Results for PARP1

General Information

Gene ID 142
Gene Symbol PARP1
Gene Name poly (ADP-ribose) polymerase 1
Gene Type protein-coding
Cytoband 1q41-q42
Ensembl ID ENSG00000143799
#miR regulators 11
Omim ID 173870
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000723: telomere maintenance
GO:0006366: transcription from RNA polymerase II promoter
GO:0006281: DNA repair
GO:0006284: base-excision repair
GO:0006302: double-strand break repair
GO:0006351: transcription, DNA-dependent
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0006471: protein ADP-ribosylation
GO:0007179: transforming growth factor beta receptor signaling pathway
GO:0010467: gene expression
GO:0016540: protein autoprocessing
GO:0032869: cellular response to insulin stimulus
GO:0040009: regulation of growth rate
GO:0042769: DNA damage response, detection of DNA damage
GO:0070212: protein poly-ADP-ribosylation
GO:0005634: nucleus
GO:0005635: nuclear envelope
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005730: nucleolus
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003950: NAD+ ADP-ribosyltransferase activity
GO:0008134: transcription factor binding
GO:0008270: zinc ion binding
GO:0047485: protein N-terminus binding
GO:0051287: NAD binding
KEGG pathways 3410: Base excision repair

PubMed abstracts associated with PARP1

PMID Title Tumor Value
10232607 Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. no no
11418138 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. no no
12140175 Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. no no
15314286 Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
15936998 Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. no no
16213662 Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. no no
16814113 Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. no no
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no
17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. no no
17959036 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. no no
19018758 Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. no no
20044614 Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. no no
20460760 Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. no no
20808934 Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. no no
21246613 Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. no no
21266106 Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. no no
21286665 Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. no no
21443800 The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. no no
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no
21720717 Induction of G?/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. no no
22057483 RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. no no
22546756 Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. no no
22674530 Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. no no
22994717 LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. no no
23527720 Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. yes no
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