Browse osteosarcoma associated abstracts
PMID | Title | Tumor | Value | #Genes |
---|---|---|---|---|
292511 | Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. | yes | yes | 1 |
1065468 | Ceruloplasmin levels in sera from human patients with osteosarcoma. | yes | yes | 1 |
1281143 | VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. | no | no | 2 |
1315190 | Regulation of C-myc protooncogene expression in osteoblastic cells by arachidonic acid metabolites: relationship to proliferation. | no | no | 1 |
1316174 | Differential migratory response of U-2 OS osteosarcoma cell to the various forms of platelet-derived growth factor. | no | no | 2 |
1320449 | Immunohistochemical study of bone GLA protein in primary bone tumors. | yes | yes | 1 |
1349175 | Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma. | yes | no | 1 |
1358045 | Overexpression of the c-erbB-2 oncogene in sarcomas and small round-cell tumors of childhood. An immunohistochemical investigation. | yes | no | 1 |
1388095 | Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. | no | no | 3 |
1416076 | Fetal antigen 2 (FA2) in human fetal osteoblasts, cultured osteoblasts and osteogenic osteosarcoma cells. | no | no | 1 |
1423262 | Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. | yes | no | 1 |
1423318 | Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. | yes | no | 2 |
1447251 | A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. | yes | no | 1 |
1459694 | Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. | no | no | 3 |
1468768 | Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors. | yes | yes | 1 |
1481722 | The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. | no | no | 4 |
1499384 | The prognostic value of serum alkaline phosphatase in osteosarcoma of the limbs. | yes | yes | 1 |
1520309 | Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth. | no | no | 1 |
1524989 | Studies of the RB1 gene and the p53 gene in human osteosarcomas. | yes | no | 2 |
1525710 | A phorbol ester induces secretion of alkaline phosphatase activity in human osteosarcoma cells. | no | no | 1 |
1568211 | Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. | yes | no | 2 |
1571831 | Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells. | no | no | 3 |
1586971 | Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. | no | no | 4 |
1622861 | Osteonectin in osteosarcomas: a marker for differential diagnosis and/or prognosis? | yes | no | 1 |
1657330 | Hormonal regulation of vitamin D receptor levels and osteocalcin synthesis in human osteosarcoma cells. | no | no | 2 |
1698437 | Homozygous deletion within the retinoblastoma gene in a native osteosarcoma specimen of a patient cured of a retinoblastoma of both eyes. | yes | no | 1 |
1726835 | Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system. | no | no | 1 |
1846564 | Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. | no | no | 3 |
1864588 | Immunophenotypic heterogeneity in osteosarcomas. | yes | yes | 3 |
1867319 | Immunohistochemical analysis of neural cell adhesion molecules. Differential expression in small round cell tumors of childhood and adolescence. | yes | no | 1 |
1884549 | Involvement of the retinoblastoma gene in primary osteosarcomas and other bone and soft-tissue tumors. | yes | no | 1 |
1932372 | Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. | no | no | 3 |
1988704 | Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. | yes | no | 1 |
2036639 | Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma. | yes | no | 1 |
2069168 | The effect of rhGM-CSF on the proliferation of osteogenic sarcoma cells. | no | no | 1 |
2115647 | The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas. | yes | no | 1 |
2143022 | Mechanisms of p53 loss in human sarcomas. | yes | no | 1 |
2153840 | Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma. | no | no | 2 |
2156959 | Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. | no | no | 3 |
2166171 | Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. | no | no | 1 |
2169996 | Expression of Ki-1 antigen (CD30) in mesenchymal tumors. | yes | no | 1 |
2233717 | p53 functions as a cell cycle control protein in osteosarcomas. | no | no | 1 |
2253237 | Frequency and structure of p53 rearrangements in human osteosarcoma. | yes | no | 1 |
2274789 | Genetic mechanisms of tumor suppression by the human p53 gene. | no | no | 1 |
2287591 | The impact of osteonectin for differential diagnosis of bone tumors. An immunohistochemical approach. | yes | no | 1 |
2298248 | Expression of transferrin and vitamin D-binding protein genes in an osteogenic sarcoma cell line. | no | no | 2 |
2443508 | Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. | no | no | 1 |
2450880 | Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA. | no | no | 2 |
2488230 | Genetic analysis of childhood sarcoma. | yes | no | 1 |
2496060 | Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma. | yes | no | 2 |
2496522 | Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies. | yes | yes | 1 |
2521862 | Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. | no | no | 4 |
2531855 | Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line. | no | no | 2 |
2541615 | Expression of the common acute lymphoblastic leukemia antigen (CD10) in mesenchymal tumors. | yes | yes | 1 |
2600089 | Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. | no | no | 4 |
2630171 | The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. | no | no | 2 |
2659348 | Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion. | no | no | 1 |
2740144 | Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas. | yes | no | 1 |
2755701 | Studies of the retinoblastoma gene in human sarcomas. | yes | no | 1 |
2776495 | Immunohistological demonstration of osteonectin in normal bone tissue and in bone tumors. | yes | yes | 1 |
2786815 | Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. | no | no | 3 |
2878716 | Chromosome 13 instability and esterase D expression in an osteosarcoma cell line. | no | no | 2 |
2898286 | Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. | yes | no | 1 |
2918936 | Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. | yes | no | 1 |
2978869 | Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line. | no | no | 2 |
3057504 | Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. | no | no | 1 |
3162593 | Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. | yes | no | 1 |
3165250 | Immunohistochemical study of osteonectin in various types of osteosarcoma. | yes | yes | 1 |
3166362 | Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin. | no | no | 1 |
3477902 | Prognostic value of serum alkaline phosphatase in osteosarcoma. | yes | yes | 2 |
3479235 | Events on different chromosomes alter the genes for the two peptides of platelet-derived growth factor in an osteogenic sarcoma. | yes | no | 2 |
6297258 | Enzyme histochemical study on bone tumors. | yes | no | 2 |
6930152 | Correlation between prognostic factors and blood variables in osteosarcoma. | yes | no | 2 |
7473836 | Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. | no | no | 2 |
7477118 | Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. | yes | yes | 1 |
7502710 | Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. | no | no | 5 |
7506120 | Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. | yes | no | 2 |
7513549 | Chromosome analysis of nine osteosarcomas. | yes | no | 2 |
7518993 | Periosteal osteosarcoma and parosteal chondrosarcoma evaluated by double immunohistochemical staining. Report of 2 cases. | yes | no | 1 |
7528503 | Quantitative RT-PCR assay detecting the transcriptional induction of vascular endothelial growth factor under hypoxia. | no | no | 1 |
7531202 | Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican. | no | no | 1 |
7541624 | The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells. | no | no | 1 |
7559091 | Changes in radiation sensitivity of human osteosarcoma cells after p53 introduction. | no | no | 1 |
7576109 | Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. | no | no | 6 |
7585551 | Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain. | no | no | 1 |
7585620 | Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. | no | no | 3 |
7591308 | MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. | yes | yes | 1 |
7593131 | Immunohistochemical analysis of nm23 protein expression in malignant bone tumors. | yes | yes | 1 |
7607566 | Characterization of two splice variants of metastasis-associated human mts1 gene. | no | no | 1 |
7612954 | The identity of proliferating cells in bone tumors with cartilaginous components: evaluation by double-immunohistochemical staining using proliferating cell nuclear antigen and S-100 protein. | yes | no | 1 |
7614454 | Complex replication error causes p53 mutation in a Li-Fraumeni family. | yes | no | 1 |
7621257 | Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. | no | no | 1 |
7639117 | IGF-II receptor number is increased in TE-85 osteosarcoma cells by combined magnetic fields. | no | no | 1 |
7640224 | Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. | yes | no | 3 |
7641470 | The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. | no | no | 8 |
7660382 | Expression of the human multidrug resistance gene (MDR1) and prognostic correlation in human osteogenic sarcoma. | yes | yes | 1 |
7684391 | Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. | no | no | 2 |
7685168 | Reverse transcription-polymerase chain reaction assay demonstrates that the 9-cis retinoic acid receptor alpha is expressed in human osteoblasts. | no | no | 1 |
7693339 | Met expression and sarcoma tumorigenicity. | yes | no | 2 |
7705958 | A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. | no | no | 2 |
7735558 | Correlation of p-glycoprotein detection by immunohistochemistry with mdr-1 mRNA levels in osteosarcomas. Pilot study. | yes | no | 1 |
7768643 | Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. | no | no | 2 |
7789337 | Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures. | no | no | 1 |
7794813 | Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. | no | no | 6 |
7802648 | Steroid hormone modulation of vitamin D receptor levels in human MG-63 osteosarcoma cells. | no | no | 1 |
7817811 | Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. | no | no | 3 |
7826985 | Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. | yes | no | 1 |
7828148 | The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. | yes | no | 3 |
7833115 | Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs. | yes | no | 1 |
7835281 | Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. | no | no | 3 |
7850751 | Mutational activation of ras genes is absent in pediatric osteosarcoma. | yes | no | 3 |
7859736 | Inhibition of apoptosis by the retinoblastoma gene product. | no | no | 2 |
7862451 | The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. | yes | no | 2 |
7904171 | Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. | yes | no | 1 |
7911380 | Rapid detection of loss of heterozygosity of chromosome 17p by polymerase chain reaction-based variable number of tandem repeat analysis and detection of single-strand conformation polymorphism of intragenic p53 polymorphisms. | yes | no | 1 |
7912235 | Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. | no | no | 2 |
7912239 | Existence of lipoprotein lipase in human sarcomas and carcinomas. | no | no | 2 |
7926730 | The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. | no | no | 2 |
7983504 | Prognostic significance of serum lactate dehydrogenase in patients with osteosarcoma of the extremities. | yes | yes | 1 |
8003023 | Human and rat osteoblast-like cells express stathmin, a growth-regulatory protein. | no | no | 1 |
8032535 | Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line. | no | no | 2 |
8033827 | Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. | no | no | 1 |
8034301 | Single base pair germ-line deletion in the p53 gene in a cancer predisposed family. | yes | no | 1 |
8039112 | Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. | yes | no | 2 |
8050825 | Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. | no | no | 2 |
8052269 | Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. | no | no | 5 |
8058007 | Secondary breast cancer in patients presenting with osteosarcoma: possible involvement of germline p53 mutations. | yes | no | 1 |
8064888 | MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. | yes | no | 2 |
8080687 | Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines. | no | no | 1 |
8099316 | Overexpression of c-fos increases recombination frequency in human osteosarcoma cells. | no | no | 1 |
8117620 | Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. | yes | no | 5 |
8123038 | Vinblastine-dependent down-modulation of TNF receptors in human osteosarcoma cells is mediated by protein kinase C activity. | no | no | 2 |
8159609 | Extracellular matrix of small round cell tumors of childhood: an immunohistochemical study of 67 cases. | yes | yes | 1 |
8164043 | Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma. | yes | no | 1 |
8166715 | Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. | no | no | 2 |
8168113 | Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. | no | no | 2 |
8187094 | Mutation spectrum of the retinoblastoma gene in osteosarcomas. | yes | yes | 1 |
8208533 | Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53. | no | no | 1 |
8217129 | An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma. | yes | no | 1 |
8226793 | FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. | no | no | 2 |
8260365 | p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas. | yes | no | 1 |
8276785 | Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. | no | no | 3 |
8281940 | Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. | no | no | 4 |
8287230 | Sporadic amplification of the MYC gene in human osteosarcomas. | yes | no | 1 |
8288590 | Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. | no | no | 3 |
8374897 | Deletion of chromosome 13 in osteosarcoma secondary to irradiation. | yes | no | 1 |
8391387 | Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. | no | no | 2 |
8401536 | Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE). | yes | no | 1 |
8402575 | Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells. | no | no | 1 |
8416741 | MDM2 gene amplification in metastatic osteosarcoma. | yes | yes | 1 |
8418091 | Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. | yes | no | 1 |
8425179 | p53 abnormalities in different subtypes of human sarcomas. | yes | no | 1 |
8435797 | Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy. | yes | yes | 1 |
8479749 | Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings. | yes | no | 1 |
8507187 | Translocation of retinoblastoma protein associated with tumor cell growth inhibition. | no | no | 1 |
8513277 | Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors. | yes | yes | 2 |
8519637 | p53 codon 213 (A-G) polymorphism in a Turkish population. | yes | no | 1 |
