Results for HPSE

General Information

Gene ID 10855
Gene Symbol HPSE
Gene Name heparanase
Gene Type protein-coding
Cytoband 4q21.3
Ensembl ID ENSG00000173083
#miR regulators 9
Omim ID 604724
Gene ontology GO:0006029: proteoglycan metabolic process
GO:0005975: carbohydrate metabolic process
GO:0006027: glycosaminoglycan catabolic process
GO:0007160: cell-matrix adhesion
GO:0010575: positive regulation vascular endothelial growth factor production
GO:0030194: positive regulation of blood coagulation
GO:0030200: heparan sulfate proteoglycan catabolic process
GO:0030203: glycosaminoglycan metabolic process
GO:0033690: positive regulation of osteoblast proliferation
GO:0044281: small molecule metabolic process
GO:0051797: regulation of hair follicle development
GO:0051798: positive regulation of hair follicle development
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0061042: vascular wound healing
GO:0005764: lysosome
GO:0005576: extracellular region
GO:0005634: nucleus
GO:0005765: lysosomal membrane
GO:0043202: lysosomal lumen
GO:0045121: membrane raft
GO:0005515: protein binding
GO:0004566: beta-glucuronidase activity
GO:0046983: protein dimerization activity
GO:0030305: heparanase activity
GO:0045545: syndecan binding
KEGG pathways 531: Glycosaminoglycan degradation
1100: Metabolic pathways

PubMed abstracts associated with HPSE

PMID Title Tumor Value
20845995 Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1α in osteosarcoma. yes no
21671176 Targeted silencing of heparanase gene by small interfering RNA inhibits invasiveness and metastasis of osteosarcoma cells. no no
title all all