Results for CDKN1B

General Information

Gene ID 1027
Gene Symbol CDKN1B
Gene Name cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Gene Type protein-coding
Cytoband 12p13.1-p12
Ensembl ID ENSG00000111276
#miR regulators 10
Omim ID 600778 610755
Gene ontology GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0006813: potassium ion transport
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050: cell cycle arrest
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0048102: autophagic cell death
GO:0007605: sensory perception of sound
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010942: positive regulation of cell death
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030308: negative regulation of cell growth
GO:0031116: positive regulation of microtubule polymerization
GO:0033673: negative regulation of kinase activity
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042326: negative regulation of phosphorylation
GO:0045087: innate immune response
GO:0045732: positive regulation of protein catabolic process
GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045930: negative regulation of mitotic cell cycle
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048839: inner ear development
GO:0051271: negative regulation of cellular component movement
GO:0060770: negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236: cellular response to antibiotic
GO:0071285: cellular response to lithium ion
GO:0071407: cellular response to organic cyclic compound
GO:0071850: mitotic cell cycle arrest
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005768: endosome
GO:0005515: protein binding
GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005072: transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0008656: cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903: protein phosphatase binding
KEGG pathways 4012: ErbB signaling pathway
4110: Cell cycle
5200: Pathways in cancer
5215: Prostate cancer
5220: Chronic myeloid leukemia
5222: Small cell lung cancer

PubMed abstracts associated with CDKN1B

PMID Title Tumor Value
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
11464280 Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27. no no
12907249 Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein. no no
15583032 Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. no no
18384113 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. no no
22916108 Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. no no
23313376 Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway. no no
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