8550801 | 1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentiation and growth arrest in a human osteosarcoma cell line. | no | no | 2 |
8562155 | Analysis of P-glycoprotein expression in osteosarcoma. | yes | yes | 1 |
8603340 | Alterations of the p15, p16,and p18 genes in osteosarcoma. | yes | no | 2 |
8616838 | Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. | no | no | 4 |
8625324 | Multidrug resistance and malignancy in human osteosarcoma. | yes | no | 1 |
8630943 | ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. | yes | yes | 1 |
8636759 | Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. | yes | yes | 1 |
8662647 | Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. | no | no | 3 |
8670156 | Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. | no | no | 3 |
8692530 | Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma. | yes | yes | 1 |
8703379 | Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma--a case report. | yes | no | 1 |
8717113 | The impact of osteonectin for differential diagnosis of osteogenic bone tumors: an immunohistochemical and in situ hybridization approach. | yes | yes | 1 |
8717537 | Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells. | no | no | 1 |
8726395 | Immunohistochemical localization of the estrogen receptor in human osteoblastic SaOS-2 cells: association of receptor levels with alkaline phosphatase activity. | no | no | 2 |
8750062 | Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. | yes | no | 3 |
8781571 | Alterations of the p53, Rb and MDM2 genes in osteosarcoma. | yes | no | 3 |
8793483 | Mutation spectrum of p53 gene in highly malignant human osteosarcomas. | yes | no | 1 |
8821948 | Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas. | yes | no | 1 |
8835762 | Enhanced expression of cathepsin L in metastatic bone tumors. | yes | no | 1 |
8840973 | Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. | no | no | 1 |
8855972 | Quantitative analysis of multidrug resistance gene expression in human osteosarcomas. | yes | yes | 1 |
8863670 | Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. | yes | no | 2 |
8865368 | Role of protein phosphatase in malignant osteogenic and soft tissue tumors. | yes | no | 1 |
8866236 | Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas. | yes | no | 1 |
8891902 | Oncogene alterations in primary, recurrent, and metastatic human bone tumors. | yes | yes | 5 |
8893761 | SAS is amplified predominantly in surface osteosarcoma. | yes | no | 1 |
8908160 | Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells. | no | no | 1 |
8922947 | Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. | yes | yes | 2 |
8954126 | Expression of prolactin receptors in human osteosarcoma cells. | no | no | 1 |
8959332 | Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein. | no | no | 2 |
8968028 | Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. | no | no | 1 |
8992882 | Constitutive expression of non-bone/liver/kidney alkaline phosphatase in human osteosarcoma cell lines. | no | yes | 1 |
9052985 | Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. | no | no | 2 |
9065577 | Expression of P-glycoprotein in high grade osteosarcomas with special emphasis on chondroblastic subtype. | yes | yes | 1 |
9066537 | Expression of MAGE genes in osteosarcoma. | yes | no | 2 |
9066701 | Immunohistochemical detection of p53 protein overexpression in primary human osteosarcomas. | yes | no | 1 |
9069169 | Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. | no | no | 4 |
9083931 | Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues. | yes | no | 1 |
9100584 | Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. | no | no | 3 |
9109391 | Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNF alpha incubation. | no | no | 2 |
9111202 | Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells. | no | no | 1 |
9118036 | p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. | yes | yes | 2 |
9136982 | Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line. | no | no | 2 |
9154817 | Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. | no | no | 11 |
9155051 | Frequent reduction or loss of DCC gene expression in human osteosarcoma. | yes | no | 1 |
9167046 | Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. | yes | no | 5 |
9175647 | Suppression of UV-induced mutations by wild-type p53 protein in human osteosarcoma cells. | no | no | 1 |
9180138 | Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma. | no | no | 1 |
9187120 | Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. | no | no | 5 |
9191521 | Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. | yes | yes | 3 |
9227342 | Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours. | yes | no | 2 |
9228255 | P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. | yes | no | 1 |
9244358 | The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma. | yes | no | 1 |
9252243 | TGF-beta1 selectively suppresses PDGF receptor signaling pathways in MG-63 human osteosarcoma cell. | no | no | 1 |
9258335 | Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. | no | no | 4 |
9267827 | Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors. | yes | yes | 1 |
9275350 | P53 gene abnormalities in osteosarcoma. | yes | no | 1 |
9309118 | Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients. | yes | no | 2 |
9322601 | Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. | yes | yes | 2 |
9355974 | Altered G1 phase regulation in osteosarcoma. | yes | yes | 3 |
9390540 | P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. | yes | yes | 1 |
9404699 | Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. | yes | yes | 1 |
9416691 | Analysis of p53 expression in osteosarcoma of the jaw: correlation with clinicopathologic and DNA ploidy findings. | yes | no | 1 |
9418642 | Prognostic factors among 130 patients with osteosarcoma. | yes | yes | 1 |
9433149 | Recombinant human granulocyte-macrophage colony-stimulating factor therapy and endogenous plasma GM-CSF, IL-3, IL-4 concentrations in pediatric patients with solid tumors. | yes | no | 1 |
9443071 | Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. | no | no | 3 |
9461020 | Reduced UV-induced mutations in human osteosarcoma cells stably expressing transfected wild-type p53 cDNA. | no | no | 1 |
9464545 | Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. | no | no | 3 |
9480851 | Suppression of high-density magnetic field (400 mT at 50 Hz)-induced mutations by wild-type p53 expression in human osteosarcoma cells. | no | no | 1 |
9492043 | p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. | no | no | 4 |
9538120 | Prognostic significance of cyclin expression in human osteosarcoma. | yes | yes | 4 |
9559293 | Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. | yes | no | 3 |
9605020 | Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis. | yes | yes | 2 |
9615784 | Copper/zinc superoxide dismutase expression by different human osteosarcoma cell lines. | no | no | 2 |
9619593 | Comparative genomic hybridization of low-grade central osteosarcoma. | yes | no | 3 |
9639407 | Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line. | no | no | 1 |
9645345 | Expression of the smooth muscle calponin gene in human osteosarcoma and its possible association with prognosis. | yes | yes | 4 |
9664132 | TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. | no | no | 5 |
9665476 | CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. | yes | no | 3 |
9672192 | Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton. | yes | yes | 2 |
9685858 | Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. | yes | yes | 5 |
9703873 | Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. | yes | no | 1 |
9703945 | Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. | no | no | 3 |
9703989 | Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. | no | no | 2 |
9714336 | p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. | no | no | 2 |
9717810 | Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells. | no | no | 3 |
9723038 | Correlation between apoptosis and TP53 status in osteosarcoma. | yes | no | 1 |
9743295 | P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. | yes | no | 2 |
9748149 | Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. | no | yes | 2 |
9762887 | Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. | yes | no | 3 |
9771482 | Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. | yes | no | 3 |
9778623 | C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression. | yes | yes | 2 |
9781640 | Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy. | yes | yes | 3 |
9788258 | Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. | yes | no | 2 |
9793960 | Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. | yes | yes | 2 |
9818023 | Abnormalities of the FHIT transcripts in osteosarcoma and Ewing sarcoma. | yes | no | 1 |
9820862 | Genetic instability in osteoblastic tumors of the skeletal system. | yes | no | 5 |
9824113 | p53 gene mutations in osteosarcomas of low-grade malignancy. | yes | no | 1 |
9824653 | A possible role for multidrug resistance-associated protein in the secretion of basic fibroblast growth factor by osteogenic sarcoma cell line (MG-63). | no | no | 2 |
9835898 | Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma. | yes | no | 1 |
9858899 | Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. | no | no | 6 |
9890264 | Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. | yes | no | 1 |
9891539 | p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. | yes | no | 2 |
9917506 | Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. | yes | yes | 3 |
9923924 | Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. | yes | yes | 2 |
9935160 | Redundancy of autocrine loops in human osteosarcoma cells. | no | no | 2 |
9935200 | CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. | yes | no | 5 |
9989824 | The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells. | no | no | 1 |
9989829 | Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. | yes | no | 3 |
10086509 | Protease expression in dedifferentiated parosteal osteosarcoma. | yes | no | 3 |
10100715 | Mechanisms of methotrexate resistance in osteosarcoma. | yes | no | 2 |
10101594 | Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. | yes | no | 3 |
10189891 | Frequent beta-catenin abnormalities in bone and soft-tissue tumors. | yes | no | 1 |
10232607 | Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. | no | no | 5 |
10234573 | ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. | no | no | 5 |
10339667 | Expression of G1 phase regulators in MG-63 osteosarcoma cell line. | no | no | 8 |
10352100 | Expression and localization of estrogen receptor-beta in murine and human bone. | no | no | 1 |
10375199 | Differential regulation of syndecan expression by osteosarcoma cell lines in response to cytokines but not osteotropic hormones. | no | no | 3 |
10388536 | Increased phosphorylation of eukaryotic initiation factor 2alpha at the G2/M boundary in human osteosarcoma cells correlates with deglycosylation of p67 and a decreased rate of protein synthesis. | no | no | 2 |
10390144 | Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. | no | no | 3 |
10411143 | Expression and regulation of the meprin beta gene in human cancer cells. | no | no | 6 |
10441007 | Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. | yes | no | 4 |
10453987 | Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. | no | no | 4 |
10491221 | The transcription factor Sox9 is involved in BMP-2 signaling. | no | no | 6 |
10493528 | S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. | no | no | 5 |
10498894 | p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis. | no | no | 2 |
10502725 | Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. | yes | yes | 4 |
10533453 | Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. | yes | yes | 3 |
10536172 | NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. | no | no | 2 |
10541973 | Expression of CD44 variants in osteosarcoma. | yes | yes | 1 |
10550312 | Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. | yes | yes | 3 |
10561353 | Expression of HER2/erbB-2 correlates with survival in osteosarcoma. | yes | yes | 3 |
10568818 | Modulation of fas-mediated apoptosis in osteosarcoma cell lines. | no | no | 1 |
10569469 | P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy. | yes | yes | 1 |
10569470 | Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. | yes | no | 3 |
10571205 | A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. | no | no | 6 |
10606250 | Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line. | no | no | 1 |
10627702 | Expression of bone morphogenetic proteins and receptors in sarcomas. | yes | yes | 6 |
10638971 | Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. | yes | yes | 1 |
10663637 | Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. | no | no | 3 |
10690541 | Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. | yes | yes | 2 |
10697522 | De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. | no | yes | 1 |
10702275 | Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. | no | no | 3 |
10703939 | Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1. | no | no | 2 |
10709992 | Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. | no | no | 2 |
10726973 | Insulin-like growth factor-I inhibits the progression of human U-2 OS osteosarcoma cells towards programmed cell death through interaction with the IGF-I receptor. | no | no | 2 |
10748103 | Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells. | no | no | 1 |
10762653 | Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma. | yes | yes | 1 |
10769661 | Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma. | no | no | 1 |
10773107 | Steroid receptor co-activator-1 mediates 1,25-dihydroxyvitamin D(3)-stimulated alkaline phosphatase in human osteosarcoma cells. | no | no | 3 |
10776793 | Serum antibodies against the heat shock protein 60 are elevated in patients with osteosarcoma. | yes | yes | 1 |
10800398 | h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors. | yes | no | 1 |
10807968 | Effect of hyperthermia on the viability and the fibrinolytic potential of human cancer cell lines. | no | no | 2 |
10810457 | P-glycoprotein levels predict poor outcome in patients with osteosarcoma. | yes | yes | 1 |
10814523 | Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. | no | no | 1 |
10846544 | Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells. | no | no | 7 |
10853014 | Expression of the SART1 tumor-rejection antigen in human osteosarcomas. | yes | yes | 1 |
10862039 | Chromosomal regions involved in the pathogenesis of osteosarcomas. | yes | yes | 1 |
10872665 | Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma: a clinicopathologic and immunohistochemical study. | yes | yes | 2 |
10874667 | Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. | yes | no | 3 |
10891538 | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. | yes | yes | 2 |
10894867 | MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. | yes | no | 1 |
