| 292511 |
Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. |
yes |
yes |
1 |
| 1065468 |
Ceruloplasmin levels in sera from human patients with osteosarcoma. |
yes |
yes |
1 |
| 1281143 |
VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. |
no |
no |
2 |
| 1315190 |
Regulation of C-myc protooncogene expression in osteoblastic cells by arachidonic acid metabolites: relationship to proliferation. |
no |
no |
1 |
| 1316174 |
Differential migratory response of U-2 OS osteosarcoma cell to the various forms of platelet-derived growth factor. |
no |
no |
2 |
| 1320449 |
Immunohistochemical study of bone GLA protein in primary bone tumors. |
yes |
yes |
1 |
| 1349175 |
Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma. |
yes |
no |
1 |
| 1358045 |
Overexpression of the c-erbB-2 oncogene in sarcomas and small round-cell tumors of childhood. An immunohistochemical investigation. |
yes |
no |
1 |
| 1388095 |
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. |
no |
no |
3 |
| 1416076 |
Fetal antigen 2 (FA2) in human fetal osteoblasts, cultured osteoblasts and osteogenic osteosarcoma cells. |
no |
no |
1 |
| 1423262 |
Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. |
yes |
no |
1 |
| 1423318 |
Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. |
yes |
no |
2 |
| 1447251 |
A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. |
yes |
no |
1 |
| 1459694 |
Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. |
no |
no |
3 |
| 1468768 |
Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors. |
yes |
yes |
1 |
| 1481722 |
The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. |
no |
no |
4 |
| 1499384 |
The prognostic value of serum alkaline phosphatase in osteosarcoma of the limbs. |
yes |
yes |
1 |
| 1520309 |
Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth. |
no |
no |
1 |
| 1524989 |
Studies of the RB1 gene and the p53 gene in human osteosarcomas. |
yes |
no |
2 |
| 1525710 |
A phorbol ester induces secretion of alkaline phosphatase activity in human osteosarcoma cells. |
no |
no |
1 |
| 1568211 |
Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. |
yes |
no |
2 |
| 1571831 |
Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells. |
no |
no |
3 |
| 1586971 |
Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. |
no |
no |
4 |
| 1622861 |
Osteonectin in osteosarcomas: a marker for differential diagnosis and/or prognosis? |
yes |
no |
1 |
| 1657330 |
Hormonal regulation of vitamin D receptor levels and osteocalcin synthesis in human osteosarcoma cells. |
no |
no |
2 |
| 1698437 |
Homozygous deletion within the retinoblastoma gene in a native osteosarcoma specimen of a patient cured of a retinoblastoma of both eyes. |
yes |
no |
1 |
| 1726835 |
Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system. |
no |
no |
1 |
| 1846564 |
Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. |
no |
no |
3 |
| 1864588 |
Immunophenotypic heterogeneity in osteosarcomas. |
yes |
yes |
3 |
| 1867319 |
Immunohistochemical analysis of neural cell adhesion molecules. Differential expression in small round cell tumors of childhood and adolescence. |
yes |
no |
1 |
| 1884549 |
Involvement of the retinoblastoma gene in primary osteosarcomas and other bone and soft-tissue tumors. |
yes |
no |
1 |
| 1932372 |
Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. |
no |
no |
3 |
| 1988704 |
Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. |
yes |
no |
1 |
| 2036639 |
Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma. |
yes |
no |
1 |
| 2069168 |
The effect of rhGM-CSF on the proliferation of osteogenic sarcoma cells. |
no |
no |
1 |
| 2115647 |
The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas. |
yes |
no |
1 |
| 2143022 |
Mechanisms of p53 loss in human sarcomas. |
yes |
no |
1 |
| 2153840 |
Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma. |
no |
no |
2 |
| 2156959 |
Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. |
no |
no |
3 |
| 2166171 |
Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. |
no |
no |
1 |
| 2169996 |
Expression of Ki-1 antigen (CD30) in mesenchymal tumors. |
yes |
no |
1 |
| 2233717 |
p53 functions as a cell cycle control protein in osteosarcomas. |
no |
no |
1 |
| 2253237 |
Frequency and structure of p53 rearrangements in human osteosarcoma. |
yes |
no |
1 |
| 2274789 |
Genetic mechanisms of tumor suppression by the human p53 gene. |
no |
no |
1 |
| 2287591 |
The impact of osteonectin for differential diagnosis of bone tumors. An immunohistochemical approach. |
yes |
no |
1 |
| 2298248 |
Expression of transferrin and vitamin D-binding protein genes in an osteogenic sarcoma cell line. |
no |
no |
2 |
| 2443508 |
Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. |
no |
no |
1 |
| 2450880 |
Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA. |
no |
no |
2 |
| 2488230 |
Genetic analysis of childhood sarcoma. |
yes |
no |
1 |
| 2496060 |
Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma. |
yes |
no |
2 |
| 2496522 |
Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies. |
yes |
yes |
1 |
| 2521862 |
Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. |
no |
no |
4 |
| 2531855 |
Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line. |
no |
no |
2 |
| 2541615 |
Expression of the common acute lymphoblastic leukemia antigen (CD10) in mesenchymal tumors. |
yes |
yes |
1 |
| 2600089 |
Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. |
no |
no |
4 |
| 2630171 |
The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. |
no |
no |
2 |
| 2659348 |
Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion. |
no |
no |
1 |
| 2740144 |
Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas. |
yes |
no |
1 |
| 2755701 |
Studies of the retinoblastoma gene in human sarcomas. |
yes |
no |
1 |
| 2776495 |
Immunohistological demonstration of osteonectin in normal bone tissue and in bone tumors. |
yes |
yes |
1 |
| 2786815 |
Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. |
no |
no |
3 |
| 2878716 |
Chromosome 13 instability and esterase D expression in an osteosarcoma cell line. |
no |
no |
2 |
| 2898286 |
Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. |
yes |
no |
1 |
| 2918936 |
Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. |
yes |
no |
1 |
| 2978869 |
Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line. |
no |
no |
2 |
| 3057504 |
Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. |
no |
no |
1 |
| 3162593 |
Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. |
yes |
no |
1 |
| 3165250 |
Immunohistochemical study of osteonectin in various types of osteosarcoma. |
yes |
yes |
1 |
| 3166362 |
Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin. |
no |
no |
1 |
| 3477902 |
Prognostic value of serum alkaline phosphatase in osteosarcoma. |
yes |
yes |
2 |
| 3479235 |
Events on different chromosomes alter the genes for the two peptides of platelet-derived growth factor in an osteogenic sarcoma. |
yes |
no |
2 |
| 6297258 |
Enzyme histochemical study on bone tumors. |
yes |
no |
2 |
| 6930152 |
Correlation between prognostic factors and blood variables in osteosarcoma. |
yes |
no |
2 |
| 7473836 |
Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. |
no |
no |
2 |
| 7477118 |
Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. |
yes |
yes |
1 |
| 7502710 |
Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. |
no |
no |
5 |
| 7506120 |
Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. |
yes |
no |
2 |
| 7513549 |
Chromosome analysis of nine osteosarcomas. |
yes |
no |
2 |
| 7518993 |
Periosteal osteosarcoma and parosteal chondrosarcoma evaluated by double immunohistochemical staining. Report of 2 cases. |
yes |
no |
1 |
| 7528503 |
Quantitative RT-PCR assay detecting the transcriptional induction of vascular endothelial growth factor under hypoxia. |
no |
no |
1 |
| 7531202 |
Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican. |
no |
no |
1 |
| 7541624 |
The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells. |
no |
no |
1 |
| 7559091 |
Changes in radiation sensitivity of human osteosarcoma cells after p53 introduction. |
no |
no |
1 |
| 7576109 |
Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. |
no |
no |
6 |
| 7585551 |
Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain. |
no |
no |
1 |
| 7585620 |
Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. |
no |
no |
3 |
| 7591308 |
MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. |
yes |
yes |
1 |
| 7593131 |
Immunohistochemical analysis of nm23 protein expression in malignant bone tumors. |
yes |
yes |
1 |
| 7607566 |
Characterization of two splice variants of metastasis-associated human mts1 gene. |
no |
no |
1 |
| 7612954 |
The identity of proliferating cells in bone tumors with cartilaginous components: evaluation by double-immunohistochemical staining using proliferating cell nuclear antigen and S-100 protein. |
yes |
no |
1 |
| 7614454 |
Complex replication error causes p53 mutation in a Li-Fraumeni family. |
yes |
no |
1 |
| 7621257 |
Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. |
no |
no |
1 |
| 7639117 |
IGF-II receptor number is increased in TE-85 osteosarcoma cells by combined magnetic fields. |
no |
no |
1 |
| 7640224 |
Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. |
yes |
no |
3 |
| 7641470 |
The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. |
no |
no |
8 |
| 7660382 |
Expression of the human multidrug resistance gene (MDR1) and prognostic correlation in human osteogenic sarcoma. |
yes |
yes |
1 |
| 7684391 |
Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. |
no |
no |
2 |
| 7685168 |
Reverse transcription-polymerase chain reaction assay demonstrates that the 9-cis retinoic acid receptor alpha is expressed in human osteoblasts. |
no |
no |
1 |
| 7693339 |
Met expression and sarcoma tumorigenicity. |
yes |
no |
2 |
| 7705958 |
A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. |
no |
no |
2 |
| 7735558 |
Correlation of p-glycoprotein detection by immunohistochemistry with mdr-1 mRNA levels in osteosarcomas. Pilot study. |
yes |
no |
1 |
| 7768643 |
Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. |
no |
no |
2 |
| 7789337 |
Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures. |
no |
no |
1 |
| 7794813 |
Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. |
no |
no |
6 |
| 7802648 |
Steroid hormone modulation of vitamin D receptor levels in human MG-63 osteosarcoma cells. |
no |
no |
1 |
| 7817811 |
Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. |
no |
no |
3 |
| 7826985 |
Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. |
yes |
no |
1 |
| 7828148 |
The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. |
yes |
no |
3 |
| 7833115 |
Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs. |
yes |
no |
1 |
| 7835281 |
Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. |
no |
no |
3 |
| 7850751 |
Mutational activation of ras genes is absent in pediatric osteosarcoma. |
yes |
no |
3 |
| 7859736 |
Inhibition of apoptosis by the retinoblastoma gene product. |
no |
no |
2 |
| 7862451 |
The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. |
yes |
no |
2 |
| 7904171 |
Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. |
yes |
no |
1 |
| 7911380 |
Rapid detection of loss of heterozygosity of chromosome 17p by polymerase chain reaction-based variable number of tandem repeat analysis and detection of single-strand conformation polymorphism of intragenic p53 polymorphisms. |
yes |
no |
1 |
| 7912235 |
Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. |
no |
no |
2 |
| 7912239 |
Existence of lipoprotein lipase in human sarcomas and carcinomas. |
no |
no |
2 |
| 7926730 |
The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. |
no |
no |
2 |
| 7983504 |
Prognostic significance of serum lactate dehydrogenase in patients with osteosarcoma of the extremities. |
yes |
yes |
1 |
| 8003023 |
Human and rat osteoblast-like cells express stathmin, a growth-regulatory protein. |
no |
no |
1 |
| 8032535 |
Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line. |
no |
no |
2 |
| 8033827 |
Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. |
no |
no |
1 |
| 8034301 |
Single base pair germ-line deletion in the p53 gene in a cancer predisposed family. |
yes |
no |
1 |
| 8039112 |
Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. |
yes |
no |
2 |
| 8050825 |
Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. |
no |
no |
2 |
| 8052269 |
Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. |
no |
no |
5 |
| 8058007 |
Secondary breast cancer in patients presenting with osteosarcoma: possible involvement of germline p53 mutations. |
yes |
no |
1 |
| 8064888 |
MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. |
yes |
no |
2 |
| 8080687 |
Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines. |
no |
no |
1 |
| 8099316 |
Overexpression of c-fos increases recombination frequency in human osteosarcoma cells. |
no |
no |
1 |
| 8117620 |
Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. |
yes |
no |
5 |
| 8123038 |
Vinblastine-dependent down-modulation of TNF receptors in human osteosarcoma cells is mediated by protein kinase C activity. |
no |
no |
2 |
| 8159609 |
Extracellular matrix of small round cell tumors of childhood: an immunohistochemical study of 67 cases. |
yes |
yes |
1 |
| 8164043 |
Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma. |
yes |
no |
1 |
| 8166715 |
Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. |
no |
no |
2 |
| 8168113 |
Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. |
no |
no |
2 |
| 8187094 |
Mutation spectrum of the retinoblastoma gene in osteosarcomas. |
yes |
yes |
1 |
| 8208533 |
Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53. |
no |
no |
1 |
| 8217129 |
An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma. |
yes |
no |
1 |
| 8226793 |
FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. |
no |
no |
2 |
| 8260365 |
p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas. |
yes |
no |
1 |
| 8276785 |
Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. |
no |
no |
3 |
| 8281940 |
Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. |
no |
no |
4 |
| 8287230 |
Sporadic amplification of the MYC gene in human osteosarcomas. |
yes |
no |
1 |
| 8288590 |
Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. |
no |
no |
3 |
| 8374897 |
Deletion of chromosome 13 in osteosarcoma secondary to irradiation. |
yes |
no |
1 |
| 8391387 |
Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. |
no |
no |
2 |
| 8401536 |
Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE). |
yes |
no |
1 |
| 8402575 |
Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells. |
no |
no |
1 |
| 8416741 |
MDM2 gene amplification in metastatic osteosarcoma. |
yes |
yes |
1 |
| 8418091 |
Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. |
yes |
no |
1 |
| 8425179 |
p53 abnormalities in different subtypes of human sarcomas. |
yes |
no |
1 |
| 8435797 |
Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy. |
yes |
yes |
1 |
| 8479749 |
Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings. |
yes |
no |
1 |
| 8507187 |
Translocation of retinoblastoma protein associated with tumor cell growth inhibition. |
no |
no |
1 |
| 8513277 |
Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors. |
yes |
yes |
2 |
| 8519637 |
p53 codon 213 (A-G) polymorphism in a Turkish population. |
yes |
no |
1 |
| 8550801 |
1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentiation and growth arrest in a human osteosarcoma cell line. |
