001569: patterning of blood vessels GO:0001666: response to hypoxia GO:0001701: in utero embryonic development GO:0001821: histamine secretion GO:0001934: positive regulation of protein phosphorylation GO:0003094: glomerular filtration GO:0007165: signal transduction GO:0006939: smooth muscle contraction GO:0007186: G-protein coupled receptor signaling pathway GO:0007190: activation of adenylate cyclase activity GO:0007202: activation of phospholipase C activity GO:0007204: elevation of cytosolic calcium ion concentration GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007266: Rho protein signal transduction GO:0007507: heart development GO:0007568: aging GO:0007585: respiratory gaseous exchange GO:0043066: negative regulation of apoptotic process GO:0008217: regulation of blood pressure GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0014032: neural crest cell development GO:0014824: artery smooth muscle contraction GO:0015758: glucose transport GO:0019233: sensory perception of pain GO:0071260: cellular response to mechanical stimulus GO:0030818: negative regulation of cAMP biosynthetic process GO:0032496: response to lipopolysaccharide GO:0042310: vasoconstriction GO:0042482: positive regulation of odontogenesis GO:0043084: penile erection GO:0043278: response to morphine GO:0048144: fibroblast proliferation GO:0048484: enteric nervous system development GO:0048659: smooth muscle cell proliferation GO:0050678: regulation of epithelial cell proliferation GO:0050729: positive regulation of inflammatory response GO:0051281: positive regulation of release of sequestered calcium ion into cytosol GO:0051482: elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0060137: maternal process involved in parturition GO:0060322: head development GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0090023: positive regulation of neutrophil chemotaxis GO:0090184: positive regulation of kidney development GO:0005886: plasma membrane GO:0016020: membrane GO:0005887: integral to plasma membrane GO:0030315: T-tubule GO:0031965: nuclear membrane GO:0005515: protein binding GO:0004435: phosphatidylinositol phospholipase C activity GO:0004962: endothelin receptor activity |
KEGG pathways |
4020: Calcium signaling pathway 4080: Neuroactive ligand-receptor interaction 4270: Vascular smooth muscle contraction |
PMID | Title | Tumor | Value |
---|---|---|---|
16417466 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. | no | no |
22446894 | Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. | no | no |
title | all | all |