10896792 | The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent. | no | no | 3 |
10914045 | Heat-shock protein 72 in human osteosarcoma: T-lymphocyte reactivity and cytotoxicity. | yes | no | 1 |
10942797 | Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. | yes | yes | 5 |
10943202 | Analysis of 12q13-15 genes in parosteal osteosarcoma. | yes | no | 3 |
10953349 | Homeobox B3, B4, and C6 gene product expression in osteosarcomas as detected by immunocytochemistry. | yes | no | 3 |
10977962 | Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. | yes | yes | 2 |
11071251 | Osteoclast differentiation factor in human osteosarcoma cell line. | no | no | 1 |
11087053 | Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. | yes | yes | 7 |
11089884 | Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. | no | no | 5 |
11093825 | Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. | no | no | 8 |
11103961 | Expression of nm23 protein in human osteosarcoma in relationship with early metastasis. | yes | no | 1 |
11115584 | Osteosarcoma in blood relatives. | yes | no | 6 |
11154005 | Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma. | yes | yes | 1 |
11155673 | Preliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma. | yes | yes | 2 |
11155789 | Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. | no | no | 2 |
11156738 | Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. | no | no | 4 |
11169148 | Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. | yes | yes | 2 |
11179483 | Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitor. | no | no | 1 |
11235987 | Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. | no | no | 3 |
11241246 | Primary pulmonary osteosarcoma: case report and molecular analysis. | yes | no | 2 |
11241308 | Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. | yes | yes | 3 |
11289134 | Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. | no | no | 4 |
11294418 | The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. | yes | yes | 2 |
11306692 | The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. | no | no | 6 |
11319838 | Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. | no | no | 4 |
11331958 | Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to differentiation of p53-deficient MG-63 osteosarcoma cells. | no | no | 1 |
11341357 | Ki-67: a proliferative marker that may predict pulmonary metastases and mortality of primary osteosarcoma. | yes | yes | 1 |
11344491 | Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. | yes | no | 2 |
11351498 | Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. | yes | no | 1 |
11358827 | Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. | no | yes | 3 |
11393276 | Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. | no | no | 2 |
11398843 | Detection of c-fos expression in benign and malignant musculoskeletal lesions. | yes | no | 1 |
11398844 | Expression of a newly defined tumor-rejection antigen SART3 in musculoskeletal tumors and induction of HLA class I-restricted cytotoxic T lymphocytes by SART3-derived peptides. | yes | yes | 1 |
11408805 | Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma. | yes | yes | 1 |
11418138 | pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. | no | no | 5 |
11425650 | Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells. | no | no | 2 |
11451946 | Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. | no | no | 3 |
11454519 | Effects of IGF-I and -II, IGF binding protein-3 (IGFBP-3), and transforming growth factor-beta (TGF-beta) on growth and apoptosis of human osteosarcoma Saos-2/B-10 cells: lack of IGF-independent IGFBP-3 effects. | no | no | 3 |
11464280 | Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. | no | no | 5 |
11498774 | Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. | no | no | 1 |
11498785 | Relative frequency and morphology of cancers in carriers of germline TP53 mutations. | yes | no | 1 |
11505415 | Amplification of the HER-2/neu oncogene is uncommon in pediatric osteosarcomas. | yes | no | 1 |
11513857 | The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. | no | no | 2 |
11545733 | The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. | no | no | 2 |
11564577 | Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. | yes | no | 2 |
11569927 | Loss of KAI1/CD82 expression in bone and soft tissue tumors is not associated with lung metastasis. | yes | no | 1 |
11595696 | Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma. | yes | yes | 1 |
11596036 | Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. | yes | no | 1 |
11689005 | Inhibition of vitronectin-mediated haptotaxis and haptoinvasion of MG-63 cells by domain 5 (D5(H)) of human high-molecular-weight kininogen and identification of a minimal amino acid sequence. | no | no | 2 |
11695244 | Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. | no | no | 3 |
11707342 | Identification of twenty-two candidate markers for human osteogenic sarcoma. | no | no | 5 |
11713566 | Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. | yes | no | 3 |
11743051 | Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. | yes | no | 1 |
11746520 | Cellular and molecular properties associated with osteosarcoma cells. | yes | no | 9 |
11746983 | Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. | yes | no | 1 |
11748477 | Prognostic significance of serum alkaline phosphatase in osteosarcoma of the extremity treated with neoadjuvant chemotherapy: recent experience at Rizzoli Institute. | yes | yes | 1 |
11753985 | Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. | yes | yes | 3 |
11768200 | Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. | no | no | 2 |
11793439 | Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. | yes | no | 1 |
11794258 | Clinical significance of P-glycoprotein immunohistochemistry and doxorubicin binding assay in patients with osteosarcoma. | yes | yes | 1 |
11797833 | Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. | yes | no | 1 |
11820362 | Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. | no | no | 5 |
11859242 | Expression of CD44 isoforms correlates with the metastatic potential of osteosarcoma. | yes | yes | 1 |
11874241 | Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. | no | no | 3 |
11895909 | Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma. | no | no | 1 |
11895910 | Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma. | yes | no | 1 |
11906172 | Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells. | no | no | 1 |
11914627 | C-kit expression in pediatric solid tumors: a comparative immunohistochemical study. | yes | no | 1 |
11920494 | ErbB2 expression is correlated with increased survival of patients with osteosarcoma. | yes | yes | 1 |
11920584 | Troglitazione affects survival of human osteosarcoma cells. | no | no | 2 |
11943335 | Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. | no | no | 3 |
11948409 | Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. | yes | yes | 3 |
11953816 | Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. | yes | yes | 1 |
11986346 | The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. | yes | no | 7 |
11992538 | Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. | no | no | 6 |
12012007 | The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. | no | no | 4 |
12014674 | Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. | no | no | 3 |
12024286 | Cyclooxygenase-2 expression in pediatric sarcomas. | yes | no | 1 |
12027404 | Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. | no | no | 1 |
12054686 | Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. | no | no | 2 |
12085209 | Investigations on a clinically and functionally unusual and novel germline p53 mutation. | yes | no | 1 |
12140175 | Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. | no | no | 1 |
12168884 | Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. | yes | yes | 2 |
12181274 | Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. | yes | no | 4 |
12188489 | Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. | yes | yes | 2 |
12209731 | Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. | yes | yes | 6 |
12218590 | Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels. | yes | no | 4 |
12220726 | Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors. | no | no | 2 |
12221644 | Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma. | yes | no | 1 |
12232677 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. | no | no | 7 |
12237108 | Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. | no | no | 6 |
12368234 | Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. | no | no | 2 |
12388161 | 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. | no | no | 5 |
12393937 | Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. | no | no | 3 |
12401825 | Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. | yes | no | 3 |
12402302 | Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. | yes | no | 1 |
12404059 | Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors. | yes | no | 2 |
12408470 | Thrombin is present in the lungs of patients with primary extremity osteosarcoma and pulmonary metastases. | yes | no | 1 |
12415617 | Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells. | no | no | 1 |
12426100 | The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. | yes | no | 1 |
12478472 | Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. | no | no | 4 |
12527715 | Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma. | yes | yes | 1 |
12529988 | Prostate-specific antigen (PSA)-mediated proliferation, androgenic regulation and inhibitory effects of LY312340 in HOS-TE85 (TE85) human osteosarcoma cells. | no | no | 1 |
12544770 | Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. | yes | yes | 1 |
12550767 | Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma. | yes | no | 3 |
12560446 | Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities. | yes | yes | 1 |
12569382 | ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. | yes | yes | 2 |
12576457 | Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. | yes | no | 1 |
12588801 | Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. | yes | no | 3 |
12616540 | Alpha 4 integrin increases anoikis of human osteosarcoma cells. | yes | no | 4 |
12621691 | Serum concentrations of sCD30 and sCD40L in patients with malignant bone tumours. | yes | yes | 2 |
12647018 | Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells. | no | no | 2 |
12660819 | Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. | no | no | 3 |
12672477 | Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. | no | no | 1 |
12673561 | Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. | yes | no | 1 |
12673693 | Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. | yes | no | 2 |
12679640 | Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. | yes | no | 1 |
12689679 | Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. | yes | yes | 5 |
12708477 | Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma. | yes | no | 2 |
12709413 | Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. | no | no | 1 |
12711293 | Survivin expression in human osteosarcoma is a marker for survival. | yes | yes | 1 |
12734318 | Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. | yes | yes | 1 |
12747978 | Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. | yes | no | 5 |
12759621 | Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. | yes | yes | 4 |
12782945 | Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. | no | no | 3 |
12789260 | Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. | no | no | 9 |
12792742 | Inactivation of the RASSF1A in osteosarcoma. | yes | no | 1 |
12799638 | Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping. | yes | no | 2 |
12802802 | Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. | yes | no | 1 |
12813132 | mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. | yes | yes | 5 |
12824921 | Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas. | yes | no | 1 |
12829666 | Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. | yes | yes | 2 |
12838325 | Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. | no | no | 4 |
12842447 | Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. | no | no | 2 |
12850370 | Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. | yes | no | 1 |
12879476 | The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. | yes | yes | 1 |
12883746 | Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression. | yes | yes | 1 |
12894891 | Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. | yes | no | 2 |
12907249 | Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. | no | no | 6 |
12912938 | Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target. | yes | no | 1 |
12917637 | Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. | yes | no | 3 |
12919886 | Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. | no | no | 6 |
12926161 | Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours. | yes | yes | 3 |
12930359 | IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. | no | no | 2 |
12943619 | Telomerase, p53 and PCNA activity in osteosarcoma. | yes | yes | 3 |
12972634 | The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. | yes | no | 2 |
12973938 | Construction of antisense transforming growth factor beta 1 gene and its effect on the proliferation by expression in osteosarcoma cells. | no | no | 1 |
14506695 | High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. | yes | no | 4 |
14506946 | Urinary excretion of pyridinium cross-links and serum osteocalcin levels in patients with primary high-grade osteosarcoma. | yes | yes | 1 |
14528100 | Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. | yes | no | 3 |
14534726 | Effect of retinoblastoma tumor suppressor gene expression on chemosensitivity of human osteosarcoma cell lines. | no | no | 1 |
14557934 | Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions. | yes | no | 1 |
14559221 | E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. | no | no | 3 |
14582536 | Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. | no | no | 5 |
14584080 | Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. | yes | yes | 2 |
14598359 | Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. | yes | yes | 9 |
14598886 | Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. | yes | yes | 1 |
14610316 | Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. | no | no | 2 |
14624456 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. | yes | no | 2 |
14629833 | Somatostatin receptor (SSTR) scintigraphy in patients with osteosarcoma. | yes | yes | 1 |
14631380 | Evaluation of the predictive value of Her-2/neu gene expression on osteosarcoma therapy in laser-microdissected paraffin-embedded tissue. | yes | yes | 1 |
14633705 | SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. | no | no | 4 |
14637192 | Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. | no | no | 5 |
