Results for TGFB2

General Information

Gene ID 7042
Gene Symbol TGFB2
Gene Name transforming growth factor, beta 2
Gene Type protein-coding
Cytoband 1q41
Ensembl ID ENSG00000092969
#miR regulators 19
Omim ID 190220 614816
Gene ontology GO:0000902: cell morphogenesis
GO:0001502: cartilage condensation
GO:0001525: angiogenesis
GO:0016049: cell growth
GO:0001654: eye development
GO:0001666: response to hypoxia
GO:0001837: epithelial to mesenchymal transition
GO:0001942: hair follicle development
GO:0001974: blood vessel remodeling
GO:0002576: platelet degranulation
GO:0003007: heart morphogenesis
GO:0007596: blood coagulation
GO:0006468: protein phosphorylation
GO:0006924: activation-induced cell death of T cells
GO:0007050: cell cycle arrest
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0007184: SMAD protein import into nucleus
GO:0007267: cell-cell signaling
GO:0009790: embryo development
GO:0007411: axon guidance
GO:0007435: salivary gland morphogenesis
GO:0007507: heart development
GO:0008219: cell death
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008347: glial cell migration
GO:0042493: response to drug
GO:0009611: response to wounding
GO:0010002: cardioblast differentiation
GO:0010628: positive regulation of gene expression
GO:0010634: positive regulation of epithelial cell migration
GO:0010693: negative regulation of alkaline phosphatase activity
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010936: negative regulation of macrophage cytokine production
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0016477: cell migration
GO:0022601: menstrual cycle phase
GO:0023014: signal transduction by phosphorylation
GO:0030097: hemopoiesis
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030199: collagen fibril organization
GO:0030307: positive regulation of cell growth
GO:0030308: negative regulation of cell growth
GO:0030593: neutrophil chemotaxis
GO:0031069: hair follicle morphogenesis
GO:0032147: activation of protein kinase activity
GO:0032570: response to progesterone stimulus
GO:0032874: positive regulation of stress-activated MAPK cascade
GO:0032909: regulation of transforming growth factor beta2 production
GO:0033630: positive regulation of cell adhesion mediated by integrin
GO:0042060: wound healing
GO:0042416: dopamine biosynthetic process
GO:0042476: odontogenesis
GO:0042637: catagen
GO:0043525: positive regulation of neuron apoptotic process
GO:0045216: cell-cell junction organization
GO:0045726: positive regulation of integrin biosynthetic process
GO:0045778: positive regulation of ossification
GO:0045787: positive regulation of cell cycle
GO:0045823: positive regulation of heart contraction
GO:0048103: somatic stem cell division
GO:0048566: embryonic digestive tract development
GO:0048663: neuron fate commitment
GO:0048666: neuron development
GO:0048699: generation of neurons
GO:0050680: negative regulation of epithelial cell proliferation
GO:0050714: positive regulation of protein secretion
GO:0050777: negative regulation of immune response
GO:0050778: positive regulation of immune response
GO:0051781: positive regulation of cell division
GO:0051795: positive regulation of catagen
GO:0051891: positive regulation of cardioblast differentiation
GO:0060038: cardiac muscle cell proliferation
GO:0060317: cardiac epithelial to mesenchymal transition
GO:0060325: face morphogenesis
GO:0060389: pathway-restricted SMAD protein phosphorylation
GO:0097191: extrinsic apoptotic signaling pathway
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0030424: axon
GO:0031012: extracellular matrix
GO:0031093: platelet alpha granule lumen
GO:0043025: neuronal cell body
GO:0005515: protein binding
GO:0001540: beta-amyloid binding
GO:0005102: receptor binding
GO:0004702: receptor signaling protein serine/threonine kinase activity
GO:0005114: type II transforming growth factor beta receptor binding
GO:0005125: cytokine activity
GO:0005160: transforming growth factor beta receptor binding
GO:0008083: growth factor activity
GO:0042803: protein homodimerization activity
GO:0046982: protein heterodimerization activity
KEGG pathways 4010: MAPK signaling pathway
4060: Cytokine-cytokine receptor interaction
4110: Cell cycle
4144: Endocytosis
4350: TGF-beta signaling pathway
4380: Osteoclast differentiation
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5144: Malaria
5145: Toxoplasmosis
5146: Amoebiasis
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5220: Chronic myeloid leukemia
5323: Rheumatoid arthritis
5410: Hypertrophic cardiomyopathy (HCM)
5414: Dilated cardiomyopathy

PubMed abstracts associated with TGFB2

PMID Title Tumor Value
8050825 Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. no no
9771482 Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. yes no
16540432 Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. no no
21421073 Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity. no no
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