General Information
Gene ID | 1499 |
---|---|
Gene Symbol | CTNNB1 |
Gene Name | catenin (cadherin-associated protein), beta 1, 88kDa |
Gene Type | protein-coding |
Cytoband | 3p21 |
Ensembl ID | ENSG00000168036 |
#miR regulators | 4 |
Omim ID | 114500 114550 116806 132600 615075 |
Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000578: embryonic axis specification GO:0001569: patterning of blood vessels GO:0001658: branching involved in ureteric bud morphogenesis GO:0001701: in utero embryonic development GO:0001702: gastrulation with mouth forming second GO:0001708: cell fate specification GO:0001711: endodermal cell fate commitment GO:0001764: neuron migration GO:0001837: epithelial to mesenchymal transition GO:0001840: neural plate development GO:0001889: liver development GO:0002052: positive regulation of neuroblast proliferation GO:0002053: positive regulation of mesenchymal cell proliferation GO:0002089: lens morphogenesis in camera-type eye GO:0003136: negative regulation of heart induction by canonical Wnt receptor signaling pathway GO:0003266: regulation of secondary heart field cardioblast proliferation GO:0003337: mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0006915: apoptotic process GO:0007155: cell adhesion GO:0016055: Wnt receptor signaling pathway GO:0006351: transcription, DNA-dependent GO:0006921: cellular component disassembly involved in execution phase of apoptosis GO:0007016: cytoskeletal anchoring at plasma membrane GO:0007160: cell-matrix adhesion GO:0007398: ectoderm development GO:0007403: glial cell fate determination GO:0007494: midgut development GO:0008285: negative regulation of cell proliferation GO:0042493: response to drug GO:0009948: anterior/posterior axis specification GO:0009950: dorsal/ventral axis specification GO:0009954: proximal/distal pattern formation GO:0010909: positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0014010: Schwann cell proliferation GO:0016337: cell-cell adhesion GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0046686: response to cadmium ion GO:0022009: central nervous system vasculogenesis GO:0030316: osteoclast differentiation GO:0030326: embryonic limb morphogenesis GO:0030521: androgen receptor signaling pathway GO:0030539: male genitalia development GO:0030900: forebrain development GO:0030902: hindbrain development GO:0030997: regulation of centriole-centriole cohesion GO:0031016: pancreas development GO:0031069: hair follicle morphogenesis GO:0031641: regulation of myelination GO:0032331: negative regulation of chondrocyte differentiation GO:0032355: response to estradiol stimulus GO:0032481: positive regulation of type I interferon production GO:0033077: T cell differentiation in thymus GO:0033234: negative regulation of protein sumoylation GO:0034097: response to cytokine stimulus GO:0034333: adherens junction assembly GO:0034394: protein localization to cell surface GO:0035050: embryonic heart tube development GO:0036023: embryonic skeletal limb joint morphogenesis GO:0035112: genitalia morphogenesis GO:0035115: embryonic forelimb morphogenesis GO:0035116: embryonic hindlimb morphogenesis GO:0035315: hair cell differentiation GO:0042129: regulation of T cell proliferation GO:0042475: odontogenesis of dentin-containing tooth GO:0042692: muscle cell differentiation GO:0042733: embryonic digit morphogenesis GO:0043065: positive regulation of apoptotic process GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043410: positive regulation of MAPK cascade GO:0043587: tongue morphogenesis GO:0044334: canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044336: canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process GO:0045087: innate immune response GO:0045445: myoblast differentiation GO:0045453: bone resorption GO:0045603: positive regulation of endothelial cell differentiation GO:0045669: positive regulation of osteoblast differentiation GO:0045671: negative regulation of osteoclast differentiation GO:0045743: positive regulation of fibroblast growth factor receptor signaling pathway GO:0045765: regulation of angiogenesis GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048145: regulation of fibroblast proliferation GO:0048262: determination of dorsal/ventral asymmetry GO:0048469: cell maturation GO:0048489: synaptic vesicle