Results for CDK4

General Information

Gene ID 1019
Gene Symbol CDK4
Gene Name cyclin-dependent kinase 4
Gene Type protein-coding
Cytoband 12q14
Ensembl ID ENSG00000135446
#miR regulators 2
Omim ID 123829 609048
Gene ontology GO:0000082: G1/S transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0051726: regulation of cell cycle
GO:0007165: signal transduction
GO:0006468: protein phosphorylation
GO:0007623: circadian rhythm
GO:0008284: positive regulation of cell proliferation
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0010288: response to lead ion
GO:0010468: regulation of gene expression
GO:0045727: positive regulation of translation
GO:0031100: organ regeneration
GO:0033574: response to testosterone stimulus
GO:0043065: positive regulation of apoptotic process
GO:0045793: positive regulation of cell size
GO:0048146: positive regulation of fibroblast proliferation
GO:0051301: cell division
GO:0055093: response to hyperoxia
GO:0000307: cyclin-dependent protein kinase holoenzyme complex
GO:0000785: chromatin
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005730: nucleolus
GO:0005923: tight junction
GO:0031965: nuclear membrane
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004693: cyclin-dependent protein serine/threonine kinase activity
GO:0005524: ATP binding
GO:0030332: cyclin binding
GO:0032403: protein complex binding
KEGG pathways 4110: Cell cycle
4115: p53 signaling pathway
4530: Tight junction
4660: T cell receptor signaling pathway
5200: Pathways in cancer
5212: Pancreatic cancer
5214: Glioma
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5222: Small cell lung cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with CDK4

PMID Title Tumor Value
7640224 Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. yes no
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
9355974 Altered G1 phase regulation in osteosarcoma. yes yes
9464545 Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. no no
9619593 Comparative genomic hybridization of low-grade central osteosarcoma. yes no
9665476 CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. yes no
9703873 Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. yes no
9935200 CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. yes no
9989829 Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. yes no
10101594 Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. yes no
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
10441007 Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. yes no
10502725 Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. yes yes
10943202 Analysis of 12q13-15 genes in parosteal osteosarcoma. yes no
11115584 Osteosarcoma in blood relatives. yes no
11464280 Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. no no
11564577 Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. yes no
12747978 Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. yes no
15167009 Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. yes yes
16596382 Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. yes no
20196171 Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. yes no
20601938 Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. yes yes
20610556 Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. yes yes
21336260 MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. yes yes
22301501 MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. yes yes
22749040 12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. yes yes
23225447 Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. yes no
23266503 Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. no no
23470834 Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. no no
title all all