Results for CDKN1A

General Information

Gene ID 1026
Gene Symbol CDKN1A
Gene Name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Gene Type protein-coding
Cytoband 6p21.2
Ensembl ID ENSG00000124762
#miR regulators 10
Omim ID 116899
Gene ontology GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000086: G2/M transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0006974: response to DNA damage stimulus
GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050: cell cycle arrest
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007265: Ras protein signal transduction
GO:0043066: negative regulation of apoptotic process
GO:0008285: negative regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0042493: response to drug
GO:0009636: response to toxic substance
GO:0009411: response to UV
GO:0010243: response to organonitrogen compound
GO:0010629: negative regulation of gene expression
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0046685: response to arsenic-containing substance
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030308: negative regulation of cell growth
GO:0030890: positive regulation of B cell proliferation
GO:0031100: organ regeneration
GO:0031668: cellular response to extracellular stimulus
GO:0033158: regulation of protein import into nucleus, translocation
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042326: negative regulation of phosphorylation
GO:0043068: positive regulation of programmed cell death
GO:0045087: innate immune response
GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048146: positive regulation of fibroblast proliferation
GO:0051412: response to corticosterone stimulus
GO:0055093: response to hyperoxia
GO:0071479: cellular response to ionizing radiation
GO:0071850: mitotic cell cycle arrest
GO:0090398: cellular senescence
GO:0090400: stress-induced premature senescence
GO:0097193: intrinsic apoptotic signaling pathway
GO:2000278: regulation of DNA biosynthetic process
GO:0000307: cyclin-dependent protein kinase holoenzyme complex
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0070557: PCNA-p21 complex
GO:0005515: protein binding
GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0046872: metal ion binding
GO:0019912: cyclin-dependent protein kinase activating kinase activity
GO:0030332: cyclin binding
GO:0032403: protein complex binding
KEGG pathways 4012: ErbB signaling pathway
4110: Cell cycle
4115: p53 signaling pathway
5160: Hepatitis C
5200: Pathways in cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia

PubMed abstracts associated with CDKN1A

PMID Title Tumor Value
7585620 Retroviral vector-mediated gene transfer of antisense cyclin G1 (CYCG1) inhibits proliferation of human osteogenic sarcoma cells. no no
8616838 Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. no no
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
10339667 Expression of G1 phase regulators in MG-63 osteosarcoma cell line. no no
10498894 p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis. no no
10571205 A point mutation of human p53, which was not detected as a mutation by a yeast functional assay, led to apoptosis but not p21Waf1/Cip1/Sdi1 expression in response to ionizing radiation in a human osteosarcoma cell line, Saos-2. no no
10942797 Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. yes yes
11289134 Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity. no no
11331958 Transcriptional activation of p21 by vitamin D(3) or vitamin K(2) leads to differentiation of p53-deficient MG-63 osteosarcoma cells. no no
11695244 Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. no no
12478472 Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response. no no
12759621 Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. yes yes
15198903 p21WAF1/CIP1 gene DNA sequencing and its expression in human osteosarcoma. yes no
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
17412493 1alpha,25-Dihydroxyvitamin D(3) antiproliferative actions involve vitamin D receptor-mediated activation of MAPK pathways and AP-1/p21(waf1) upregulation in human osteosarcoma. no no
17569615 IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells. no no
17611411 P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. no no
17786325 The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. no no
18384113 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. no no
18567798 Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. yes no
18931939 Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. no no
19159633 Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. no no
19455146 Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation. no no
19559722 Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. no no
19734943 Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. no no
19778378 U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. no no
20053387 RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cells. no no
20067614 Smoothened as a new therapeutic target for human osteosarcoma. yes no
20350217 Expression of Smad and its signalling cascade in osteosarcoma. yes no
20433742 Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. no no
20465837 Expression analysis of genes associated with human osteosarcoma tumors shows correlation of RUNX2 overexpression with poor response to chemotherapy. yes yes
20664979 N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells. no no
21266106 Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. no no
21506130 Role of GLI2 in the growth of human osteosarcoma. yes yes
21720717 Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. no no
21993662 Plumbagin induces apoptosis via the p53 pathway and generation of reactive oxygen species in human osteosarcoma cells. no no
22068640 Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. no no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22916108 Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
23322324 Effects of Kruppel-like factor 6 on osteosarcoma cell biological behavior. no no
23451817 Metformin synergistically enhances antitumor activity of histone deacetylase inhibitor trichostatin a against osteosarcoma cell line. no no
title all all