Results for PDE4B

General Information

Gene ID 5142
Gene Symbol PDE4B
Gene Name phosphodiesterase 4B, cAMP-specific
Gene Type protein-coding
Cytoband 1p31
Ensembl ID ENSG00000184588
#miR regulators 12
Omim ID 600127
Gene ontology GO:0001780: neutrophil homeostasis
GO:0006198: cAMP catabolic process
GO:0050852: T cell receptor signaling pathway
GO:0030593: neutrophil chemotaxis
GO:0032729: positive regulation of interferon-gamma production
GO:0032743: positive regulation of interleukin-2 production
GO:0035690: cellular response to drug
GO:0050900: leukocyte migration
GO:0071222: cellular response to lipopolysaccharide
GO:0071872: cellular response to epinephrine stimulus
GO:0086004: regulation of cardiac muscle cell contraction
GO:1901841: regulation of high voltage-gated calcium channel activity
GO:1901898: negative regulation of relaxation of cardiac muscle
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005891: voltage-gated calcium channel complex
GO:0030018: Z disc
GO:0048471: perinuclear region of cytoplasm
GO:0004114: 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115: 3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872: metal ion binding
GO:0030552: cAMP binding
GO:0044325: ion channel binding
KEGG pathways 230: Purine metabolism

PubMed abstracts associated with PDE4B

PMID Title Tumor Value
12782945 Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. no no
15627479 Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. no no
16010295 Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation. no no
title all all