Browse osteosarcoma associated abstracts

PMID Title Tumor Value #Genes
292511 Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. yes yes 1
1065468 Ceruloplasmin levels in sera from human patients with osteosarcoma. yes yes 1
1281143 VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. no no 2
1315190 Regulation of C-myc protooncogene expression in osteoblastic cells by arachidonic acid metabolites: relationship to proliferation. no no 1
1316174 Differential migratory response of U-2 OS osteosarcoma cell to the various forms of platelet-derived growth factor. no no 2
1320449 Immunohistochemical study of bone GLA protein in primary bone tumors. yes yes 1
1349175 Germ-line and somatic p53 gene mutations in multifocal osteogenic sarcoma. yes no 1
1358045 Overexpression of the c-erbB-2 oncogene in sarcomas and small round-cell tumors of childhood. An immunohistochemical investigation. yes no 1
1388095 Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. no no 3
1416076 Fetal antigen 2 (FA2) in human fetal osteoblasts, cultured osteoblasts and osteogenic osteosarcoma cells. no no 1
1423262 Mutation spectrum of the p53 gene in bone and soft tissue sarcomas. yes no 1
1423318 Analysis of a metastasizing testicular mixed gonadal stromal tumor with osteosarcoma components suggests that a malignant tumor with the histology of osteosarcoma may develop without primary involvement of RB1 and TP53. yes no 2
1447251 A significant proportion of patients with osteosarcoma may belong to Li-Fraumeni cancer families. yes no 1
1459694 Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. no no 3
1468768 Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors. yes yes 1
1481722 The effect of transforming growth factor beta on the plasminogen activator activity of normal human osteoblast-like cells and a human osteosarcoma cell line MG-63. no no 4
1499384 The prognostic value of serum alkaline phosphatase in osteosarcoma of the limbs. yes yes 1
1520309 Human platelet factor 4 is a direct inhibitor of human osteoblast-like osteosarcoma cell growth. no no 1
1524989 Studies of the RB1 gene and the p53 gene in human osteosarcomas. yes no 2
1525710 A phorbol ester induces secretion of alkaline phosphatase activity in human osteosarcoma cells. no no 1
1568211 Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q. yes no 2
1571831 Effects of interleukin-1, tumor necrosis factor -beta, and forskolin on tissue plasminogen activator activity in human osteoblastic osteosarcoma cells. no no 3
1586971 Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. no no 4
1622861 Osteonectin in osteosarcomas: a marker for differential diagnosis and/or prognosis? yes no 1
1657330 Hormonal regulation of vitamin D receptor levels and osteocalcin synthesis in human osteosarcoma cells. no no 2
1698437 Homozygous deletion within the retinoblastoma gene in a native osteosarcoma specimen of a patient cured of a retinoblastoma of both eyes. yes no 1
1726835 Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system. no no 1
1846564 Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. no no 3
1864588 Immunophenotypic heterogeneity in osteosarcomas. yes yes 3
1867319 Immunohistochemical analysis of neural cell adhesion molecules. Differential expression in small round cell tumors of childhood and adolescence. yes no 1
1884549 Involvement of the retinoblastoma gene in primary osteosarcomas and other bone and soft-tissue tumors. yes no 1
1932372 Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines. no no 3
1988704 Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. yes no 1
2036639 Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma. yes no 1
2069168 The effect of rhGM-CSF on the proliferation of osteogenic sarcoma cells. no no 1
2115647 The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas. yes no 1
2143022 Mechanisms of p53 loss in human sarcomas. yes no 1
2153840 Insulinlike growth factor I: a potent mitogen for human osteogenic sarcoma. no no 2
2156959 Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. no no 3
2166171 Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells. no no 1
2169996 Expression of Ki-1 antigen (CD30) in mesenchymal tumors. yes no 1
2233717 p53 functions as a cell cycle control protein in osteosarcomas. no no 1
2253237 Frequency and structure of p53 rearrangements in human osteosarcoma. yes no 1
2274789 Genetic mechanisms of tumor suppression by the human p53 gene. no no 1
2287591 The impact of osteonectin for differential diagnosis of bone tumors. An immunohistochemical approach. yes no 1
2298248 Expression of transferrin and vitamin D-binding protein genes in an osteogenic sarcoma cell line. no no 2
2443508 Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor. no no 1
2450880 Tumor necrosis factor stimulates proliferation of human osteosarcoma cells and accumulation of c-myc messenger RNA. no no 2
2488230 Genetic analysis of childhood sarcoma. yes no 1
2496060 Amplification of both c-myc and c-raf-1 oncogenes in a human osteosarcoma. yes no 2
2496522 Immunocytochemical identification of osteogenic bone tumors by osteonectin antibodies. yes yes 1
2521862 Regulation of expression of the cell adhesion receptors, integrins, by recombinant human interleukin-1 beta in human osteosarcoma cells: inhibition of cell proliferation and stimulation of alkaline phosphatase activity. no no 4
2531855 Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line. no no 2
2541615 Expression of the common acute lymphoblastic leukemia antigen (CD10) in mesenchymal tumors. yes yes 1
2600089 Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin. no no 4
2630171 The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells. no no 2
2659348 Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells. A model to study the different effects of thrombospondin in cell adhesion. no no 1
2740144 Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas. yes no 1
2755701 Studies of the retinoblastoma gene in human sarcomas. yes no 1
2776495 Immunohistological demonstration of osteonectin in normal bone tissue and in bone tumors. yes yes 1
2786815 Signal transduction via the beta 1 integrins is a required intermediate in interleukin-1 beta induction of alkaline phosphatase activity in human osteosarcoma cells. no no 3
2878716 Chromosome 13 instability and esterase D expression in an osteosarcoma cell line. no no 2
2898286 Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. yes no 1
2918936 Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma. yes no 1
2978869 Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line. no no 2
3057504 Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin. no no 1
3162593 Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. yes no 1
3165250 Immunohistochemical study of osteonectin in various types of osteosarcoma. yes yes 1
3166362 Release of alkaline phosphatase from human osteosarcoma cells by phosphatidylinositol phospholipase C: effect of tunicamycin. no no 1
3477902 Prognostic value of serum alkaline phosphatase in osteosarcoma. yes yes 2
3479235 Events on different chromosomes alter the genes for the two peptides of platelet-derived growth factor in an osteogenic sarcoma. yes no 2
6297258 Enzyme histochemical study on bone tumors. yes no 2
6930152 Correlation between prognostic factors and blood variables in osteosarcoma. yes no 2
7473836 Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone. no no 2
7477118 Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome. yes yes 1
7502710 Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha. no no 5
7506120 Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. yes no 2
7513549 Chromosome analysis of nine osteosarcomas. yes no 2
7518993 Periosteal osteosarcoma and parosteal chondrosarcoma evaluated by double immunohistochemical staining. Report of 2 cases. yes no 1
7528503 Quantitative RT-PCR assay detecting the transcriptional induction of vascular endothelial growth factor under hypoxia. no no 1
7531202 Repression of a malignant cell-substratum adhesion phenotype by inhibiting the production of the anti-adhesive proteoglycan, PG-M/versican. no no 1
7541624 The effects of mechanical stimulation on the distribution of beta 1 integrin and expression of beta 1-integrin mRNA in TE-85 human osteosarcoma cells. no no 1
7559091 Changes in radiation sensitivity of human osteosarcoma cells after p53 introduction. no no 1
7576109 Analysis of oncogenes, tumor suppressor genes, autocrine growth-factor production, and differentiation state of human osteosarcoma cell lines. no no 6
7585551 Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain. no no 1
7585620 Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. no no 3
7591308 MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. yes yes 1
7593131 Immunohistochemical analysis of nm23 protein expression in malignant bone tumors. yes yes 1
7607566 Characterization of two splice variants of metastasis-associated human mts1 gene. no no 1
7612954 The identity of proliferating cells in bone tumors with cartilaginous components: evaluation by double-immunohistochemical staining using proliferating cell nuclear antigen and S-100 protein. yes no 1
7614454 Complex replication error causes p53 mutation in a Li-Fraumeni family. yes no 1
7621257 Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. no no 1
7639117 IGF-II receptor number is increased in TE-85 osteosarcoma cells by combined magnetic fields. no no 1
7640224 Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. yes no 3
7641470 The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. no no 8
7660382 Expression of the human multidrug resistance gene (MDR1) and prognostic correlation in human osteogenic sarcoma. yes yes 1
7684391 Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells. no no 2
7685168 Reverse transcription-polymerase chain reaction assay demonstrates that the 9-cis retinoic acid receptor alpha is expressed in human osteoblasts. no no 1
7693339 Met expression and sarcoma tumorigenicity. yes no 2
7705958 A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. no no 2
7735558 Correlation of p-glycoprotein detection by immunohistochemistry with mdr-1 mRNA levels in osteosarcomas. Pilot study. yes no 1
7768643 Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG-63 human osteosarcoma cells. no no 2
7789337 Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures. no no 1
7794813 Phenotypic modification of human osteosarcoma cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. no no 6
7802648 Steroid hormone modulation of vitamin D receptor levels in human MG-63 osteosarcoma cells. no no 1
7817811 Effects of transforming growth factor beta 1 on the regulation of osteocalcin synthesis in human MG-63 osteosarcoma cells. no no 3
7826985 Plasminogen activators and their inhibitor in osteosarcomas and other bone tumors. yes no 1
7828148 The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. yes no 3
7833115 Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs. yes no 1
7835281 Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production. no no 3
7850751 Mutational activation of ras genes is absent in pediatric osteosarcoma. yes no 3
7859736 Inhibition of apoptosis by the retinoblastoma gene product. no no 2
7862451 The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. yes no 2
7904171 Expression of the mdr1 gene in bone and soft tissue sarcomas of adult patients. yes no 1
7911380 Rapid detection of loss of heterozygosity of chromosome 17p by polymerase chain reaction-based variable number of tandem repeat analysis and detection of single-strand conformation polymorphism of intragenic p53 polymorphisms. yes no 1
7912235 Pre-treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin. no no 2
7912239 Existence of lipoprotein lipase in human sarcomas and carcinomas. no no 2
7926730 The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. no no 2
7983504 Prognostic significance of serum lactate dehydrogenase in patients with osteosarcoma of the extremities. yes yes 1
8003023 Human and rat osteoblast-like cells express stathmin, a growth-regulatory protein. no no 1
8032535 Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line. no no 2
8033827 Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. no no 1
8034301 Single base pair germ-line deletion in the p53 gene in a cancer predisposed family. yes no 1
8039112 Immunohistochemical detection of bone morphogenetic proteins in bone and soft-tissue sarcomas. yes no 2
8050825 Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells. no no 2
8052269 Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. no no 5
8058007 Secondary breast cancer in patients presenting with osteosarcoma: possible involvement of germline p53 mutations. yes no 1
8064888 MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. yes no 2
8080687 Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines. no no 1
8099316 Overexpression of c-fos increases recombination frequency in human osteosarcoma cells. no no 1
8117620 Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. yes no 5
8123038 Vinblastine-dependent down-modulation of TNF receptors in human osteosarcoma cells is mediated by protein kinase C activity. no no 2
8159609 Extracellular matrix of small round cell tumors of childhood: an immunohistochemical study of 67 cases. yes yes 1
8164043 Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma. yes no 1
8166715 Osteonectin/SPARC regulates cellular secretion rates of fibronectin and laminin extracellular matrix proteins. no no 2
8168113 Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. no no 2
8187094 Mutation spectrum of the retinoblastoma gene in osteosarcomas. yes yes 1
8208533 Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53. no no 1
8217129 An association of the RB gene with osteosarcoma: molecular genetic evaluation of a case of hereditary retinoblastoma. yes no 1
8226793 FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line. no no 2
8260365 p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas. yes no 1
8276785 Interleukin 1 alpha stimulates nuclear phospholipase C in human osteosarcoma SaOS-2 cells. no no 3
8281940 Insulin-like growth factor-1 modulates steroid hormone effects on osteocalcin synthesis in human MG-63 osteosarcoma cells. no no 4
8287230 Sporadic amplification of the MYC gene in human osteosarcomas. yes no 1
8288590 Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. no no 3
8374897 Deletion of chromosome 13 in osteosarcoma secondary to irradiation. yes no 1
8391387 Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line. no no 2
8401536 Screening for TP53 mutations in osteosarcomas using constant denaturant gel electrophoresis (CDGE). yes no 1
8402575 Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells. no no 1
8416741 MDM2 gene amplification in metastatic osteosarcoma. yes yes 1
8418091 Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone. yes no 1
8425179 p53 abnormalities in different subtypes of human sarcomas. yes no 1
8435797 Prognostic significance of serum alkaline phosphatase measurements in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy. yes yes 1
8479749 Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings. yes no 1
