Results for AIFM1

General Information

Gene ID 9131
Gene Symbol AIFM1
Gene Name apoptosis-inducing factor, mitochondrion-associated, 1
Gene Type protein-coding
Cytoband Xq26.1
Ensembl ID ENSG00000156709
#miR regulators 1
Omim ID 300169 300816 310490
Gene ontology GO:0006915: apoptotic process
GO:0045454: cell redox homeostasis
GO:0006309: apoptotic DNA fragmentation
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030182: neuron differentiation
GO:0032981: mitochondrial respiratory chain complex I assembly
GO:0051402: neuron apoptotic process
GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005743: mitochondrial inner membrane
GO:0005758: mitochondrial intermembrane space
GO:0048471: perinuclear region of cytoplasm
GO:0009055: electron carrier activity
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0016651: oxidoreductase activity, acting on NAD(P)H
GO:0050660: flavin adenine dinucleotide binding
KEGG pathways 4210: Apoptosis

PubMed abstracts associated with AIFM1

PMID Title Tumor Value
17356895 Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. no no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
22688575 Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. no no
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