Results for CLU

General Information

Gene ID 1191
Gene Symbol CLU
Gene Name clusterin
Gene Type protein-coding
Cytoband 8p21-p12
Ensembl ID ENSG00000120885
#miR regulators 11
Omim ID 185430
Gene ontology GO:0001836: release of cytochrome c from mitochondria
GO:0002576: platelet degranulation
GO:0009615: response to virus
GO:0007596: blood coagulation
GO:0006956: complement activation
GO:0006629: lipid metabolic process
GO:0006958: complement activation, classical pathway
GO:0050821: protein stabilization
GO:0030168: platelet activation
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463: negative regulation of protein homooligomerization
GO:0043065: positive regulation of apoptotic process
GO:0043691: reverse cholesterol transport
GO:0045087: innate immune response
GO:0051092: positive regulation of NF-kappaB transcription factor activity
GO:0051788: response to misfolded protein
GO:0061077: chaperone-mediated protein folding
GO:0097193: intrinsic apoptotic signaling pathway
GO:1902230: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244: positive regulation of intrinsic apoptotic signaling pathway
GO:0005739: mitochondrion
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005783: endoplasmic reticulum
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0031012: extracellular matrix
GO:0031093: platelet alpha granule lumen
GO:0031966: mitochondrial membrane
GO:0034366: spherical high-density lipoprotein particle
GO:0042583: chromaffin granule
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0051787: misfolded protein binding
GO:0031625: ubiquitin protein ligase binding
KEGG pathways ---

PubMed abstracts associated with CLU

PMID Title Tumor Value
14996747 Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. no no
15247015 Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. no no
15649646 Differential effects of clusterin/apolipoprotein J on cellular growth and survival. no no
17096323 Development of resistance to chemotherapeutic drugs in human osteosarcoma cell lines largely depends on up-regulation of Clusterin/Apolipoprotein J. no no
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