14647441 | FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. | no | no | 6 |
14660053 | Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. | no | no | 4 |
14669798 | Biological properties and gene expression associated with metastatic potential of human osteosarcoma. | no | no | 5 |
14676807 | Gene expression array profile of human osteosarcoma. | yes | no | 1 |
14679136 | Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. | yes | yes | 3 |
14682477 | Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. | no | no | 4 |
14695161 | A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo. | no | no | 1 |
14704791 | The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. | no | yes | 2 |
14706926 | Effect of human granulocyte macrophage-colony stimulating factor on differentiation and apoptosis of the human osteosarcoma cell line SaOS-2. | no | no | 3 |
14713104 | S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. | no | no | 5 |
14719070 | Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. | no | no | 2 |
14719113 | Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. | no | no | 3 |
14735475 | Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. | yes | yes | 1 |
14760101 | Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. | no | no | 3 |
14973099 | High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. | yes | yes | 2 |
14975209 | Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. | no | no | 4 |
14996747 | Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. | no | no | 1 |
14999771 | Mutation analysis of the apoptotic \death-receptors\ and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. | yes | no | 1 |
15015580 | PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS). | no | no | 1 |
15026342 | Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. | yes | no | 3 |
15026814 | A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. | no | no | 2 |
15049011 | Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. | no | no | 1 |
15055356 | Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. | no | no | 3 |
15067366 | The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. | no | no | 1 |
15069760 | HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. | yes | no | 2 |
15087387 | Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. | no | no | 3 |
15093570 | Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcomas. | yes | no | 1 |
15095405 | IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. | no | no | 6 |
15112275 | Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. | yes | yes | 4 |
15138564 | Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. | no | no | 6 |
15144225 | Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. | no | no | 5 |
15145525 | CD9 expression is not a prognostic factor in human osteosarcoma. | yes | no | 1 |
15167009 | Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. | yes | yes | 7 |
15174116 | Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. | no | no | 11 |
15193436 | Overexpression through amplification of genes in chromosome region 17p11.2 approximately p12 in high-grade osteosarcoma. | yes | no | 3 |
15198903 | p21WAF1/CIP1 gene DNA sequencing and its expression in human osteosarcoma. | yes | no | 1 |
15201972 | Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma. | yes | no | 1 |
15205094 | Identification of a transcriptionally inactive p53 mutant by functional analysis of separated alleles in yeasts (FASAY) in a child osteosarcoma tumor: a case report. | yes | yes | 1 |
15207713 | Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. | no | no | 6 |
15210853 | Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. | yes | yes | 1 |
15211578 | Annexin 2 expression is reduced in human osteosarcoma metastases. | yes | no | 1 |
15221963 | Mutation analysis of the RECQL4 gene in sporadic osteosarcomas. | yes | no | 1 |
15237589 | Low expression of p63 and p73 in osteosarcoma. | yes | no | 2 |
15247015 | Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. | no | no | 1 |
15250258 | Effects of TGF beta1 autocrine blockage on osteosarcoma cells. | no | no | 1 |
15262428 | Characterization of PMP22 expression in osteosarcoma. | yes | no | 1 |
15268905 | Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation. | no | no | 2 |
15289892 | A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. | no | no | 1 |
15298715 | Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. | yes | no | 10 |
15310147 | Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. | yes | no | 4 |
15313187 | Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts. | no | no | 2 |
15314286 | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | no | no | 4 |
15318945 | Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. | no | no | 3 |
15325100 | Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. | yes | no | 3 |
15346048 | VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI. | yes | yes | 1 |
15365076 | Telomerase expression predicts unfavorable outcome in osteosarcoma. | yes | yes | 1 |
15370596 | Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. | yes | no | 4 |
15390286 | Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. | no | no | 4 |
15390294 | Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. | yes | no | 1 |
15448009 | Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: a meta-analysis. | yes | yes | 1 |
15455381 | Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. | no | no | 4 |
15467717 | von Willebrand factor expression in osteosarcoma metastasis. | yes | no | 1 |
15488761 | Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. | yes | no | 2 |
15492501 | Differential oncogenic Ras signaling and senescence in tumor cells. | no | no | 2 |
15516323 | Effect of TNF-alpha on human osteosarcoma cell line Saos2--TNF-alpha regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells. | no | no | 4 |
15538723 | Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. | no | no | 2 |
15540114 | Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. | no | no | 3 |
15540165 | Gene amplifications in osteosarcoma-CGH microarray analysis. | yes | no | 2 |
15547696 | Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. | no | no | 6 |
15583032 | Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. | no | no | 3 |
15585647 | Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. | yes | no | 1 |
15609301 | Altered expression and deletion of RMO1 in osteosarcoma. | yes | yes | 1 |
15625311 | Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. | no | no | 3 |
15627479 | Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. | no | no | 13 |
15649646 | Differential effects of clusterin/apolipoprotein J on cellular growth and survival. | no | no | 1 |
15656333 | Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: experience at Rizzoli on 1421 patients treated over the last 30 years. | yes | yes | 1 |
15662138 | The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. | no | no | 5 |
15670817 | Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. | no | no | 12 |
15701832 | Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. | no | no | 3 |
15705874 | Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. | no | no | 5 |
15735124 | TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. | yes | no | 1 |
15735172 | An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma. | yes | yes | 2 |
15742288 | Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. | no | no | 6 |
15746965 | Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. | no | no | 6 |
15753370 | An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. | yes | no | 8 |
15796961 | Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. | yes | no | 2 |
15800315 | Prognostic significance of allelic imbalance at the c-kit gene locus and c-kit overexpression by immunohistochemistry in pediatric osteosarcomas. | yes | yes | 1 |
15814634 | Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. | yes | yes | 3 |
15816563 | Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. | no | no | 3 |
15827336 | p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. | no | no | 2 |
15870699 | Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. | no | no | 3 |
15883045 | Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. | no | no | 3 |
15900593 | Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. | yes | yes | 3 |
15912538 | CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. | yes | no | 3 |
15913990 | Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. | yes | yes | 2 |
15922739 | Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity. | no | no | 1 |
15923123 | Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). | no | no | 3 |
15936998 | Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. | no | no | 5 |
15939402 | Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expression. | no | no | 1 |
15946696 | Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. | no | no | 4 |
15965098 | Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. | no | no | 2 |
15985268 | Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. | no | no | 3 |
16007340 | Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. | no | no | 5 |
16007579 | Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. | no | no | 3 |
16008557 | Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. | yes | no | 2 |
16010295 | Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation. | no | no | 5 |
16026999 | Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. | no | no | 3 |
16035619 | Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. | no | no | 2 |
16083752 | Matrix metalloproteinases participate in osteosarcoma invasion. | no | no | 2 |
16119739 | Expression and significance of TGF-beta isoform and VEGF in osteosarcoma. | yes | yes | 1 |
16140185 | Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). | no | no | 1 |
16157226 | Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. | yes | yes | 1 |
16167336 | Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. | no | no | 6 |
16196299 | Relationship between the expression of MTA-1 gene and the metastasis and invasion in human osteosarcoma. | no | no | 1 |
16206219 | CGH evaluation of two de novo synchronous tumors in a child with a germline p53 mutation. | yes | no | 1 |
16211088 | Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin. | yes | no | 1 |
16211448 | HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. | yes | no | 1 |
16213662 | Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. | no | no | 5 |
16219634 | Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. | no | no | 2 |
16259979 | Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. | no | no | 6 |
16269403 | Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation. | no | no | 1 |
16273216 | Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. | no | no | 1 |
16282894 | Fas expression in lung metastasis from osteosarcoma patients. | yes | yes | 1 |
16327977 | Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. | yes | yes | 2 |
16327988 | Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. | no | no | 2 |
16328036 | Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. | no | no | 3 |
16354601 | Immunohistochemical examination of cytological differentiation in osteosarcomas. | yes | no | 2 |
16369996 | Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. | no | no | 2 |
16380506 | Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. | no | no | 2 |
16394764 | Aberrant methylation of p14ARF gene correlates with poor survival in osteosarcoma. | yes | yes | 1 |
16417466 | Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. | no | no | 6 |
16421247 | CD99 acts as an oncosuppressor in osteosarcoma. | no | no | 3 |
16437349 | Expression of a novel alternatively spliced UCP-2 transcript in osteogenic sarcoma. | yes | no | 1 |
16466985 | Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. | no | no | 4 |
16470222 | RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. | no | no | 6 |
16475708 | Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. | no | no | 5 |
16502411 | Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. | yes | yes | 4 |
16528367 | CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. | yes | yes | 2 |
16533764 | Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. | no | no | 6 |
16540432 | Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. | no | no | 3 |
16547468 | Immunohistochemical detection of WT1 protein in a variety of cancer cells. | yes | no | 1 |
16571651 | Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. | no | no | 6 |
16596382 | Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. | yes | no | 7 |
16677779 | Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. | yes | yes | 1 |
16683887 | Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions. | yes | yes | 1 |
16696324 | Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell. | no | no | 2 |
16705726 | Expression of survivin and correlation with PCNA in osteosarcoma. | yes | yes | 2 |
16734381 | Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. | no | no | 6 |
16751779 | Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. | no | no | 1 |
16759849 | PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. | no | no | 2 |
16764926 | Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. | yes | no | 1 |
16773198 | HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. | no | no | 3 |
16786118 | Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? | yes | no | 1 |
16795036 | Okadaic acid induces phosphorylation of p65NF-kappaB on serine 536 and activates NF-kappaB transcriptional activity in human osteoblastic MG63 cells. | no | no | 1 |
16797629 | Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. | no | no | 6 |
16798617 | Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. | no | no | 6 |
16814113 | Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. | no | no | 4 |
16818639 | Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. | no | no | 1 |
16822878 | Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. | yes | yes | 1 |
16826116 | Vascular endothelial growth factor expression in osteosarcoma. | yes | yes | 1 |
16827134 | Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells. | no | no | 2 |
16849574 | E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. | no | no | 3 |
16857797 | High WT1 expression is associated with very poor survival of patients with osteogenic sarcoma metastasis. | yes | yes | 1 |
16878156 | Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. | no | no | 6 |
16933368 | Effects of hyperthermia on heat shock protein expression, alkaline phosphatase activity and proliferation in human osteosarcoma cells. | no | no | 2 |
16938571 | hCDC4 variation in osteosarcoma. | yes | no | 1 |
16944980 | KAI-1 expression in pediatric high-grade osteosarcoma. | yes | no | 1 |
16956425 | Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. | no | no | 3 |
16962318 | Expression of transcription factor Yin Yang 1 in human osteosarcomas. | yes | yes | 1 |
16982772 | Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. | no | no | 5 |
