Results for NOTCH2

General Information

Gene ID 4853
Gene Symbol NOTCH2
Gene Name notch 2
Gene Type protein-coding
Cytoband 1p13-p11
Ensembl ID ENSG00000134250 ENSG00000266766
#miR regulators 29
Omim ID 102500 600275 610205
Gene ontology GO:0016049: cell growth
GO:0001701: in utero embryonic development
GO:0001709: cell fate determination
GO:0002011: morphogenesis of an epithelial sheet
GO:0002437: inflammatory response to antigenic stimulus
GO:0003184: pulmonary valve morphogenesis
GO:0006355: regulation of transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0006959: humoral immune response
GO:0007050: cell cycle arrest
GO:0007219: Notch signaling pathway
GO:0007220: Notch receptor processing
GO:0007275: multicellular organismal development
GO:0007368: determination of left/right symmetry
GO:0009887: organ morphogenesis
GO:0007399: nervous system development
GO:0043066: negative regulation of apoptotic process
GO:0008285: negative regulation of cell proliferation
GO:0010467: gene expression
GO:0019827: stem cell maintenance
GO:0030097: hemopoiesis
GO:0030326: embryonic limb morphogenesis
GO:0046579: positive regulation of Ras protein signal transduction
GO:0046849: bone remodeling
GO:0060413: atrial septum morphogenesis
GO:0060674: placenta blood vessel development
GO:0061314: Notch signaling involved in heart development
GO:0072602: interleukin-4 secretion
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005789: endoplasmic reticulum membrane
GO:0009986: cell surface
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0004872: receptor activity
KEGG pathways 4320: Dorso-ventral axis formation
4330: Notch signaling pathway

PubMed abstracts associated with NOTCH2

PMID Title Tumor Value
18483362 Critical role of notch signaling in osteosarcoma invasion and metastasis. yes yes
19455146 Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. no no
20213410 How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. no yes
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