General Information
Gene ID | 11200 |
---|---|
Gene Symbol | CHEK2 |
Gene Name | checkpoint kinase 2 |
Gene Type | protein-coding |
Cytoband | 22q12.1 |
Ensembl ID | ENSG00000183765 |
#miR regulators | 1 |
Omim ID | 114480 176807 259500 604373 609265 |
Gene ontology |
GO:0000077: DNA damage checkpoint GO:0000086: G2/M transition of mitotic cell cycle GO:0006302: double-strand break repair GO:0006351: transcription, DNA-dependent GO:0006355: regulation of transcription, DNA-dependent GO:0006468: protein phosphorylation GO:0006974: response to DNA damage stimulus GO:0006975: DNA damage induced protein phosphorylation GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage GO:0010332: response to gamma radiation GO:0045893: positive regulation of transcription, DNA-dependent GO:0050821: protein stabilization GO:0042176: regulation of protein catabolic process GO:0042770: signal transduction in response to DNA damage GO:0044257: cellular protein catabolic process GO:0046777: protein autophosphorylation GO:0051301: cell division GO:0072428: signal transduction involved in intra-S DNA damage checkpoint GO:0090307: spindle assembly involved in mitosis GO:0090399: replicative senescence GO:0000781: chromosome, telomeric region GO:0005654: nucleoplasm GO:0016605: PML body GO:0005515: protein binding GO:0004674: protein serine/threonine kinase activity GO:0046872: metal ion binding GO:0005524: ATP binding GO:0019901: protein kinase binding GO:0031625: ubiquitin protein ligase binding GO:0042803: protein homodimerization activity |
KEGG pathways |
4110: Cell cycle 4115: p53 signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
11746983 | Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. | yes | no |
title | all | all |