17001316 | PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. | yes | no | 2 |
17012855 | Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells. | no | no | 1 |
17014383 | Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. | no | no | 1 |
17018686 | Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker. | yes | yes | 1 |
17022822 | Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. | yes | no | 3 |
17034065 | Survivin expression levels as independent predictors of survival for osteosarcoma patients. | yes | yes | 1 |
17045162 | Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies. | no | no | 3 |
17079093 | Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. | yes | no | 1 |
17088985 | May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. | yes | yes | 1 |
17089020 | Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. | yes | no | 1 |
17096323 | Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. | no | no | 1 |
17096406 | Germ-line genetic variation of TP53 in osteosarcoma. | yes | no | 1 |
17113707 | Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. | no | no | 1 |
17116726 | Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. | no | no | 12 |
17120184 | Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. | no | no | 7 |
17136003 | p53 gene gets altered by various mechanisms: studies in childhood sarcomas and retinoblastoma. | yes | no | 1 |
17189270 | alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. | no | no | 4 |
17203229 | Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. | yes | yes | 1 |
17206471 | The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell cycle arrest and apoptosis. | no | no | 1 |
17218775 | Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. | no | no | 7 |
17218778 | Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. | no | no | 8 |
17222495 | Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. | no | no | 2 |
17230544 | Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors. | yes | no | 1 |
17234448 | Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. | no | no | 4 |
17234543 | Low-grade central osteosarcoma of the mandible: a case study report. | yes | no | 3 |
17237146 | Overexpression of hypoxia-inducible factor-1alpha in human osteosarcoma: correlation with clinicopathological parameters and survival outcome. | yes | yes | 1 |
17254772 | RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. | no | no | 3 |
17256128 | The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase. | no | no | 1 |
17262820 | RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. | no | no | 3 |
17279585 | Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. | no | no | 3 |
17294449 | KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? | yes | no | 2 |
17310851 | Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. | no | no | 2 |
17317953 | Loss of TP53 in sarcomas with 17p12 to approximately p11 gain. A fine-resolution oligonucleotide array comparative genomic hybridization study. | yes | no | 3 |
17318900 | Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. | no | no | 12 |
17320498 | The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells. | no | no | 1 |
17323424 | Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. | no | no | 7 |
17342313 | Bax gene therapy for human osteosarcoma using cationic liposomes in vivo. | no | no | 1 |
17343982 | Negative growth control of osteosarcoma cell by Bowman-Birk protease inhibitor from soybean; involvement of connexin 43. | no | no | 1 |
17353802 | Ezrin expression predicts survival in stage IIB osteosarcomas. | yes | yes | 1 |
17356895 | Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. | no | no | 6 |
17366602 | COPS3 amplification and clinical outcome in osteosarcoma. | yes | yes | 2 |
17372931 | Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. | no | no | 8 |
17376718 | Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production. | no | no | 3 |
17390023 | Determination of the prognostic value of loss of heterozygosity at the retinoblastoma gene in osteosarcoma. | yes | no | 1 |
17391929 | Expression and pathological relevance of inducible nitric oxide synthase in osteosarcoma of the jaws. | yes | yes | 1 |
17395421 | Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. | no | no | 3 |
17410535 | Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. | yes | no | 3 |
17412493 | 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. | no | no | 9 |
17415755 | Expression of major vault protein gene in osteosarcoma patients. | yes | yes | 1 |
17440083 | Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. | yes | no | 1 |
17458711 | Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. | no | no | 4 |
17465200 | LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. | no | no | 3 |
17471233 | Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. | no | no | 10 |
17473184 | The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. | yes | no | 2 |
17483704 | TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. | yes | no | 1 |
17493842 | Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132. | no | no | 1 |
17505002 | Epidermal growth factor receptor expression in high-grade osteosarcomas is associated with a good clinical outcome. | yes | yes | 1 |
17506944 | Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines. | no | no | 2 |
17506984 | Midkine as a novel target for antibody therapy in osteosarcoma. | yes | yes | 1 |
17509570 | Osteosarcoma cell-calcium signaling through tissue factor-factor VIIa complex and factor Xa. | no | no | 3 |
17509661 | Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis. | no | no | 1 |
17513610 | Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. | no | no | 3 |
17520676 | Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | no | no | 9 |
17536311 | Expression of cyclooxygenase-2 in osteosarcoma of bone. | yes | yes | 1 |
17549480 | Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line. | no | no | 2 |
17560052 | High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. | yes | yes | 1 |
17568187 | Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. | no | no | 4 |
17569615 | IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. | no | no | 6 |
17598902 | Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. | yes | no | 1 |
17609619 | High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. | yes | yes | 1 |
17611411 | P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. | no | no | 4 |
17611684 | Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. | no | no | 4 |
17611696 | Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. | no | no | 6 |
17627080 | Regulation of the mGluR5, EAAT1 and GS expression by glucocorticoids in MG-63 osteoblast-like osteosarcoma cells. | no | no | 2 |
17632732 | Livin and Bcl-2 expression in high-grade osteosarcoma. | yes | yes | 2 |
17645699 | Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. | yes | no | 3 |
17660802 | Prognostic significance of drug-regulated genes in high-grade osteosarcoma. | yes | yes | 9 |
17682054 | Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. | no | no | 3 |
17683065 | Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis. | yes | yes | 3 |
17684144 | Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma. | yes | yes | 1 |
17690908 | Possible prognostic role of IL-17R in osteosarcoma. | no | yes | 2 |
17699771 | Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. | no | yes | 3 |
17786187 | Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. | yes | yes | 3 |
17786325 | The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. | no | no | 2 |
17786474 | Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. | yes | yes | 3 |
17849429 | Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. | no | no | 5 |
17873971 | Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression. | no | yes | 1 |
17886294 | Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. | yes | yes | 1 |
17892509 | Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. | no | no | 2 |
17934334 | Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. | no | no | 3 |
17952379 | The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA. | no | yes | 1 |
17956871 | Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. | no | no | 3 |
17959036 | Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. | no | no | 7 |
17980151 | Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. | no | no | 4 |
17980359 | Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. | no | no | 8 |
17981215 | Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization. | no | no | 2 |
17982618 | Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. | no | no | 3 |
17987039 | A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. | yes | yes | 2 |
17998668 | Prognostic and predictive value of c-erbB2 overexpression in osteogenic sarcoma. | no | no | 2 |
18019405 | Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. | yes | no | 3 |
18047805 | Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. | no | no | 2 |
18048360 | Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. | no | no | 3 |
18081879 | Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. | yes | no | 4 |
18090928 | Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. | yes | no | 1 |
18093185 | Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells. | no | no | 3 |
18097539 | Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines. | no | no | 6 |
18158779 | Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. | yes | yes | 3 |
18161867 | Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. | yes | yes | 3 |
18171692 | Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. | no | no | 1 |
18196972 | Regulation of the p14ARF promoter by DNA methylation. | no | no | 1 |
18215331 | A complex pattern of chemokine receptor expression is seen in osteosarcoma. | yes | yes | 5 |
18223689 | Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. | no | no | 2 |
18245529 | Prognostic value of CCN3 in osteosarcoma. | yes | yes | 1 |
18252811 | Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. | no | no | 2 |
18307025 | A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene. | yes | no | 1 |
18332870 | Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. | no | no | 7 |
18338812 | Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. | yes | no | 4 |
18339860 | Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. | no | no | 3 |
18348660 | Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma. | yes | no | 1 |
18359978 | CDH11 expression is associated with survival in patients with osteosarcoma. | yes | yes | 1 |
18359981 | The proteome profile of the human osteosarcoma U2OS cell line. | no | no | 10 |
18374478 | Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin. | no | no | 2 |
18384113 | 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. | no | no | 4 |
18385200 | Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. | yes | no | 2 |
18414033 | Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. | no | no | 6 |
18421709 | C-erbB-2 expression and prognostic significance in osteosarcoma. | yes | no | 1 |
18438338 | VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. | yes | no | 3 |
18443365 | Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. | yes | no | 1 |
18445685 | PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. | yes | no | 5 |
18464244 | Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas. | yes | yes | 1 |
18465804 | Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. | yes | no | 1 |
18472964 | Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. | no | no | 1 |
18483362 | Critical role of notch signaling in osteosarcoma invasion and metastasis. | yes | yes | 4 |
18488713 | Silencing of YY1 downregulates RIZ1 promoter in human osteosarcoma. | no | no | 2 |
18498722 | Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. | yes | no | 1 |
18501891 | Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. | no | no | 10 |
18505923 | Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. | no | no | 2 |
18507006 | Identification of potential chemoresistance genes in osteosarcoma. | no | no | 4 |
18507025 | Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412. | no | no | 1 |
18510171 | Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. | no | no | 9 |
18520037 | BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. | no | no | 1 |
18524773 | FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. | no | no | 4 |
18528739 | Hypoxia markers in human osteosarcoma: an exploratory study. | yes | no | 2 |
18554951 | Expression and significance of hypoxemia-inducible factor-1alpha in osteosarcoma of the jaws. | yes | yes | 1 |
18563508 | Expression of macrophage migration inhibitory factor relates to survival in high-grade osteosarcoma. | yes | no | 2 |
18567798 | Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. | yes | no | 10 |
18598236 | Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells. | no | no | 3 |
18606492 | The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. | no | no | 5 |
18607665 | Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. | no | no | 2 |
18612712 | S100A6 expression and function in human osteosarcoma. | yes | yes | 1 |
18645001 | c-Jun knockdown sensitizes osteosarcoma to doxorubicin. | yes | no | 1 |
18675369 | Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells. | no | no | 1 |
18701490 | Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. | no | no | 1 |
18704985 | Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. | yes | no | 2 |
18726921 | High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma. | no | no | 1 |
18757369 | Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. | no | no | 10 |
18758062 | Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. | no | no | 5 |
18771083 | VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. | no | no | 2 |
18775026 | Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins. | yes | no | 1 |
18787415 | scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. | no | no | 1 |
18797196 | COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. | yes | yes | 1 |
18814141 | Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. | no | no | 10 |
18831895 | Expression of c-kit protein and mutational status of the c-kit gene in osteosarcoma and their clinicopathological significance. | yes | yes | 1 |
18838962 | Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. | no | no | 5 |
18854653 | Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. | yes | yes | 2 |
18925963 | Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. | yes | no | 2 |
18931939 | Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. | no | no | 4 |
18941626 | Detection and characterization of CD133+ cancer stem cells in human solid tumours. | no | no | 3 |
18972316 | The expression of novel gene URG4 in osteosarcoma: correlation with patients' prognosis. | yes | yes | 1 |
18981708 | (18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation. | yes | no | 1 |
