General Information
| Gene ID | 9131 |
|---|---|
| Gene Symbol | AIFM1 |
| Gene Name | apoptosis-inducing factor, mitochondrion-associated, 1 |
| Gene Type | protein-coding |
| Cytoband | Xq26.1 |
| Ensembl ID | ENSG00000156709 |
| #miR regulators | 1 |
| Omim ID | 300169 300816 310490 |
| Gene ontology |
GO:0006915: apoptotic process GO:0045454: cell redox homeostasis GO:0006309: apoptotic DNA fragmentation GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0030182: neuron differentiation GO:0032981: mitochondrial respiratory chain complex I assembly GO:0051402: neuron apoptotic process GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0005739: mitochondrion GO:0005829: cytosol GO:0005634: nucleus GO:0005743: mitochondrial inner membrane GO:0005758: mitochondrial intermembrane space GO:0048471: perinuclear region of cytoplasm GO:0009055: electron carrier activity GO:0005515: protein binding GO:0003677: DNA binding GO:0016651: oxidoreductase activity, acting on NAD(P)H GO:0050660: flavin adenine dinucleotide binding |
| KEGG pathways |
4210: Apoptosis |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 17356895 | Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. | no | no |
| 21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
| 22688575 | Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. | no | no |
| title | all | all |