General Information
Gene ID | 3315 |
---|---|
Gene Symbol | HSPB1 |
Gene Name | heat shock 27kDa protein 1 |
Gene Type | protein-coding |
Cytoband | 7q11.23 |
Ensembl ID | ENSG00000106211 |
#miR regulators | --- |
Omim ID | 602195 606595 608634 |
Gene ontology |
GO:0006986: response to unfolded protein GO:0009615: response to virus GO:0006446: regulation of translational initiation GO:0006469: negative regulation of protein kinase activity GO:0006928: cellular component movement GO:0007243: intracellular protein kinase cascade GO:0043066: negative regulation of apoptotic process GO:0008219: cell death GO:0010467: gene expression GO:0016070: RNA metabolic process GO:0016071: mRNA metabolic process GO:0032731: positive regulation of interleukin-1 beta production GO:0035924: cellular response to vascular endothelial growth factor stimulus GO:0038033: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0042535: positive regulation of tumor necrosis factor biosynthetic process GO:0043122: regulation of I-kappaB kinase/NF-kappaB cascade GO:0043536: positive regulation of blood vessel endothelial cell migration GO:0045766: positive regulation of angiogenesis GO:1902176: negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress GO:2001028: positive regulation of endothelial cell chemotaxis GO:0005886: plasma membrane GO:0000502: proteasome complex GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005819: spindle GO:0005856: cytoskeleton GO:0009986: cell surface GO:0030018: Z disc GO:0005515: protein binding GO:0005080: protein kinase C binding GO:0008426: protein kinase C inhibitor activity GO:0019901: protein kinase binding GO:0043130: ubiquitin binding |
KEGG pathways |
4010: MAPK signaling pathway 4370: VEGF signaling pathway 5146: Amoebiasis |
PMID | Title | Tumor | Value |
---|---|---|---|
9191521 | Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. | yes | yes |
11087053 | Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. | yes | yes |
20632817 | Expression of heat shock proteins in osteosarcomas. | yes | yes |
20944138 | Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. | no | no |
23027359 | Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. | no | no |
23091618 | Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. | no | no |
title | all | all |