General Information
| Gene ID | 1514 |
|---|---|
| Gene Symbol | CTSL1 |
| Gene Name | cathepsin L1 |
| Gene Type | protein-coding |
| Cytoband | 9q21.33 |
| Ensembl ID | ENSG00000135047 |
| #miR regulators | 1 |
| Omim ID | 116880 |
| Gene ontology |
GO:0002224: toll-like receptor signaling pathway GO:0002250: adaptive immune response GO:0006508: proteolysis GO:0019882: antigen processing and presentation GO:0019886: antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0022617: extracellular matrix disassembly GO:0030198: extracellular matrix organization GO:0030574: collagen catabolic process GO:0045087: innate immune response GO:0071888: macrophage apoptotic process GO:0097067: cellular response to thyroid hormone stimulus GO:0005764: lysosome GO:0005576: extracellular region GO:0005634: nucleus GO:0036021: endolysosome lumen GO:0043202: lysosomal lumen GO:0005515: protein binding GO:0004197: cysteine-type endopeptidase activity GO:0042393: histone binding GO:0008234: cysteine-type peptidase activity |
| KEGG pathways |
4142: Lysosome 4145: Phagosome 4612: Antigen processing and presentation 5323: Rheumatoid arthritis |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 8835762 | Enhanced expression of cathepsin L in metastatic bone tumors. | yes | no |
| 11498774 | Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. | no | no |
| 17683065 | Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis. | yes | yes |
| title | all | all |