8507187 Translocation of retinoblastoma protein associated with tumor cell growth inhibition. no no 1
8513277 Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors. yes yes 2
8519637 p53 codon 213 (A-G) polymorphism in a Turkish population. yes no 1
8550801 1 alpha, 25-dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol (Ro24-5531) modulation of insulin-like growth factor-binding protein-3 and induction of differentiation and growth arrest in a human osteosarcoma cell line. no no 2
8562155 Analysis of P-glycoprotein expression in osteosarcoma. yes yes 1
8603340 Alterations of the p15, p16,and p18 genes in osteosarcoma. yes no 2
8616838 Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. no no 4
8625324 Multidrug resistance and malignancy in human osteosarcoma. yes no 1
8630943 ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. yes yes 1
8636759 Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. yes yes 1
8662647 Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors. no no 3
8670156 Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. no no 3
8692530 Bone-specific alkaline phosphatase in plasma as tumour marker for osteosarcoma. yes yes 1
8703379 Deletion of Rb1 gene in late osteosarcoma from survivor of unilateral retinoblastoma--a case report. yes no 1
8717113 The impact of osteonectin for differential diagnosis of osteogenic bone tumors: an immunohistochemical and in situ hybridization approach. yes yes 1
8717537 Bone morphogenetic protein-2 but not bone morphogenetic protein-4 and -6 stimulates chemotactic migration of human osteoblasts, human marrow osteoblasts, and U2-OS cells. no no 1
8726395 Immunohistochemical localization of the estrogen receptor in human osteoblastic SaOS-2 cells: association of receptor levels with alkaline phosphatase activity. no no 2
8750062 Expression of p53 protein, PCNA, and Ki-67 in osteosarcomas of bone. yes no 3
8781571 Alterations of the p53, Rb and MDM2 genes in osteosarcoma. yes no 3
8793483 Mutation spectrum of p53 gene in highly malignant human osteosarcomas. yes no 1
8821948 Molecular and immunohistochemical identification of p53 alterations in bone and soft tissue sarcomas. yes no 1
8835762 Enhanced expression of cathepsin L in metastatic bone tumors. yes no 1
8840973 Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. no no 1
8855972 Quantitative analysis of multidrug resistance gene expression in human osteosarcomas. yes yes 1
8863670 Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors. yes no 2
8865368 Role of protein phosphatase in malignant osteogenic and soft tissue tumors. yes no 1
8866236 Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas. yes no 1
8891902 Oncogene alterations in primary, recurrent, and metastatic human bone tumors. yes yes 5
8893761 SAS is amplified predominantly in surface osteosarcoma. yes no 1
8908160 Amplification of a rearranged form of the high-mobility group protein gene HMGIC in OsA-CI osteosarcoma cells. no no 1
8922947 Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. yes yes 2
8954126 Expression of prolactin receptors in human osteosarcoma cells. no no 1
8959332 Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein. no no 2
8968028 Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. no no 1
8992882 Constitutive expression of non-bone/liver/kidney alkaline phosphatase in human osteosarcoma cell lines. no yes 1
9052985 Integrin alpha 2 beta 1 in tumorigenic human osteosarcoma cell lines regulates cell adhesion, migration, and invasion by interaction with type I collagen. no no 2
9065577 Expression of P-glycoprotein in high grade osteosarcomas with special emphasis on chondroblastic subtype. yes yes 1
9066537 Expression of MAGE genes in osteosarcoma. yes no 2
9066701 Immunohistochemical detection of p53 protein overexpression in primary human osteosarcomas. yes no 1
9069169 Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. no no 4
9083931 Molecular analysis of the adenomatous polyposis coli gene in sarcomas, hematological malignancies and noncolonic, neoplastic tissues. yes no 1
9100584 Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. no no 3
9109391 Human osteosarcoma cell susceptibility to natural killer cell lysis depends on CD54 and increases after TNF alpha incubation. no no 2
9111202 Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells. no no 1
9118036 p53 and MDM2 alterations in osteosarcomas: correlation with clinicopathologic features and proliferative rate. yes yes 2
9136982 Differentiation induced by RB expression and apoptosis induced by p53 expression in an osteosarcoma cell line. no no 2
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no 11
9155051 Frequent reduction or loss of DCC gene expression in human osteosarcoma. yes no 1
9167046 Histological and immunohistochemical diversities, and proliferative activity and grading in osteosarcomas. yes no 5
9175647 Suppression of UV-induced mutations by wild-type p53 protein in human osteosarcoma cells. no no 1
9180138 Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma. no no 1
9187120 Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. no no 5
9191521 Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis. yes yes 3
9227342 Point mutations and nucleotide insertions in the MDM2 zinc finger structure of human tumours. yes no 2
9228255 P-glycoprotein expression in high grade central osteosarcoma and normal bone cells. An immunohistochemical study. yes no 1
9244358 The p19INK4D cyclin dependent kinase inhibitor gene is altered in osteosarcoma. yes no 1
9252243 TGF-beta1 selectively suppresses PDGF receptor signaling pathways in MG-63 human osteosarcoma cell. no no 1
9258335 Induction in human osteoblastic cells (SaOS2) of the early response genes fos, jun, and myc by the amino terminal fragment (ATF) of urokinase. no no 4
9267827 Expression of c-met proto-oncogene product (c-MET) in benign and malignant bone tumors. yes yes 1
9275350 P53 gene abnormalities in osteosarcoma. yes no 1
9309118 Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients. yes no 2
9322601 Osteocalcin and osteonectin immunoreactivity in the diagnosis of osteosarcoma. yes yes 2
9355974 Altered G1 phase regulation in osteosarcoma. yes yes 3
9390540 P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy. yes yes 1
9404699 Expression of transforming growth factor-beta (TGF-beta) isoforms in osteosarcomas: TGF-beta3 is related to disease progression. yes yes 1
9416691 Analysis of p53 expression in osteosarcoma of the jaw: correlation with clinicopathologic and DNA ploidy findings. yes no 1
9418642 Prognostic factors among 130 patients with osteosarcoma. yes yes 1
9433149 Recombinant human granulocyte-macrophage colony-stimulating factor therapy and endogenous plasma GM-CSF, IL-3, IL-4 concentrations in pediatric patients with solid tumors. yes no 1
9443071 Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. no no 3
9461020 Reduced UV-induced mutations in human osteosarcoma cells stably expressing transfected wild-type p53 cDNA. no no 1
9464545 Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. no no 3
9480851 Suppression of high-density magnetic field (400 mT at 50 Hz)-induced mutations by wild-type p53 expression in human osteosarcoma cells. no no 1
9492043 p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. no no 4
9538120 Prognostic significance of cyclin expression in human osteosarcoma. yes yes 4
9559293 Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. yes no 3
9605020 Relation between histological intensity of transforming growth factor-beta isoforms in human osteosarcoma and the rate of lung metastasis. yes yes 2
9615784 Copper/zinc superoxide dismutase expression by different human osteosarcoma cell lines. no no 2
9619593 Comparative genomic hybridization of low-grade central osteosarcoma. yes no 3
9639407 Antisense inhibition of urokinase: effect on malignancy in a human osteosarcoma cell line. no no 1
9645345 Expression of the smooth muscle calponin gene in human osteosarcoma and its possible association with prognosis. yes yes 4
9664132 TNF-alpha but not IL-1 and IL-6 modifies the susceptibility of human osteosarcoma cells to NK lysis. no no 5
9665476 CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. yes no 3
9672192 Immunohistochemical detection of c-fos and c-jun expression in osseous and cartilaginous tumours of the skeleton. yes yes 2
9685858 Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. yes yes 5
9703873 Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. yes no 1
9703945 Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells. no no 3
9703989 Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells. no no 2
9714336 p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. no no 2
9717810 Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells. no no 3
9723038 Correlation between apoptosis and TP53 status in osteosarcoma. yes no 1
9743295 P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. yes no 2
9748149 Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. no yes 2
9762887 Expression of insulin-like growth factor receptor, IGF-1, and IGF-2 in primary and metastatic osteosarcoma. yes no 3
9771482 Expression of transforming growth factor beta isoforms in osteosarcoma variants: association of TGF beta 1 with high-grade osteosarcomas. yes no 3
9778623 C-myc and c-fos in human osteosarcoma: prognostic value of mRNA and protein expression. yes yes 2
9781640 Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy. yes yes 3
9788258 Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors. yes no 2
9793960 Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. yes yes 2
9818023 Abnormalities of the FHIT transcripts in osteosarcoma and Ewing sarcoma. yes no 1
9820862 Genetic instability in osteoblastic tumors of the skeletal system. yes no 5
9824113 p53 gene mutations in osteosarcomas of low-grade malignancy. yes no 1
9824653 A possible role for multidrug resistance-associated protein in the secretion of basic fibroblast growth factor by osteogenic sarcoma cell line (MG-63). no no 2
9835898 Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma. yes no 1
9858899 Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. no no 6
9890264 Immunohistochemical analysis of Fas ligand expression in sarcomas. Sarcomas express high level of FasL in vivo. yes no 1
9891539 p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: a ten-year follow-up study. yes no 2
9917506 Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma. yes yes 3
9923924 Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. yes yes 2
9935160 Redundancy of autocrine loops in human osteosarcoma cells. no no 2
9935200 CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. yes no 5
9989824 The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells. no no 1
9989829 Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. yes no 3
10086509 Protease expression in dedifferentiated parosteal osteosarcoma. yes no 3
10100715 Mechanisms of methotrexate resistance in osteosarcoma. yes no 2
10101594 Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. yes no 3
10189891 Frequent beta-catenin abnormalities in bone and soft-tissue tumors. yes no 1
10232607 Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. no no 5
10234573 ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. no no 5
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no 8
10352100 Expression and localization of estrogen receptor-beta in murine and human bone. no no 1
10375199 Differential regulation of syndecan expression by osteosarcoma cell lines in response to cytokines but not osteotropic hormones. no no 3
10388536 Increased phosphorylation of eukaryotic initiation factor 2alpha at the G2/M boundary in human osteosarcoma cells correlates with deglycosylation of p67 and a decreased rate of protein synthesis. no no 2
10390144 Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells. no no 3
10411143 Expression and regulation of the meprin beta gene in human cancer cells. no no 6
10441007 Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. yes no 4
10453987 Insulin-like growth factor I activates insulin receptor substrate 1 and Ras in human osteosarcoma cells. no no 4
10491221 The transcription factor Sox9 is involved in BMP-2 signaling. no no 6
10493528 S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme. no no 5
10498894 p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis. no no 2
10502725 Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. yes yes 4
10533453 Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. yes yes 3
10536172 NK binding capacity and lytic activity depend on the expression of ICAM-1 on target bone tumours. no no 2
10541973 Expression of CD44 variants in osteosarcoma. yes yes 1
10550312 Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. yes yes 3
10561353 Expression of HER2/erbB-2 correlates with survival in osteosarcoma. yes yes 3
10568818 Modulation of fas-mediated apoptosis in osteosarcoma cell lines. no no 1
10569469 P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy. yes yes 1
10569470 Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. yes no 3
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no 6
10606250 Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line. no no 1
10627702 Expression of bone morphogenetic proteins and receptors in sarcomas. yes yes 6
10638971 Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy. yes yes 1
10663637 Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. no no 3
10690541 Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. yes yes 2
10697522 De novo deletions of p53 gene and wild-type p53 correlate with acquired cisplatin-resistance in human osteosarcoma OST cell line. no yes 1
10702275 Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells. no no 3
10703939 Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1. no no 2
10709992 Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene. no no 2
10726973 Insulin-like growth factor-I inhibits the progression of human U-2 OS osteosarcoma cells towards programmed cell death through interaction with the IGF-I receptor. no no 2
10748103 Selective activation of the glucocorticoid receptor by steroid antagonists in human breast cancer and osteosarcoma cells. no no 1
10762653 Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma. yes yes 1
10769661 Sensitization and caffeine potentiation of cisplatin cytotoxicity resulting from introduction of wild-type p53 gene in human osteosarcoma. no no 1
10773107 Steroid receptor co-activator-1 mediates 1,25-dihydroxyvitamin D(3)-stimulated alkaline phosphatase in human osteosarcoma cells. no no 3
10776793 Serum antibodies against the heat shock protein 60 are elevated in patients with osteosarcoma. yes yes 1
10800398 h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors. yes no 1
10807968 Effect of hyperthermia on the viability and the fibrinolytic potential of human cancer cell lines. no no 2
10810457 P-glycoprotein levels predict poor outcome in patients with osteosarcoma. yes yes 1
10814523 Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. no no 1
10846544 Expression of bone morphogenetic proteins in human osteogenic and epithelial tumor cells. no no 7