no |
no |
2 |
| 8562155 |
Analysis of P-glycoprotein expression in osteosarcoma. |
yes |
yes |
1 |
| 8603340 |
Alterations of the p15, p16,and p18 genes in osteosarcoma. |
yes |
no |
2 |
| 8616838 |
Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. |
no |
no |
4 |
| 8625324 |
Multidrug resistance and malignancy in human osteosarcoma. |
yes |
no |
1 |
| 8630943 |
ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. |
yes |
yes |
1 |
| 8636759 |
Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. |
yes |
yes |
1 |
| 8662647 |
Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. |
no |
no |
3 |
| 8670156 |
Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. |
no |
no |
3 |
| 8692530 |
Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma. |
yes |
yes |
1 |
| 8703379 |
Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma--a case report. |
yes |
no |
1 |
| 8717113 |
The impact of osteonectin for differential diagnosis of osteogenic bone tumors: an immunohistochemical and in situ hybridization approach. |
yes |
yes |
1 |
| 8717537 |
Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells. |
no |
no |
1 |
| 8726395 |
Immunohistochemical localization of the estrogen receptor in human osteoblastic SaOS-2 cells: association of receptor levels with alkaline phosphatase activity. |
no |
no |
2 |
| 8750062 |
Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. |
yes |
no |
3 |
| 8781571 |
Alterations of the p53, Rb and MDM2 genes in osteosarcoma. |
yes |
no |
3 |
| 8793483 |
Mutation spectrum of p53 gene in highly malignant human osteosarcomas. |
yes |
no |
1 |
| 8821948 |
Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas. |
yes |
no |
1 |
| 8835762 |
Enhanced expression of cathepsin L in metastatic bone tumors. |
yes |
no |
1 |
| 8840973 |
Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. |
no |
no |
1 |
| 8855972 |
Quantitative analysis of multidrug resistance gene expression in human osteosarcomas. |
yes |
yes |
1 |
| 8863670 |
Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. |
yes |
no |
2 |
| 8865368 |
Role of protein phosphatase in malignant osteogenic and soft tissue tumors. |
yes |
no |
1 |
| 8866236 |
Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas. |
yes |
no |
1 |
| 8891902 |
Oncogene alterations in primary, recurrent, and metastatic human bone tumors. |
yes |
yes |
5 |
| 8893761 |
SAS is amplified predominantly in surface osteosarcoma. |
yes |
no |
1 |
| 8908160 |
Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells. |
no |
no |
1 |
| 8922947 |
Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. |
yes |
yes |
2 |
| 8954126 |
Expression of prolactin receptors in human osteosarcoma cells. |
no |
no |
1 |
| 8959332 |
Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein. |
no |
no |
2 |
| 8968028 |
Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. |
no |
no |
1 |
| 8992882 |
Constitutive expression of non-bone/liver/kidney alkaline phosphatase in human osteosarcoma cell lines. |
no |
yes |
1 |
| 9052985 |
Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. |
no |
no |
2 |
| 9065577 |
Expression of P-glycoprotein in high grade osteosarcomas with special emphasis on chondroblastic subtype. |
yes |
yes |
1 |
| 9066537 |
Expression of MAGE genes in osteosarcoma. |
yes |
no |
2 |
| 9066701 |
Immunohistochemical detection of p53 protein overexpression in primary human osteosarcomas. |
yes |
no |
1 |
| 9069169 |
Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. |
no |
no |
4 |
| 9083931 |
Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues. |
yes |
no |
1 |
| 9100584 |
Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. |
no |
no |
3 |
| 9109391 |
Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNF alpha incubation. |
no |
no |
2 |
| 9111202 |
Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells. |
no |
no |
1 |
| 9118036 |
p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. |
yes |
yes |
2 |
| 9136982 |
Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line. |
no |
no |
2 |
| 9154817 |
Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. |
no |
no |
11 |
| 9155051 |
Frequent reduction or loss of DCC gene expression in human osteosarcoma. |
yes |
no |
1 |
| 9167046 |
Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. |
yes |
no |
5 |
| 9175647 |
Suppression of UV-induced mutations by wild-type p53 protein in human osteosarcoma cells. |
no |
no |
1 |
| 9180138 |
Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma. |
no |
no |
1 |
| 9187120 |
Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. |
no |
no |
5 |
| 9191521 |
Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. |
yes |
yes |
3 |
| 9227342 |
Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours. |
yes |
no |
2 |
| 9228255 |
P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. |
yes |
no |
1 |
| 9244358 |
The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma. |
yes |
no |
1 |
| 9252243 |
TGF-beta1 selectively suppresses PDGF receptor signaling pathways in MG-63 human osteosarcoma cell. |
no |
no |
1 |
| 9258335 |
Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. |
no |
no |
4 |
| 9267827 |
Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors. |
yes |
yes |
1 |
| 9275350 |
P53 gene abnormalities in osteosarcoma. |
yes |
no |
1 |
| 9309118 |
Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients. |
yes |
no |
2 |
| 9322601 |
Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. |
yes |
yes |
2 |
| 9355974 |
Altered G1 phase regulation in osteosarcoma. |
yes |
yes |
3 |
| 9390540 |
P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. |
yes |
yes |
1 |
| 9404699 |
Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. |
yes |
yes |
1 |
| 9416691 |
Analysis of p53 expression in osteosarcoma of the jaw: correlation with clinicopathologic and DNA ploidy findings. |
yes |
no |
1 |
| 9418642 |
Prognostic factors among 130 patients with osteosarcoma. |
yes |
yes |
1 |
| 9433149 |
Recombinant human granulocyte-macrophage colony-stimulating factor therapy and endogenous plasma GM-CSF, IL-3, IL-4 concentrations in pediatric patients with solid tumors. |
yes |
no |
1 |
| 9443071 |
Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. |
no |
no |
3 |
| 9461020 |
Reduced UV-induced mutations in human osteosarcoma cells stably expressing transfected wild-type p53 cDNA. |
no |
no |
1 |
| 9464545 |
Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. |
no |
no |
3 |
| 9480851 |
Suppression of high-density magnetic field (400 mT at 50 Hz)-induced mutations by wild-type p53 expression in human osteosarcoma cells. |
no |
no |
1 |
| 9492043 |
p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. |
no |
no |
4 |
| 9538120 |
Prognostic significance of cyclin expression in human osteosarcoma. |
yes |
yes |
4 |
| 9559293 |
Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. |
yes |
no |
3 |
| 9605020 |
Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis. |
yes |
yes |
2 |
| 9615784 |
Copper/zinc superoxide dismutase expression by different human osteosarcoma cell lines. |
no |
no |
2 |
| 9619593 |
Comparative genomic hybridization of low-grade central osteosarcoma. |
yes |
no |
3 |
| 9639407 |
Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line. |
no |
no |
1 |
| 9645345 |
Expression of the smooth muscle calponin gene in human osteosarcoma and its possible association with prognosis. |
yes |
yes |
4 |
| 9664132 |
TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. |
no |
no |
5 |
| 9665476 |
CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. |
yes |
no |
3 |
| 9672192 |
Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton. |
yes |
yes |
2 |
| 9685858 |
Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. |
yes |
yes |
5 |
| 9703873 |
Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. |
yes |
no |
1 |
| 9703945 |
Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. |
no |
no |
3 |
| 9703989 |
Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. |
no |
no |
2 |
| 9714336 |
p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. |
no |
no |
2 |
| 9717810 |
Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells. |
no |
no |
3 |
| 9723038 |
Correlation between apoptosis and TP53 status in osteosarcoma. |
yes |
no |
1 |
| 9743295 |
P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. |
yes |
no |
2 |
| 9748149 |
Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. |
no |
yes |
2 |
| 9762887 |
Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. |
yes |
no |
3 |
| 9771482 |
Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. |
yes |
no |
3 |
| 9778623 |
C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression. |
yes |
yes |
2 |
| 9781640 |
Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy. |
yes |
yes |
3 |
| 9788258 |
Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. |
yes |
no |
2 |
| 9793960 |
Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. |
yes |
yes |
2 |
| 9818023 |
Abnormalities of the FHIT transcripts in osteosarcoma and Ewing sarcoma. |
yes |
no |
1 |
| 9820862 |
Genetic instability in osteoblastic tumors of the skeletal system. |
yes |
no |
5 |
| 9824113 |
p53 gene mutations in osteosarcomas of low-grade malignancy. |
yes |
no |
1 |
| 9824653 |
A possible role for multidrug resistance-associated protein in the secretion of basic fibroblast growth factor by osteogenic sarcoma cell line (MG-63). |
no |
no |
2 |
| 9835898 |
Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma. |
yes |
no |
1 |
| 9858899 |
Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. |
no |
no |
6 |
| 9890264 |
Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. |
yes |
no |
1 |
| 9891539 |
p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. |
yes |
no |
2 |
| 9917506 |
Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. |
yes |
yes |
3 |
| 9923924 |
Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. |
yes |
yes |
2 |
| 9935160 |
Redundancy of autocrine loops in human osteosarcoma cells. |
no |
no |
2 |
| 9935200 |
CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. |
yes |
no |
5 |
| 9989824 |
The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells. |
no |
no |
1 |
| 9989829 |
Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. |
yes |
no |
3 |
| 10086509 |
Protease expression in dedifferentiated parosteal osteosarcoma. |
yes |
no |
3 |
| 10100715 |
Mechanisms of methotrexate resistance in osteosarcoma. |
yes |
no |
2 |
| 10101594 |
Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. |
yes |
no |
3 |
| 10189891 |
Frequent beta-catenin abnormalities in bone and soft-tissue tumors. |
yes |
no |
1 |
| 10232607 |
Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. |
no |
no |
5 |
| 10234573 |
ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. |
no |
no |
5 |
| 10339667 |
Expression of G1 phase regulators in MG-63 osteosarcoma cell line. |
no |
no |
8 |
| 10352100 |
Expression and localization of estrogen receptor-beta in murine and human bone. |
no |
no |
1 |
| 10375199 |
Differential regulation of syndecan expression by osteosarcoma cell lines in response to cytokines but not osteotropic hormones. |
no |
no |
3 |
| 10388536 |
Increased phosphorylation of eukaryotic initiation factor 2alpha at the G2/M boundary in human osteosarcoma cells correlates with deglycosylation of p67 and a decreased rate of protein synthesis. |
no |
no |
2 |
| 10390144 |
Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. |
no |
no |
3 |
| 10411143 |
Expression and regulation of the meprin beta gene in human cancer cells. |
no |
no |
6 |
| 10441007 |
Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. |
yes |
no |
4 |
| 10453987 |
Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. |
no |
no |
4 |
| 10491221 |
The transcription factor Sox9 is involved in BMP-2 signaling. |
no |
no |
6 |
| 10493528 |
S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. |
no |
no |
5 |
| 10498894 |
p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis. |
no |
no |
2 |
| 10502725 |
Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. |
yes |
yes |
4 |
| 10533453 |
Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. |
yes |
yes |
3 |
| 10536172 |
NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. |
no |
no |
2 |
| 10541973 |
Expression of CD44 variants in osteosarcoma. |
yes |
yes |
1 |
| 10550312 |
Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. |
yes |
yes |
3 |
| 10561353 |
Expression of HER2/erbB-2 correlates with survival in osteosarcoma. |
yes |
yes |
3 |
| 10568818 |
Modulation of fas-mediated apoptosis in osteosarcoma cell lines. |
no |
no |
1 |
| 10569469 |
P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy. |
yes |
yes |
1 |
| 10569470 |
Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. |
yes |
no |
3 |
| 10571205 |
A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. |
no |
no |
6 |
| 10606250 |
Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line. |
no |
no |
1 |
| 10627702 |
Expression of bone morphogenetic proteins and receptors in sarcomas. |
yes |
yes |
6 |
| 10638971 |
Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. |
yes |
yes |
1 |
| 10663637 |
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. |
no |
no |
3 |
| 10690541 |
Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. |
yes |
yes |
2 |
| 10697522 |
De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. |
no |
yes |
1 |
| 10702275 |
Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. |
no |
no |
3 |
| 10703939 |
Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1. |
no |
no |
2 |
| 10709992 |
Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. |
no |
no |
2 |
| 10726973 |
Insulin-like growth factor-I inhibits the progression of human U-2 OS osteosarcoma cells towards programmed cell death through interaction with the IGF-I receptor. |
no |
no |
2 |
| 10748103 |
Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells. |
no |
no |
1 |
| 10762653 |
Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma. |
yes |
yes |
1 |
| 10769661 |
Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma. |
no |
no |
1 |
| 10773107 |
Steroid receptor co-activator-1 mediates 1,25-dihydroxyvitamin D(3)-stimulated alkaline phosphatase in human osteosarcoma cells. |
no |
no |
3 |
| 10776793 |
Serum antibodies against the heat shock protein 60 are elevated in patients with osteosarcoma. |
yes |
yes |
1 |
| 10800398 |
h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors. |
yes |
no |
1 |
| 10807968 |
Effect of hyperthermia on the viability and the fibrinolytic potential of human cancer cell lines. |
no |
no |
2 |
| 10810457 |
P-glycoprotein levels predict poor outcome in patients with osteosarcoma. |
yes |
yes |
1 |
| 10814523 |
Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. |
no |
no |
1 |
| 10846544 |
Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells. |
no |
no |
7 |
| 10853014 |
Expression of the SART1 tumor-rejection antigen in human osteosarcomas. |
yes |
yes |
1 |
| 10862039 |
Chromosomal regions involved in the pathogenesis of osteosarcomas. |
yes |
yes |
1 |
| 10872665 |
Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma: a clinicopathologic and immunohistochemical study. |
yes |
yes |
2 |
| 10874667 |
Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. |
yes |
no |
3 |
| 10891538 |
Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
yes |
yes |
2 |
| 10894867 |
MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. |
yes |
no |
1 |
| 10896792 |
The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent. |
no |
no |
