Results for TNFSF11

General Information

Gene ID 8600
Gene Symbol TNFSF11
Gene Name tumor necrosis factor (ligand) superfamily, member 11
Gene Type protein-coding
Cytoband 13q14
Ensembl ID ENSG00000120659
#miR regulators 12
Omim ID 259710 602642
Gene ontology GO:0001503: ossification
GO:0002158: osteoclast proliferation
GO:0002548: monocyte chemotaxis
GO:0006955: immune response
GO:0007257: activation of JUN kinase activity
GO:0009887: organ morphogenesis
GO:0010740: positive regulation of intracellular protein kinase cascade
GO:0019221: cytokine-mediated signaling pathway
GO:0030316: osteoclast differentiation
GO:0033209: tumor necrosis factor-mediated signaling pathway
GO:0033598: mammary gland epithelial cell proliferation
GO:0034112: positive regulation of homotypic cell-cell adhesion
GO:0051260: protein homooligomerization
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043406: positive regulation of MAP kinase activity
GO:0045453: bone resorption
GO:0045672: positive regulation of osteoclast differentiation
GO:0045780: positive regulation of bone resorption
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046330: positive regulation of JNK cascade
GO:0050870: positive regulation of T cell activation
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051466: positive regulation of corticotropin-releasing hormone secretion
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0055074: calcium ion homeostasis
GO:0060749: mammary gland alveolus development
GO:0070371: ERK1 and ERK2 cascade
GO:0071812: positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847: TNFSF11-mediated signaling pathway
GO:0071848: positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005615: extracellular space
GO:0005737: cytoplasm
GO:0005125: cytokine activity
GO:0005164: tumor necrosis factor receptor binding
GO:0032813: tumor necrosis factor receptor superfamily binding
KEGG pathways 4060: Cytokine-cytokine receptor interaction
4380: Osteoclast differentiation
5323: Rheumatoid arthritis

PubMed abstracts associated with TNFSF11

PMID Title Tumor Value
11071251 Osteoclast differentiation factor in human osteosarcoma cell line. no no
15313187 Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts. no no
16533764 Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. no no
17323424 Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. no no
17645699 Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. yes no
17982618 Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. no no
17987039 A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. yes yes
20955951 Markers of bone remodeling in neoplastic and bone-related lesions. yes no
21370405 RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. yes yes
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