10853014 Expression of the SART1 tumor-rejection antigen in human osteosarcomas. yes yes 1
10862039 Chromosomal regions involved in the pathogenesis of osteosarcomas. yes yes 1
10872665 Comparison of histological changes and changes in nm23 and c-MET expression between primary and metastatic sites in osteosarcoma: a clinicopathologic and immunohistochemical study. yes yes 2
10874667 Platelet-derived growth factor-AA and -alpha receptor expression suggests an autocrine and/or paracrine loop in osteosarcoma. yes no 3
10891538 Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. yes yes 2
10894867 MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study. yes no 1
10896792 The regulation of PGE(2) biosynthesis in MG-63 osteosarcoma cells by IL-1 and FGF is cell density-dependent. no no 3
10914045 Heat-shock protein 72 in human osteosarcoma: T-lymphocyte reactivity and cytotoxicity. yes no 1
10942797 Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. yes yes 5
10943202 Analysis of 12q13-15 genes in parosteal osteosarcoma. yes no 3
10953349 Homeobox B3, B4, and C6 gene product expression in osteosarcomas as detected by immunocytochemistry. yes no 3
10977962 Leptin and apoptosis inhibitor soluble Fas antigen in the serum of patients with osteosarcoma and neuroectodermal bone tumors. yes yes 2
11071251 Osteoclast differentiation factor in human osteosarcoma cell line. no no 1
11087053 Expression of heat shock proteins in osteosarcoma and its relationship to prognosis. yes yes 7
11089884 Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. no no 5
11093825 Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. no no 8
11103961 Expression of nm23 protein in human osteosarcoma in relationship with early metastasis. yes no 1
11115584 Osteosarcoma in blood relatives. yes no 6
11154005 Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma. yes yes 1
11155673 Preliminary observation on the correlation between nm23 expression and Ki-67 antigen with early metastasis of human osteosarcoma. yes yes 2
11155789 Interleukin-6 upregulates glucocorticoid receptor numbers in human osteoblast-like cells. no no 2
11156738 Novel findings in gene expression detected in human osteosarcoma by cDNA microarray. no no 4
11169148 Expression of CD31, Met/hepatocyte growth factor receptor and bone morphogenetic protein in bone metastasis of osteosarcoma. yes yes 2
11179483 Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitor. no no 1
11235987 Antioxidants inhibit TNFalpha-induced motility and invasion of human osteosarcoma cells: possible involvement of NFkappaB activation. no no 3
11241246 Primary pulmonary osteosarcoma: case report and molecular analysis. yes no 2
11241308 Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. yes yes 3
11289134 Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. no no 4
11294418 The co-expression of p53 protein and P-glycoprotein is correlated to a poor prognosis in osteosarcoma. yes yes 2
11306692 The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. no no 6
11319838 Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells. no no 4
11331958 Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to differentiation of p53-deficient MG-63 osteosarcoma cells. no no 1
11341357 Ki-67: a proliferative marker that may predict pulmonary metastases and mortality of primary osteosarcoma. yes yes 1
11344491 Circulating concentrations of IGF-I and IGFBP-3 are not predictive of incidence or clinical behavior of pediatric osteosarcoma. yes no 2
11351498 Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. yes no 1
11358827 Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells. no yes 3
11393276 Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. no no 2
11398843 Detection of c-fos expression in benign and malignant musculoskeletal lesions. yes no 1
11398844 Expression of a newly defined tumor-rejection antigen SART3 in musculoskeletal tumors and induction of HLA class I-restricted cytotoxic T lymphocytes by SART3-derived peptides. yes yes 1
11408805 Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma. yes yes 1
11418138 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. no no 5
11425650 Thermostable (SULT1A1) and thermolabile (SULT1A3) phenol sulfotransferases in human osteosarcoma and osteoblast cells. no no 2
11451946 Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation. no no 3
11454519 Effects of IGF-I and -II, IGF binding protein-3 (IGFBP-3), and transforming growth factor-beta (TGF-beta) on growth and apoptosis of human osteosarcoma Saos-2/B-10 cells: lack of IGF-independent IGFBP-3 effects. no no 3
11464280 Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. no no 5
11498774 Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. no no 1
11498785 Relative frequency and morphology of cancers in carriers of germline TP53 mutations. yes no 1
11505415 Amplification of the HER-2/neu oncogene is uncommon in pediatric osteosarcomas. yes no 1
11513857 The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. no no 2
11545733 The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. no no 2
11564577 Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. yes no 2
11569927 Loss of KAI1/CD82 expression in bone and soft tissue tumors is not associated with lung metastasis. yes no 1
11595696 Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma. yes yes 1
11596036 Comparison of p53 mutations in patients with localized osteosarcoma and metastatic osteosarcoma. yes no 1
11689005 Inhibition of vitronectin-mediated haptotaxis and haptoinvasion of MG-63 cells by domain 5 (D5(H)) of human high-molecular-weight kininogen and identification of a minimal amino acid sequence. no no 2
11695244 Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. no no 3
11707342 Identification of twenty-two candidate markers for human osteogenic sarcoma. no no 5
11713566 Plasminogen activators and their inhibitor in bone tumors and tumor-like damages. yes no 3
11743051 Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. yes no 1
11746520 Cellular and molecular properties associated with osteosarcoma cells. yes no 9
11746983 Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. yes no 1
11748477 Prognostic significance of serum alkaline phosphatase in osteosarcoma of the extremity treated with neoadjuvant chemotherapy: recent experience at Rizzoli Institute. yes yes 1
11753985 Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. yes yes 3
11768200 Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. no no 2
11793439 Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. yes no 1
11794258 Clinical significance of P-glycoprotein immunohistochemistry and doxorubicin binding assay in patients with osteosarcoma. yes yes 1
11797833 Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone. yes no 1
11820362 Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. no no 5
11859242 Expression of CD44 isoforms correlates with the metastatic potential of osteosarcoma. yes yes 1
11874241 Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. no no 3
11895909 Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma. no no 1
11895910 Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma. yes no 1
11906172 Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells. no no 1
11914627 C-kit expression in pediatric solid tumors: a comparative immunohistochemical study. yes no 1
11920494 ErbB2 expression is correlated with increased survival of patients with osteosarcoma. yes yes 1
11920584 Troglitazione affects survival of human osteosarcoma cells. no no 2
11943335 Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. no no 3
11948409 Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. yes yes 3
11953816 Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. yes yes 1
11986346 The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. yes no 7
11992538 Chemotherapeutic agents sensitize osteogenic sarcoma cells, but not normal human bone cells, to Apo2L/TRAIL-induced apoptosis. no no 6
12012007 The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. no no 4
12014674 Interleukin-12 and interleukin-18 induce indoleamine 2,3-dioxygenase (IDO) activity in human osteosarcoma cell lines independently from interferon-gamma. no no 3
12024286 Cyclooxygenase-2 expression in pediatric sarcomas. yes no 1
12027404 Overexpression of IL-6 but not IL-8 increases paclitaxel resistance of U-2OS human osteosarcoma cells. no no 1
12054686 Cytotoxic and cytostatic effects induced by 4-hydroxynonenal in human osteosarcoma cells. no no 2
12085209 Investigations on a clinically and functionally unusual and novel germline p53 mutation. yes no 1
12140175 Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. no no 1
12168884 Serum concentrations of APO-1/Fas and interleukin-1beta-converting enzyme in osteosarcoma correlate with response to chemotherapy. yes yes 2
12181274 Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. yes no 4
12188489 Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells. yes yes 2
12209731 Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis. yes yes 6
12218590 Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels. yes no 4
12220726 Expression of mRNA for growth hormone-releasing hormone and splice variants of GHRH receptors in human malignant bone tumors. no no 2
12221644 Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma. yes no 1
12232677 Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2. no no 7
12237108 Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. no no 6
12368234 Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. no no 2
12388161 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. no no 5
12393937 Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. no no 3
12401825 Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. yes no 3
12402302 Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. yes no 1
12404059 Expression of osteopontin and vascular endothelial growth factor in benign and malignant bone tumors. yes no 2
12408470 Thrombin is present in the lungs of patients with primary extremity osteosarcoma and pulmonary metastases. yes no 1
12415617 Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells. no no 1
12426100 The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. yes no 1
12478472 Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. no no 4
12527715 Expression of platelet-derived growth factor-AA is associated with tumor progression in osteosarcoma. yes yes 1
12529988 Prostate-specific antigen (PSA)-mediated proliferation, androgenic regulation and inhibitory effects of LY312340 in HOS-TE85 (TE85) human osteosarcoma cells. no no 1
12544770 Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. yes yes 1
12550767 Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma. yes no 3
12560446 Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities. yes yes 1
12569382 ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. yes yes 2
12576457 Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples. yes no 1
12588801 Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. yes no 3
12616540 Alpha 4 integrin increases anoikis of human osteosarcoma cells. yes no 4
12621691 Serum concentrations of sCD30 and sCD40L in patients with malignant bone tumours. yes yes 2
12647018 Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells. no no 2
12660819 Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. no no 3
12672477 Suramin suppresses growth, alkaline-phosphatase and telomerase activity of human osteosarcoma cells in vitro. no no 1
12673561 Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. yes no 1
12673693 Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma. yes no 2
12679640 Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. yes no 1
12689679 Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. yes yes 5
12708477 Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma. yes no 2
12709413 Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma. no no 1
12711293 Survivin expression in human osteosarcoma is a marker for survival. yes yes 1
12734318 Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. yes yes 1
12747978 Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. yes no 5
12759621 Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. yes yes 4
12782945 Phosphodiesterase 4 in osteoblastic osteosarcoma cells as a potential target for growth inhibition. no no 3
12789260 Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. no no 9
12792742 Inactivation of the RASSF1A in osteosarcoma. yes no 1
12799638 Genetic alterations in primary osteosarcoma from 54 children and adolescents by targeted allelotyping. yes no 2
12802802 Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. yes no 1
12813132 mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. yes yes 5
12824921 Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas. yes no 1
12829666 Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. yes yes 2
12838325 Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. no no 4
12842447 Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. no no 2
12850370 Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. yes no 1
12879476 The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. yes yes 1
12883746 Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression. yes yes 1
12894891 Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. yes no 2
12907249 Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. no no 6
12912938 Clinicopathologic assessment of postradiation sarcomas: KIT as a potential treatment target. yes no 1
12917637 Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. yes no 3
12919886 Chemotherapeutic agents sensitize sarcoma cell lines to tumor necrosis factor-related apoptosis-inducing ligand-induced caspase-8 activation, apoptosis and loss of mitochondrial membrane potential. no no 6
12926161 Serum levels of TNF-beta and sTNF-R in patients with malignant bone tumours. yes yes 3
12930359 IL-17 enhances the susceptibility of U-2 OS osteosarcoma cells to NK cell lysis. no no 2
12943619 Telomerase, p53 and PCNA activity in osteosarcoma. yes yes 3
12972634 The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. yes no 2
12973938 Construction of antisense transforming growth factor beta 1 gene and its effect on the proliferation by expression in osteosarcoma cells. no no 1
14506695 High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. yes no 4
14506946 Urinary excretion of pyridinium cross-links and serum osteocalcin levels in patients with primary high-grade osteosarcoma. yes yes 1
14528100 Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. yes no 3
14534726 Effect of retinoblastoma tumor suppressor gene expression on chemosensitivity of human osteosarcoma cell lines. no no 1
14557934 Proliferative activity of osteosarcoma cells: comparison of osteoblastic and nonosteoblastic regions. yes no 1
14559221 E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. no no 3
14582536 Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. no no 5
14584080 Reduced folate carrier protein expression in osteosarcoma: implications for the prediction of tumor chemosensitivity. yes yes 2
14598359 Cytokine and cytokine receptor serum levels in adult bone sarcoma patients: correlations with local tumor extent and prognosis. yes yes 9
