General Information
Gene ID | 1030 |
---|---|
Gene Symbol | CDKN2B |
Gene Name | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
Gene Type | protein-coding |
Cytoband | 9p21 |
Ensembl ID | ENSG00000147883 |
#miR regulators | 14 |
Omim ID | 600431 |
Gene ontology |
GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000086: G2/M transition of mitotic cell cycle GO:0000278: mitotic cell cycle GO:0006351: transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0007050: cell cycle arrest GO:0007093: mitotic cell cycle checkpoint GO:0007179: transforming growth factor beta receptor signaling pathway GO:0008285: negative regulation of cell proliferation GO:0010467: gene expression GO:0014070: response to organic cyclic compound GO:0030219: megakaryocyte differentiation GO:0030511: positive regulation of transforming growth factor beta receptor signaling pathway GO:0030858: positive regulation of epithelial cell differentiation GO:0031668: cellular response to extracellular stimulus GO:0031670: cellular response to nutrient GO:0034097: response to cytokine stimulus GO:0042326: negative regulation of phosphorylation GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048536: spleen development GO:0050680: negative regulation of epithelial cell proliferation GO:2000134: negative regulation of G1/S transition of mitotic cell cycle GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005515: protein binding GO:0004861: cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0019901: protein kinase binding |
KEGG pathways |
4110: Cell cycle 4350: TGF-beta signaling pathway 5200: Pathways in cancer 5222: Small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
8603340 | Alterations of the p15, p16,and p18 genes in osteosarcoma. | yes | no |
10942797 | Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 genes and their prognostic implications in osteosarcoma and Ewing sarcoma. | yes | yes |
11695244 | Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines. | no | no |
12894891 | Deletions and point mutations of p16,p15 gene in primary tumors and tumor cell lines. | yes | no |
23137772 | A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. | yes | no |
title | all | all |