18986328 | Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. | no | no | 5 |
18989156 | Germline p53 mutation in a Micronesian child with adrenocortical carcinoma and subsequent osteosarcoma. | yes | no | 1 |
18996209 | Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro. | no | no | 1 |
19010839 | Endosialin protein expression and therapeutic target potential in human solid tumors: sarcoma versus carcinoma. | yes | yes | 1 |
19012332 | Somatic TP53 mutation mosaicism in a patient with Li-Fraumeni syndrome. | yes | no | 1 |
19018758 | Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. | no | no | 5 |
19020756 | Increased osteoclast activity is associated with aggressiveness of osteosarcoma. | yes | no | 3 |
19050913 | Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. | yes | yes | 1 |
19052873 | Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. | no | no | 1 |
19060919 | The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. | no | no | 4 |
19066961 | Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death. | no | no | 1 |
19082467 | The expression of CRM1 is associated with prognosis in human osteosarcoma. | yes | yes | 1 |
19105235 | Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. | no | no | 4 |
19125251 | RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines. | no | no | 1 |
19125294 | Down-regulation of ribosomal protein L7A in human osteosarcoma. | yes | yes | 1 |
19142873 | De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. | no | no | 3 |
19148492 | Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. | no | no | 5 |
19159633 | Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. | no | no | 3 |
19159907 | Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. | yes | no | 2 |
19160414 | Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. | no | no | 11 |
19192721 | Expression of insulin-like growth factor-II mRNA binding protein 3 (IMP3) in osteosarcoma. | yes | yes | 1 |
19212684 | The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. | yes | yes | 5 |
19212829 | Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell. | yes | no | 10 |
19228774 | Notch signaling contributes to the pathogenesis of human osteosarcomas. | no | no | 6 |
19229591 | Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. | no | no | 2 |
19242128 | Characterization of stem cell attributes in human osteosarcoma cell lines. | no | no | 1 |
19242607 | Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. | yes | no | 1 |
19244100 | The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. | yes | no | 1 |
19258511 | Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. | yes | no | 4 |
19284568 | Characterization of STAT3 activation and expression in canine and human osteosarcoma. | no | no | 2 |
19307728 | Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. | no | no | 2 |
19326179 | Cyclooxygenase-2 overexpression predicts poor survival in patients with high-grade extremity osteosarcoma: a pilot study. | yes | yes | 1 |
19331807 | Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. | yes | no | 3 |
19338516 | Immunohistochemical profile of ephrin A4 expression in human osteosarcoma. | yes | yes | 1 |
19346874 | Her-2/neu, p-53, and their coexpression in osteosarcoma. | yes | no | 2 |
19347870 | Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. | no | no | 3 |
19351757 | Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. | yes | no | 1 |
19366061 | Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. | yes | yes | 2 |
19393247 | Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. | no | no | 6 |
19427670 | Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma. | yes | no | 1 |
19434073 | Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. | yes | yes | 1 |
19441093 | LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. | yes | yes | 1 |
19445706 | An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. | yes | yes | 1 |
19449377 | Molecular characterization of the response to chemotherapy in conventional osteosarcomas: predictive value of HSD17B10 and IFITM2. | yes | yes | 4 |
19451596 | Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival. | yes | yes | 2 |
19455146 | Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. | no | no | 12 |
19483233 | The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma. | yes | no | 1 |
19486338 | Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. | no | no | 2 |
19488908 | A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. | no | no | 2 |
19492781 | Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. | yes | no | 2 |
19496172 | Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. | no | no | 9 |
19505574 | C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. | no | no | 2 |
19541929 | Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. | no | no | 3 |
19544560 | Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. | no | no | 1 |
19559722 | Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. | no | no | 8 |
19561643 | Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. | no | no | 3 |
19574207 | Pre-treatment serum lactate dehydrogenase level is an important prognostic factor in high-grade extremity osteosarcoma. | yes | yes | 1 |
19584295 | Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. | no | no | 3 |
19596932 | Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. | yes | yes | 1 |
19597468 | Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. | yes | yes | 2 |
19621435 | VEGF expression as a prognostic marker in osteosarcoma. | yes | yes | 1 |
19624845 | Risedronate inhibits human osteosarcoma cell invasion. | no | no | 2 |
19632201 | Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. | yes | no | 4 |
19638450 | Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. | no | no | 1 |
19668151 | Glial fibrillary acidic protein in tumor types with cartilaginous differentiation. | yes | no | 1 |
19670450 | Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. | yes | no | 2 |
19682073 | Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. | no | no | 3 |
19688969 | Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma. | yes | yes | 3 |
19709164 | A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma. | yes | yes | 1 |
19719941 | Integrated assessment of potential value of erbB-2 amplification or expression status as novel therapy target in Chinese children and adolescents with osteosarcoma. | yes | no | 1 |
19724913 | Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. | yes | yes | 1 |
19730790 | Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. | no | no | 5 |
19734943 | Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. | no | no | 4 |
19746447 | Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. | no | no | 5 |
19747555 | Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells. | no | no | 3 |
19757179 | beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. | no | no | 5 |
19760520 | The role of VE-cadherin in osteosarcoma cells. | no | no | 1 |
19778378 | U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. | no | no | 5 |
19779497 | p73 is essential for vitamin D-mediated osteoblastic differentiation. | no | no | 2 |
19789339 | The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. | no | no | 2 |
19802733 | Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma. | yes | yes | 1 |
19818735 | Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. | no | no | 3 |
19836228 | VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. | yes | yes | 2 |
19882675 | Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. | yes | no | 4 |
19885603 | Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. | yes | no | 8 |
19888226 | Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. | yes | no | 2 |
19894220 | Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. | no | no | 2 |
19895174 | Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma. | yes | yes | 1 |
19896763 | Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. | yes | no | 1 |
19900100 | Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. | yes | no | 1 |
19936974 | mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. | yes | yes | 2 |
19951606 | Tenascin-C as a prognostic biomarker in osteosarcoma? | yes | yes | 1 |
19996593 | Antitumor efficacy of two novel non-thiazolidinedione compounds as peroxisome proliferator-activated receptor-gamma agonists in human osteosarcoma cells in vitro. | no | no | 1 |
20003259 | Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. | yes | no | 6 |
20015022 | Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. | no | no | 2 |
20027339 | Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas. | yes | no | 4 |
20032373 | Preferential expression of the secreted and membrane forms of tumor endothelial marker 7 transcripts in osteosarcoma. | yes | no | 1 |
20037818 | Expression of Beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity. | yes | no | 1 |
20038829 | Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB. | no | no | 2 |
20041491 | Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. | no | no | 7 |
20042639 | The kinase Mirk is a potential therapeutic target in osteosarcoma. | yes | yes | 1 |
20044614 | Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no | 5 |
20048075 | Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. | yes | no | 2 |
20053387 | RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. | no | no | 8 |
20063378 | Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. | yes | yes | 1 |
20067614 | Smoothened as a new therapeutic target for human osteosarcoma. | yes | no | 11 |
20071790 | Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome. | yes | yes | 1 |
20082321 | 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells. | no | no | 1 |
20114058 | Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells. | no | no | 7 |
20127006 | The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth. | yes | no | 2 |
20132188 | Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma. | yes | yes | 1 |
20144850 | Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. | no | yes | 1 |
20156969 | Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues. | yes | no | 1 |
20158913 | Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis. | yes | yes | 2 |
20159990 | Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. | yes | yes | 1 |
20181727 | A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia. | no | no | 2 |
20190807 | Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells. | no | no | 2 |
20196171 | Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. | yes | no | 2 |
20197388 | Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. | yes | yes | 1 |
20208568 | Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. | no | no | 3 |
20213410 | How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. | no | yes | 6 |
20213411 | The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. | no | no | 2 |
20218738 | APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. | yes | yes | 1 |
20222016 | Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration. | no | no | 3 |
20225287 | Bone deposition, bone resorption, and osteosarcoma. | yes | yes | 5 |
20309879 | Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. | no | no | 4 |
20340016 | Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcoma. | yes | no | 5 |
20348881 | Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. | yes | yes | 1 |
20349215 | Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. | yes | yes | 2 |
20350217 | Expression of Smad and its signalling cascade in osteosarcoma. | yes | no | 3 |
20354825 | Int7G24A variant of transforming growth factor-beta receptor 1 is associated with osteosarcoma susceptibility in a Chinese population. | yes | yes | 1 |
20357441 | Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. | no | no | 5 |
20362224 | Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. | yes | yes | 12 |
20368414 | IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. | no | no | 4 |
20371684 | Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. | no | no | 3 |
20376536 | Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. | no | no | 4 |
20399482 | Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. | yes | yes | 1 |
20403045 | Expression of podoplanin in human bone and bone tumors: New marker of osteogenic and chondrogenic bone tumors. | yes | yes | 1 |
20406948 | Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. | no | no | 5 |
20429896 | Association between TGFBR1*6A and osteosarcoma: a Chinese case-control study. | yes | yes | 1 |
20433742 | Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. | no | no | 5 |
20459648 | The expression and significance of IDH1 and p53 in osteosarcoma. | yes | yes | 2 |
20459702 | Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. | yes | no | 5 |
20460510 | CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. | no | no | 3 |
20460760 | Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. | no | no | 3 |
20465837 | Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. | yes | yes | 9 |
20480266 | MicroRNA-21 is involved in osteosarcoma cell invasion and migration. | no | no | 2 |
20484142 | Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. | yes | no | 1 |
20486173 | R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. | no | no | 2 |
20491773 | Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma. | yes | no | 1 |
20512478 | Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. | no | no | 2 |
20520719 | Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. | no | no | 1 |
20530675 | Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. | yes | no | 1 |
20530678 | High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. | no | no | 4 |
20546860 | Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma. | yes | no | 1 |
20551950 | Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone. | yes | no | 2 |
20562647 | Immunoexpression of Ezrin and CD44 in patients with osteosarcoma. | yes | no | 2 |
20563836 | Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. | yes | no | 2 |
20577141 | Glutathione S-transferase polymorphisms in osteosarcoma patients. | yes | no | 3 |
20580954 | Functional and biological analysis of Bcl-xL expression in human osteosarcoma. | yes | no | 6 |
20592496 | Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. | no | no | 4 |
20594821 | Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. | yes | no | 2 |
20596639 | Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. | no | no | 5 |
20601938 | Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. | yes | yes | 2 |
20610556 | Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. | yes | yes | 2 |
20625943 | Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells. | no | no | 1 |
20627196 | Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. | no | no | 6 |
20632817 | Expression of heat shock proteins in osteosarcomas. | yes | yes | 3 |
20637078 | Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. | no | no | 2 |
20664979 | N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. | no | no | 3 |
