General Information
Gene ID | 142 |
---|---|
Gene Symbol | PARP1 |
Gene Name | poly (ADP-ribose) polymerase 1 |
Gene Type | protein-coding |
Cytoband | 1q41-q42 |
Ensembl ID | ENSG00000143799 |
#miR regulators | 11 |
Omim ID | 173870 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000723: telomere maintenance GO:0006366: transcription from RNA polymerase II promoter GO:0006281: DNA repair GO:0006284: base-excision repair GO:0006302: double-strand break repair GO:0006351: transcription, DNA-dependent GO:0006367: transcription initiation from RNA polymerase II promoter GO:0006471: protein ADP-ribosylation GO:0007179: transforming growth factor beta receptor signaling pathway GO:0010467: gene expression GO:0016540: protein autoprocessing GO:0032869: cellular response to insulin stimulus GO:0040009: regulation of growth rate GO:0042769: DNA damage response, detection of DNA damage GO:0070212: protein poly-ADP-ribosylation GO:0005634: nucleus GO:0005635: nuclear envelope GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005730: nucleolus GO:0005515: protein binding GO:0003677: DNA binding GO:0003950: NAD+ ADP-ribosyltransferase activity GO:0008134: transcription factor binding GO:0008270: zinc ion binding GO:0047485: protein N-terminus binding GO:0051287: NAD binding |
KEGG pathways |
3410: Base excision repair |
PMID | Title | Tumor | Value |
---|---|---|---|
10232607 | Poly(ADP-ribosyl)ation of p53 during apoptosis in human osteosarcoma cells. | no | no |
11418138 | pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. | no | no |
12140175 | Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. | no | no |
15314286 | Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells. | no | no |
15670817 | Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. | no | no |
15936998 | Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling. | no | no |
16213662 | Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. | no | no |
16814113 | Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade. | no | no |
17218775 | Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. | no | no |
17520676 | Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. | no | no |
17959036 | Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis. | no | no |
19018758 | Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. | no | no |
20044614 | Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. | no | no |
20460760 | Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. | no | no |
20808934 | Overexpression of inosine 5'-monophosphate dehydrogenase type II mediates chemoresistance to human osteosarcoma cells. | no | no |
21246613 | Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. | no | no |
21266106 | Depletion of Neuroguidin/CANu1 sensitizes human osteosarcoma U2OS cells to doxorubicin. | no | no |
21286665 | Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. | no | no |
21443800 | The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. | no | no |
21617882 | Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. | no | no |
21720717 | Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. | no | no |
22057483 | RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. | no | no |
22546756 | Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. | no | no |
22674530 | Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway. | no | no |
22994717 | LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. | no | no |
23527720 | Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. | yes | no |
title | all | all |