Results for CDKN2B

General Information

Gene ID 1030
Gene Symbol CDKN2B
Gene Name cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Gene Type protein-coding
Cytoband 9p21
Ensembl ID ENSG00000147883
#miR regulators 14
Omim ID 600431
Gene ontology GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086: G2/M transition of mitotic cell cycle
GO:0000278: mitotic cell cycle
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0007050: cell cycle arrest
GO:0007093: mitotic cell cycle checkpoint
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0008285: negative regulation of cell proliferation
GO:0010467: gene expression
GO:0014070: response to organic cyclic compound
GO:0030219: megakaryocyte differentiation
GO:0030511: positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030858: positive regulation of epithelial cell differentiation
GO:0031668: cellular response to extracellular stimulus
GO:0031670: cellular response to nutrient
GO:0034097: response to cytokine stimulus
GO:0042326: negative regulation of phosphorylation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048536: spleen development
GO:0050680: negative regulation of epithelial cell proliferation
GO:2000134: negative regulation of G1/S transition of mitotic cell cycle
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005515: protein binding
GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0019901: protein kinase binding
KEGG pathways 4110: Cell cycle
4350: TGF-beta signaling pathway
5200: Pathways in cancer
5222: Small cell lung cancer

PubMed abstracts associated with CDKN2B

PMID Title Tumor Value
8603340 Alterations of the p15, p16,and p18 genes in osteosarcoma. yes no
10942797 Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. yes yes
11695244 Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. no no
12894891 Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. yes no
23137772 A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. yes no
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