20678472 | Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways. | no | no | 2 |
20682173 | Sensitization of osteosarcoma cell line SaOS-2 to chemotherapy by downregulating survivin. | no | no | 1 |
20701666 | Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. | yes | no | 3 |
20737480 | Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma. | yes | no | 1 |
20798956 | TIMP-1 interaction with αvβ3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-α-induced apoptosis. | no | no | 5 |
20806347 | Elevated expression of CXC chemokines in pediatric osteosarcoma patients. | yes | yes | 2 |
20808934 | Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. | no | no | 6 |
20819644 | Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. | no | no | 3 |
20823153 | Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases. | yes | yes | 1 |
20845987 | +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. | no | no | 2 |
20845995 | Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1α in osteosarcoma. | yes | no | 2 |
20854211 | Glucose transporter protein 1-targeted RNA interference inhibits growth and invasion of the osteosarcoma cell line MG63 in vitro. | no | no | 1 |
20855150 | Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells. | no | no | 3 |
20859706 | Expression change of ezrin as a prognostic factor in primary osteosarcoma. | yes | yes | 1 |
20878132 | microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. | yes | no | 2 |
20880700 | Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. | yes | yes | 5 |
20881269 | Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. | yes | no | 2 |
20926002 | Celecoxib inhibits β-catenin-dependent survival of the human osteosarcoma MG-63 cell line. | no | no | 4 |
20944138 | Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. | no | no | 1 |
20949564 | Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response. | yes | yes | 5 |
20955951 | Markers of bone remodeling in neoplastic and bone-related lesions. | yes | no | 4 |
20970221 | 2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. | no | no | 2 |
20973064 | Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma. | yes | yes | 1 |
20978190 | Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. | no | no | 4 |
21056138 | Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt. | no | no | 2 |
21079421 | Gene expression profiles of human osteosarcoma cell sublines with different pulmonary metastatic potentials. | no | no | 2 |
21080877 | Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome. | yes | no | 1 |
21084254 | Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. | yes | yes | 3 |
21104436 | Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma. | yes | yes | 1 |
21113498 | Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. | yes | yes | 4 |
21116120 | Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells. | no | no | 2 |
21137073 | Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. | yes | yes | 1 |
21145881 | Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. | no | no | 7 |
21149578 | Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. | no | no | 4 |
21152068 | Lysophosphatidic acid acyltransferase β (LPAATβ) promotes the tumor growth of human osteosarcoma. | no | no | 1 |
21159888 | Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. | yes | no | 4 |
21163271 | Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. | no | no | 6 |
21165567 | Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws. | yes | no | 1 |
21166698 | De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway. | no | no | 5 |
21166699 | Therapeutic potential of CAMPATH-1H in skeletal tumours. | yes | no | 1 |
21178508 | BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. | no | no | 6 |
21192060 | Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil. | yes | no | 1 |
21207222 | Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. | yes | yes | 1 |
21215367 | Massive genomic rearrangement acquired in a single catastrophic event during cancer development. | yes | no | 5 |
21234653 | Anti-tumor effects of dihydroartemisinin on human osteosarcoma. | no | no | 10 |
21236332 | 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. | no | no | 5 |
21240382 | Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. | yes | yes | 7 |
21246613 | Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. | no | no | 7 |
21249357 | Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma. | yes | yes | 1 |
21266106 | Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. | no | no | 5 |
21283769 | Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. | yes | no | 2 |
21286665 | Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. | no | no | 3 |
21287529 | Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. | no | no | 3 |
21287809 | Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. | no | no | 4 |
21292304 | Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma. | yes | no | 1 |
21297379 | Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. | no | no | 1 |
21311599 | Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma. | yes | no | 1 |
21312266 | CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. | yes | yes | 1 |
21321933 | Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells. | yes | no | 3 |
21331449 | Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. | no | no | 6 |
21336260 | MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. | yes | yes | 2 |
21340507 | Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. | no | no | 1 |
21345075 | Multiple malignancies in a child with de novo TP53 mutation. | yes | no | 1 |
21370405 | RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. | yes | yes | 1 |
21375766 | RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. | no | no | 4 |
21378337 | The role of MAPK pathway in bone and soft tissue tumors. | yes | no | 3 |
21387396 | ROCK1 as a potential therapeutic target in osteosarcoma. | yes | no | 1 |
21399492 | Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. | no | no | 1 |
21411701 | Interferon-α/β receptor as a prognostic marker in osteosarcoma. | yes | yes | 2 |
21416580 | A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. | yes | yes | 1 |
21421073 | Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity. | no | no | 6 |
21424568 | Relationship between hypermethylated MGMT gene and osteosarcoma necrosis rate after chemotherapy. | yes | no | 1 |
21427707 | MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. | no | no | 2 |
21436869 | RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells. | yes | no | 1 |
21440986 | Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. | no | no | 3 |
21443800 | The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. | no | no | 6 |
21453059 | Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma. | yes | yes | 1 |
21458381 | Cyclin E1 is amplified and overexpressed in osteosarcoma. | yes | yes | 1 |
21460855 | Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. | yes | no | 1 |
21481226 | Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. | no | no | 3 |
21490307 | The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. | no | no | 8 |
21495021 | Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. | yes | yes | 1 |
21506130 | Role of GLI2 in the growth of human osteosarcoma. | yes | yes | 5 |
21508379 | Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma. | yes | no | 1 |
21517265 | SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. | no | no | 3 |
21520041 | Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. | no | no | 2 |
21527497 | Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. | no | no | 5 |
21528673 | Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report. | yes | no | 1 |
21529352 | WEE1 inhibition sensitizes osteosarcoma to radiotherapy. | yes | yes | 1 |
21542455 | Knockdown of MED19 by lentivirus-mediated shRNA in human osteosarcoma cells inhibits cell proliferation by inducing cell cycle arrest in the G0/G1 phase. | no | no | 1 |
21563968 | CD86 + 1057G/A polymorphism and susceptibility to osteosarcoma. | yes | yes | 1 |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no | 16 |
21573994 | Silencing of HMGA1 expression by RNA interference suppresses growth of osteogenic sarcoma. | no | no | 1 |
21617855 | Caffeine activates tumor suppressor PTEN in sarcoma cells. | no | no | 2 |
21617882 | Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. | no | no | 6 |
21619552 | The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. | yes | no | 1 |
21619704 | A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. | yes | yes | 8 |
21631272 | p63 expression in giant cell-containing lesions of bone and soft tissue. | yes | yes | 1 |
21640141 | Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. | no | no | 3 |
21656314 | Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. | no | no | 1 |
21665377 | Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation. | no | no | 1 |
21666078 | MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. | yes | no | 3 |
21667022 | The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. | no | no | 8 |
21671176 | Targeted silencing of heparanase gene by small interfering RNA inhibits invasiveness and metastasis of osteosarcoma cells. | no | no | 1 |
21671177 | Influence of β-catenin small interfering RNA on human osteosarcoma cells. | no | no | 2 |
21681744 | Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. | yes | no | 2 |
21691740 | Insights on PRAME and osteosarcoma by means of gene expression profiling. | yes | no | 1 |
21706236 | Plasma membrane proteomic analysis of human osteosarcoma and osteoblastic cells: revealing NDRG1 as a marker for osteosarcoma. | yes | yes | 1 |
21717192 | Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. | no | no | 7 |
21720717 | Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. | no | no | 8 |
21750404 | Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. | yes | yes | 2 |
21751201 | Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. | no | no | 1 |
21751203 | Cell surface receptor expression patterns in osteosarcoma. | yes | no | 7 |
21780101 | P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. | no | no | 2 |
21801875 | Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. | yes | no | 4 |
21805050 | Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. | no | no | 5 |
21822121 | BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity. | no | no | 1 |
21822538 | p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. | no | no | 4 |
21826087 | Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. | yes | yes | 3 |
21826611 | Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. | no | no | 4 |
21834878 | Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration. | no | no | 3 |
21843050 | IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. | no | no | 1 |
21843952 | Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. | no | no | 1 |
21866554 | Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. | yes | yes | 1 |
21868524 | Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. | no | no | 1 |
21874265 | Vasodilator-stimulated phosphoprotein regulates osteosarcoma cell migration. | no | no | 2 |
21887680 | Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. | yes | no | 4 |
21890444 | Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. | yes | yes | 3 |
21901524 | Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. | no | no | 3 |
21925315 | USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. | no | no | 4 |
21927024 | Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. | yes | no | 2 |
21941146 | Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray. | yes | no | 1 |
21945933 | RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration. | no | no | 3 |
21951664 | RUNX2 expression in developing human bones and various bone tumors. | yes | no | 2 |
21959981 | MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93. | no | no | 2 |
21963453 | Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D₃ action in osteosarcoma. | no | no | 3 |
21964477 | Okadaic acid induces apoptosis through the PKR, NF-κB and caspase pathway in human osteoblastic osteosarcoma MG63 cells. | no | no | 3 |
21986150 | Difference in pre- and postchemotherapy vascular endothelial growth factor levels as a prognostic indicator in osteosarcoma. | yes | yes | 1 |
21993662 | Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. | no | no | 9 |
22006429 | High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. | yes | no | 8 |
22009167 | Cancer-testis antigens expressed in osteosarcoma identified by gene microarray correlate with a poor patient prognosis. | yes | yes | 3 |
22009216 | Prostate-specific membrane antigen: a new potential prognostic marker of osteosarcoma. | yes | yes | 1 |
22009832 | Apoptotic effects of curcumin on human osteosarcoma U2OS cells. | no | no | 7 |
22009965 | Expression of b-FGF and endostatin and their clinical significance in human osteosarcoma. | yes | yes | 3 |
22012179 | Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. | no | no | 3 |
22016816 | Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study. | yes | yes | 2 |
22021909 | TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. | no | no | 1 |
22037351 | Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. | no | no | 11 |
22042095 | The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. | yes | no | 2 |
22047406 | YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma. | yes | yes | 1 |
22057483 | RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. | no | no | 6 |
22068640 | Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. | no | no | 6 |
22075555 | Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases. | yes | no | 1 |
22090361 | Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma. | yes | no | 1 |
22093834 | miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. | yes | no | 2 |
22099874 | Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma. | yes | no | 1 |
22102692 | HMGB1 promotes drug resistance in osteosarcoma. | no | no | 4 |
22126551 | Relationships between serum biomarker levels and clinical presentation of human osteosarcomas. | yes | no | 3 |
22126901 | Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. | no | no | 7 |
22128168 | Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. | no | no | 9 |
22135725 | C-kit expression in human osteosarcoma and in vitro assays. | yes | no | 1 |
22138223 | Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. | no | no | 2 |
22147261 | Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. | no | no | 1 |
22147650 | Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. | yes | no | 9 |
22154052 | MAPK7 and MAP2K4 as prognostic markers in osteosarcoma. | yes | yes | 2 |
22158627 | Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. | no | no | 3 |
22173290 | Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma. | yes | yes | 3 |
22173710 | Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. | no | no | 1 |
