General Information
Gene ID | 5111 |
---|---|
Gene Symbol | PCNA |
Gene Name | proliferating cell nuclear antigen |
Gene Type | protein-coding |
Cytoband | 20pter-p12 |
Ensembl ID | ENSG00000132646 |
#miR regulators | --- |
Omim ID | 176740 |
Gene ontology |
GO:0006260: DNA replication GO:0000082: G1/S transition of mitotic cell cycle GO:0000083: regulation of transcription involved in G1/S phase of mitotic cell cycle GO:0000278: mitotic cell cycle GO:0000722: telomere maintenance via recombination GO:0000723: telomere maintenance GO:0006271: DNA strand elongation involved in DNA replication GO:0006275: regulation of DNA replication GO:0006281: DNA repair GO:0006283: transcription-coupled nucleotide-excision repair GO:0006284: base-excision repair GO:0006289: nucleotide-excision repair GO:0006297: nucleotide-excision repair, DNA gap filling GO:0006298: mismatch repair GO:0007507: heart development GO:0008283: cell proliferation GO:0046686: response to cadmium ion GO:0048015: phosphatidylinositol-mediated signaling GO:0019985: translesion synthesis GO:0032077: positive regulation of deoxyribonuclease activity GO:0032201: telomere maintenance via semi-conservative replication GO:0033993: response to lipid GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005663: DNA replication factor C complex GO:0043626: PCNA complex GO:0015630: microtubule cytoskeleton GO:0043596: nuclear replication fork GO:0070557: PCNA-p21 complex GO:0005515: protein binding GO:0000701: purine-specific mismatch base pair DNA N-glycosylase activity GO:0030971: receptor tyrosine kinase binding GO:0042802: identical protein binding GO:0030337: DNA polymerase processivity factor activity GO:0032139: dinucleotide insertion or deletion binding GO:0032405: MutLalpha complex binding |
KEGG pathways |
3030: DNA replication 3410: Base excision repair 3420: Nucleotide excision repair 3430: Mismatch repair 4110: Cell cycle |
PMID | Title | Tumor | Value |
---|---|---|---|
7518993 | Periosteal osteosarcoma and parosteal chondrosarcoma evaluated by double immunohistochemical staining. Report of 2 cases. | yes | no |
7612954 | The identity of proliferating cells in bone tumors with cartilaginous components: evaluation by double-immunohistochemical staining using proliferating cell nuclear antigen and S-100 protein. | yes | no |
7912239 | Existence of lipoprotein lipase in human sarcomas and carcinomas. | no | no |
8670156 | Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. | no | no |
8750062 | Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. | yes | no |
8922947 | Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. | yes | yes |
9167046 | Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. | yes | no |
12747978 | Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. | yes | no |
12943619 | Telomerase, p53 and PCNA activity in osteosarcoma. | yes | yes |
14557934 | Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions. | yes | no |
14559221 | E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. | no | no |
15144225 | Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. | no | no |
16705726 | Expression of survivin and correlation with PCNA in osteosarcoma. | yes | yes |
17234543 | Low-grade central osteosarcoma of the mandible: a case study report. | yes | no |
20357441 | Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. | no | no |
22743617 | STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. | no | no |
22922684 | The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. | yes | no |
23208072 | Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. | no | no |
22849560 | Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. | no | no |
23879172 | FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. | no | no |
title | all | all |