General Information
Gene ID | 4853 |
---|---|
Gene Symbol | NOTCH2 |
Gene Name | notch 2 |
Gene Type | protein-coding |
Cytoband | 1p13-p11 |
Ensembl ID | ENSG00000134250 ENSG00000266766 |
#miR regulators | 29 |
Omim ID | 102500 600275 610205 |
Gene ontology |
GO:0016049: cell growth GO:0001701: in utero embryonic development GO:0001709: cell fate determination GO:0002011: morphogenesis of an epithelial sheet GO:0002437: inflammatory response to antigenic stimulus GO:0003184: pulmonary valve morphogenesis GO:0006355: regulation of transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0006959: humoral immune response GO:0007050: cell cycle arrest GO:0007219: Notch signaling pathway GO:0007220: Notch receptor processing GO:0007275: multicellular organismal development GO:0007368: determination of left/right symmetry GO:0009887: organ morphogenesis GO:0007399: nervous system development GO:0043066: negative regulation of apoptotic process GO:0008285: negative regulation of cell proliferation GO:0010467: gene expression GO:0019827: stem cell maintenance GO:0030097: hemopoiesis GO:0030326: embryonic limb morphogenesis GO:0046579: positive regulation of Ras protein signal transduction GO:0046849: bone remodeling GO:0060413: atrial septum morphogenesis GO:0060674: placenta blood vessel development GO:0061314: Notch signaling involved in heart development GO:0072602: interleukin-4 secretion GO:0005886: plasma membrane GO:0000139: Golgi membrane GO:0005576: extracellular region GO:0005887: integral to plasma membrane GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005789: endoplasmic reticulum membrane GO:0009986: cell surface GO:0005515: protein binding GO:0005509: calcium ion binding GO:0004872: receptor activity |
KEGG pathways |
4320: Dorso-ventral axis formation 4330: Notch signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
18483362 | Critical role of notch signaling in osteosarcoma invasion and metastasis. | yes | yes |
19455146 | Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. | no | no |
20213410 | How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. | no | yes |
title | all | all |