14598886 Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. yes yes 1
14610316 Increased mdm-2 expression in a p53-independent manner blocks UV-induced cell cycle arrest and apoptosis in human osteosarcoma cells. no no 2
14624456 Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. yes no 2
14629833 Somatostatin receptor (SSTR) scintigraphy in patients with osteosarcoma. yes yes 1
14631380 Evaluation of the predictive value of Her-2/neu gene expression on osteosarcoma therapy in laser-microdissected paraffin-embedded tissue. yes yes 1
14633705 SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells. no no 4
14637192 Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner. no no 5
14647441 FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells. no no 6
14660053 Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. no no 4
14669798 Biological properties and gene expression associated with metastatic potential of human osteosarcoma. no no 5
14676807 Gene expression array profile of human osteosarcoma. yes no 1
14679136 Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. yes yes 3
14682477 Effects of progesterone and 18-methyl levonorgestrel on osteoblastic cells. no no 4
14695161 A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo. no no 1
14704791 The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. no yes 2
14706926 Effect of human granulocyte macrophage-colony stimulating factor on differentiation and apoptosis of the human osteosarcoma cell line SaOS-2. no no 3
14713104 S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. no no 5
14719070 Ribozyme mediated down-regulation of thrombospondin receptor CD36 inhibits the growth of the human osteosarcoma cell line. no no 2
14719113 Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells. no no 3
14735475 Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma. yes yes 1
14760101 Interleukin-12 enhances the sensitivity of human osteosarcoma cells to 4-hydroperoxycyclophosphamide by a mechanism involving the Fas/Fas-ligand pathway. no no 3
14973099 High-throughput detection of glutathione s-transferase polymorphic alleles in a pediatric cancer population. yes yes 2
14975209 Effect of human osteopontin on proliferation, transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells. no no 4
14996747 Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. no no 1
14999771 Mutation analysis of the apoptotic \death-receptors\ and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. yes no 1
15015580 PCR and flow cytometric analysis of paclitaxel-inhibited arylamine N-acetyltransferase activity and gene expression in human osteogenic sarcoma cells (U-2 OS). no no 1
15026342 Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. yes no 3
15026814 A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin. no no 2
15049011 Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. no no 1
15055356 Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line. no no 3
15067366 The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. no no 1
15069760 HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. yes no 2
15087387 Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. no no 3
15093570 Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcomas. yes no 1
15095405 IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. no no 6
15112275 Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. yes yes 4
15138564 Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. no no 6
15144225 Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. no no 5
15145525 CD9 expression is not a prognostic factor in human osteosarcoma. yes no 1
15167009 Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. yes yes 7
15174116 Differential expression of osteogenic factors associated with osteoinductivity of human osteosarcoma cell lines. no no 11
15193436 Overexpression through amplification of genes in chromosome region 17p11.2 approximately p12 in high-grade osteosarcoma. yes no 3
15198903 p21WAF1/CIP1 gene DNA sequencing and its expression in human osteosarcoma. yes no 1
15201972 Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma. yes no 1
15205094 Identification of a transcriptionally inactive p53 mutant by functional analysis of separated alleles in yeasts (FASAY) in a child osteosarcoma tumor: a case report. yes yes 1
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no 6
15210853 Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. yes yes 1
15211578 Annexin 2 expression is reduced in human osteosarcoma metastases. yes no 1
15221963 Mutation analysis of the RECQL4 gene in sporadic osteosarcomas. yes no 1
15237589 Low expression of p63 and p73 in osteosarcoma. yes no 2
15247015 Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. no no 1
15250258 Effects of TGF beta1 autocrine blockage on osteosarcoma cells. no no 1
15262428 Characterization of PMP22 expression in osteosarcoma. yes no 1
15268905 Extracellular signal-regulated kinase-1 and -2 are both essential for the shear stress-induced human osteoblast proliferation. no no 2
15289892 A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. no no 1
15298715 Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. yes no 10
15310147 Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. yes no 4
15313187 Vitamin A differentially regulates RANKL and OPG expression in human osteoblasts. no no 2
15314286 Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. no no 4
15318945 Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. no no 3
15325100 Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma. yes no 3
15346048 VEGF expression in osteosarcoma correlates with vascular permeability by dynamic MRI. yes yes 1
15365076 Telomerase expression predicts unfavorable outcome in osteosarcoma. yes yes 1
15370596 Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. yes no 4
15390286 Interferon-gamma sensitizes osteosarcoma cells to Fas-induced apoptosis by up-regulating Fas receptors and caspase-8. no no 4
15390294 Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation. yes no 1
15448009 Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: a meta-analysis. yes yes 1
15455381 Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. no no 4
15467717 von Willebrand factor expression in osteosarcoma metastasis. yes no 1
15488761 Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. yes no 2
15492501 Differential oncogenic Ras signaling and senescence in tumor cells. no no 2
15516323 Effect of TNF-alpha on human osteosarcoma cell line Saos2--TNF-alpha regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells. no no 4
15538723 Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. no no 2
15540114 Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP. no no 3
15540165 Gene amplifications in osteosarcoma-CGH microarray analysis. yes no 2
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no 6
15583032 Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. no no 3
15585647 Increased Fas expression reduces the metastatic potential of human osteosarcoma cells. yes no 1
15609301 Altered expression and deletion of RMO1 in osteosarcoma. yes yes 1
15625311 Okadaic acid induces apoptosis through double-stranded RNA-dependent protein kinase/eukaryotic initiation factor-2alpha pathway in human osteoblastic MG63 cells. no no 3
15627479 Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. no no 13
15649646 Differential effects of clusterin/apolipoprotein J on cellular growth and survival. no no 1
15656333 Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: experience at Rizzoli on 1421 patients treated over the last 30 years. yes yes 1
15662138 The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. no no 5
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no 12
15701832 Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. no no 3
15705874 Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. no no 5
15735124 TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. yes no 1
15735172 An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma. yes yes 2
15742288 Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. no no 6
15746965 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. no no 6
15753370 An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. yes no 8
15796961 Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes. yes no 2
15800315 Prognostic significance of allelic imbalance at the c-kit gene locus and c-kit overexpression by immunohistochemistry in pediatric osteosarcomas. yes yes 1
15814634 Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma. yes yes 3
15816563 Induction of apoptosis by sodium fluorosilicate treatment in human osteogenic sarcoma (HOS) cells. no no 3
15827336 p53 gene therapy of human osteosarcoma using a transferrin-modified cationic liposome. no no 2
15870699 Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. no no 3
15883045 Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. no no 3
15900593 Frequent genomic abnormalities at TWIST in human pediatric osteosarcomas. yes yes 3
15912538 CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. yes no 3
15913990 Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. yes yes 2
15922739 Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity. no no 1
15923123 Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). no no 3
15936998 Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. no no 5
15939402 Mechanosensitivity of human osteosarcoma cells and phospholipase C beta2 expression. no no 1
15946696 Nicotine affects mineralized nodule formation by the human osteosarcoma cell line Saos-2. no no 4
15965098 Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. no no 2
15985268 Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells. no no 3
16007340 Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation. no no 5
16007579 Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. no no 3
16008557 Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells. yes no 2
16010295 Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation. no no 5
16026999 Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells. no no 3
16035619 Association of alphavbeta3 integrin expression with the metastatic potential and migratory and chemotactic ability of human osteosarcoma cells. no no 2
16083752 Matrix metalloproteinases participate in osteosarcoma invasion. no no 2
16119739 Expression and significance of TGF-beta isoform and VEGF in osteosarcoma. yes yes 1
16140185 Paclitaxel induces apoptosis via caspase-3 activation in human osteogenic sarcoma cells (U-2 OS). no no 1
16157226 Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. yes yes 1
16167336 Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. no no 6
16196299 Relationship between the expression of MTA-1 gene and the metastasis and invasion in human osteosarcoma. no no 1
16206219 CGH evaluation of two de novo synchronous tumors in a child with a germline p53 mutation. yes no 1
16211088 Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin. yes no 1
16211448 HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. yes no 1
16213662 Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. no no 5
16219634 Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. no no 2
16259979 Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. no no 6
16269403 Identification and characterization of novel IGFBP5 interacting protein: evidence IGFBP5-IP is a potential regulator of osteoblast cell proliferation. no no 1
16273216 Voacamine, an alkaloid extracted from Peschiera fuchsiaefolia, inhibits P-glycoprotein action in multidrug-resistant tumor cells. no no 1
16282894 Fas expression in lung metastasis from osteosarcoma patients. yes yes 1
16327977 Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. yes yes 2
16327988 Anticancer agents sensitize osteosarcoma cells to TNF-related apoptosis-inducing ligand downmodulating IAP family proteins. no no 2
16328036 Effect of Vinorelbine on cell growth and apoptosis induction in human osteosarcoma in vitro. no no 3
16354601 Immunohistochemical examination of cytological differentiation in osteosarcomas. yes no 2
16369996 Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. no no 2
16380506 Interleukin-12 up-regulates Fas expression in human osteosarcoma and Ewing's sarcoma cells by enhancing its promoter activity. no no 2
16394764 Aberrant methylation of p14ARF gene correlates with poor survival in osteosarcoma. yes yes 1
16417466 Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma. no no 6
16421247 CD99 acts as an oncosuppressor in osteosarcoma. no no 3
16437349 Expression of a novel alternatively spliced UCP-2 transcript in osteogenic sarcoma. yes no 1
16466985 Recombinant antisense C-myc adenovirus increase in vitro sensitivity of osteosarcoma MG-63 cells to cisplatin. no no 4
16470222 RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. no no 6
16475708 Bone-related growth factors and zoledronic acid regulate the PTHrP/PTH.1 receptor bioregulation systems in MG-63 human osteosarcoma cells. no no 5
16502411 Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma. yes yes 4
16528367 CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. yes yes 2
16533764 Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. no no 6
16540432 Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. no no 3
16547468 Immunohistochemical detection of WT1 protein in a variety of cancer cells. yes no 1
16571651 Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. no no 6
16596382 Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. yes no 7
16677779 Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma. yes yes 1
16683887 Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions. yes yes 1
16696324 Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell. no no 2
16705726 Expression of survivin and correlation with PCNA in osteosarcoma. yes yes 2
16734381 Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. no no 6
16751779 Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. no no 1
16759849 PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. no no 2
16764926 Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. yes no 1
16773198 HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. no no 3
16786118 Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma? yes no 1
16795036 Okadaic acid induces phosphorylation of p65NF-kappaB on serine 536 and activates NF-kappaB transcriptional activity in human osteoblastic MG63 cells. no no 1
16797629 Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. no no 6
16798617 Hypoxia and ionizing radiation: changes in adhesive properties and cell adhesion molecule expression in MG-63 three-dimensional tumor spheroids. no no 6
16814113 Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. no no 4
16818639 Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. no no 1
16822878 Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma. yes yes 1
16826116 Vascular endothelial growth factor expression in osteosarcoma. yes yes 1
16827134 Differential expression and functional characterization of system L amino acid transporters in human normal osteoblast cells and osteogenic sarcoma cells. no no 2