3 |
| 10914045 |
Heat-shock protein 72 in human osteosarcoma: T-lymphocyte reactivity and cytotoxicity. |
yes |
no |
1 |
| 10942797 |
Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. |
yes |
yes |
5 |
| 10943202 |
Analysis of 12q13-15 genes in parosteal osteosarcoma. |
yes |
no |
3 |
| 10953349 |
Homeobox B3, B4, and C6 gene product expression in osteosarcomas as detected by immunocytochemistry. |
yes |
no |
3 |
| 10977962 |
Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. |
yes |
yes |
2 |
| 11071251 |
Osteoclast differentiation factor in human osteosarcoma cell line. |
no |
no |
1 |
| 11087053 |
Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. |
yes |
yes |
7 |
| 11089884 |
Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. |
no |
no |
5 |
| 11093825 |
Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. |
no |
no |
8 |
| 11103961 |
Expression of nm23 protein in human osteosarcoma in relationship with early metastasis. |
yes |
no |
1 |
| 11115584 |
Osteosarcoma in blood relatives. |
yes |
no |
6 |
| 11154005 |
Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma. |
yes |
yes |
1 |
| 11155673 |
Preliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma. |
yes |
yes |
2 |
| 11155789 |
Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. |
no |
no |
2 |
| 11156738 |
Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. |
no |
no |
4 |
| 11169148 |
Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. |
yes |
yes |
2 |
| 11179483 |
Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitor. |
no |
no |
1 |
| 11235987 |
Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. |
no |
no |
3 |
| 11241246 |
Primary pulmonary osteosarcoma: case report and molecular analysis. |
yes |
no |
2 |
| 11241308 |
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. |
yes |
yes |
3 |
| 11289134 |
Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. |
no |
no |
4 |
| 11294418 |
The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. |
yes |
yes |
2 |
| 11306692 |
The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. |
no |
no |
6 |
| 11319838 |
Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. |
no |
no |
4 |
| 11331958 |
Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to differentiation of p53-deficient MG-63 osteosarcoma cells. |
no |
no |
1 |
| 11341357 |
Ki-67: a proliferative marker that may predict pulmonary metastases and mortality of primary osteosarcoma. |
yes |
yes |
1 |
| 11344491 |
Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. |
yes |
no |
2 |
| 11351498 |
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. |
yes |
no |
1 |
| 11358827 |
Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. |
no |
yes |
3 |
| 11393276 |
Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. |
no |
no |
2 |
| 11398843 |
Detection of c-fos expression in benign and malignant musculoskeletal lesions. |
yes |
no |
1 |
| 11398844 |
Expression of a newly defined tumor-rejection antigen SART3 in musculoskeletal tumors and induction of HLA class I-restricted cytotoxic T lymphocytes by SART3-derived peptides. |
yes |
yes |
1 |
| 11408805 |
Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma. |
yes |
yes |
1 |
| 11418138 |
pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. |
no |
no |
5 |
| 11425650 |
Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells. |
no |
no |
2 |
| 11451946 |
Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. |
no |
no |
3 |
| 11454519 |
Effects of IGF-I and -II, IGF binding protein-3 (IGFBP-3), and transforming growth factor-beta (TGF-beta) on growth and apoptosis of human osteosarcoma Saos-2/B-10 cells: lack of IGF-independent IGFBP-3 effects. |
no |
no |
3 |
| 11464280 |
Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. |
no |
no |
5 |
| 11498774 |
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. |
no |
no |
1 |
| 11498785 |
Relative frequency and morphology of cancers in carriers of germline TP53 mutations. |
yes |
no |
1 |
| 11505415 |
Amplification of the HER-2/neu oncogene is uncommon in pediatric osteosarcomas. |
yes |
no |
1 |
| 11513857 |
The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. |
no |
no |
2 |
| 11545733 |
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. |
no |
no |
2 |
| 11564577 |
Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. |
yes |
no |
2 |
| 11569927 |
Loss of KAI1/CD82 expression in bone and soft tissue tumors is not associated with lung metastasis. |
yes |
no |
1 |
| 11595696 |
Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma. |
yes |
yes |
1 |
| 11596036 |
Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. |
yes |
no |
1 |
| 11689005 |
Inhibition of vitronectin-mediated haptotaxis and haptoinvasion of MG-63 cells by domain 5 (D5(H)) of human high-molecular-weight kininogen and identification of a minimal amino acid sequence. |
no |
no |
2 |
| 11695244 |
Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. |
no |
no |
3 |
| 11707342 |
Identification of twenty-two candidate markers for human osteogenic sarcoma. |
no |
no |
5 |
| 11713566 |
Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. |
yes |
no |
3 |
| 11743051 |
Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. |
yes |
no |
1 |
| 11746520 |
Cellular and molecular properties associated with osteosarcoma cells. |
yes |
no |
9 |
| 11746983 |
Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. |
yes |
no |
1 |
| 11748477 |
Prognostic significance of serum alkaline phosphatase in osteosarcoma of the extremity treated with neoadjuvant chemotherapy: recent experience at Rizzoli Institute. |
yes |
yes |
1 |
| 11753985 |
Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. |
yes |
yes |
3 |
| 11768200 |
Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. |
no |
no |
2 |
| 11793439 |
Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. |
yes |
no |
1 |
| 11794258 |
Clinical significance of P-glycoprotein immunohistochemistry and doxorubicin binding assay in patients with osteosarcoma. |
yes |
yes |
1 |
| 11797833 |
Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. |
yes |
no |
1 |
| 11820362 |
Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. |
no |
no |
5 |
| 11859242 |
Expression of CD44 isoforms correlates with the metastatic potential of osteosarcoma. |
yes |
yes |
1 |
| 11874241 |
Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. |
no |
no |
3 |
| 11895909 |
Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma. |
no |
no |
1 |
| 11895910 |
Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma. |
yes |
no |
1 |
| 11906172 |
Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells. |
no |
no |
1 |
| 11914627 |
C-kit expression in pediatric solid tumors: a comparative immunohistochemical study. |
yes |
no |
1 |
| 11920494 |
ErbB2 expression is correlated with increased survival of patients with osteosarcoma. |
yes |
yes |
1 |
| 11920584 |
Troglitazione affects survival of human osteosarcoma cells. |
no |
no |
2 |
| 11943335 |
Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. |
no |
no |
3 |
| 11948409 |
Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. |
yes |
yes |
3 |
| 11953816 |
Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. |
yes |
yes |
1 |
| 11986346 |
The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. |
yes |
no |
7 |
| 11992538 |
Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. |
no |
no |
6 |
| 12012007 |
The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. |
no |
no |
4 |
| 12014674 |
Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. |
no |
no |
3 |
| 12024286 |
Cyclooxygenase-2 expression in pediatric sarcomas. |
yes |
no |
1 |
| 12027404 |
Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. |
no |
no |
1 |
| 12054686 |
Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. |
no |
no |
2 |
| 12085209 |
Investigations on a clinically and functionally unusual and novel germline p53 mutation. |
yes |
no |
1 |
| 12140175 |
Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. |
no |
no |
1 |
| 12168884 |
Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. |
yes |
yes |
2 |
| 12181274 |
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. |
yes |
no |
4 |
| 12188489 |
Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. |
yes |
yes |
2 |
| 12209731 |
Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. |
yes |
yes |
6 |
| 12218590 |
Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels. |
yes |
no |
4 |
| 12220726 |
Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors. |
no |
no |
2 |
| 12221644 |
Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma. |
yes |
no |
1 |
| 12232677 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. |
no |
no |
7 |
| 12237108 |
Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. |
no |
no |
6 |
| 12368234 |
Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. |
no |
no |
2 |
| 12388161 |
1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. |
no |
no |
5 |
| 12393937 |
Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. |
no |
no |
3 |
| 12401825 |
Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. |
yes |
no |
3 |
| 12402302 |
Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. |
yes |
no |
1 |
| 12404059 |
Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors. |
yes |
no |
2 |
| 12408470 |
Thrombin is present in the lungs of patients with primary extremity osteosarcoma and pulmonary metastases. |
yes |
no |
1 |
| 12415617 |
Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells. |
no |
no |
1 |
| 12426100 |
The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. |
yes |
no |
1 |
| 12478472 |
Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. |
no |
no |
4 |
| 12527715 |
Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma. |
yes |
yes |
1 |
| 12529988 |
Prostate-specific antigen (PSA)-mediated proliferation, androgenic regulation and inhibitory effects of LY312340 in HOS-TE85 (TE85) human osteosarcoma cells. |
no |
no |
1 |
| 12544770 |
Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. |
yes |
yes |
1 |
| 12550767 |
Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma. |
yes |
no |
3 |
| 12560446 |
Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities. |
yes |
yes |
1 |
| 12569382 |
ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. |
yes |
yes |
2 |
| 12576457 |
Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. |
yes |
no |
1 |
| 12588801 |
Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. |
yes |
no |
3 |
| 12616540 |
Alpha 4 integrin increases anoikis of human osteosarcoma cells. |
yes |
no |
4 |
| 12621691 |
Serum concentrations of sCD30 and sCD40L in patients with malignant bone tumours. |
yes |
yes |
2 |
| 12647018 |
Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells. |
no |
no |
2 |
| 12660819 |
Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. |
no |
no |
3 |
| 12672477 |
Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. |
no |
no |
1 |
| 12673561 |
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. |
yes |
no |
1 |
| 12673693 |
Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. |
yes |
no |
2 |
| 12679640 |
Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. |
yes |
no |
1 |
| 12689679 |
Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. |
yes |
yes |
5 |
| 12708477 |
Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma. |
yes |
no |
2 |
| 12709413 |
Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. |
no |
no |
1 |
| 12711293 |
Survivin expression in human osteosarcoma is a marker for survival. |
yes |
yes |
1 |
| 12734318 |
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. |
yes |
yes |
1 |
| 12747978 |
Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. |
yes |
no |
5 |
| 12759621 |
Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. |
yes |
yes |
4 |
| 12782945 |
Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. |
no |
no |
3 |
| 12789260 |
Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. |
no |
no |
9 |
| 12792742 |
Inactivation of the RASSF1A in osteosarcoma. |
yes |
no |
1 |
| 12799638 |
Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping. |
yes |
no |
2 |
| 12802802 |
Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. |
yes |
no |
1 |
| 12813132 |
mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. |
yes |
yes |
5 |
| 12824921 |
Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas. |
yes |
no |
1 |
| 12829666 |
Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. |
yes |
yes |
2 |
| 12838325 |
Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. |
no |
no |
4 |
| 12842447 |
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. |
no |
no |
2 |
| 12850370 |
Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. |
yes |
no |
1 |
| 12879476 |
The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. |
yes |
yes |
1 |
| 12883746 |
Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression. |
yes |
yes |
1 |
| 12894891 |
Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. |
yes |
no |
2 |
| 12907249 |
Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. |
no |
no |
6 |
| 12912938 |
Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target. |
yes |
no |
1 |
| 12917637 |
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. |
yes |
no |
3 |
| 12919886 |
Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. |
no |
no |
6 |
| 12926161 |
Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours. |
yes |
yes |
3 |
| 12930359 |
IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. |
no |
no |
2 |
| 12943619 |
Telomerase, p53 and PCNA activity in osteosarcoma. |
yes |
yes |
3 |
| 12972634 |
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. |
yes |
no |
2 |
| 12973938 |
Construction of antisense transforming growth factor beta 1 gene and its effect on the proliferation by expression in osteosarcoma cells. |
no |
no |
1 |
| 14506695 |
High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. |
yes |
no |
4 |
| 14506946 |
Urinary excretion of pyridinium cross-links and serum osteocalcin levels in patients with primary high-grade osteosarcoma. |
yes |
yes |
1 |
| 14528100 |
Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. |
yes |
no |
3 |
| 14534726 |
Effect of retinoblastoma tumor suppressor gene expression on chemosensitivity of human osteosarcoma cell lines. |
no |
no |
1 |
| 14557934 |
Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions. |
yes |
no |
1 |
| 14559221 |
E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. |
no |
no |
3 |
| 14582536 |
Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. |
no |
no |
5 |
| 14584080 |
Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. |
yes |
yes |
2 |
| 14598359 |
Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. |
yes |
yes |
9 |
| 14598886 |
Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. |
yes |
yes |
1 |
| 14610316 |
Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. |
no |
no |
2 |
| 14624456 |
Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. |
yes |
no |
2 |
| 14629833 |
Somatostatin receptor (SSTR) scintigraphy in patients with osteosarcoma. |
yes |
yes |
1 |
| 14631380 |
Evaluation of the predictive value of Her-2/neu gene expression on osteosarcoma therapy in laser-microdissected paraffin-embedded tissue. |
yes |
yes |
1 |
| 14633705 |
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. |
no |
no |
4 |
| 14637192 |
Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. |
no |
no |
5 |
| 14647441 |
FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. |
no |
no |
6 |
| 14660053 |
Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. |
no |
no |
4 |
| 14669798 |
Biological properties and gene expression associated with metastatic potential of human osteosarcoma. |
no |
no |
5 |
| 14676807 |
Gene expression array profile of human osteosarcoma. |
yes |
no |
1 |
| 14679136 |
Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. |
yes |
yes |
3 |
| 14682477 |
Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. |
no |
no |
4 |
| 14695161 |
A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo. |
no |
no |
1 |
| 14704791 |
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. |
no |
yes |
2 |
| 14706926 |
Effect of human granulocyte macrophage-colony stimulating factor on differentiation and apoptosis of the human osteosarcoma cell line SaOS-2. |
no |
no |
3 |
| 14713104 |
S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. |
no |
no |
5 |
| 14719070 |
Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. |
no |
no |
2 |
| 14719113 |
Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. |
no |
no |
3 |
| 14735475 |
Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. |
yes |
yes |
1 |
| 14760101 |
Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. |
no |
no |
3 |
| 14973099 |
High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. |
yes |
yes |
2 |
| 14975209 |
Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. |
no |
no |
4 |
| 14996747 |
Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. |
no |
no |
1 |
| 14999771 |
Mutation analysis of the apoptotic \death-receptors\ and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. |
yes |
no |
1 |
| 15015580 |
PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS). |
no |
no |
1 |
| 15026342 |
Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. |
yes |
no |
3 |
| 15026814 |
A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. |
no |
no |
2 |
| 15049011 |
Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. |
no |
no |
1 |
| 15055356 |
Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. |
no |
no |
3 |
| 15067366 |
The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. |
no |
no |
1 |
| 15069760 |
HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. |
yes |
no |
2 |
| 15087387 |
Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. |
no |
no |
3 |
| 15093570 |
Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcomas. |
yes |
no |
1 |
| 15095405 |
IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. |
no |
no |
6 |
| 15112275 |
Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. |
yes |
yes |
4 |
| 15138564 |
Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. |
no |
no |
6 |
| 15144225 |
Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. |
no |
no |
5 |
| 15145525 |
CD9 expression is not a prognostic factor in human osteosarcoma. |
yes |
no |
1 |
| 15167009 |
Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. |
yes |
yes |
7 |
| 15174116 |
Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. |
no |
no |
11 |
| 15193436 |
Overexpression through amplification of genes in chromosome region 17p11.2 approximately p12 in high-grade osteosarcoma. |
yes |
no |
3 |
| 15198903 |
p21WAF1/CIP1 gene DNA sequencing and its expression in human osteosarcoma. |
yes |
no |
1 |
| 15201972 |
Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma. |
yes |
no |
1 |
| 15205094 |
Identification of a transcriptionally inactive p53 mutant by functional analysis of separated alleles in yeasts (FASAY) in a child osteosarcoma tumor: a case report. |
yes |
yes |
1 |
| 15207713 |
Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. |
no |
no |
6 |
| 15210853 |
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. |
yes |
yes |
1 |
| 15211578 |
Annexin 2 expression is reduced in human osteosarcoma metastases. |
yes |
no |
1 |
| 15221963 |
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas. |
yes |
no |
1 |
| 15237589 |
Low expression of p63 and p73 in osteosarcoma. |
yes |
no |
2 |
| 15247015 |
Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. |
no |
no |
1 |
| 15250258 |
Effects of TGF beta1 autocrine blockage on osteosarcoma cells. |
no |
no |
1 |
| 15262428 |
Characterization of PMP22 expression in osteosarcoma. |
yes |
no |
1 |
| 15268905 |
Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation. |
no |
no |
2 |
| 15289892 |
A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. |
no |
no |
1 |
| 15298715 |
Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. |
yes |
no |
10 |
| 15310147 |
Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. |
yes |
no |
4 |
| 15313187 |
Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts. |
no |
no |
2 |
| 15314286 |
Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. |
no |
no |
4 |
| 15318945 |
Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. |
no |
no |
3 |
| 15325100 |
Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. |
yes |
no |
3 |
| 15346048 |
VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI. |
yes |
yes |
1 |
| 15365076 |
Telomerase expression predicts unfavorable outcome in osteosarcoma. |
yes |
yes |
1 |
| 15370596 |
Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. |
yes |
no |
4 |
| 15390286 |
Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. |
no |
no |
4 |
| 15390294 |
Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. |
yes |
no |
1 |
| 15448009 |
Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: a meta-analysis. |
yes |
yes |
1 |
| 15455381 |
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. |
no |
no |
4 |
| 15467717 |
von Willebrand factor expression in osteosarcoma metastasis. |
yes |
no |
1 |
| 15488761 |
Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. |
yes |
no |
2 |
| 15492501 |
Differential oncogenic Ras signaling and senescence in tumor cells. |
no |
no |
2 |
| 15516323 |
Effect of TNF-alpha on human osteosarcoma cell line Saos2--TNF-alpha regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells. |
no |
no |
4 |
| 15538723 |
Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. |
no |
no |
2 |
| 15540114 |
Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. |
no |
no |
3 |
| 15540165 |
Gene amplifications in osteosarcoma-CGH microarray analysis. |
yes |
no |
2 |
| 15547696 |
Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. |
no |
no |
6 |
| 15583032 |
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. |
no |
no |
3 |
| 15585647 |
Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. |
yes |
no |
1 |
| 15609301 |
Altered expression and deletion of RMO1 in osteosarcoma. |
yes |
yes |
1 |
| 15625311 |
Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. |
no |
no |
3 |
| 15627479 |
Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. |
no |
no |
13 |
| 15649646 |
Differential effects of clusterin/apolipoprotein J on cellular growth and survival. |
no |
no |
1 |
| 15656333 |
Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: experience at Rizzoli on 1421 patients treated over the last 30 years. |
yes |
yes |
1 |
| 15662138 |
The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. |
no |
no |
5 |
| 15670817 |
Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. |
no |
no |
12 |
| 15701832 |
Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. |
no |
no |
3 |
| 15705874 |
Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. |
no |
no |
5 |
| 15735124 |
TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. |
yes |
no |
1 |
| 15735172 |
An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma. |
yes |
yes |
2 |
| 15742288 |
Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. |
no |
no |
6 |
| 15746965 |
Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. |
no |
no |
6 |
| 15753370 |
An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. |
yes |
no |
8 |
| 15796961 |
Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. |
yes |
no |
2 |
| 15800315 |
Prognostic significance of allelic imbalance at the c-kit gene locus and c-kit overexpression by immunohistochemistry in pediatric osteosarcomas. |
yes |
yes |
1 |
| 15814634 |
Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. |
yes |
yes |
3 |
| 15816563 |
Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. |
no |
no |
3 |
| 15827336 |
p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. |
no |
no |
2 |
| 15870699 |
Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. |
no |
no |
3 |
| 15883045 |
Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. |
no |
no |
3 |
| 15900593 |
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. |
yes |
yes |
3 |
| 15912538 |
CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. |
yes |
no |
3 |
| 15913990 |
Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. |
yes |
yes |
2 |
| 15922739 |
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity. |
no |
no |
1 |
| 15923123 |
Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). |
no |
no |
3 |
| 15936998 |
Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. |
no |
no |
5 |
| 15939402 |
Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expression. |
no |
no |
1 |
| 15946696 |
Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. |
no |
no |
4 |
| 15965098 |
Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. |
no |
no |
2 |
| 15985268 |
Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. |
no |
no |
3 |
| 16007340 |
Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. |
no |
no |
5 |
| 16007579 |
Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. |
no |
no |
3 |
| 16008557 |
Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. |
yes |
no |
2 |
| 16010295 |
Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation. |
no |
no |
5 |
| 16026999 |
Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. |
no |
no |
3 |
| 16035619 |
Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. |
no |
no |
2 |
| 16083752 |
Matrix metalloproteinases participate in osteosarcoma invasion. |
no |
no |
2 |
| 16119739 |
Expression and significance of TGF-beta isoform and VEGF in osteosarcoma. |
yes |
yes |
1 |
| 16140185 |
Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). |
no |
no |
1 |
| 16157226 |
Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. |
yes |
yes |
1 |
| 16167336 |
Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. |
no |
no |
6 |
| 16196299 |
Relationship between the expression of MTA-1 gene and the metastasis and invasion in human osteosarcoma. |
no |
no |
1 |
| 16206219 |
CGH evaluation of two de novo synchronous tumors in a child with a germline p53 mutation. |
yes |
no |
1 |
| 16211088 |
Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin. |
yes |
no |
1 |
| 16211448 |
HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. |
yes |
no |
1 |
| 16213662 |
Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. |
no |
no |
5 |
| 16219634 |
Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. |
no |
no |
2 |
| 16259979 |
Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. |
no |
no |
6 |
| 16269403 |
Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation. |
no |
no |
1 |
| 16273216 |
Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. |
no |
no |
1 |
| 16282894 |
Fas expression in lung metastasis from osteosarcoma patients. |
yes |
yes |
1 |
| 16327977 |
Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. |
yes |
yes |
2 |
| 16327988 |
Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. |
no |
no |
2 |
| 16328036 |
Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. |
no |
no |
3 |
| 16354601 |
Immunohistochemical examination of cytological differentiation in osteosarcomas. |
yes |
no |
2 |
| 16369996 |
Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. |
no |
no |
2 |
| 16380506 |
Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. |
no |
no |
2 |
| 16394764 |
Aberrant methylation of p14ARF gene correlates with poor survival in osteosarcoma. |
yes |
yes |
1 |
| 16417466 |
Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. |
no |
no |
6 |
| 16421247 |
CD99 acts as an oncosuppressor in osteosarcoma. |
no |
no |
3 |
| 16437349 |
Expression of a novel alternatively spliced UCP-2 transcript in osteogenic sarcoma. |
yes |
no |
1 |
| 16466985 |
Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. |
no |
no |
4 |
| 16470222 |
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. |
no |
no |
6 |
| 16475708 |
Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. |
no |
no |
5 |
| 16502411 |
Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. |
yes |
yes |
4 |
| 16528367 |
CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. |
yes |
yes |
2 |
| 16533764 |
Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. |
no |
no |
6 |
| 16540432 |
Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. |
no |
no |
3 |
| 16547468 |
Immunohistochemical detection of WT1 protein in a variety of cancer cells. |
yes |
no |
1 |
| 16571651 |
Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. |
no |
no |
6 |
| 16596382 |
Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. |
yes |
no |
7 |
| 16677779 |
Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. |
yes |
yes |
1 |
| 16683887 |
Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions. |
yes |
yes |
1 |
| 16696324 |
Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell. |
no |
no |
2 |
| 16705726 |
Expression of survivin and correlation with PCNA in osteosarcoma. |
yes |
yes |
2 |
| 16734381 |
Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. |
no |
no |
6 |
| 16751779 |
Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. |
no |
no |
1 |
| 16759849 |
PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. |
no |
no |
2 |
| 16764926 |
Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. |
yes |
no |
1 |
| 16773198 |
HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. |
no |
no |
3 |
| 16786118 |
Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? |
yes |
no |
1 |
| 16795036 |
Okadaic acid induces phosphorylation of p65NF-kappaB on serine 536 and activates NF-kappaB transcriptional activity in human osteoblastic MG63 cells. |
no |
no |
1 |
| 16797629 |
Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. |
no |
no |
6 |
| 16798617 |
Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. |
no |
no |
6 |
| 16814113 |
Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. |
no |
no |
4 |
| 16818639 |
Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. |
no |
no |
1 |
| 16822878 |
Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. |
yes |
yes |
1 |
| 16826116 |
Vascular endothelial growth factor expression in osteosarcoma. |
yes |
yes |
1 |
| 16827134 |
Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells. |
no |
no |
2 |
| 16849574 |
E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. |
no |
no |
3 |
| 16857797 |
High WT1 expression is associated with very poor survival of patients with osteogenic sarcoma metastasis. |
yes |
yes |
1 |
| 16878156 |
Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. |
no |
no |
6 |
| 16933368 |
Effects of hyperthermia on heat shock protein expression, alkaline phosphatase activity and proliferation in human osteosarcoma cells. |
no |
no |
2 |
| 16938571 |
hCDC4 variation in osteosarcoma. |
yes |
no |
1 |
| 16944980 |
KAI-1 expression in pediatric high-grade osteosarcoma. |
yes |
no |
1 |
| 16956425 |
Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. |
no |
no |
3 |
| 16962318 |
Expression of transcription factor Yin Yang 1 in human osteosarcomas. |
yes |
yes |
1 |
| 16982772 |
Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. |
no |
no |
5 |
| 17001316 |
PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. |
yes |
no |
2 |
| 17012855 |
Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells. |
no |
no |
1 |
| 17014383 |
Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. |
no |
no |
1 |
| 17018686 |
Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker. |
yes |
yes |
1 |
| 17022822 |
Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. |
yes |
no |
3 |
| 17034065 |
Survivin expression levels as independent predictors of survival for osteosarcoma patients. |
yes |
yes |
1 |
| 17045162 |
Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies. |
no |
no |
3 |
| 17079093 |
Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. |
yes |
no |
1 |
| 17088985 |
May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. |
yes |
yes |
1 |
| 17089020 |
Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. |
yes |
no |
1 |
| 17096323 |
Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. |
no |
no |
1 |
| 17096406 |
Germ-line genetic variation of TP53 in osteosarcoma. |
yes |
no |
1 |
| 17113707 |
Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. |
no |
no |
1 |
| 17116726 |
Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. |
no |
no |
12 |
| 17120184 |
Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. |
no |
no |
7 |
| 17136003 |
p53 gene gets altered by various mechanisms: studies in childhood sarcomas and retinoblastoma. |
yes |
no |
1 |
| 17189270 |
alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. |
no |
no |
4 |
| 17203229 |
Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. |
yes |
yes |
1 |
| 17206471 |
The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell cycle arrest and apoptosis. |
no |
no |
1 |
| 17218775 |
Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. |
no |
no |
7 |
| 17218778 |
Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. |
no |
no |
8 |
| 17222495 |
Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. |
no |
no |
2 |
| 17230544 |
Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors. |
yes |
no |
1 |
| 17234448 |
Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. |
no |
no |
4 |
| 17234543 |
Low-grade central osteosarcoma of the mandible: a case study report. |
yes |
no |
3 |
| 17237146 |
Overexpression of hypoxia-inducible factor-1alpha in human osteosarcoma: correlation with clinicopathological parameters and survival outcome. |
yes |
yes |
1 |
| 17254772 |
RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. |
no |
no |
3 |
| 17256128 |
The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase. |
no |
no |
1 |
| 17262820 |
RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. |
no |
no |
3 |
| 17279585 |
Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. |
no |
no |
3 |
| 17294449 |
KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? |
yes |
no |
2 |
| 17310851 |
Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. |
no |
no |
2 |
| 17317953 |
Loss of TP53 in sarcomas with 17p12 to approximately p11 gain. A fine-resolution oligonucleotide array comparative genomic hybridization study. |
yes |
no |
3 |
| 17318900 |
Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. |
no |
no |
12 |
| 17320498 |
The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells. |
no |
no |
1 |
| 17323424 |
Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. |
no |
no |
7 |
| 17342313 |
Bax gene therapy for human osteosarcoma using cationic liposomes in vivo. |
no |
no |
1 |
| 17343982 |
Negative growth control of osteosarcoma cell by Bowman-Birk protease inhibitor from soybean; involvement of connexin 43. |
no |
no |
1 |
| 17353802 |
Ezrin expression predicts survival in stage IIB osteosarcomas. |
yes |
yes |
1 |
| 17356895 |
Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. |
no |
no |
6 |
| 17366602 |
COPS3 amplification and clinical outcome in osteosarcoma. |
yes |
yes |
2 |
| 17372931 |
Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. |
no |
no |
8 |
| 17376718 |
Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production. |
no |
no |
3 |
| 17390023 |
Determination of the prognostic value of loss of heterozygosity at the retinoblastoma gene in osteosarcoma. |
yes |
no |
1 |
| 17391929 |
Expression and pathological relevance of inducible nitric oxide synthase in osteosarcoma of the jaws. |
yes |
yes |
1 |
| 17395421 |
Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. |
no |
no |
3 |
| 17410535 |
Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. |
yes |
no |
3 |
| 17412493 |
1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. |
no |
no |
9 |
| 17415755 |
Expression of major vault protein gene in osteosarcoma patients. |
yes |
yes |
1 |
| 17440083 |
Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. |
yes |
no |
1 |
| 17458711 |
Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. |
no |
no |
4 |
| 17465200 |
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. |
no |
no |
3 |
| 17471233 |
Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. |
no |
no |
10 |
| 17473184 |
The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. |
yes |
no |
2 |
| 17483704 |
TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. |
yes |
no |
1 |
| 17493842 |
Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132. |
no |
no |
1 |
| 17505002 |
Epidermal growth factor receptor expression in high-grade osteosarcomas is associated with a good clinical outcome. |
yes |
yes |
1 |
| 17506944 |
Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines. |
no |
no |
2 |
| 17506984 |
Midkine as a novel target for antibody therapy in osteosarcoma. |
yes |
yes |
1 |
| 17509570 |
Osteosarcoma cell-calcium signaling through tissue factor-factor VIIa complex and factor Xa. |
no |
no |
3 |
| 17509661 |
Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis. |
no |
no |
1 |
| 17513610 |
Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. |
no |
no |
3 |
| 17520676 |
Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. |
no |
no |
9 |
| 17536311 |
Expression of cyclooxygenase-2 in osteosarcoma of bone. |
yes |
yes |
1 |
| 17549480 |
Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line. |
no |
no |
2 |
| 17560052 |
High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. |
yes |
yes |
1 |
| 17568187 |
Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. |
no |
no |
4 |
| 17569615 |
IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. |
no |
no |
6 |
| 17598902 |
Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. |
yes |
no |
1 |
| 17609619 |
High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. |
yes |
yes |
1 |
| 17611411 |
P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. |
no |
no |
4 |
| 17611684 |
Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. |
no |
no |
4 |
| 17611696 |
Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. |
no |
no |
6 |
| 17627080 |
Regulation of the mGluR5, EAAT1 and GS expression by glucocorticoids in MG-63 osteoblast-like osteosarcoma cells. |
no |
no |
2 |
| 17632732 |
Livin and Bcl-2 expression in high-grade osteosarcoma. |
yes |
yes |
2 |
| 17645699 |
Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. |
yes |
no |
3 |
| 17660802 |
Prognostic significance of drug-regulated genes in high-grade osteosarcoma. |
yes |
yes |
9 |
| 17682054 |
Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. |
no |
no |
3 |
| 17683065 |
Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis. |
yes |
yes |
3 |
| 17684144 |
Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma. |
yes |
yes |
1 |
| 17690908 |
Possible prognostic role of IL-17R in osteosarcoma. |
no |
yes |
2 |
| 17699771 |
Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. |
no |
yes |
3 |
| 17786187 |
Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. |
yes |
yes |
3 |
| 17786325 |
The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. |
no |
no |
2 |
| 17786474 |
Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. |
yes |
yes |
3 |
| 17849429 |
Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. |
no |
no |
5 |
| 17873971 |
Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression. |
no |
yes |
1 |
| 17886294 |
Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. |
yes |
yes |
1 |
| 17892509 |
Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. |
no |
no |
2 |
| 17934334 |
Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. |
no |
no |
3 |
| 17952379 |
The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA. |
no |
yes |
1 |
| 17956871 |
Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. |
no |
no |
3 |
| 17959036 |
Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. |
no |
no |
7 |
| 17980151 |
Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. |
no |
no |
4 |
| 17980359 |
Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. |
no |
no |
8 |
| 17981215 |
Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization. |
no |
no |
2 |
| 17982618 |
Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. |
no |
no |
3 |
| 17987039 |
A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. |
yes |
yes |
2 |
| 17998668 |
Prognostic and predictive value of c-erbB2 overexpression in osteogenic sarcoma. |
no |
no |
2 |
| 18019405 |
Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. |
yes |
no |
3 |
| 18047805 |
Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. |
no |
no |
2 |
| 18048360 |
Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. |
no |
no |
3 |
| 18081879 |
Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. |
yes |
no |
4 |
| 18090928 |
Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. |
yes |
no |
1 |
| 18093185 |
Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells. |
no |
no |
3 |
| 18097539 |
Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines. |
no |
no |
6 |
| 18158779 |
Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. |
yes |
yes |
3 |
| 18161867 |
Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. |
yes |
yes |
3 |
| 18171692 |
Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. |
no |
no |
1 |
| 18196972 |
Regulation of the p14ARF promoter by DNA methylation. |
no |
no |
1 |
| 18215331 |
A complex pattern of chemokine receptor expression is seen in osteosarcoma. |
yes |
yes |
5 |
| 18223689 |
Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. |
no |
no |
2 |
| 18245529 |
Prognostic value of CCN3 in osteosarcoma. |
yes |
yes |
1 |
| 18252811 |
Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. |
no |
no |
2 |
| 18307025 |
A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene. |
yes |
no |
1 |
| 18332870 |
Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. |
no |
no |
7 |
| 18338812 |
Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. |
yes |
no |
4 |
| 18339860 |
Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. |
no |
no |
3 |
| 18348660 |
Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma. |
yes |
no |
1 |
| 18359978 |
CDH11 expression is associated with survival in patients with osteosarcoma. |
yes |
yes |
1 |
| 18359981 |
The proteome profile of the human osteosarcoma U2OS cell line. |
no |
no |
10 |
| 18374478 |
Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin. |
no |
no |
2 |
| 18384113 |
2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. |
no |
no |
4 |
| 18385200 |
Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. |
yes |
no |
2 |
| 18414033 |
Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. |
no |
no |
6 |
| 18421709 |
C-erbB-2 expression and prognostic significance in osteosarcoma. |
yes |
no |
1 |
| 18438338 |
VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. |
yes |
no |
3 |
| 18443365 |
Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. |
yes |
no |
1 |
| 18445685 |
PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. |
yes |
no |
5 |
| 18464244 |
Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas. |
yes |
yes |
1 |
| 18465804 |
Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. |
yes |
no |
1 |
| 18472964 |
Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. |
no |
no |
1 |
| 18483362 |
Critical role of notch signaling in osteosarcoma invasion and metastasis. |
yes |
yes |
4 |
| 18488713 |
Silencing of YY1 downregulates RIZ1 promoter in human osteosarcoma. |
no |
no |
2 |
| 18498722 |
Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. |
yes |
no |
1 |
| 18501891 |
Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. |
no |
no |
10 |
| 18505923 |
Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. |
no |
no |
2 |
| 18507006 |
Identification of potential chemoresistance genes in osteosarcoma. |
no |
no |
4 |
| 18507025 |
Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412. |
no |
no |
1 |
| 18510171 |
Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. |
no |
no |
9 |
| 18520037 |
BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. |
no |
no |
1 |
| 18524773 |
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. |
no |
no |
4 |
| 18528739 |
Hypoxia markers in human osteosarcoma: an exploratory study. |
yes |
no |
2 |
| 18554951 |
Expression and significance of hypoxemia-inducible factor-1alpha in osteosarcoma of the jaws. |
yes |
yes |
1 |
| 18563508 |
Expression of macrophage migration inhibitory factor relates to survival in high-grade osteosarcoma. |
yes |
no |
2 |
| 18567798 |
Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. |
yes |
no |
10 |
| 18598236 |
Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells. |
no |
no |
3 |
| 18606492 |
The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. |
no |
no |
5 |
| 18607665 |
Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. |
no |
no |
2 |
| 18612712 |
S100A6 expression and function in human osteosarcoma. |
yes |
yes |
1 |
| 18645001 |
c-Jun knockdown sensitizes osteosarcoma to doxorubicin. |
yes |
no |
1 |
| 18675369 |
Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells. |
no |
no |
1 |
| 18701490 |
Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. |
no |
no |
1 |
| 18704985 |
Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. |
yes |
no |
2 |
| 18726921 |
High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma. |
no |
no |
1 |
| 18757369 |
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. |
no |
no |
10 |
| 18758062 |
Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. |
no |
no |
5 |
| 18771083 |
VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. |
no |
no |
2 |
| 18775026 |
Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins. |
yes |
no |
1 |
| 18787415 |
scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. |
no |
no |
1 |
| 18797196 |
COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. |
yes |
yes |
1 |
| 18814141 |
Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. |
no |
no |
10 |
| 18831895 |
Expression of c-kit protein and mutational status of the c-kit gene in osteosarcoma and their clinicopathological significance. |
yes |
yes |
1 |
| 18838962 |
Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. |
no |
no |
5 |
| 18854653 |
Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. |
yes |
yes |
2 |
| 18925963 |
Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. |
yes |
no |
2 |
| 18931939 |
Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. |
no |
no |
4 |
| 18941626 |
Detection and characterization of CD133+ cancer stem cells in human solid tumours. |
no |
no |
3 |
| 18972316 |
The expression of novel gene URG4 in osteosarcoma: correlation with patients' prognosis. |
yes |
yes |
1 |
| 18981708 |
(18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation. |
yes |
no |
1 |
| 18986328 |
Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. |
no |
no |
5 |
| 18989156 |
Germline p53 mutation in a Micronesian child with adrenocortical carcinoma and subsequent osteosarcoma. |
yes |
no |
1 |
| 18996209 |
Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro. |
no |
no |
1 |
| 19010839 |
Endosialin protein expression and therapeutic target potential in human solid tumors: sarcoma versus carcinoma. |
yes |
yes |
1 |
| 19012332 |
Somatic TP53 mutation mosaicism in a patient with Li-Fraumeni syndrome. |
yes |
no |
1 |
| 19018758 |
Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. |
no |
no |
5 |
| 19020756 |
Increased osteoclast activity is associated with aggressiveness of osteosarcoma. |
yes |
no |
3 |
| 19050913 |
Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. |
yes |
yes |
1 |
| 19052873 |
Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. |
no |
no |
1 |
| 19060919 |
The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. |
no |
no |
4 |
| 19066961 |
Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death. |
no |
no |
1 |
| 19082467 |
The expression of CRM1 is associated with prognosis in human osteosarcoma. |
yes |
yes |
1 |
| 19105235 |
Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. |
no |
no |
4 |
| 19125251 |
RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines. |
no |
no |
1 |
| 19125294 |
Down-regulation of ribosomal protein L7A in human osteosarcoma. |
yes |
yes |
1 |
| 19142873 |
De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. |
no |
no |
3 |
| 19148492 |
Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. |
no |
no |
5 |
| 19159633 |
Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. |
no |
no |
3 |
| 19159907 |
Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. |
yes |
no |
2 |
| 19160414 |
Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. |
no |
no |
11 |
| 19192721 |
Expression of insulin-like growth factor-II mRNA binding protein 3 (IMP3) in osteosarcoma. |
yes |
yes |
1 |
| 19212684 |
The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. |
yes |
yes |
5 |
| 19212829 |
Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell. |
yes |
no |
10 |
| 19228774 |
Notch signaling contributes to the pathogenesis of human osteosarcomas. |
no |
no |
6 |
| 19229591 |
Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. |
no |
no |
2 |
| 19242128 |
Characterization of stem cell attributes in human osteosarcoma cell lines. |
no |
no |
1 |
| 19242607 |
Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. |
yes |
no |
1 |
| 19244100 |
The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. |
yes |
no |
1 |
| 19258511 |
Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. |
yes |
no |
4 |
| 19284568 |
Characterization of STAT3 activation and expression in canine and human osteosarcoma. |
no |
no |
2 |
| 19307728 |
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. |
no |
no |
2 |
| 19326179 |
Cyclooxygenase-2 overexpression predicts poor survival in patients with high-grade extremity osteosarcoma: a pilot study. |
yes |
yes |
1 |
| 19331807 |
Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. |
yes |
no |
3 |
| 19338516 |
Immunohistochemical profile of ephrin A4 expression in human osteosarcoma. |
yes |
yes |
1 |
| 19346874 |
Her-2/neu, p-53, and their coexpression in osteosarcoma. |
yes |
no |
2 |
| 19347870 |
Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. |
no |
no |
3 |
| 19351757 |
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. |
yes |
no |
1 |
| 19366061 |
Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. |
yes |
yes |
2 |
| 19393247 |
Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. |
no |
no |
6 |
| 19427670 |
Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma. |
yes |
no |
1 |
| 19434073 |
Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. |
yes |
yes |
1 |
| 19441093 |
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. |
yes |
yes |
1 |
| 19445706 |
An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. |
yes |
yes |
1 |
| 19449377 |
Molecular characterization of the response to chemotherapy in conventional osteosarcomas: predictive value of HSD17B10 and IFITM2. |
yes |
yes |
4 |
| 19451596 |
Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival. |
yes |
yes |
2 |
| 19455146 |
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. |
no |
no |
12 |
| 19483233 |
The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma. |
yes |
no |
1 |
| 19486338 |
Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. |
no |
no |
2 |
| 19488908 |
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. |
no |
no |
2 |
| 19492781 |
Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. |
yes |
no |
2 |
| 19496172 |
Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. |
no |
no |
9 |
| 19505574 |
C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. |
no |
no |
2 |
| 19541929 |
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. |
no |
no |
3 |
| 19544560 |
Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. |
no |
no |
1 |
| 19559722 |
Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. |
no |
no |
8 |
| 19561643 |
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. |
no |
no |
3 |
| 19574207 |
Pre-treatment serum lactate dehydrogenase level is an important prognostic factor in high-grade extremity osteosarcoma. |
yes |
yes |
1 |
| 19584295 |
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. |
no |
no |
3 |
| 19596932 |
Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. |
yes |
yes |
1 |
| 19597468 |
Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. |
yes |
yes |
2 |
| 19621435 |
VEGF expression as a prognostic marker in osteosarcoma. |
yes |
yes |
1 |
| 19624845 |
Risedronate inhibits human osteosarcoma cell invasion. |
no |
no |
2 |
| 19632201 |
Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. |
yes |
no |
4 |
| 19638450 |
Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. |
no |
no |
1 |
| 19668151 |
Glial fibrillary acidic protein in tumor types with cartilaginous differentiation. |
yes |
no |
1 |
| 19670450 |
Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. |
yes |
no |
2 |
| 19682073 |
Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. |
no |
no |
3 |
| 19688969 |
Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma. |
yes |
yes |
3 |
| 19709164 |
A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma. |
yes |
yes |
1 |
| 19719941 |
Integrated assessment of potential value of erbB-2 amplification or expression status as novel therapy target in Chinese children and adolescents with osteosarcoma. |
yes |
no |
1 |
| 19724913 |
Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. |
yes |
yes |
1 |
| 19730790 |
Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. |
no |
no |
5 |
| 19734943 |
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. |
no |
no |
4 |
| 19746447 |
Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. |
no |
no |
5 |
| 19747555 |
Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells. |
no |
no |
3 |
| 19757179 |
beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. |
no |
no |
5 |
| 19760520 |
The role of VE-cadherin in osteosarcoma cells. |
no |
no |
1 |
| 19778378 |
U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. |
no |
no |
5 |
| 19779497 |
p73 is essential for vitamin D-mediated osteoblastic differentiation. |
no |
no |
2 |
| 19789339 |
The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. |
no |
no |
2 |
| 19802733 |
Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma. |
yes |
yes |
1 |
| 19818735 |
Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. |
no |
no |
3 |
| 19836228 |
VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. |
yes |
yes |
2 |
| 19882675 |
Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. |
yes |
no |
4 |
| 19885603 |
Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. |
yes |
no |
8 |
| 19888226 |
Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. |
yes |
no |
2 |
| 19894220 |
Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. |
no |
no |
2 |
| 19895174 |
Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma. |
yes |
yes |
1 |
| 19896763 |
Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. |
yes |
no |
1 |
| 19900100 |
Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. |
yes |
no |
1 |
| 19936974 |
mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. |
yes |
yes |
2 |
| 19951606 |
Tenascin-C as a prognostic biomarker in osteosarcoma? |
yes |
yes |
1 |
| 19996593 |
Antitumor efficacy of two novel non-thiazolidinedione compounds as peroxisome proliferator-activated receptor-gamma agonists in human osteosarcoma cells in vitro. |
no |
no |
1 |
| 20003259 |
Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. |
yes |
no |
6 |
| 20015022 |
Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. |
no |
no |
2 |
| 20027339 |
Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas. |
yes |
no |
4 |
| 20032373 |
Preferential expression of the secreted and membrane forms of tumor endothelial marker 7 transcripts in osteosarcoma. |
yes |
no |
1 |
| 20037818 |
Expression of Beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity. |
yes |
no |
1 |
| 20038829 |
Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB. |
no |
no |
2 |
| 20041491 |
Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. |
no |
no |
7 |
| 20042639 |
The kinase Mirk is a potential therapeutic target in osteosarcoma. |
yes |
yes |
1 |
| 20044614 |
Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. |
no |
no |
5 |
| 20048075 |
Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. |
yes |
no |
2 |
| 20053387 |
RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. |
no |
no |
8 |
| 20063378 |
Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. |
yes |
yes |
1 |
| 20067614 |
Smoothened as a new therapeutic target for human osteosarcoma. |
yes |
no |
11 |
| 20071790 |
Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome. |
yes |
yes |
1 |
| 20082321 |
2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells. |
no |
no |
1 |
| 20114058 |
Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells. |
no |
no |
7 |
| 20127006 |
The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth. |
yes |
no |
2 |
| 20132188 |
Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma. |
yes |
yes |
1 |
| 20144850 |
Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. |
no |
yes |
1 |
| 20156969 |
Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues. |
yes |
no |
1 |
| 20158913 |
Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis. |
yes |
yes |
2 |
| 20159990 |
Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. |
yes |
yes |
1 |
| 20181727 |
A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia. |
no |
no |
2 |
| 20190807 |
Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells. |
no |
no |
2 |
| 20196171 |
Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. |
yes |
no |
2 |
| 20197388 |
Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. |
yes |
yes |
1 |
| 20208568 |
Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. |
no |
no |
3 |
| 20213410 |
How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. |
no |
yes |
6 |
| 20213411 |
The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. |
no |
no |
2 |
| 20218738 |
APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. |
yes |
yes |
1 |
| 20222016 |
Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration. |
no |
no |
3 |
| 20225287 |
Bone deposition, bone resorption, and osteosarcoma. |
yes |
yes |
5 |
| 20309879 |
Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. |
no |
no |
4 |
| 20340016 |
Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcoma. |
yes |
no |
5 |
| 20348881 |
Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. |
yes |
yes |
1 |
| 20349215 |
Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. |
yes |
yes |
2 |
| 20350217 |
Expression of Smad and its signalling cascade in osteosarcoma. |
yes |
no |
3 |
| 20354825 |
Int7G24A variant of transforming growth factor-beta receptor 1 is associated with osteosarcoma susceptibility in a Chinese population. |
yes |
yes |
1 |
| 20357441 |
Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. |
no |
no |
5 |
| 20362224 |
Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. |
yes |
yes |
12 |
| 20368414 |
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. |
no |
no |
4 |
| 20371684 |
Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. |
no |
no |
3 |
| 20376536 |
Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. |
no |
no |
4 |
| 20399482 |
Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. |
yes |
yes |
1 |
| 20403045 |
Expression of podoplanin in human bone and bone tumors: New marker of osteogenic and chondrogenic bone tumors. |
yes |
yes |
1 |
| 20406948 |
Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. |
no |
no |
5 |
| 20429896 |
Association between TGFBR1*6A and osteosarcoma: a Chinese case-control study. |
yes |
yes |
1 |
| 20433742 |
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. |
no |
no |
5 |
| 20459648 |
The expression and significance of IDH1 and p53 in osteosarcoma. |
yes |
yes |
2 |
| 20459702 |
Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. |
yes |
no |
5 |
| 20460510 |
CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. |
no |
no |
3 |
| 20460760 |
Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. |
no |
no |
3 |
| 20465837 |
Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. |
yes |
yes |
9 |
| 20480266 |
MicroRNA-21 is involved in osteosarcoma cell invasion and migration. |
no |
no |
2 |
| 20484142 |
Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. |
yes |
no |
1 |
| 20486173 |
R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. |
no |
no |
2 |
| 20491773 |
Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma. |
yes |
no |
1 |
| 20512478 |
Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. |
no |
no |
2 |
| 20520719 |
Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. |
no |
no |
1 |
| 20530675 |
Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. |
yes |
no |
1 |
| 20530678 |
High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. |
no |
no |
4 |
| 20546860 |
Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma. |
yes |
no |
1 |
| 20551950 |
Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone. |
yes |
no |
2 |
| 20562647 |
Immunoexpression of Ezrin and CD44 in patients with osteosarcoma. |
yes |
no |
2 |
| 20563836 |
Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. |
yes |
no |
2 |
| 20577141 |
Glutathione S-transferase polymorphisms in osteosarcoma patients. |
yes |
no |
3 |
| 20580954 |
Functional and biological analysis of Bcl-xL expression in human osteosarcoma. |
yes |
no |
6 |
| 20592496 |
Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. |
no |
no |
4 |
| 20594821 |
Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. |
yes |
no |
2 |
| 20596639 |
Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. |
no |
no |
5 |
| 20601938 |
Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. |
yes |
yes |
2 |
| 20610556 |
Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. |
yes |
yes |
2 |
| 20625943 |
Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells. |
no |
no |
1 |
| 20627196 |
Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. |
no |
no |
6 |
| 20632817 |
Expression of heat shock proteins in osteosarcomas. |
yes |
yes |
3 |
| 20637078 |
Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. |
no |
no |
2 |
| 20664979 |
N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. |
