Results for COL1A1

General Information

Gene ID 1277
Gene Symbol COL1A1
Gene Name collagen, type I, alpha 1
Gene Type protein-coding
Cytoband 17q21.33
Ensembl ID ENSG00000108821
#miR regulators 7
Omim ID 114000 120150 130000 130060 166200 166210 166220 166710 259420
Gene ontology GO:0001501: skeletal system development
GO:0001568: blood vessel development
GO:0001649: osteoblast differentiation
GO:0001957: intramembranous ossification
GO:0001958: endochondral ossification
GO:0007596: blood coagulation
GO:0007584: response to nutrient
GO:0007601: visual perception
GO:0007605: sensory perception of sound
GO:0010718: positive regulation of epithelial to mesenchymal transition
GO:0010812: negative regulation of cell-substrate adhesion
GO:0015031: protein transport
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0022617: extracellular matrix disassembly
GO:0071230: cellular response to amino acid stimulus
GO:0071260: cellular response to mechanical stimulus
GO:0030168: platelet activation
GO:0030198: extracellular matrix organization
GO:0030199: collagen fibril organization
GO:0030335: positive regulation of cell migration
GO:0030574: collagen catabolic process
GO:0031960: response to corticosteroid stimulus
GO:0032964: collagen biosynthetic process
GO:0034504: protein localization to nucleus
GO:0034505: tooth mineralization
GO:0042542: response to hydrogen peroxide
GO:0043434: response to peptide hormone stimulus
GO:0043589: skin morphogenesis
GO:0048706: embryonic skeletal system development
GO:0050900: leukocyte migration
GO:0051591: response to cAMP
GO:0060325: face morphogenesis
GO:0060346: bone trabecula formation
GO:0060351: cartilage development involved in endochondral bone morphogenesis
GO:0070208: protein heterotrimerization
GO:0071300: cellular response to retinoic acid
GO:0071560: cellular response to transforming growth factor beta stimulus
GO:0090263: positive regulation of canonical Wnt receptor signaling pathway
GO:0005576: extracellular region
GO:0005584: collagen type I
GO:0005615: extracellular space
GO:0005788: endoplasmic reticulum lumen
GO:0031012: extracellular matrix
GO:0005515: protein binding
GO:0005201: extracellular matrix structural constituent
GO:0046872: metal ion binding
GO:0042802: identical protein binding
GO:0048407: platelet-derived growth factor binding
KEGG pathways 4510: Focal adhesion
4512: ECM-receptor interaction
4974: Protein digestion and absorption
5146: Amoebiasis

PubMed abstracts associated with COL1A1

PMID Title Tumor Value
8288590 Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. no no
9443071 Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. no no
14528100 Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. yes no
15742288 Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. no no
15746965 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. no no
17458711 Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. no no
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