16849574 E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. no no 3
16857797 High WT1 expression is associated with very poor survival of patients with osteogenic sarcoma metastasis. yes yes 1
16878156 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. no no 6
16933368 Effects of hyperthermia on heat shock protein expression, alkaline phosphatase activity and proliferation in human osteosarcoma cells. no no 2
16938571 hCDC4 variation in osteosarcoma. yes no 1
16944980 KAI-1 expression in pediatric high-grade osteosarcoma. yes no 1
16956425 Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. no no 3
16962318 Expression of transcription factor Yin Yang 1 in human osteosarcomas. yes yes 1
16982772 Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. no no 5
17001316 PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. yes no 2
17012855 Silencing stathmin gene expression by survivin promoter-driven siRNA vector to reverse malignant phenotype of tumor cells. no no 1
17014383 Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. no no 1
17018686 Expression of c-kit in human osteosarcoma and its relevance as a prognostic marker. yes yes 1
17022822 Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. yes no 3
17034065 Survivin expression levels as independent predictors of survival for osteosarcoma patients. yes yes 1
17045162 Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies. no no 3
17079093 Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma. yes no 1
17088985 May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. yes yes 1
17089020 Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma. yes no 1
17096323 Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. no no 1
17096406 Germ-line genetic variation of TP53 in osteosarcoma. yes no 1
17113707 Growth inhibition and sensitization to cisplatin by zoledronic acid in osteosarcoma cells. no no 1
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no 12
17120184 Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro. no no 7
17136003 p53 gene gets altered by various mechanisms: studies in childhood sarcomas and retinoblastoma. yes no 1
17189270 alpha-Synuclein stimulates differentiation of osteosarcoma cells: relevance to down-regulation of proteasome activity. no no 4
17203229 Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system. yes yes 1
17206471 The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell cycle arrest and apoptosis. no no 1
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no 7
17218778 Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. no no 8
17222495 Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. no no 2
17230544 Estrogen sulfotransferase (SULT1E1) expression in benign and malignant human bone tumors. yes no 1
17234448 Modulation of apoptotic signalling by 9-hydroxystearic acid in osteosarcoma cells. no no 4
17234543 Low-grade central osteosarcoma of the mandible: a case study report. yes no 3
17237146 Overexpression of hypoxia-inducible factor-1alpha in human osteosarcoma: correlation with clinicopathological parameters and survival outcome. yes yes 1
17254772 RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. no no 3
17256128 The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase. no no 1
17262820 RECK expression in osteosarcoma: correlation with matrix metalloproteinases activation and tumor invasiveness. no no 3
17279585 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. no no 3
17294449 KIT gene in pediatric osteosarcomas: could it be a new therapeutic target? yes no 2
17310851 Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. no no 2
17317953 Loss of TP53 in sarcomas with 17p12 to approximately p11 gain. A fine-resolution oligonucleotide array comparative genomic hybridization study. yes no 3
17318900 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. no no 12
17320498 The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells. no no 1
17323424 Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. no no 7
17342313 Bax gene therapy for human osteosarcoma using cationic liposomes in vivo. no no 1
17343982 Negative growth control of osteosarcoma cell by Bowman-Birk protease inhibitor from soybean; involvement of connexin 43. no no 1
17353802 Ezrin expression predicts survival in stage IIB osteosarcomas. yes yes 1
17356895 Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. no no 6
17366602 COPS3 amplification and clinical outcome in osteosarcoma. yes yes 2
17372931 Alteration of the insulin-like growth factor axis during in vitro differentiation of the human osteosarcoma cell line HOS 58. no no 8
17376718 Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production. no no 3
17390023 Determination of the prognostic value of loss of heterozygosity at the retinoblastoma gene in osteosarcoma. yes no 1
17391929 Expression and pathological relevance of inducible nitric oxide synthase in osteosarcoma of the jaws. yes yes 1
17395421 Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. no no 3
17410535 Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. yes no 3
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no 9
17415755 Expression of major vault protein gene in osteosarcoma patients. yes yes 1
17440083 Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma. yes no 1
17458711 Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. no no 4
17465200 LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. no no 3
17471233 Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53. no no 10
17473184 The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. yes no 2
17483704 TNF-alpha, TNF-beta, IL-6, IL-10, PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma. yes no 1
17493842 Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132. no no 1
17505002 Epidermal growth factor receptor expression in high-grade osteosarcomas is associated with a good clinical outcome. yes yes 1
17506944 Comparative proteomic analysis of human osteosarcoma and SV40-immortalized normal osteoblastic cell lines. no no 2
17506984 Midkine as a novel target for antibody therapy in osteosarcoma. yes yes 1
17509570 Osteosarcoma cell-calcium signaling through tissue factor-factor VIIa complex and factor Xa. no no 3
17509661 Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis. no no 1
17513610 Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells. no no 3
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no 9
17536311 Expression of cyclooxygenase-2 in osteosarcoma of bone. yes yes 1
17549480 Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line. no no 2
17560052 High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma. yes yes 1
17568187 Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines. no no 4
17569615 IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. no no 6
17598902 Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. yes no 1
17609619 High level of ezrin mRNA expression in an osteosarcoma biopsy sample with lung metastasis. yes yes 1
17611411 P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. no no 4
17611684 Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. no no 4
17611696 Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells. no no 6
17627080 Regulation of the mGluR5, EAAT1 and GS expression by glucocorticoids in MG-63 osteoblast-like osteosarcoma cells. no no 2
17632732 Livin and Bcl-2 expression in high-grade osteosarcoma. yes yes 2
17645699 Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. yes no 3
17660802 Prognostic significance of drug-regulated genes in high-grade osteosarcoma. yes yes 9
17682054 Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. no no 3
17683065 Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis. yes yes 3
17684144 Analysis of genes critical for growth regulation identifies Insulin-like Growth Factor 2 Receptor variations with possible functional significance as risk factors for osteosarcoma. yes yes 1
17690908 Possible prognostic role of IL-17R in osteosarcoma. no yes 2
17699771 Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. no yes 3
17786187 Involvement of MET/TWIST/APC combination or the potential role of ossification factors in pediatric high-grade osteosarcoma oncogenesis. yes yes 3
17786325 The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. no no 2
17786474 Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas. yes yes 3
17849429 Expression of serum amyloid A transcripts in human bone tissues, differentiated osteoblast-like stem cells and human osteosarcoma cell lines. no no 5
17873971 Inhibiting proliferation and enhancing chemosensitivity to taxanes in osteosarcoma cells by RNA interference-mediated downregulation of stathmin expression. no yes 1
17886294 Prognostic significance of immunohistochemical expression of ezrin in non-metastatic high-grade osteosarcoma. yes yes 1
17892509 Vector-based Ape1 small interfering RNA enhances the sensitivity of human osteosarcoma cells to endostatin in vivo. no no 2
17934334 Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. no no 3
17952379 The inhibition of in vivo tumorigenesis of osteosarcoma (OS)-732 cells by antisense human osteopontin RNA. no yes 1
17956871 Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. no no 3
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no 7
17980151 Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation. no no 4
17980359 Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. no no 8
17981215 Identification of cryptic microaberrations in osteosarcoma by high-definition oligonucleotide array comparative genomic hybridization. no no 2
17982618 Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells. no no 3
17987039 A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. yes yes 2
17998668 Prognostic and predictive value of c-erbB2 overexpression in osteogenic sarcoma. no no 2
18019405 Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. yes no 3
18047805 Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. no no 2
18048360 Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. no no 3
18081879 Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. yes no 4
18090928 Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. yes no 1
18093185 Lumican expression is positively correlated with the differentiation and negatively with the growth of human osteosarcoma cells. no no 3
18097539 Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines. no no 6
18158779 Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma. yes yes 3
18161867 Prognostic value of bax, bcl-2, and p53 staining in primary osteosarcoma. yes yes 3
18171692 Antiproliferative and proapoptotic activities of new pyrazolo[3,4-d]pyrimidine derivative Src kinase inhibitors in human osteosarcoma cells. no no 1
18196972 Regulation of the p14ARF promoter by DNA methylation. no no 1
18215331 A complex pattern of chemokine receptor expression is seen in osteosarcoma. yes yes 5
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. no no 2
18245529 Prognostic value of CCN3 in osteosarcoma. yes yes 1
18252811 Statin-induced inhibition of 3-hydroxy-3-methyl glutaryl coenzyme a reductase sensitizes human osteosarcoma cells to anticancer drugs. no no 2
18307025 A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene. yes no 1
18332870 Cisplatin treatment increases survival and expansion of a highly tumorigenic side-population fraction by upregulating VEGF/Flt1 autocrine signaling. no no 7
18338812 Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. yes no 4
18339860 Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. no no 3
18348660 Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma. yes no 1
18359978 CDH11 expression is associated with survival in patients with osteosarcoma. yes yes 1
18359981 The proteome profile of the human osteosarcoma U2OS cell line. no no 10
18374478 Lysyl oxidase (LOX) mRNA expression and genes of the differentiated osteoblastic phenotype are upregulated in human osteosarcoma cells by suramin. no no 2
18384113 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. no no 4
18385200 Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. yes no 2
18414033 Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model. no no 6
18421709 C-erbB-2 expression and prognostic significance in osteosarcoma. yes no 1
18438338 VEGF-siRNA silencing induces apoptosis, inhibits proliferation and suppresses vasculogenic mimicry in osteosarcoma in vitro. yes no 3
18443365 Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. yes no 1
18445685 PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. yes no 5
18464244 Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas. yes yes 1
18465804 Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. yes no 1
18472964 Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. no no 1
18483362 Critical role of notch signaling in osteosarcoma invasion and metastasis. yes yes 4
18488713 Silencing of YY1 downregulates RIZ1 promoter in human osteosarcoma. no no 2
18498722 Methylenetetrahydrofolate reductase C677T gene polymorphism in osteosarcoma and chondrosarcoma patients. yes no 1
18501891 Changes in genomic imprinting and gene expression associated with transformation in a model of human osteosarcoma. no no 10
18505923 Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. no no 2
18507006 Identification of potential chemoresistance genes in osteosarcoma. no no 4
18507025 Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412. no no 1
18510171 Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. no no 9
18520037 BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells. no no 1
18524773 FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. no no 4
18528739 Hypoxia markers in human osteosarcoma: an exploratory study. yes no 2
18554951 Expression and significance of hypoxemia-inducible factor-1alpha in osteosarcoma of the jaws. yes yes 1
18563508 Expression of macrophage migration inhibitory factor relates to survival in high-grade osteosarcoma. yes no 2
18567798 Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. yes no 10
18598236 Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells. no no 3
18606492 The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. no no 5
18607665 Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. no no 2
18612712 S100A6 expression and function in human osteosarcoma. yes yes 1
18645001 c-Jun knockdown sensitizes osteosarcoma to doxorubicin. yes no 1
18675369 Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells. no no 1
18701490 Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma. no no 1
18704985 Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. yes no 2
18726921 High level of mitogen-activated protein kinase phosphatase-1 expression is associated with cisplatin resistance in osteosarcoma. no no 1
18757369 Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. no no 10
18758062 Proteome profiling of U2OS cell line in response to a prenylphenol antibiotic isolated from a phytopathogenic fungus. no no 5
18771083 VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. no no 2
18775026 Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins. yes no 1
18787415 scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. no no 1
