Results for CDK2

General Information

Gene ID 1017
Gene Symbol CDK2
Gene Name cyclin-dependent kinase 2
Gene Type protein-coding
Cytoband 12q13
Ensembl ID ENSG00000123374
#miR regulators 8
Omim ID 116953
Gene ontology GO:0006260: DNA replication
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000085: G2 phase of mitotic cell cycle
GO:0000086: G2/M transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0007596: blood coagulation
GO:0006281: DNA repair
GO:0006813: potassium ion transport
GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007067: mitosis
GO:0007126: meiosis
GO:0007265: Ras protein signal transduction
GO:0008284: positive regulation of cell proliferation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0016572: histone phosphorylation
GO:0031145: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571: mitotic G1 DNA damage checkpoint
GO:0032298: positive regulation of DNA-dependent DNA replication initiation
GO:0051298: centrosome duplication
GO:0051301: cell division
GO:0051439: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060968: regulation of gene silencing
GO:0071732: cellular response to nitric oxide
GO:0000793: condensed chromosome
GO:0000307: cyclin-dependent protein kinase holoenzyme complex
GO:0000781: chromosome, telomeric region
GO:0000805: X chromosome
GO:0000806: Y chromosome
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005768: endosome
GO:0005813: centrosome
GO:0015030: Cajal body
GO:0005515: protein binding
GO:0004693: cyclin-dependent protein serine/threonine kinase activity
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0030332: cyclin binding
GO:0035173: histone kinase activity
KEGG pathways 4110: Cell cycle
4114: Oocyte meiosis
4115: p53 signaling pathway
4914: Progesterone-mediated oocyte maturation
5200: Pathways in cancer
5215: Prostate cancer
5222: Small cell lung cancer

PubMed abstracts associated with CDK2

PMID Title Tumor Value
8052269 Insulin-like growth factor-I induces cyclin-D1 expression in MG63 human osteosarcoma cells in vitro. no no
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
10234573 ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells. no no
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
11289134 Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. no no
11464280 Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. no no
12907249 Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. no no
15705874 Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. no no
16982772 Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells. no no
21490307 The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. no no
21720717 Induction of G?/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. no no
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