Results for CHEK2

General Information

Gene ID 11200
Gene Symbol CHEK2
Gene Name checkpoint kinase 2
Gene Type protein-coding
Cytoband 22q12.1
Ensembl ID ENSG00000183765
#miR regulators 1
Omim ID 114480 176807 259500 604373 609265
Gene ontology GO:0000077: DNA damage checkpoint
GO:0000086: G2/M transition of mitotic cell cycle
GO:0006302: double-strand break repair
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0006468: protein phosphorylation
GO:0006974: response to DNA damage stimulus
GO:0006975: DNA damage induced protein phosphorylation
GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332: response to gamma radiation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0050821: protein stabilization
GO:0042176: regulation of protein catabolic process
GO:0042770: signal transduction in response to DNA damage
GO:0044257: cellular protein catabolic process
GO:0046777: protein autophosphorylation
GO:0051301: cell division
GO:0072428: signal transduction involved in intra-S DNA damage checkpoint
GO:0090307: spindle assembly involved in mitosis
GO:0090399: replicative senescence
GO:0000781: chromosome, telomeric region
GO:0005654: nucleoplasm
GO:0016605: PML body
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0019901: protein kinase binding
GO:0031625: ubiquitin protein ligase binding
GO:0042803: protein homodimerization activity
KEGG pathways 4110: Cell cycle
4115: p53 signaling pathway

PubMed abstracts associated with CHEK2

PMID Title Tumor Value
11746983 Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. yes no
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