22179790 | RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. | no | no | 2 |
22186140 | miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. | no | no | 4 |
22202598 | CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients. | yes | yes | 1 |
22205265 | The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. | yes | no | 2 |
22212432 | Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. | no | no | 4 |
22213004 | Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma. | yes | yes | 1 |
22213073 | ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9. | yes | no | 2 |
22215309 | Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis and prognosis in patients with osteosarcoma. | yes | yes | 1 |
22227330 | Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. | no | no | 3 |
22231496 | Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no | 8 |
22245111 | Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. | yes | no | 1 |
22246399 | Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. | no | no | 5 |
22248279 | Overexpression of potassium channel ether à go-go in human osteosarcoma. | yes | no | 1 |
22263786 | Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-κB pathway. | no | no | 2 |
22271434 | Different expression of CD146 in human normal and osteosarcoma cell lines. | no | no | 2 |
22274866 | The prognostic value of elevated vascular endothelial growth factor in patients with osteosarcoma: a meta-analysis and systemic review. | yes | yes | 2 |
22286748 | siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells. | no | no | 1 |
22292074 | Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma. | yes | no | 9 |
22292654 | Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9. | yes | yes | 2 |
22297550 | Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival. | yes | no | 1 |
22301501 | MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. | yes | yes | 2 |
22301993 | Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. | no | no | 4 |
22333159 | High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. | yes | yes | 2 |
22338054 | CD138 (syndecan-1) expression in bone-forming tumors. | yes | no | 1 |
22340557 | Increased expression of serum gelsolin in patients with osteosarcoma. | yes | yes | 1 |
22344865 | Nestin expression in high-grade osteosarcomas and its clinical significance. | yes | no | 1 |
22350417 | miRNA signatures associate with pathogenesis and progression of osteosarcoma. | yes | no | 10 |
22354724 | Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma. | no | no | 1 |
22371553 | A preliminary investigation of Beta-hCG expression in patients with osteosarcoma. | yes | yes | 1 |
22382389 | Inhibition of nuclear factor-κB by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells. | no | no | 1 |
22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no | 11 |
22390926 | Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death. | no | no | 1 |
22390931 | Expression and prognostic relevance of PRAME in primary osteosarcoma. | yes | yes | 1 |
22422053 | Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. | no | no | 2 |
22426824 | PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma. | yes | yes | 2 |
22446894 | Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. | no | no | 2 |
22454324 | Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data. | yes | no | 2 |
22457788 | MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. | no | no | 2 |
22471458 | KISS1 expression in osteosarcoma: high in chinese clinical cases, but lower in cell lines. | yes | yes | 1 |
22471480 | Glutathione S-transferase polymorphisms and bone tumor risk in China. | yes | yes | 2 |
22471498 | Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells. | no | no | 2 |
22472569 | MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. | yes | no | 2 |
22506069 | CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. | no | no | 2 |
22521131 | Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. | no | no | 1 |
22525461 | Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. | yes | no | 4 |
22527131 | Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. | no | no | 4 |
22531343 | Syndecan-4 and fibronectin in osteosarcoma. | yes | yes | 2 |
22534782 | Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. | no | no | 2 |
22542077 | Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma. | yes | yes | 3 |
22542792 | Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma. | yes | no | 1 |
22544557 | Expression and stability of hypoxia inducible factor 1α in osteosarcoma. | yes | no | 2 |
22546756 | Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. | no | no | 7 |
22578565 | P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy. | yes | yes | 1 |
22583777 | Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. | yes | no | 4 |
22623071 | Nuclear p63 expression in osteoblastic tumors. | yes | yes | 1 |
22641358 | Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. | no | no | 5 |
22665540 | Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. | yes | no | 1 |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no | 9 |
22682017 | Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. | yes | yes | 5 |
22682620 | MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. | no | no | 11 |
22688575 | Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. | no | no | 6 |
22715593 | Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. | no | no | 4 |
22719058 | Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments. | yes | yes | 2 |
22736026 | HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis. | no | no | 1 |
22743617 | STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. | no | no | 5 |
22749040 | 12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. | yes | yes | 2 |
22771636 | Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. | yes | no | 1 |
22791884 | Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. | yes | yes | 1 |
22797704 | NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. | no | no | 2 |
22799338 | Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. | no | no | 1 |
22817659 | Invariant NKT cells increase drug-induced osteosarcoma cell death. | no | no | 1 |
22820099 | Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. | no | no | 2 |
22843172 | MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. | no | no | 2 |
22847601 | Prognostic value of Twist and E-cadherin in patients with osteosarcoma. | yes | yes | 2 |
22849560 | Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. | no | no | 6 |
22855058 | Expression and significance of Kruppel-like factor 6 gene in osteosarcoma. | yes | yes | 1 |
22855059 | Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. | yes | yes | 3 |
22870217 | Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. | no | no | 10 |
22870593 | Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. | yes | yes | 2 |
22886393 | TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | yes | no | 5 |
22889802 | A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. | no | no | 1 |
22911823 | Lysyl oxidase polymorphisms and susceptibility to osteosarcoma. | yes | yes | 1 |
22916108 | Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. | no | no | 3 |
22922684 | The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. | yes | no | 4 |
22922800 | miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. | no | no | 2 |
22922827 | miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. | no | no | 3 |
22923031 | Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. | no | no | 4 |
22926753 | SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. | no | no | 4 |
22935974 | Mitogen-activated protein kinase pathway in osteosarcoma. | yes | yes | 5 |
22938445 | Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. | yes | yes | 3 |
22939995 | IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. | yes | no | 6 |
22948234 | Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. | no | no | 3 |
22949168 | The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. | no | no | 1 |
22968906 | Targeting hedgehog-GLI-2 pathway in osteosarcoma. | yes | yes | 1 |
22992985 | Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner. | no | no | 6 |
22993301 | Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. | no | no | 5 |
22994717 | LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. | no | no | 4 |
23000411 | Domain 5 of high molecular weight kininogen inhibits collagen-mediated cancer cell adhesion and invasion in association with α-actinin-4. | no | no | 2 |
23015149 | Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study. | yes | yes | 1 |
23027359 | Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. | no | no | 4 |
23031740 | Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: increased expression of a CD44 variant isoform after chemotherapy. | yes | no | 2 |
23045411 | Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. | yes | no | 2 |
23052169 | Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas. | yes | no | 3 |
23071517 | Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. | no | no | 7 |
23091618 | Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. | no | no | 5 |
23098477 | Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. | yes | yes | 2 |
23108792 | SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. | no | no | 4 |
23113351 | The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. | no | no | 7 |
23133552 | Modulation of the osteosarcoma expression phenotype by microRNAs. | yes | no | 43 |
23137772 | A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. | yes | no | 9 |
23142238 | Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma. | yes | yes | 2 |
23144859 | Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. | yes | no | 6 |
23145797 | Ether à go-go 1 silencing in combination with TRAIL overexpression has synergistic antitumor effects on osteosarcoma. | no | no | 2 |
23164673 | The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. | no | no | 8 |
23167426 | Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. | yes | yes | 5 |
23167620 | Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells. | no | no | 1 |
23168047 | Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. | no | no | 4 |
23175213 | Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. | no | no | 2 |
23192273 | IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. | yes | no | 5 |
23201449 | Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. | no | no | 6 |
23208072 | Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. | no | no | 8 |
23219526 | Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. | no | no | 5 |
23225447 | Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. | yes | no | 3 |
23232982 | Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway. | no | no | 5 |
23255321 | Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. | yes | no | 1 |
23262982 | Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. | no | no | 11 |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no | 8 |
23269581 | A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma. | yes | yes | 3 |
23269582 | Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma. | yes | yes | 1 |
23291185 | Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. | yes | yes | 3 |
23311495 | MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. | yes | yes | 2 |
23313376 | Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. | no | no | 10 |
23317281 | Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. | yes | yes | 3 |
23321165 | Identification of serum microRNA-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma. | yes | yes | 1 |
23321467 | NPRL2 is an independent prognostic factor of osteosarcoma. | yes | yes | 1 |
23322324 | Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. | no | no | 4 |
23341181 | Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis. | yes | yes | 1 |
23352643 | Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development. | no | no | 2 |
23372675 | MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. | no | no | 1 |
23383046 | FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. | yes | no | 3 |
23403511 | Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. | no | no | 3 |
23430441 | Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma. | yes | yes | 1 |
23430952 | Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. | no | no | 7 |
23433115 | Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells. | no | no | 1 |
23450030 | The prognostic value of the serum level of C-reactive protein for the survival of patients with a primary sarcoma of bone. | yes | yes | 1 |
23451817 | Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. | no | no | 5 |
23461061 | C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. | no | no | 3 |
23462806 | Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma. | no | no | 3 |
23470834 | Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. | no | no | 4 |
23507142 | miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. | yes | no | 7 |
23527718 | The role and clinical significance of YES-associated protein 1 in human osteosarcoma. | no | yes | 4 |
23527720 | Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. | yes | no | 4 |
23530647 | Induction of cell cycle arrest and apoptosis in human osteosarcoma U-2 OS cells by Solanum lyratum extracts. | yes | no | 1 |
23559304 | Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours. | yes | yes | 1 |
23568006 | Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. | no | no | 2 |
23574781 | MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma. | yes | no | 3 |
23578572 | MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAATβ. | no | no | 2 |
23589053 | A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma. | yes | yes | 1 |
23631646 | MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. | yes | no | 2 |
23661525 | RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9. | no | no | 2 |
23681112 | Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma. | yes | yes | 1 |
23684620 | Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients. | yes | yes | 3 |
23725133 | Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis. | yes | no | 1 |
23727862 | Genome-wide association study identifies two susceptibility loci for osteosarcoma. | yes | yes | 1 |
23740448 | Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. | no | no | 3 |
23813624 | Overexpression of fibroblast activation protein and its clinical implications in patients with osteosarcoma. | yes | yes | 1 |
23827457 | MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31. | no | no | 2 |
23831057 | Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells. | no | no | 1 |
23872151 | MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1. | no | no | 2 |
23879172 | FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. | no | no | 6 |
24009496 | How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation | no | no | 13 |
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