Results for CHEK1

General Information

Gene ID 1111
Gene Symbol CHEK1
Gene Name checkpoint kinase 1
Gene Type protein-coding
Cytoband 11q24.2
Ensembl ID ENSG00000149554
#miR regulators 6
Omim ID 603078
Gene ontology GO:0006260: DNA replication
GO:0000077: DNA damage checkpoint
GO:0000086: G2/M transition of mitotic cell cycle
GO:0006281: DNA repair
GO:0048096: chromatin-mediated maintenance of transcription
GO:0006974: response to DNA damage stimulus
GO:0006975: DNA damage induced protein phosphorylation
GO:0010569: regulation of double-strand break repair via homologous recombination
GO:0010767: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0018107: peptidyl-threonine phosphorylation
GO:0071260: cellular response to mechanical stimulus
GO:0031572: G2 DNA damage checkpoint
GO:0033261: regulation of S phase
GO:0042127: regulation of cell proliferation
GO:0045839: negative regulation of mitosis
GO:0046602: regulation of mitotic centrosome separation
GO:0071313: cellular response to caffeine
GO:0090399: replicative senescence
GO:2000615: regulation of histone H3-K9 acetylation
GO:0000794: condensed nuclear chromosome
GO:0000781: chromosome, telomeric region
GO:0000785: chromatin
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005654: nucleoplasm
GO:0005657: replication fork
GO:0005813: centrosome
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0005524: ATP binding
GO:0035402: histone kinase activity (H3-T11 specific)
KEGG pathways 4110: Cell cycle
4115: p53 signaling pathway

PubMed abstracts associated with CHEK1

PMID Title Tumor Value
15705874 Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response. no no
17611684 Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. no no
19778378 U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint. no no
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