Results for HGF

General Information

Gene ID 3082
Gene Symbol HGF
Gene Name hepatocyte growth factor (hepapoietin A; scatter factor)
Gene Type protein-coding
Cytoband 7q21.1
Ensembl ID ENSG00000019991
#miR regulators 9
Omim ID 142409 608265
Gene ontology GO:0000187: activation of MAPK activity
GO:0001837: epithelial to mesenchymal transition
GO:0001889: liver development
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0007067: mitosis
GO:0043066: negative regulation of apoptotic process
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0030168: platelet activation
GO:0030335: positive regulation of cell migration
GO:0031100: organ regeneration
GO:0035729: cellular response to hepatocyte growth factor stimulus
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669: positive regulation of osteoblast differentiation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048012: hepatocyte growth factor receptor signaling pathway
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918: positive chemotaxis
GO:0051450: myoblast proliferation
GO:0060326: cell chemotaxis
GO:0060665: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090201: negative regulation of release of cytochrome c from mitochondria
GO:1901299: negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000573: positive regulation of DNA biosynthetic process
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0008083: growth factor activity
GO:0042802: identical protein binding
GO:0042056: chemoattractant activity
GO:0046982: protein heterodimerization activity
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4510: Focal adhesion
5144: Malaria
5200: Pathways in cancer
5211: Renal cell carcinoma
5218: Melanoma

PubMed abstracts associated with HGF

PMID Title Tumor Value
7693339 Met expression and sarcoma tumorigenicity. yes no
7862451 The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. yes no
8863670 Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. yes no
9788258 Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. yes no
12388161 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. no no
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no
22820099 Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. no no
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