Results for CDKN2A

General Information

Gene ID 1029
Gene Symbol CDKN2A
Gene Name cyclin-dependent kinase inhibitor 2A
Gene Type protein-coding
Cytoband 9p21
Ensembl ID ENSG00000147889
#miR regulators 3
Omim ID 155601 155755 600160 606719
Gene ontology GO:0000075: cell cycle checkpoint
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000209: protein polyubiquitination
GO:0000278: mitotic cell cycle
GO:0001953: negative regulation of cell-matrix adhesion
GO:0006309: apoptotic DNA fragmentation
GO:0006351: transcription, DNA-dependent
GO:0006364: rRNA processing
GO:0006469: negative regulation of protein kinase activity
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007050: cell cycle arrest
GO:0007265: Ras protein signal transduction
GO:0008285: negative regulation of cell proliferation
GO:0008637: apoptotic mitochondrial changes
GO:0010389: regulation of G2/M transition of mitotic cell cycle
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0050821: protein stabilization
GO:0030308: negative regulation of cell growth
GO:0030889: negative regulation of B cell proliferation
GO:0031647: regulation of protein stability
GO:0031648: protein destabilization
GO:0032088: negative regulation of NF-kappaB transcription factor activity
GO:0033088: negative regulation of immature T cell proliferation in thymus
GO:0033235: positive regulation of protein sumoylation
GO:0034393: positive regulation of smooth muscle cell apoptotic process
GO:0035986: senescence-associated heterochromatin focus assembly
GO:0042326: negative regulation of phosphorylation
GO:0043517: positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045736: negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046825: regulation of protein export from nucleus
GO:0048103: somatic stem cell division
GO:0051444: negative regulation of ubiquitin-protein ligase activity
GO:0070534: protein K63-linked ubiquitination
GO:0071158: positive regulation of cell cycle arrest
GO:0090398: cellular senescence
GO:0090399: replicative senescence
GO:2000111: positive regulation of macrophage apoptotic process
GO:2000774: positive regulation of cellular senescence
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005730: nucleolus
GO:0016604: nuclear body
GO:0035985: senescence-associated heterochromatin focus
GO:0043234: protein complex
GO:0005515: protein binding
GO:0002039: p53 binding
GO:0003677: DNA binding
GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0008134: transcription factor binding
GO:0019901: protein kinase binding
GO:0051059: NF-kappaB binding
GO:0055105: ubiquitin-protein ligase inhibitor activity
GO:0097371: MDM2/MDM4 family protein binding
KEGG pathways 4110: Cell cycle
4115: p53 signaling pathway
5200: Pathways in cancer
5212: Pancreatic cancer
5214: Glioma
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5223: Non-small cell lung cancer

PubMed abstracts associated with CDKN2A

PMID Title Tumor Value
7640224 Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1. yes no
8603340 Alterations of the p15, p16,and p18 genes in osteosarcoma. yes no
9187120 Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. no no
9309118 Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients. yes no
9464545 Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. no no
9665476 CDKN2A gene deletions and loss of p16 expression occur in osteosarcomas that lack RB alterations. yes no
9685858 Association of loss of heterozygosity at the p53 locus with chemoresistance in osteosarcomas. yes yes
9714336 p53-independent induction of WAF1/Cip1 is correlated with osteoblastic differentiation by vitamin D3. no no
9820862 Genetic instability in osteoblastic tumors of the skeletal system. yes no
9935200 CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. yes no
10502725 Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. yes yes
10942797 Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. yes yes
11241308 Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas. yes yes
11695244 Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. no no
11753985 Involvement of INK4A gene products in the pathogenesis and development of human osteosarcoma. yes yes
11943335 Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. no no
12012007 The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. no no
12181274 Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. yes no
12759621 Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas. yes yes
12894891 Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. yes no
15167009 Deregulation of the G1 to S-phase cell cycle checkpoint is involved in the pathogenesis of human osteosarcoma. yes yes
15207713 Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression. no no
15310147 Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma. yes no
15662138 The tumor suppressor p33ING1b enhances taxol-induced apoptosis by p53-dependent pathway in human osteosarcoma U2OS cells. no no
16394764 Aberrant methylation of p14ARF gene correlates with poor survival in osteosarcoma. yes yes
16696324 Effect of exogenous p16ink4a and hRb1 genes on cell cycle regulation of osteosarcoma cell. no no
17218778 Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. no no
17611411 P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. no no
18196972 Regulation of the p14ARF promoter by DNA methylation. no no
20737480 Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma. yes no
21159888 Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis. yes no
22227330 Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. no no
22578565 P16 expression predicts necrotic response among patients with osteosarcoma receiving neoadjuvant chemotherapy. yes yes
23137772 A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. yes no
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