Results for PCNA

General Information

Gene ID 5111
Gene Symbol PCNA
Gene Name proliferating cell nuclear antigen
Gene Type protein-coding
Cytoband 20pter-p12
Ensembl ID ENSG00000132646
#miR regulators ---
Omim ID 176740
Gene ontology GO:0006260: DNA replication
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0000722: telomere maintenance via recombination
GO:0000723: telomere maintenance
GO:0006271: DNA strand elongation involved in DNA replication
GO:0006275: regulation of DNA replication
GO:0006281: DNA repair
GO:0006283: transcription-coupled nucleotide-excision repair
GO:0006284: base-excision repair
GO:0006289: nucleotide-excision repair
GO:0006297: nucleotide-excision repair, DNA gap filling
GO:0006298: mismatch repair
GO:0007507: heart development
GO:0008283: cell proliferation
GO:0046686: response to cadmium ion
GO:0048015: phosphatidylinositol-mediated signaling
GO:0019985: translesion synthesis
GO:0032077: positive regulation of deoxyribonuclease activity
GO:0032201: telomere maintenance via semi-conservative replication
GO:0033993: response to lipid
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005663: DNA replication factor C complex
GO:0043626: PCNA complex
GO:0015630: microtubule cytoskeleton
GO:0043596: nuclear replication fork
GO:0070557: PCNA-p21 complex
GO:0005515: protein binding
GO:0000701: purine-specific mismatch base pair DNA N-glycosylase activity
GO:0030971: receptor tyrosine kinase binding
GO:0042802: identical protein binding
GO:0030337: DNA polymerase processivity factor activity
GO:0032139: dinucleotide insertion or deletion binding
GO:0032405: MutLalpha complex binding
KEGG pathways 3030: DNA replication
3410: Base excision repair
3420: Nucleotide excision repair
3430: Mismatch repair
4110: Cell cycle

PubMed abstracts associated with PCNA

PMID Title Tumor Value
7518993 Periosteal osteosarcoma and parosteal chondrosarcoma evaluated by double immunohistochemical staining. Report of 2 cases. yes no
7612954 The identity of proliferating cells in bone tumors with cartilaginous components: evaluation by double-immunohistochemical staining using proliferating cell nuclear antigen and S-100 protein. yes no
7912239 Existence of lipoprotein lipase in human sarcomas and carcinomas. no no
8670156 Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. no no
8750062 Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. yes no
8922947 Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. yes yes
9167046 Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. yes no
12747978 Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. yes no
12943619 Telomerase, p53 and PCNA activity in osteosarcoma. yes yes
14557934 Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions. yes no
14559221 E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. no no
15144225 Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. no no
16705726 Expression of survivin and correlation with PCNA in osteosarcoma. yes yes
17234543 Low-grade central osteosarcoma of the mandible: a case study report. yes no
20357441 Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. no no
22743617 STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. no no
22922684 The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. yes no
23208072 Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. no no
22849560 Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. no no
23879172 FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. no no
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