no |
no |
3 |
| 20678472 |
Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways. |
no |
no |
2 |
| 20682173 |
Sensitization of osteosarcoma cell line SaOS-2 to chemotherapy by downregulating survivin. |
no |
no |
1 |
| 20701666 |
Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. |
yes |
no |
3 |
| 20737480 |
Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma. |
yes |
no |
1 |
| 20798956 |
TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis. |
no |
no |
5 |
| 20806347 |
Elevated expression of CXC chemokines in pediatric osteosarcoma patients. |
yes |
yes |
2 |
| 20808934 |
Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. |
no |
no |
6 |
| 20819644 |
Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. |
no |
no |
3 |
| 20823153 |
Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases. |
yes |
yes |
1 |
| 20845987 |
+Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. |
no |
no |
2 |
| 20845995 |
Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1α in osteosarcoma. |
yes |
no |
2 |
| 20854211 |
Glucose transporter protein 1-targeted RNA interference inhibits growth and invasion of the osteosarcoma cell line MG63 in vitro. |
no |
no |
1 |
| 20855150 |
Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells. |
no |
no |
3 |
| 20859706 |
Expression change of ezrin as a prognostic factor in primary osteosarcoma. |
yes |
yes |
1 |
| 20878132 |
microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. |
yes |
no |
2 |
| 20880700 |
Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. |
yes |
yes |
5 |
| 20881269 |
Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. |
yes |
no |
2 |
| 20926002 |
Celecoxib inhibits β-catenin-dependent survival of the human osteosarcoma MG-63 cell line. |
no |
no |
4 |
| 20944138 |
Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. |
no |
no |
1 |
| 20949564 |
Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response. |
yes |
yes |
5 |
| 20955951 |
Markers of bone remodeling in neoplastic and bone-related lesions. |
yes |
no |
4 |
| 20970221 |
2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. |
no |
no |
2 |
| 20973064 |
Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma. |
yes |
yes |
1 |
| 20978190 |
Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. |
no |
no |
4 |
| 21056138 |
Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt. |
no |
no |
2 |
| 21079421 |
Gene expression profiles of human osteosarcoma cell sublines with different pulmonary metastatic potentials. |
no |
no |
2 |
| 21080877 |
Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome. |
yes |
no |
1 |
| 21084254 |
Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. |
yes |
yes |
3 |
| 21104436 |
Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma. |
yes |
yes |
1 |
| 21113498 |
Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. |
yes |
yes |
4 |
| 21116120 |
Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells. |
no |
no |
2 |
| 21137073 |
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. |
yes |
yes |
1 |
| 21145881 |
Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. |
no |
no |
7 |
| 21149578 |
Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. |
no |
no |
4 |
| 21152068 |
Lysophosphatidic acid acyltransferase β (LPAATβ) promotes the tumor growth of human osteosarcoma. |
no |
no |
1 |
| 21159888 |
Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. |
yes |
no |
4 |
| 21163271 |
Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. |
no |
no |
6 |
| 21165567 |
Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws. |
yes |
no |
1 |
| 21166698 |
De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway. |
no |
no |
5 |
| 21166699 |
Therapeutic potential of CAMPATH-1H in skeletal tumours. |
yes |
no |
1 |
| 21178508 |
BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. |
no |
no |
6 |
| 21192060 |
Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil. |
yes |
no |
1 |
| 21207222 |
Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. |
yes |
yes |
1 |
| 21215367 |
Massive genomic rearrangement acquired in a single catastrophic event during cancer development. |
yes |
no |
5 |
| 21234653 |
Anti-tumor effects of dihydroartemisinin on human osteosarcoma. |
no |
no |
10 |
| 21236332 |
15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. |
no |
no |
5 |
| 21240382 |
Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. |
yes |
yes |
7 |
| 21246613 |
Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. |
no |
no |
7 |
| 21249357 |
Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma. |
yes |
yes |
1 |
| 21266106 |
Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. |
no |
no |
5 |
| 21283769 |
Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. |
yes |
no |
2 |
| 21286665 |
Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. |
no |
no |
3 |
| 21287529 |
Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. |
no |
no |
3 |
| 21287809 |
Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. |
no |
no |
4 |
| 21292304 |
Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma. |
yes |
no |
1 |
| 21297379 |
Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. |
no |
no |
1 |
| 21311599 |
Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma. |
yes |
no |
1 |
| 21312266 |
CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. |
yes |
yes |
1 |
| 21321933 |
Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells. |
yes |
no |
3 |
| 21331449 |
Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. |
no |
no |
6 |
| 21336260 |
MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. |
yes |
yes |
2 |
| 21340507 |
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. |
no |
no |
1 |
| 21345075 |
Multiple malignancies in a child with de novo TP53 mutation. |
yes |
no |
1 |
| 21370405 |
RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. |
yes |
yes |
1 |
| 21375766 |
RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. |
no |
no |
4 |
| 21378337 |
The role of MAPK pathway in bone and soft tissue tumors. |
yes |
no |
3 |
| 21387396 |
ROCK1 as a potential therapeutic target in osteosarcoma. |
yes |
no |
1 |
| 21399492 |
Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. |
no |
no |
1 |
| 21411701 |
Interferon-α/β receptor as a prognostic marker in osteosarcoma. |
yes |
yes |
2 |
| 21416580 |
A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. |
yes |
yes |
1 |
| 21421073 |
Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity. |
no |
no |
6 |
| 21424568 |
Relationship between hypermethylated MGMT gene and osteosarcoma necrosis rate after chemotherapy. |
yes |
no |
1 |
| 21427707 |
MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. |
no |
no |
2 |
| 21436869 |
RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells. |
yes |
no |
1 |
| 21440986 |
Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. |
no |
no |
3 |
| 21443800 |
The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. |
no |
no |
6 |
| 21453059 |
Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma. |
yes |
yes |
1 |
| 21458381 |
Cyclin E1 is amplified and overexpressed in osteosarcoma. |
yes |
yes |
1 |
| 21460855 |
Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. |
yes |
no |
1 |
| 21481226 |
Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. |
no |
no |
3 |
| 21490307 |
The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. |
no |
no |
8 |
| 21495021 |
Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. |
yes |
yes |
1 |
| 21506130 |
Role of GLI2 in the growth of human osteosarcoma. |
yes |
yes |
5 |
| 21508379 |
Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma. |
yes |
no |
1 |
| 21517265 |
SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. |
no |
no |
3 |
| 21520041 |
Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. |
no |
no |
2 |
| 21527497 |
Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. |
no |
no |
5 |
| 21528673 |
Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report. |
yes |
no |
1 |
| 21529352 |
WEE1 inhibition sensitizes osteosarcoma to radiotherapy. |
yes |
yes |
1 |
| 21542455 |
Knockdown of MED19 by lentivirus-mediated shRNA in human osteosarcoma cells inhibits cell proliferation by inducing cell cycle arrest in the G0/G1 phase. |
no |
no |
1 |
| 21563968 |
CD86 + 1057G/A polymorphism and susceptibility to osteosarcoma. |
yes |
yes |
1 |
| 21573491 |
Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. |
no |
no |
16 |
| 21573994 |
Silencing of HMGA1 expression by RNA interference suppresses growth of osteogenic sarcoma. |
no |
no |
1 |
| 21617855 |
Caffeine activates tumor suppressor PTEN in sarcoma cells. |
no |
no |
2 |
| 21617882 |
Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. |
no |
no |
6 |
| 21619552 |
The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. |
yes |
no |
1 |
| 21619704 |
A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. |
yes |
yes |
8 |
| 21631272 |
p63 expression in giant cell-containing lesions of bone and soft tissue. |
yes |
yes |
1 |
| 21640141 |
Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. |
no |
no |
3 |
| 21656314 |
Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. |
no |
no |
1 |
| 21665377 |
Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation. |
no |
no |
1 |
| 21666078 |
MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. |
yes |
no |
3 |
| 21667022 |
The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. |
no |
no |
8 |
| 21671176 |
Targeted silencing of heparanase gene by small interfering RNA inhibits invasiveness and metastasis of osteosarcoma cells. |
no |
no |
1 |
| 21671177 |
Influence of β-catenin small interfering RNA on human osteosarcoma cells. |
no |
no |
2 |
| 21681744 |
Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. |
yes |
no |
2 |
| 21691740 |
Insights on PRAME and osteosarcoma by means of gene expression profiling. |
yes |
no |
1 |
| 21706236 |
Plasma membrane proteomic analysis of human osteosarcoma and osteoblastic cells: revealing NDRG1 as a marker for osteosarcoma. |
yes |
yes |
1 |
| 21717192 |
Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. |
no |
no |
7 |
| 21720717 |
Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. |
no |
no |
8 |
| 21750404 |
Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. |
yes |
yes |
2 |
| 21751201 |
Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. |
no |
no |
1 |
| 21751203 |
Cell surface receptor expression patterns in osteosarcoma. |
yes |
no |
7 |
| 21780101 |
P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. |
no |
no |
2 |
| 21801875 |
Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. |
yes |
no |
4 |
| 21805050 |
Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. |
no |
no |
5 |
| 21822121 |
BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity. |
no |
no |
1 |
| 21822538 |
p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. |
no |
no |
4 |
| 21826087 |
Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. |
yes |
yes |
3 |
| 21826611 |
Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. |
no |
no |
4 |
| 21834878 |
Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration. |
no |
no |
3 |
| 21843050 |
IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. |
no |
no |
1 |
| 21843952 |
Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. |
no |
no |
1 |
| 21866554 |
Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. |
yes |
yes |
1 |
| 21868524 |
Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. |
no |
no |
1 |
| 21874265 |
Vasodilator-stimulated phosphoprotein regulates osteosarcoma cell migration. |
no |
no |
2 |
| 21887680 |
Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. |
yes |
no |
4 |
| 21890444 |
Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. |
yes |
yes |
3 |
| 21901524 |
Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. |
no |
no |
3 |
| 21925315 |
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. |
no |
no |
4 |
| 21927024 |
Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. |
yes |
no |
2 |
| 21941146 |
Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray. |
yes |
no |
1 |
| 21945933 |
RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration. |
no |
no |
3 |
| 21951664 |
RUNX2 expression in developing human bones and various bone tumors. |
yes |
no |
2 |
| 21959981 |
MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93. |
no |
no |
2 |
| 21963453 |
Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D₃ action in osteosarcoma. |
no |
no |
3 |
| 21964477 |
Okadaic acid induces apoptosis through the PKR, NF-κB and caspase pathway in human osteoblastic osteosarcoma MG63 cells. |
no |
no |
3 |
| 21986150 |
Difference in pre- and postchemotherapy vascular endothelial growth factor levels as a prognostic indicator in osteosarcoma. |
yes |
yes |
1 |
| 21993662 |
Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. |
no |
no |
9 |
| 22006429 |
High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. |
yes |
no |
8 |
| 22009167 |
Cancer-testis antigens expressed in osteosarcoma identified by gene microarray correlate with a poor patient prognosis. |
yes |
yes |
3 |
| 22009216 |
Prostate-specific membrane antigen: a new potential prognostic marker of osteosarcoma. |
yes |
yes |
1 |
| 22009832 |
Apoptotic effects of curcumin on human osteosarcoma U2OS cells. |
no |
no |
7 |
| 22009965 |
Expression of b-FGF and endostatin and their clinical significance in human osteosarcoma. |
yes |
yes |
3 |
| 22012179 |
Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. |
no |
no |
3 |
| 22016816 |
Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study. |
yes |
yes |
2 |
| 22021909 |
TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. |
no |
no |
1 |
| 22037351 |
Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. |
no |
no |
11 |
| 22042095 |
The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. |
yes |
no |
2 |
| 22047406 |
YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma. |
yes |
yes |
1 |
| 22057483 |
RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. |
no |
no |
6 |
| 22068640 |
Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. |
no |
no |
6 |
| 22075555 |
Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases. |
yes |
no |
1 |
| 22090361 |
Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma. |
yes |
no |
1 |
| 22093834 |
miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. |
yes |
no |
2 |
| 22099874 |
Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma. |
yes |
no |
1 |
| 22102692 |
HMGB1 promotes drug resistance in osteosarcoma. |
no |
no |
4 |
| 22126551 |
Relationships between serum biomarker levels and clinical presentation of human osteosarcomas. |
yes |
no |
3 |
| 22126901 |
Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. |
no |
no |
7 |
| 22128168 |
Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. |
no |
no |
9 |
| 22135725 |
C-kit expression in human osteosarcoma and in vitro assays. |
yes |
no |
1 |
| 22138223 |
Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. |
no |
no |
2 |
| 22147261 |
Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. |
no |
no |
1 |
| 22147650 |
Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. |
yes |
no |
9 |
| 22154052 |
MAPK7 and MAP2K4 as prognostic markers in osteosarcoma. |
yes |
yes |
2 |
| 22158627 |
Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. |
no |
no |
3 |
| 22173290 |
Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma. |
yes |
yes |
3 |
| 22173710 |
Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. |
no |
