General Information
| Gene ID | 5142 |
|---|---|
| Gene Symbol | PDE4B |
| Gene Name | phosphodiesterase 4B, cAMP-specific |
| Gene Type | protein-coding |
| Cytoband | 1p31 |
| Ensembl ID | ENSG00000184588 |
| #miR regulators | 12 |
| Omim ID | 600127 |
| Gene ontology |
GO:0001780: neutrophil homeostasis GO:0006198: cAMP catabolic process GO:0050852: T cell receptor signaling pathway GO:0030593: neutrophil chemotaxis GO:0032729: positive regulation of interferon-gamma production GO:0032743: positive regulation of interleukin-2 production GO:0035690: cellular response to drug GO:0050900: leukocyte migration GO:0071222: cellular response to lipopolysaccharide GO:0071872: cellular response to epinephrine stimulus GO:0086004: regulation of cardiac muscle cell contraction GO:1901841: regulation of high voltage-gated calcium channel activity GO:1901898: negative regulation of relaxation of cardiac muscle GO:0005829: cytosol GO:0005634: nucleus GO:0005891: voltage-gated calcium channel complex GO:0030018: Z disc GO:0048471: perinuclear region of cytoplasm GO:0004114: 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004115: 3',5'-cyclic-AMP phosphodiesterase activity GO:0046872: metal ion binding GO:0030552: cAMP binding GO:0044325: ion channel binding |
| KEGG pathways |
230: Purine metabolism |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 12782945 | Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. | no | no |
| 15627479 | Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. | no | no |
| 16010295 | Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation. | no | no |
| title | all | all |