General Information
| Gene ID | 51741 |
|---|---|
| Gene Symbol | WWOX |
| Gene Name | WW domain containing oxidoreductase |
| Gene Type | protein-coding |
| Cytoband | 16q23.3-q24.1 |
| Ensembl ID | ENSG00000186153 |
| #miR regulators | 5 |
| Omim ID | 133239 605131 |
| Gene ontology |
GO:0001649: osteoblast differentiation GO:0006915: apoptotic process GO:0016055: Wnt receptor signaling pathway GO:0055114: oxidation-reduction process GO:0008202: steroid metabolic process GO:0030178: negative regulation of Wnt receptor signaling pathway GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048705: skeletal system morphogenesis GO:0071560: cellular response to transforming growth factor beta stimulus GO:2001238: positive regulation of extrinsic apoptotic signaling pathway GO:0005886: plasma membrane GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005794: Golgi apparatus GO:0005902: microvillus GO:0005515: protein binding GO:0016491: oxidoreductase activity GO:0046983: protein dimerization activity GO:0019899: enzyme binding GO:0048037: cofactor binding GO:0050662: coenzyme binding |
| KEGG pathways | --- |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 19896763 | Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. | yes | no |
| 21165567 | Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws. | yes | no |
| title | all | all |