no |
1 |
| 22179790 |
RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. |
no |
no |
2 |
| 22186140 |
miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. |
no |
no |
4 |
| 22202598 |
CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients. |
yes |
yes |
1 |
| 22205265 |
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. |
yes |
no |
2 |
| 22212432 |
Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. |
no |
no |
4 |
| 22213004 |
Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma. |
yes |
yes |
1 |
| 22213073 |
ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9. |
yes |
no |
2 |
| 22215309 |
Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis and prognosis in patients with osteosarcoma. |
yes |
yes |
1 |
| 22227330 |
Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. |
no |
no |
3 |
| 22231496 |
Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. |
no |
no |
8 |
| 22245111 |
Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. |
yes |
no |
1 |
| 22246399 |
Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. |
no |
no |
5 |
| 22248279 |
Overexpression of potassium channel ether à go-go in human osteosarcoma. |
yes |
no |
1 |
| 22263786 |
Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-κB pathway. |
no |
no |
2 |
| 22271434 |
Different expression of CD146 in human normal and osteosarcoma cell lines. |
no |
no |
2 |
| 22274866 |
The prognostic value of elevated vascular endothelial growth factor in patients with osteosarcoma: a meta-analysis and systemic review. |
yes |
yes |
2 |
| 22286748 |
siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells. |
no |
no |
1 |
| 22292074 |
Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma. |
yes |
no |
9 |
| 22292654 |
Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9. |
yes |
yes |
2 |
| 22297550 |
Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival. |
yes |
no |
1 |
| 22301501 |
MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. |
yes |
yes |
2 |
| 22301993 |
Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. |
no |
no |
4 |
| 22333159 |
High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. |
yes |
yes |
2 |
| 22338054 |
CD138 (syndecan-1) expression in bone-forming tumors. |
yes |
no |
1 |
| 22340557 |
Increased expression of serum gelsolin in patients with osteosarcoma. |
yes |
yes |
1 |
| 22344865 |
Nestin expression in high-grade osteosarcomas and its clinical significance. |
yes |
no |
1 |
| 22350417 |
miRNA signatures associate with pathogenesis and progression of osteosarcoma. |
yes |
no |
10 |
| 22354724 |
Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma. |
no |
no |
1 |
| 22371553 |
A preliminary investigation of Beta-hCG expression in patients with osteosarcoma. |
yes |
yes |
1 |
| 22382389 |
Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells. |
no |
no |
1 |
| 22387266 |
Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. |
no |
no |
11 |
| 22390926 |
Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death. |
no |
no |
1 |
| 22390931 |
Expression and prognostic relevance of PRAME in primary osteosarcoma. |
yes |
yes |
1 |
| 22422053 |
Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. |
no |
no |
2 |
| 22426824 |
PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma. |
yes |
yes |
2 |
| 22446894 |
Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. |
no |
no |
2 |
| 22454324 |
Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data. |
yes |
no |
2 |
| 22457788 |
MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. |
no |
no |
2 |
| 22471458 |
KISS1 expression in osteosarcoma: high in chinese clinical cases, but lower in cell lines. |
yes |
yes |
1 |
| 22471480 |
Glutathione S-transferase polymorphisms and bone tumor risk in China. |
yes |
yes |
2 |
| 22471498 |
Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells. |
no |
no |
2 |
| 22472569 |
MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. |
yes |
no |
2 |
| 22506069 |
CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. |
no |
no |
2 |
| 22521131 |
Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. |
no |
no |
1 |
| 22525461 |
Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. |
yes |
no |
4 |
| 22527131 |
Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. |
no |
no |
4 |
| 22531343 |
Syndecan-4 and fibronectin in osteosarcoma. |
yes |
yes |
2 |
| 22534782 |
Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. |
no |
no |
2 |
| 22542077 |
Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma. |
yes |
yes |
3 |
| 22542792 |
Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma. |
yes |
no |
1 |
| 22544557 |
Expression and stability of hypoxia inducible factor 1α in osteosarcoma. |
yes |
no |
2 |
| 22546756 |
Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. |
no |
no |
7 |
| 22578565 |
P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy. |
yes |
yes |
1 |
| 22583777 |
Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. |
yes |
no |
4 |
| 22623071 |
Nuclear p63 expression in osteoblastic tumors. |
yes |
yes |
1 |
| 22641358 |
Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. |
no |
no |
5 |
| 22665540 |
Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. |
yes |
no |
1 |
| 22674530 |
Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. |
no |
no |
9 |
| 22682017 |
Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. |
yes |
yes |
5 |
| 22682620 |
MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. |
no |
no |
11 |
| 22688575 |
Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. |
no |
no |
6 |
| 22715593 |
Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. |
no |
no |
4 |
| 22719058 |
Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments. |
yes |
yes |
2 |
| 22736026 |
HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis. |
no |
no |
1 |
| 22743617 |
STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. |
no |
no |
5 |
| 22749040 |
12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. |
yes |
yes |
2 |
| 22771636 |
Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. |
yes |
no |
1 |
| 22791884 |
Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. |
yes |
yes |
1 |
| 22797704 |
NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. |
no |
no |
2 |
| 22799338 |
Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. |
no |
no |
1 |
| 22817659 |
Invariant NKT cells increase drug-induced osteosarcoma cell death. |
no |
no |
1 |
| 22820099 |
Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. |
no |
no |
2 |
| 22843172 |
MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. |
no |
no |
2 |
| 22847601 |
Prognostic value of Twist and E-cadherin in patients with osteosarcoma. |
yes |
yes |
2 |
| 22849560 |
Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. |
no |
no |
6 |
| 22855058 |
Expression and significance of Kruppel-like factor 6 gene in osteosarcoma. |
yes |
yes |
1 |
| 22855059 |
Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. |
yes |
yes |
3 |
| 22870217 |
Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. |
no |
no |
10 |
| 22870593 |
Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. |
yes |
yes |
2 |
| 22886393 |
TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. |
yes |
no |
5 |
| 22889802 |
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. |
no |
no |
1 |
| 22911823 |
Lysyl oxidase polymorphisms and susceptibility to osteosarcoma. |
yes |
yes |
1 |
| 22916108 |
Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. |
no |
no |
3 |
| 22922684 |
The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. |
yes |
no |
4 |
| 22922800 |
miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. |
no |
no |
2 |
| 22922827 |
miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. |
no |
no |
3 |
| 22923031 |
Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. |
no |
no |
4 |
| 22926753 |
SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. |
no |
no |
4 |
| 22935974 |
Mitogen-activated protein kinase pathway in osteosarcoma. |
yes |
yes |
5 |
| 22938445 |
Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. |
yes |
yes |
3 |
| 22939995 |
IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. |
yes |
no |
6 |
| 22948234 |
Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. |
no |
no |
3 |
| 22949168 |
The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. |
no |
no |
1 |
| 22968906 |
Targeting hedgehog-GLI-2 pathway in osteosarcoma. |
yes |
yes |
1 |
| 22992985 |
Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner. |
no |
no |
6 |
| 22993301 |
Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. |
no |
no |
5 |
| 22994717 |
LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. |
no |
no |
4 |
| 23000411 |
Domain 5 of high molecular weight kininogen inhibits collagen-mediated cancer cell adhesion and invasion in association with α-actinin-4. |
no |
no |
2 |
| 23015149 |
Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study. |
yes |
yes |
1 |
| 23027359 |
Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. |
no |
no |
4 |
| 23031740 |
Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: increased expression of a CD44 variant isoform after chemotherapy. |
yes |
no |
2 |
| 23045411 |
Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. |
yes |
no |
2 |
| 23052169 |
Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas. |
yes |
no |
3 |
| 23071517 |
Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. |
no |
no |
7 |
| 23091618 |
Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. |
no |
no |
5 |
| 23098477 |
Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. |
yes |
yes |
2 |
| 23108792 |
SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. |
no |
no |
4 |
| 23113351 |
The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. |
no |
no |
7 |
| 23133552 |
Modulation of the osteosarcoma expression phenotype by microRNAs. |
yes |
no |
43 |
| 23137772 |
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. |
yes |
no |
9 |
| 23142238 |
Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma. |
yes |
yes |
2 |
| 23144859 |
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. |
yes |
no |
6 |
| 23145797 |
Ether à go-go 1 silencing in combination with TRAIL overexpression has synergistic antitumor effects on osteosarcoma. |
no |
no |
2 |
| 23164673 |
The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. |
no |
no |
8 |
| 23167426 |
Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. |
yes |
yes |
5 |
| 23167620 |
Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells. |
no |
no |
1 |
| 23168047 |
Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. |
no |
no |
4 |
| 23175213 |
Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. |
no |
no |
2 |
| 23192273 |
IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. |
yes |
no |
5 |
| 23201449 |
Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. |
no |
no |
6 |
| 23208072 |
Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. |
no |
no |
8 |
| 23219526 |
Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. |
no |
no |
5 |
| 23225447 |
Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. |
yes |
no |
3 |
| 23232982 |
Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. |
no |
no |
5 |
| 23255321 |
Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. |
yes |
no |
1 |
| 23262982 |
Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. |
no |
no |
11 |
| 23266503 |
Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. |
no |
no |
8 |
| 23269581 |
A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma. |
yes |
yes |
3 |
| 23269582 |
Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma. |
yes |
yes |
1 |
| 23291185 |
Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. |
yes |
yes |
3 |
| 23311495 |
MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. |
yes |
yes |
2 |
| 23313376 |
Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. |
no |
no |
10 |
| 23317281 |
Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. |
yes |
yes |
3 |
| 23321165 |
Identification of serum microRNA-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma. |
yes |
yes |
1 |
| 23321467 |
NPRL2 is an independent prognostic factor of osteosarcoma. |
yes |
yes |
1 |
| 23322324 |
Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. |
no |
no |
4 |
| 23341181 |
Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis. |
yes |
yes |
1 |
| 23352643 |
Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development. |
no |
no |
2 |
| 23372675 |
MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. |
no |
no |
1 |
| 23383046 |
FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. |
yes |
no |
3 |
| 23403511 |
Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. |
no |
no |
3 |
| 23430441 |
Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma. |
yes |
yes |
1 |
| 23430952 |
Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. |
no |
no |
7 |
| 23433115 |
Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells. |
no |
no |
1 |
| 23450030 |
The prognostic value of the serum level of C-reactive protein for the survival of patients with a primary sarcoma of bone. |
yes |
yes |
1 |
| 23451817 |
Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. |
no |
no |
5 |
| 23461061 |
C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. |
no |
no |
3 |
| 23462806 |
Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma. |
no |
no |
3 |
| 23470834 |
Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. |
no |
no |
4 |
| 23507142 |
miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. |
yes |
no |
7 |
| 23527718 |
The role and clinical significance of YES-associated protein 1 in human osteosarcoma. |
no |
yes |
4 |
| 23527720 |
Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. |
yes |
no |
4 |
| 23530647 |
Induction of cell cycle arrest and apoptosis in human osteosarcoma U-2 OS cells by Solanum lyratum extracts. |
yes |
no |
1 |
| 23559304 |
Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours. |
yes |
yes |
1 |
| 23568006 |
Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. |
no |
no |
2 |
| 23574781 |
MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma. |
yes |
no |
3 |
| 23578572 |
MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAATβ. |
no |
no |
2 |
| 23589053 |
A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma. |
yes |
yes |
1 |
| 23631646 |
MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. |
yes |
no |
2 |
| 23661525 |
RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9. |
no |
no |
2 |
| 23681112 |
Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma. |
yes |
yes |
1 |
| 23684620 |
Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients. |
yes |
yes |
3 |
| 23725133 |
Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis. |
yes |
no |
1 |
| 23727862 |
Genome-wide association study identifies two susceptibility loci for osteosarcoma. |
yes |
yes |
1 |
| 23740448 |
Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. |
no |
no |
3 |
| 23813624 |
Overexpression of fibroblast activation protein and its clinical implications in patients with osteosarcoma. |
yes |
yes |
1 |
| 23827457 |
MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31. |
no |
no |
2 |
| 23831057 |
Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells. |
no |
no |
1 |
| 23872151 |
MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1. |
no |
no |
2 |
| 23879172 |
FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. |
no |
no |
6 |
| 24009496 |
How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation |
no |
no |
13 |
