Results for HSPB1

General Information

Gene ID 3315
Gene Symbol HSPB1
Gene Name heat shock 27kDa protein 1
Gene Type protein-coding
Cytoband 7q11.23
Ensembl ID ENSG00000106211
#miR regulators ---
Omim ID 602195 606595 608634
Gene ontology GO:0006986: response to unfolded protein
GO:0009615: response to virus
GO:0006446: regulation of translational initiation
GO:0006469: negative regulation of protein kinase activity
GO:0006928: cellular component movement
GO:0007243: intracellular protein kinase cascade
GO:0043066: negative regulation of apoptotic process
GO:0008219: cell death
GO:0010467: gene expression
GO:0016070: RNA metabolic process
GO:0016071: mRNA metabolic process
GO:0032731: positive regulation of interleukin-1 beta production
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0038033: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535: positive regulation of tumor necrosis factor biosynthetic process
GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0045766: positive regulation of angiogenesis
GO:1902176: negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
GO:2001028: positive regulation of endothelial cell chemotaxis
GO:0005886: plasma membrane
GO:0000502: proteasome complex
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005819: spindle
GO:0005856: cytoskeleton
GO:0009986: cell surface
GO:0030018: Z disc
GO:0005515: protein binding
GO:0005080: protein kinase C binding
GO:0008426: protein kinase C inhibitor activity
GO:0019901: protein kinase binding
GO:0043130: ubiquitin binding
KEGG pathways 4010: MAPK signaling pathway
4370: VEGF signaling pathway
5146: Amoebiasis

PubMed abstracts associated with HSPB1

PMID Title Tumor Value
9191521 Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. yes yes
11087053 Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. yes yes
20632817 Expression of heat shock proteins in osteosarcomas. yes yes
20944138 Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. no no
23027359 Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. no no
23091618 Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. no no
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