18797196 COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. yes yes 1
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no 10
18831895 Expression of c-kit protein and mutational status of the c-kit gene in osteosarcoma and their clinicopathological significance. yes yes 1
18838962 Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. no no 5
18854653 Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. yes yes 2
18925963 Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines. yes no 2
18931939 Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. no no 4
18941626 Detection and characterization of CD133+ cancer stem cells in human solid tumours. no no 3
18972316 The expression of novel gene URG4 in osteosarcoma: correlation with patients' prognosis. yes yes 1
18981708 (18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation. yes no 1
18986328 Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. no no 5
18989156 Germline p53 mutation in a Micronesian child with adrenocortical carcinoma and subsequent osteosarcoma. yes no 1
18996209 Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro. no no 1
19010839 Endosialin protein expression and therapeutic target potential in human solid tumors: sarcoma versus carcinoma. yes yes 1
19012332 Somatic TP53 mutation mosaicism in a patient with Li-Fraumeni syndrome. yes no 1
19018758 Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. no no 5
19020756 Increased osteoclast activity is associated with aggressiveness of osteosarcoma. yes no 3
19050913 Ezrin immunohistochemical expression in cartilaginous tumours: a useful tool for differential diagnosis between chondroblastic osteosarcoma and chondrosarcoma. yes yes 1
19052873 Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. no no 1
19060919 The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. no no 4
19066961 Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death. no no 1
19082467 The expression of CRM1 is associated with prognosis in human osteosarcoma. yes yes 1
19105235 Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. no no 4
19125251 RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines. no no 1
19125294 Down-regulation of ribosomal protein L7A in human osteosarcoma. yes yes 1
19142873 De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. no no 3
19148492 Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. no no 5
19159633 Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. no no 3
19159907 Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. yes no 2
19160414 Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment. no no 11
19192721 Expression of insulin-like growth factor-II mRNA binding protein 3 (IMP3) in osteosarcoma. yes yes 1
19212684 The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. yes yes 5
19212829 Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell. yes no 10
19228774 Notch signaling contributes to the pathogenesis of human osteosarcomas. no no 6
19229591 Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells. no no 2
19242128 Characterization of stem cell attributes in human osteosarcoma cell lines. no no 1
19242607 Recurrent RECQL4 imbalance and increased gene expression levels are associated with structural chromosomal instability in sporadic osteosarcoma. yes no 1
19244100 The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. yes no 1
19258511 Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma. yes no 4
19284568 Characterization of STAT3 activation and expression in canine and human osteosarcoma. no no 2
19307728 Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. no no 2
19326179 Cyclooxygenase-2 overexpression predicts poor survival in patients with high-grade extremity osteosarcoma: a pilot study. yes yes 1
19331807 Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma. yes no 3
19338516 Immunohistochemical profile of ephrin A4 expression in human osteosarcoma. yes yes 1
19346874 Her-2/neu, p-53, and their coexpression in osteosarcoma. yes no 2
19347870 Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. no no 3
19351757 Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. yes no 1
19366061 Expression of ezrin and metastatic tumor antigen in osteosarcomas of the jaw. yes yes 2
19393247 Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. no no 6
19427670 Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma. yes no 1
19434073 Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. yes yes 1
19441093 LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization. yes yes 1
19445706 An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. yes yes 1
19449377 Molecular characterization of the response to chemotherapy in conventional osteosarcomas: predictive value of HSD17B10 and IFITM2. yes yes 4
19451596 Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival. yes yes 2
19455146 Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. no no 12
19483233 The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma. yes no 1
19486338 Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. no no 2
19488908 A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. no no 2
19492781 Proteomic analysis of chemonaive pediatric osteosarcomas and corresponding normal bone reveals multiple altered molecular targets. yes no 2
19496172 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. no no 9
19505574 C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. no no 2
19541929 Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. no no 3
19544560 Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs. no no 1
19559722 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. no no 8
19561643 Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling. no no 3
19574207 Pre-treatment serum lactate dehydrogenase level is an important prognostic factor in high-grade extremity osteosarcoma. yes yes 1
19584295 Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. no no 3
19596932 Insulin-like growth factor-binding protein-3 in osteosarcomas and normal bone tissues. yes yes 1
19597468 Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. yes yes 2
19621435 VEGF expression as a prognostic marker in osteosarcoma. yes yes 1
19624845 Risedronate inhibits human osteosarcoma cell invasion. no no 2
19632201 Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples. yes no 4
19638450 Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. no no 1
19668151 Glial fibrillary acidic protein in tumor types with cartilaginous differentiation. yes no 1
19670450 Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. yes no 2
19682073 Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. no no 3
19688969 Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma. yes yes 3
19709164 A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma. yes yes 1
19719941 Integrated assessment of potential value of erbB-2 amplification or expression status as novel therapy target in Chinese children and adolescents with osteosarcoma. yes no 1
19724913 Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma. yes yes 1
19730790 Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/?-catenin antagonists against human osteosarcoma cells. no no 5
19734943 Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. no no 4
19746447 Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosis. no no 5
19747555 Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells. no no 3
19757179 beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. no no 5
19760520 The role of VE-cadherin in osteosarcoma cells. no no 1
19778378 U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. no no 5
19779497 p73 is essential for vitamin D-mediated osteoblastic differentiation. no no 2
19789339 The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. no no 2
19802733 Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma. yes yes 1
19818735 Enhanced chemosensitivity of drug-resistant osteosarcoma cells by lentivirus-mediated Bcl-2 silencing. no no 3
19836228 VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. yes yes 2
19882675 Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. yes no 4
19885603 Different expression patterns of organic anion transporting polypeptides in osteosarcomas, bone metastases and aneurysmal bone cysts. yes no 8
19888226 Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. yes no 2
19894220 Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. no no 2
19895174 Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma. yes yes 1
19896763 Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma. yes no 1
19900100 Immunohistochemistry for human telomerase reverse transcriptase catalytic subunit (hTERT): a study of 143 benign and malignant soft tissue and bone tumours. yes no 1
19936974 mTOR/p70S6K signal transduction pathway contributes to osteosarcoma progression and patients' prognosis. yes yes 2
19951606 Tenascin-C as a prognostic biomarker in osteosarcoma? yes yes 1
19996593 Antitumor efficacy of two novel non-thiazolidinedione compounds as peroxisome proliferator-activated receptor-gamma agonists in human osteosarcoma cells in vitro. no no 1
20003259 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways. yes no 6
20015022 Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. no no 2
20027339 Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas. yes no 4
20032373 Preferential expression of the secreted and membrane forms of tumor endothelial marker 7 transcripts in osteosarcoma. yes no 1
20037818 Expression of Beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity. yes no 1
20038829 Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB. no no 2
20041491 Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells. no no 7
20042639 The kinase Mirk is a potential therapeutic target in osteosarcoma. yes yes 1
20044614 Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no 5
20048075 Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma. yes no 2
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no 8
20063378 Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. yes yes 1
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no 11
20071790 Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome. yes yes 1
20082321 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells. no no 1
20114058 Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells. no no 7
20127006 The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth. yes no 2
20132188 Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma. yes yes 1
20144850 Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. no yes 1
20156969 Immunohistochemical identification of the PTHR1 parathyroid hormone receptor in normal and neoplastic human tissues. yes no 1
20158913 Neoadjuvant multidrug chemotherapy including high-dose methotrexate modifies VEGF expression in osteosarcoma: an immunohistochemical analysis. yes yes 2
20159990 Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. yes yes 1
20181727 A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia. no no 2
20190807 Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells. no no 2
20196171 Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. yes no 2
20197388 Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. yes yes 1
20208568 Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness. no no 3
20213410 How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. no yes 6
20213411 The role of Fas/FasL in the metastatic potential of osteosarcoma and targeting this pathway for the treatment of osteosarcoma lung metastases. no no 2
20218738 APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival. yes yes 1
20222016 Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration. no no 3
20225287 Bone deposition, bone resorption, and osteosarcoma. yes yes 5
20309879 Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. no no 4
20340016 Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcoma. yes no 5
20348881 Phosphorylated ezrin is located in the nucleus of the osteosarcoma cell. yes yes 1
20349215 Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma. yes yes 2
20350217 Expression of Smad and its signalling cascade in osteosarcoma. yes no 3
20354825 Int7G24A variant of transforming growth factor-beta receptor 1 is associated with osteosarcoma susceptibility in a Chinese population. yes yes 1
20357441 Molecular mechanism of cell apoptosis by paclitaxel and pirarubicin in a human osteosarcoma cell line. no no 5
20362224 Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. yes yes 12
20368414 IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. no no 4
20371684 Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. no no 3
20376536 Lentivirus-mediated shRNA targeting insulin-like growth factor-1 receptor (IGF-1R) enhances chemosensitivity of osteosarcoma cells in vitro and in vivo. no no 4
20399482 Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. yes yes 1
20403045 Expression of podoplanin in human bone and bone tumors: New marker of osteogenic and chondrogenic bone tumors. yes yes 1
20406948 Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. no no 5
20429896 Association between TGFBR1*6A and osteosarcoma: a Chinese case-control study. yes yes 1
20433742 Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. no no 5
20459648 The expression and significance of IDH1 and p53 in osteosarcoma. yes yes 2
20459702 Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. yes no 5
20460510 CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. no no 3
20460760 Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. no no 3
20465837 Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. yes yes 9
20480266 MicroRNA-21 is involved in osteosarcoma cell invasion and migration. no no 2
20484142 Sox9 expression is not limited to chondroid neoplasms: variable occurrence in other soft tissue and bone tumors with frequent expression by synovial sarcomas. yes no 1
20486173 R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. no no 2
20491773 Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma. yes no 1
20512478 Induction of G(1)/S phase arrest and apoptosis by quercetin in human osteosarcoma cells. no no 2
20520719 Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. no no 1
20530675 Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. yes no 1
20530678 High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. no no 4
20546860 Clinical value of signal transducers and activators of transcription 3 (STAT3) gene expression in human osteosarcoma. yes no 1
20551950 Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone. yes no 2
20562647 Immunoexpression of Ezrin and CD44 in patients with osteosarcoma. yes no 2
20563836 Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. yes no 2
20577141 Glutathione S-transferase polymorphisms in osteosarcoma patients. yes no 3
20580954 Functional and biological analysis of Bcl-xL expression in human osteosarcoma. yes no 6
20592496 Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. no no 4
20594821 Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. yes no 2
20596639 Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. no no 5
20601938 Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. yes yes 2
