General Information
| Gene ID | 1493 |
|---|---|
| Gene Symbol | CTLA4 |
| Gene Name | cytotoxic T-lymphocyte-associated protein 4 |
| Gene Type | protein-coding |
| Cytoband | 2q33 |
| Ensembl ID | ENSG00000163599 |
| #miR regulators | 5 |
| Omim ID | 123890 140300 601388 609755 |
| Gene ontology |
GO:0006955: immune response GO:0006974: response to DNA damage stimulus GO:0030889: negative regulation of B cell proliferation GO:0031295: T cell costimulation GO:0043065: positive regulation of apoptotic process GO:0045590: negative regulation of regulatory T cell differentiation GO:0050853: B cell receptor signaling pathway GO:0005886: plasma membrane GO:0005887: integral to plasma membrane GO:0005794: Golgi apparatus GO:0009897: external side of plasma membrane GO:0045334: clathrin-coated endocytic vesicle GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding |
| KEGG pathways |
4514: Cell adhesion molecules (CAMs) 4660: T cell receptor signaling pathway 5320: Autoimmune thyroid disease 5323: Rheumatoid arthritis |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 15912538 | CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. | yes | no |
| 21453059 | Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma. | yes | yes |
| title | all | all |