General Information
Gene ID | 1019 |
---|---|
Gene Symbol | CDK4 |
Gene Name | cyclin-dependent kinase 4 |
Gene Type | protein-coding |
Cytoband | 12q14 |
Ensembl ID | ENSG00000135446 |
#miR regulators | 2 |
Omim ID | 123829 609048 |
Gene ontology |
GO:0000082: G1/S transition of mitotic cell cycle GO:0000278: mitotic cell cycle GO:0051726: regulation of cell cycle GO:0007165: signal transduction GO:0006468: protein phosphorylation GO:0007623: circadian rhythm GO:0008284: positive regulation of cell proliferation GO:0042493: response to drug GO:0009636: response to toxic substance GO:0010288: response to lead ion GO:0010468: regulation of gene expression GO:0045727: positive regulation of translation GO:0031100: organ regeneration GO:0033574: response to testosterone stimulus GO:0043065: positive regulation of apoptotic process GO:0045793: positive regulation of cell size GO:0048146: positive regulation of fibroblast proliferation GO:0051301: cell division GO:0055093: response to hyperoxia GO:0000307: cyclin-dependent protein kinase holoenzyme complex GO:0000785: chromatin GO:0005829: cytosol GO:0005634: nucleus GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005730: nucleolus GO:0005923: tight junction GO:0031965: nuclear membrane GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0004693: cyclin-dependent protein serine/threonine kinase activity GO:0005524: ATP binding GO:0030332: cyclin binding GO:0032403: protein complex binding |
KEGG pathways |
4110: Cell cycle 4115: p53 signaling pathway 4530: Tight junction 4660: T cell receptor signaling pathway 5200: Pathways in cancer 5212: Pancreatic cancer 5214: Glioma 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5222: Small cell lung cancer 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
7640224 | Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. | yes | no |
9154817 | Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. | no | no |
9355974 | Altered G1 phase regulation in osteosarcoma. | yes | yes |
9464545 | Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. | no | no |
9619593 | Comparative genomic hybridization of low-grade central osteosarcoma. | yes | no |
9665476 | CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. | yes | no |
9703873 | Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation. | yes | no |
9935200 | CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. | yes | no |
9989829 | Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. | yes | no |
10101594 | Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. | yes | no |
10339667 | Expression of G1 phase regulators in MG-63 osteosarcoma cell line. | no | no |
10441007 | Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma. | yes | no |
10502725 | Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. | yes | yes |
10943202 | Analysis of 12q13-15 genes in parosteal osteosarcoma. | yes | no |
11115584 | Osteosarcoma in blood relatives. | yes | no |
11464280 | Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. | no | no |
11564577 | Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. | yes | no |
12747978 | Clinicopathological and immunohistochemical analysis of twenty-five head and neck osteosarcomas. | yes | no |
15167009 | Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. | yes | yes |
16596382 | Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. | yes | no |
20196171 | Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. | yes | no |
20601938 | Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. | yes | yes |
20610556 | Genomic alterations and allelic imbalances are strong prognostic predictors in osteosarcoma. | yes | yes |
21336260 | MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. | yes | yes |
22301501 | MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. | yes | yes |
22749040 | 12q amplification defines a subtype of extraskeletal osteosarcoma with good prognosis that is the soft tissue homologue of parosteal osteosarcoma. | yes | yes |
23225447 | Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. | yes | no |
23266503 | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. | no | no |
23470834 | Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. | no | no |
title | all | all |