20610556 Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. yes yes 2
20625943 Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells. no no 1
20627196 Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. no no 6
20632817 Expression of heat shock proteins in osteosarcomas. yes yes 3
20637078 Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor. no no 2
20664979 N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. no no 3
20678472 Sanguinarine induces apoptosis of human osteosarcoma cells through the extrinsic and intrinsic pathways. no no 2
20682173 Sensitization of osteosarcoma cell line SaOS-2 to chemotherapy by downregulating survivin. no no 1
20701666 Proliferative, apoptotic and angiogenic potentials in jaws and long bones osteosarcomas: a comparative immunohistochemical study. yes no 3
20737480 Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma. yes no 1
20798956 TIMP-1 interaction with ?v?3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNF-?-induced apoptosis. no no 5
20806347 Elevated expression of CXC chemokines in pediatric osteosarcoma patients. yes yes 2
20808934 Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. no no 6
20819644 Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells. no no 3
20823153 Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases. yes yes 1
20845987 +Antisense oligonucleotide targeting survivin inhibits growth by inducing apoptosis in human osteosarcoma cells MG-63. no no 2
20845995 Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1? in osteosarcoma. yes no 2
20854211 Glucose transporter protein 1-targeted RNA interference inhibits growth and invasion of the osteosarcoma cell line MG63 in vitro. no no 1
20855150 Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells. no no 3
20859706 Expression change of ezrin as a prognostic factor in primary osteosarcoma. yes yes 1
20878132 microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. yes no 2
20880700 Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. yes yes 5
20881269 Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. yes no 2
20926002 Celecoxib inhibits ?-catenin-dependent survival of the human osteosarcoma MG-63 cell line. no no 4
20944138 Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. no no 1
20949564 Micro-RNA profiles in osteosarcoma as a predictive tool for ifosfamide response. yes yes 5
20955951 Markers of bone remodeling in neoplastic and bone-related lesions. yes no 4
20970221 2-Hydroxypropyl-?-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors. no no 2
20973064 Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma. yes yes 1
20978190 Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. no no 4
21056138 Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt. no no 2
21079421 Gene expression profiles of human osteosarcoma cell sublines with different pulmonary metastatic potentials. no no 2
21080877 Expression of platelet-derived growth factor-alpha receptor in human osteosarcoma is not a predictor of outcome. yes no 1
21084254 Clinical utility of biochemical bone turnover markers in children and adolescents with osteosarcoma. yes yes 3
21104436 Paraoxonase 1 192 and 55 polymorphisms in osteosarcoma. yes yes 1
21113498 Matrix metalloproteinases 2, 7, 9 and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. yes yes 4
21116120 Mutations of lysophosphatidic acid receptor genes in human osteosarcoma cells. no no 2
21137073 Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. yes yes 1
21145881 Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves ?v?5 integrin, ILK and AP-1-dependent pathways. no no 7
21149578 Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63. no no 4
21152068 Lysophosphatidic acid acyltransferase ? (LPAAT?) promotes the tumor growth of human osteosarcoma. no no 1
21159888 Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. yes no 4
21163271 Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. no no 6
21165567 Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws. yes no 1
21166698 De novo expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway. no no 5
21166699 Therapeutic potential of CAMPATH-1H in skeletal tumours. yes no 1
21178508 BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. no no 6
21192060 Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil. yes no 1
21207222 Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. yes yes 1
21215367 Massive genomic rearrangement acquired in a single catastrophic event during cancer development. yes no 5
21234653 Anti-tumor effects of dihydroartemisinin on human osteosarcoma. no no 10
21236332 15-Deoxy-?12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. no no 5
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes 7
21246613 Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. no no 7
21249357 Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma. yes yes 1
21266106 Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. no no 5
21283769 Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1. yes no 2
21286665 Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. no no 3
21287529 Effect of the histone deacetylase inhibitor SNDX-275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases. no no 3
21287809 Novel gene P28GANK confers multidrug resistance by modulating the expression of MDR-1, Bcl-2 and Bax in osteosarcoma cells. no no 4
21292304 Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma. yes no 1
21297379 Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. no no 1
21311599 Overexpression of BMI-1 promotes cell growth and resistance to cisplatin treatment in osteosarcoma. yes no 1
21312266 CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. yes yes 1
21321933 Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells. yes no 3
21331449 Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. no no 6
21336260 MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. yes yes 2
21340507 Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. no no 1
21345075 Multiple malignancies in a child with de novo TP53 mutation. yes no 1
21370405 RANKL expression is related to treatment outcome of patients with localized, high-grade osteosarcoma. yes yes 1
21375766 RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. no no 4
21378337 The role of MAPK pathway in bone and soft tissue tumors. yes no 3
21387396 ROCK1 as a potential therapeutic target in osteosarcoma. yes no 1
21399492 Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. no no 1
21411701 Interferon-?/? receptor as a prognostic marker in osteosarcoma. yes yes 2
21416580 A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. yes yes 1
21421073 Lumican regulates osteosarcoma cell adhesion by modulating TGF?2 activity. no no 6
21424568 Relationship between hypermethylated MGMT gene and osteosarcoma necrosis rate after chemotherapy. yes no 1
21427707 MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. no no 2
21436869 RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells. yes no 1
21440986 Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. no no 3
21443800 The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. no no 6
21453059 Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma. yes yes 1
21458381 Cyclin E1 is amplified and overexpressed in osteosarcoma. yes yes 1
21460855 Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma. yes no 1
21481226 Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines. no no 3
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no 8
21495021 Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma. yes yes 1
21506130 Role of GLI2 in the growth of human osteosarcoma. yes yes 5
21508379 Involvement of cancer biomarker C7orf24 in the growth of human osteosarcoma. yes no 1
21517265 SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. no no 3
21520041 Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells. no no 2
21527497 Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. no no 5
21528673 Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report. yes no 1
21529352 WEE1 inhibition sensitizes osteosarcoma to radiotherapy. yes yes 1
21542455 Knockdown of MED19 by lentivirus-mediated shRNA in human osteosarcoma cells inhibits cell proliferation by inducing cell cycle arrest in the G0/G1 phase. no no 1
21563968 CD86 + 1057G/A polymorphism and susceptibility to osteosarcoma. yes yes 1
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no 16
21573994 Silencing of HMGA1 expression by RNA interference suppresses growth of osteogenic sarcoma. no no 1
21617855 Caffeine activates tumor suppressor PTEN in sarcoma cells. no no 2
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no 6
21619552 The significance of MGMT protein detection in evaluation of osteosarcoma necrosis rate after cisplatin chemotherapy. yes no 1
21619704 A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. yes yes 8
21631272 p63 expression in giant cell-containing lesions of bone and soft tissue. yes yes 1
21640141 Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. no no 3
21656314 Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis. no no 1
21665377 Low concentrations of alendronate increase the local invasive potential of osteoblastic sarcoma cell lines via connexin 43 activation. no no 1
21666078 MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. yes no 3
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no 8
21671176 Targeted silencing of heparanase gene by small interfering RNA inhibits invasiveness and metastasis of osteosarcoma cells. no no 1
21671177 Influence of ?-catenin small interfering RNA on human osteosarcoma cells. no no 2
21681744 Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma. yes no 2
21691740 Insights on PRAME and osteosarcoma by means of gene expression profiling. yes no 1
21706236 Plasma membrane proteomic analysis of human osteosarcoma and osteoblastic cells: revealing NDRG1 as a marker for osteosarcoma. yes yes 1
21717192 Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. no no 7
21720717 Induction of G?/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. no no 8
21750404 Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. yes yes 2
21751201 Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth. no no 1
21751203 Cell surface receptor expression patterns in osteosarcoma. yes no 7
21780101 P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. no no 2
21801875 Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. yes no 4
21805050 Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. no no 5
21822121 BI 2536-mediated PLK1 inhibition suppresses HOS and MG-63 osteosarcoma cell line growth and clonogenicity. no no 1
21822538 p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. no no 4
21826087 Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. yes yes 3
21826611 Sodium selenite-induced apoptosis mediated by ROS attack in human osteosarcoma U2OS cells. no no 4
21834878 Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration. no no 3
21843050 IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines. no no 1
21843952 Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. no no 1
21866554 Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma. yes yes 1
21868524 Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. no no 1
21874265 Vasodilator-stimulated phosphoprotein regulates osteosarcoma cell migration. no no 2
21887680 Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study. yes no 4
21890444 Expressions of p53, c-MYC, BCL-2 and apoptotic index in human osteosarcoma and their correlations with prognosis of patients. yes yes 3
21901524 Knockdown of Mad2 induces osteosarcoma cell apoptosis-involved Rad21 cleavage. no no 3
21925315 USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. no no 4
21927024 Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. yes no 2
21941146 Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray. yes no 1
21945933 RLIM interacts with Smurf2 and promotes TGF-? induced U2OS cell migration. no no 3
21951664 RUNX2 expression in developing human bones and various bone tumors. yes no 2
21959981 MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93. no no 2
21963453 Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D? action in osteosarcoma. no no 3
21964477 Okadaic acid induces apoptosis through the PKR, NF-?B and caspase pathway in human osteoblastic osteosarcoma MG63 cells. no no 3
21986150 Difference in pre- and postchemotherapy vascular endothelial growth factor levels as a prognostic indicator in osteosarcoma. yes yes 1
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no 9
22006429 High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. yes no 8
22009167 Cancer-testis antigens expressed in osteosarcoma identified by gene microarray correlate with a poor patient prognosis. yes yes 3
22009216 Prostate-specific membrane antigen: a new potential prognostic marker of osteosarcoma. yes yes 1
22009832 Apoptotic effects of curcumin on human osteosarcoma U2OS cells. no no 7
22009965 Expression of b-FGF and endostatin and their clinical significance in human osteosarcoma. yes yes 3
22012179 Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling. no no 3
22016816 Effect of ABCB1 and ABCC3 polymorphisms on osteosarcoma survival after chemotherapy: a pharmacogenetic study. yes yes 2
22021909 TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma. no no 1
22037351 Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma. no no 11
22042095 The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. yes no 2
22047406 YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma. yes yes 1
22057483 RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. no no 6
22068640 Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. no no 6
22075555 Genetically modified T cells targeting interleukin-11 receptor ?-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases. yes no 1
22090361 Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma. yes no 1
22093834 miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. yes no 2
22099874 Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma. yes no 1
22102692 HMGB1 promotes drug resistance in osteosarcoma. no no 4
22126551 Relationships between serum biomarker levels and clinical presentation of human osteosarcomas. yes no 3
22126901 Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro. no no 7
22128168 Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression. no no 9
22135725 C-kit expression in human osteosarcoma and in vitro assays. yes no 1
22138223 Upregulation of Polo-like kinase 2 gene expression by GATA-1 acetylation in human osteosarcoma MG-63 cells. no no 2
22147261 Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma. no no 1
22147650 Prion proteins (PRNP and PRND) are over-expressed in osteosarcoma. yes no 9
22154052 MAPK7 and MAP2K4 as prognostic markers in osteosarcoma. yes yes 2
22158627 Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility. no no 3
22173290 Strong expression of CXCL12 is associated with a favorable outcome in osteosarcoma. yes yes 3
22173710 Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. no no 1
22179790 RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro. no no 2
