General Information
Gene ID | 2099 |
---|---|
Gene Symbol | ESR1 |
Gene Name | estrogen receptor 1 |
Gene Type | protein-coding |
Cytoband | 6q25.1 |
Ensembl ID | ENSG00000091831 |
#miR regulators | 17 |
Omim ID | 114480 133430 608446 615363 |
Gene ontology |
GO:0001547: antral ovarian follicle growth GO:0002064: epithelial cell development GO:0007165: signal transduction GO:0006351: transcription, DNA-dependent GO:0006355: regulation of transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0007200: phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204: elevation of cytosolic calcium ion concentration GO:0008209: androgen metabolic process GO:0008584: male gonad development GO:0010467: gene expression GO:0010629: negative regulation of gene expression GO:0010863: positive regulation of phospholipase C activity GO:0042981: regulation of apoptotic process GO:0030518: intracellular steroid hormone receptor signaling pathway GO:0030520: intracellular estrogen receptor signaling pathway GO:0032355: response to estradiol stimulus GO:0043124: negative regulation of I-kappaB kinase/NF-kappaB cascade GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity GO:0043627: response to estrogen stimulus GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048146: positive regulation of fibroblast proliferation GO:0048386: positive regulation of retinoic acid receptor signaling pathway GO:0051000: positive regulation of nitric-oxide synthase activity GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity GO:0060065: uterus development GO:0060068: vagina development GO:0060523: prostate epithelial cord elongation GO:0060527: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060687: regulation of branching involved in prostate gland morphogenesis GO:0060745: mammary gland branching involved in pregnancy GO:0060749: mammary gland alveolus development GO:0060750: epithelial cell proliferation involved in mammary gland duct elongation GO:0071392: cellular response to estradiol stimulus GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0016020: membrane GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005794: Golgi apparatus GO:0005515: protein binding GO:0001046: core promoter sequence-specific DNA binding GO:0003682: chromatin binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003707: steroid hormone receptor activity GO:0005496: steroid binding GO:0008013: beta-catenin binding GO:0008134: transcription factor binding GO:0008270: zinc ion binding GO:0042802: identical protein binding GO:0019899: enzyme binding GO:0030235: nitric-oxide synthase regulator activity GO:0030284: estrogen receptor activity GO:0034056: estrogen response element binding GO:0038052: estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
KEGG pathways | --- |
PMID | Title | Tumor | Value |
---|---|---|---|
6930152 | Correlation between prognostic factors and blood variables in osteosarcoma. | yes | no |
8033827 | Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. | no | no |
8726395 | Immunohistochemical localization of the estrogen receptor in human osteoblastic SaOS-2 cells: association of receptor levels with alkaline phosphatase activity. | no | no |
10411143 | Expression and regulation of the meprin beta gene in human cancer cells. | no | no |
14528100 | Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. | yes | no |
19347870 | Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. | no | no |
title | all | all |