Results for MAPK14

General Information

Gene ID 1432
Gene Symbol MAPK14
Gene Name mitogen-activated protein kinase 14
Gene Type protein-coding
Cytoband 6p21.3-p21.2
Ensembl ID ENSG00000112062
#miR regulators 8
Omim ID 600289
Gene ontology GO:0000077: DNA damage checkpoint
GO:0000187: activation of MAPK activity
GO:0000902: cell morphogenesis
GO:0001525: angiogenesis
GO:0002062: chondrocyte differentiation
GO:0002224: toll-like receptor signaling pathway
GO:0002755: MyD88-dependent toll-like receptor signaling pathway
GO:0002756: MyD88-independent toll-like receptor signaling pathway
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006006: glucose metabolic process
GO:0006351: transcription, DNA-dependent
GO:0006928: cellular component movement
GO:0006935: chemotaxis
GO:0006950: response to stress
GO:0007166: cell surface receptor signaling pathway
GO:0007243: intracellular protein kinase cascade
GO:0007265: Ras protein signal transduction
GO:0007519: skeletal muscle tissue development
GO:0010467: gene expression
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0016070: RNA metabolic process
GO:0016071: mRNA metabolic process
GO:0018105: peptidyl-serine phosphorylation
GO:0019395: fatty acid oxidation
GO:0030168: platelet activation
GO:0030316: osteoclast differentiation
GO:0031663: lipopolysaccharide-mediated signaling pathway
GO:0032495: response to muramyl dipeptide
GO:0034134: toll-like receptor 2 signaling pathway
GO:0034138: toll-like receptor 3 signaling pathway
GO:0034142: toll-like receptor 4 signaling pathway
GO:0034146: toll-like receptor 5 signaling pathway
GO:0034162: toll-like receptor 9 signaling pathway
GO:0034166: toll-like receptor 10 signaling pathway
GO:0035666: TRIF-dependent toll-like receptor signaling pathway
GO:0035924: cellular response to vascular endothelial growth factor stimulus
GO:0038123: toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124: toll-like receptor TLR6:TLR2 signaling pathway
GO:0042307: positive regulation of protein import into nucleus
GO:0042692: muscle cell differentiation
GO:0042770: signal transduction in response to DNA damage
GO:0045087: innate immune response
GO:0045648: positive regulation of erythrocyte differentiation
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0051090: regulation of sequence-specific DNA binding transcription factor activity
GO:0051146: striated muscle cell differentiation
GO:0051149: positive regulation of muscle cell differentiation
GO:0051403: stress-activated MAPK cascade
GO:0070935: 3'-UTR-mediated mRNA stabilization
GO:0071479: cellular response to ionizing radiation
GO:0090400: stress-induced premature senescence
GO:0000922: spindle pole
GO:0005739: mitochondrion
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0004674: protein serine/threonine kinase activity
GO:0004707: MAP kinase activity
GO:0004708: MAP kinase kinase activity
GO:0005524: ATP binding
GO:0051525: NFAT protein binding
KEGG pathways 4010: MAPK signaling pathway
4370: VEGF signaling pathway
4380: Osteoclast differentiation
4620: Toll-like receptor signaling pathway
4621: NOD-like receptor signaling pathway
4622: RIG-I-like receptor signaling pathway
4660: T cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4670: Leukocyte transendothelial migration
4722: Neurotrophin signaling pathway
4912: GnRH signaling pathway
4914: Progesterone-mediated oocyte maturation
5014: Amyotrophic lateral sclerosis (ALS)
5120: Epithelial cell signaling in Helicobacter pylori infection
5131: Shigellosis
5140: Leishmaniasis
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5160: Hepatitis C

PubMed abstracts associated with MAPK14

PMID Title Tumor Value
11820362 Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no
17222495 Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. no no
17323424 Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B. no no
18567798 Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. yes no
18606492 The novel isoflavone 7-hydroxy-3',4'-benzoisoflavone induces cell apoptosis in human osteosarcoma cells. no no
18814141 Platelet-derived growth factor stimulates osteoprotegerin production in osteoblastic cells. no no
18986328 Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3. no no
20406948 Driven to death: inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death. no no
21236332 15-Deoxy-?12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. no no
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
22068640 Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines. no no
22227330 Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
23219526 Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal-regulating kinase 1 in human osteosarcoma. no no
22849560 Gallic acid induces the apoptosis of human osteosarcoma cells in vitro and in vivo via the regulation of mitogen-activated protein kinase pathways. no no
23262982 Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. no no
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