22186140 miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression. no no 4
22202598 CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients. yes yes 1
22205265 The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. yes no 2
22212432 Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. no no 4
22213004 Overexpression of ZEB1 relates to metastasis and invasion in osteosarcoma. yes yes 1
22213073 ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9. yes no 2
22215309 Upregulation of a disintegrin and metalloprotease 8 influences tumor metastasis and prognosis in patients with osteosarcoma. yes yes 1
22227330 Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. no no 3
22231496 Daphnoretin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no 8
22245111 Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. yes no 1
22246399 Millimeter wave treatment induces apoptosis via activation of the mitochondrial-dependent pathway in human osteosarcoma cells. no no 5
22248279 Overexpression of potassium channel ether à go-go in human osteosarcoma. yes no 1
22263786 Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-?B pathway. no no 2
22271434 Different expression of CD146 in human normal and osteosarcoma cell lines. no no 2
22274866 The prognostic value of elevated vascular endothelial growth factor in patients with osteosarcoma: a meta-analysis and systemic review. yes yes 2
22286748 siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells. no no 1
22292074 Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma. yes no 9
22292654 Knockdown of S100A4 decreases tumorigenesis and metastasis in osteosarcoma cells by repression of matrix metalloproteinase-9. yes yes 2
22297550 Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival. yes no 1
22301501 MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. yes yes 2
22301993 Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma. no no 4
22333159 High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China. yes yes 2
22338054 CD138 (syndecan-1) expression in bone-forming tumors. yes no 1
22340557 Increased expression of serum gelsolin in patients with osteosarcoma. yes yes 1
22344865 Nestin expression in high-grade osteosarcomas and its clinical significance. yes no 1
22350417 miRNA signatures associate with pathogenesis and progression of osteosarcoma. yes no 10
22354724 Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma. no no 1
22371553 A preliminary investigation of Beta-hCG expression in patients with osteosarcoma. yes yes 1
22382389 Inhibition of nuclear factor-?B by dehydroxymethylepoxyquinomicin induces schedule-dependent chemosensitivity to anticancer drugs and enhances chemoinduced apoptosis in osteosarcoma cells. no no 1
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no 11
22390926 Targeting Werner syndrome protein sensitizes U-2 OS osteosarcoma cells to selenium-induced DNA damage response and necrotic death. no no 1
22390931 Expression and prognostic relevance of PRAME in primary osteosarcoma. yes yes 1
22422053 Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. no no 2
22426824 PKD1 negatively regulates cell invasion, migration and proliferation ability of human osteosarcoma. yes yes 2
22446894 Knockdown of endothelin A receptor expression inhibits osteosarcoma pulmonary metastasis in an orthotopic xenograft mouse model. no no 2
22454324 Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data. yes no 2
22457788 MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. no no 2
22471458 KISS1 expression in osteosarcoma: high in chinese clinical cases, but lower in cell lines. yes yes 1
22471480 Glutathione S-transferase polymorphisms and bone tumor risk in China. yes yes 2
22471498 Cisplatin induces apoptosis via upregulating Wrap53 in U-2OS osteosarcoma cells. no no 2
22472569 MicroRNA-145 targets vascular endothelial growth factor and inhibits invasion and metastasis of osteosarcoma cells. yes no 2
22506069 CCL5 and CCR5 interaction promotes cell motility in human osteosarcoma. no no 2
22521131 Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. no no 1
22525461 Down-regulation of miR-183 promotes migration and invasion of osteosarcoma by targeting Ezrin. yes no 4
22527131 Tissue transglutaminase (TG2) activity regulates osteoblast differentiation and mineralization in the SAOS-2 cell line. no no 4
22531343 Syndecan-4 and fibronectin in osteosarcoma. yes yes 2
22534782 Glycogen synthase kinase-3?, NF-?B signaling, and tumorigenesis of human osteosarcoma. no no 2
22542077 Clinicopathologic correlation of vitamin D receptor expression with retinoid X receptor and MIB-1 expression in primary and metastatic osteosarcoma. yes yes 3
22542792 Mutations in the mitochondrial ATPase6 gene are frequent in human osteosarcoma. yes no 1
22544557 Expression and stability of hypoxia inducible factor 1? in osteosarcoma. yes no 2
22546756 Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. no no 7
22578565 P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy. yes yes 1
22583777 Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. yes no 4
22623071 Nuclear p63 expression in osteoblastic tumors. yes yes 1
22641358 Combined administration of EGCG and IL-1 receptor antagonist efficiently downregulates IL-1-induced tumorigenic factors in U-2 OS human osteosarcoma cells. no no 5
22665540 Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. yes no 1
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no 9
22682017 Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. yes yes 5
22682620 MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. no no 11
22688575 Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells. no no 6
22715593 Overexpression of LIMK1 promotes migration ability of multidrug-resistant osteosarcoma cells. no no 4
22719058 Expression of 11?-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments. yes yes 2
22736026 HIF-1? induced by ?-elemene protects human osteosarcoma cells from undergoing apoptosis. no no 1
22743617 STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. no no 5
22749040 12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. yes yes 2
22771636 Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. yes no 1
22791884 Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. yes yes 1
22797704 NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation. no no 2
22799338 Antitumor activity of histone deacetylase inhibitor trichostatin A in osteosarcoma cells. no no 1
22817659 Invariant NKT cells increase drug-induced osteosarcoma cell death. no no 1
22820099 Inhibition of c-Met activation sensitizes osteosarcoma cells to cisplatin via suppression of the PI3K-Akt signaling. no no 2
22843172 MDM2 inhibitor Nutlin-3a suppresses proliferation and promotes apoptosis in osteosarcoma cells. no no 2
22847601 Prognostic value of Twist and E-cadherin in patients with osteosarcoma. yes yes 2
22849560 Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. no no 6
22855058 Expression and significance of Kruppel-like factor 6 gene in osteosarcoma. yes yes 1
22855059 Expression of Vascular Endothelial Growth Factor correlates with the advance of clinical osteosarcoma. yes yes 3
22870217 Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma. no no 10
22870593 Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. yes yes 2
22886393 TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. yes no 5
22889802 A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. no no 1
22911823 Lysyl oxidase polymorphisms and susceptibility to osteosarcoma. yes yes 1
22916108 Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. no no 3
22922684 The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. yes no 4
22922800 miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells. no no 2
22922827 miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma. no no 3
22923031 Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. no no 4
22926753 SC-1, a sorafenib derivative, shows anti-tumor effects in osteogenic sarcoma cells. no no 4
22935974 Mitogen-activated protein kinase pathway in osteosarcoma. yes yes 5
22938445 Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. yes yes 3
22939995 IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. yes no 6
22948234 Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. no no 3
22949168 The cancer-related transcription factor Runx2 modulates cell proliferation in human osteosarcoma cell lines. no no 1
22968906 Targeting hedgehog-GLI-2 pathway in osteosarcoma. yes yes 1
22992985 Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1?-dependent manner. no no 6
22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways. no no 5
22994717 LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. no no 4
23000411 Domain 5 of high molecular weight kininogen inhibits collagen-mediated cancer cell adhesion and invasion in association with ?-actinin-4. no no 2
23015149 Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study. yes yes 1
23027359 Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor. no no 4
23031740 Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: increased expression of a CD44 variant isoform after chemotherapy. yes no 2
23045411 Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. yes no 2
23052169 Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas. yes no 3
23071517 Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. no no 7
23091618 Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. no no 5
23098477 Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. yes yes 2
23108792 SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell. no no 4
23113351 The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. no no 7
23133552 Modulation of the osteosarcoma expression phenotype by microRNAs. yes no 43
23137772 A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. yes no 9
23142238 Cell adhesion molecule 1 is a new osteoblastic cell adhesion molecule and a diagnostic marker for osteosarcoma. yes yes 2
23144859 Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma. yes no 6
23145797 Ether à go-go 1 silencing in combination with TRAIL overexpression has synergistic antitumor effects on osteosarcoma. no no 2
23164673 The glycogen synthase kinase-3?/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells. no no 8
23167426 Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. yes yes 5
23167620 Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells. no no 1
23168047 Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. no no 4
23175213 Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. no no 2
23192273 IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. yes no 5
23201449 Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. no no 6
23208072 Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. no no 8
23219526 Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. no no 5
23225447 Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. yes no 3
23232982 Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-?B pathway. no no 5
23255321 Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts. yes no 1
23262982 Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. no no 11
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no 8
23269581 A three-plasma miRNA signature serves as novel biomarkers for osteosarcoma. yes yes 3
23269582 Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma. yes yes 1
23291185 Inhibition of the Wnt-?-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. yes yes 3
23311495 MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma. yes yes 2
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no 10
23317281 Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. yes yes 3
23321165 Identification of serum microRNA-21 as a biomarker for chemosensitivity and prognosis in human osteosarcoma. yes yes 1
23321467 NPRL2 is an independent prognostic factor of osteosarcoma. yes yes 1
23322324 Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. no no 4
23341181 Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis. yes yes 1
23352643 Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development. no no 2
23372675 MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma. no no 1
23383046 FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. yes no 3
23403511 Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia. no no 3
23430441 Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma. yes yes 1
23430952 Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling. no no 7
23433115 Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells. no no 1
23450030 The prognostic value of the serum level of C-reactive protein for the survival of patients with a primary sarcoma of bone. yes yes 1
23451817 Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. no no 5
23461061 C-Myc overexpression promotes osteosarcoma cell invasion via activation of MEK-ERK pathway. no no 3
23462806 Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma. no no 3
23470834 Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. no no 4
23507142 miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1-MEK1/2-ERK1/2 pathway in osteosarcoma. yes no 7
23527718 The role and clinical significance of YES-associated protein 1 in human osteosarcoma. no yes 4
23527720 Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. yes no 4
23530647 Induction of cell cycle arrest and apoptosis in human osteosarcoma U-2 OS cells by Solanum lyratum extracts. yes no 1
23559304 Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours. yes yes 1
23568006 Enhanced chemosensitivity by simultaneously inhibiting cell cycle progression and promoting apoptosis of drug-resistant osteosarcoma MG63/DXR cells by targeting Cyclin D1 and Bcl-2. no no 2
23574781 MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma. yes no 3
23578572 MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAAT?. no no 2
23589053 A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma. yes yes 1
23631646 MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. yes no 2
23661525 RNAi-mediated knockdown of relaxin decreases in vitro proliferation and invasiveness of osteosarcoma MG-63 cells by inhibition of MMP-9. no no 2
23681112 Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma. yes yes 1
23684620 Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients. yes yes 3
23725133 Down-regulation of long non-coding RNA TUG1 inhibits osteosarcoma cell proliferation and promotes apoptosis. yes no 1
23727862 Genome-wide association study identifies two susceptibility loci for osteosarcoma. yes yes 1
23740448 Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. no no 3
23813624 Overexpression of fibroblast activation protein and its clinical implications in patients with osteosarcoma. yes yes 1
23827457 MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31. no no 2
23831057 Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells. no no 1
23872151 MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1. no no 2
23879172 FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas. no no 6
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no 13
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