General Information
Gene ID | 1277 |
---|---|
Gene Symbol | COL1A1 |
Gene Name | collagen, type I, alpha 1 |
Gene Type | protein-coding |
Cytoband | 17q21.33 |
Ensembl ID | ENSG00000108821 |
#miR regulators | 7 |
Omim ID | 114000 120150 130000 130060 166200 166210 166220 166710 259420 |
Gene ontology |
GO:0001501: skeletal system development GO:0001568: blood vessel development GO:0001649: osteoblast differentiation GO:0001957: intramembranous ossification GO:0001958: endochondral ossification GO:0007596: blood coagulation GO:0007584: response to nutrient GO:0007601: visual perception GO:0007605: sensory perception of sound GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0010812: negative regulation of cell-substrate adhesion GO:0015031: protein transport GO:0045893: positive regulation of transcription, DNA-dependent GO:0022617: extracellular matrix disassembly GO:0071230: cellular response to amino acid stimulus GO:0071260: cellular response to mechanical stimulus GO:0030168: platelet activation GO:0030198: extracellular matrix organization GO:0030199: collagen fibril organization GO:0030335: positive regulation of cell migration GO:0030574: collagen catabolic process GO:0031960: response to corticosteroid stimulus GO:0032964: collagen biosynthetic process GO:0034504: protein localization to nucleus GO:0034505: tooth mineralization GO:0042542: response to hydrogen peroxide GO:0043434: response to peptide hormone stimulus GO:0043589: skin morphogenesis GO:0048706: embryonic skeletal system development GO:0050900: leukocyte migration GO:0051591: response to cAMP GO:0060325: face morphogenesis GO:0060346: bone trabecula formation GO:0060351: cartilage development involved in endochondral bone morphogenesis GO:0070208: protein heterotrimerization GO:0071300: cellular response to retinoic acid GO:0071560: cellular response to transforming growth factor beta stimulus GO:0090263: positive regulation of canonical Wnt receptor signaling pathway GO:0005576: extracellular region GO:0005584: collagen type I GO:0005615: extracellular space GO:0005788: endoplasmic reticulum lumen GO:0031012: extracellular matrix GO:0005515: protein binding GO:0005201: extracellular matrix structural constituent GO:0046872: metal ion binding GO:0042802: identical protein binding GO:0048407: platelet-derived growth factor binding |
KEGG pathways |
4510: Focal adhesion 4512: ECM-receptor interaction 4974: Protein digestion and absorption 5146: Amoebiasis |
PMID | Title | Tumor | Value |
---|---|---|---|
8288590 | Suppressed collagen gene expression and induction of alpha 2 beta 1 integrin-type collagen receptor in tumorigenic derivatives of human osteogenic sarcoma (HOS) cell line. | no | no |
9443071 | Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. | no | no |
14528100 | Analysis of polymorphisms of the vitamin D receptor, estrogen receptor, and collagen Ialpha1 genes and their relationship with height in children with bone cancer. | yes | no |
15742288 | Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation. | no | no |
15746965 | Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. | no | no |
17458711 | Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. | no | no |
title | all | all |