General Information
| Gene ID | 3676 |
|---|---|
| Gene Symbol | ITGA4 |
| Gene Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Gene Type | protein-coding |
| Cytoband | 2q31.3 |
| Ensembl ID | ENSG00000115232 |
| #miR regulators | 5 |
| Omim ID | 192975 |
| Gene ontology |
GO:0007157: heterophilic cell-cell adhesion GO:0001974: blood vessel remodeling GO:0007596: blood coagulation GO:0007159: leukocyte cell-cell adhesion GO:0007229: integrin-mediated signaling pathway GO:0007507: heart development GO:0030183: B cell differentiation GO:0050776: regulation of immune response GO:0050900: leukocyte migration GO:0060324: face development GO:0060710: chorio-allantoic fusion GO:0005886: plasma membrane GO:0008305: integrin complex GO:0009897: external side of plasma membrane GO:0009986: cell surface GO:0070062: extracellular vesicular exosome GO:0005515: protein binding GO:0001968: fibronectin binding GO:0046872: metal ion binding |
| KEGG pathways |
4510: Focal adhesion 4512: ECM-receptor interaction 4514: Cell adhesion molecules (CAMs) 4640: Hematopoietic cell lineage 4670: Leukocyte transendothelial migration 4672: Intestinal immune network for IgA production 4810: Regulation of actin cytoskeleton 5140: Leishmaniasis 5410: Hypertrophic cardiomyopathy (HCM) 5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5414: Dilated cardiomyopathy |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 1281143 | VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. | no | no |
| 12616540 | Alpha 4 integrin increases anoikis of human osteosarcoma cells. | yes | no |
| title | all | all |