transport GO:0048538: thymus development GO:0048599: oocyte development GO:0048617: embryonic foregut morphogenesis GO:0048660: regulation of smooth muscle cell proliferation GO:0048715: negative regulation of oligodendrocyte differentiation GO:0050808: synapse organization GO:0051145: smooth muscle cell differentiation GO:0051149: positive regulation of muscle cell differentiation GO:0051291: protein heterooligomerization GO:0060066: oviduct development GO:0060070: canonical Wnt receptor signaling pathway GO:0060440: trachea formation GO:0060441: epithelial tube branching involved in lung morphogenesis GO:0060479: lung cell differentiation GO:0060484: lung-associated mesenchyme development GO:0060492: lung induction GO:0060742: epithelial cell differentiation involved in prostate gland development GO:0060769: positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060789: hair follicle placode formation GO:0060916: mesenchymal cell proliferation involved in lung development GO:0061047: positive regulation of branching involved in lung morphogenesis GO:0061154: endothelial tube morphogenesis GO:0061198: fungiform papilla formation GO:0061324: canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0070602: regulation of centromeric sister chromatid cohesion GO:0071363: cellular response to growth factor stimulus GO:0071681: cellular response to indole-3-methanol GO:0072033: renal vesicle formation GO:0072053: renal inner medulla development GO:0072054: renal outer medulla development GO:0072079: nephron tubule formation GO:0072182: regulation of nephron tubule epithelial cell differentiation GO:0090279: regulation of calcium ion import GO:2000008: regulation of protein localization to cell surface GO:2000017: positive regulation of determination of dorsal identity GO:0005886: plasma membrane GO:0000922: spindle pole GO:0016020: membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005667: transcription factor complex GO:0005813: centrosome GO:0005911: cell-cell junction GO:0005912: adherens junction GO:0005913: cell-cell adherens junction GO:0005915: zonula adherens GO:0005916: fascia adherens GO:0005924: cell-substrate adherens junction GO:0005938: cell cortex GO:0009898: internal side of plasma membrane GO:0016323: basolateral plasma membrane GO:0016328: lateral plasma membrane GO:0016342: catenin complex GO:0030018: Z disc GO:0030027: lamellipodium GO:0030054: cell junction GO:0030057: desmosome GO:0030877: beta-catenin destruction complex GO:0031528: microvillus membrane GO:0032993: protein-DNA complex GO:0034750: Scrib-APC-beta-catenin complex GO:0043198: dendritic shaft GO:0045177: apical part of cell GO:0045202: synapse GO:0048471: perinuclear region of cytoplasm GO:0070369: beta-catenin-TCF7L2 complex GO:0071944: cell periphery GO:0005515: protein binding GO:0001102: RNA polymerase II activating transcription factor binding GO:0003682: chromatin binding GO:0003690: double-stranded DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003713: transcription coactivator activity GO:0004871: signal transducer activity GO:0005198: structural molecule activity GO:0008022: protein C-terminus binding GO:0008134: transcription factor binding GO:0044212: transcription regulatory region DNA binding GO:0019899: enzyme binding GO:0019900: kinase binding GO:0019901: protein kinase binding GO:0019903: protein phosphatase binding GO:0030331: estrogen receptor binding GO:0032403: protein complex binding GO:0035255: ionotropic glutamate receptor binding GO:0035257: nuclear hormone receptor binding GO:0044325: ion channel binding GO:0045294: alpha-catenin binding GO:0045296: cadherin binding GO:0046332: SMAD binding GO:0050681: androgen receptor binding GO:0070411: I-SMAD binding GO:0070412: R-SMAD binding GO:0070491: repressing transcription factor binding |
KEGG pathways |
4310: Wnt signaling pathway 4510: Focal adhesion 4520: Adherens junction 4530: Tight junction 4670: Leukocyte transendothelial migration 4916: Melanogenesis 5100: Bacterial invasion of epithelial cells 5130: Pathogenic Escherichia coli infection 5200: Pathways in cancer 5210: Colorectal cancer 5213: Endometrial cancer 5215: Prostate cancer 5216: Thyroid cancer 5217: Basal cell carcinoma 5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
PMID | Title | Tumor | Value |
---|---|---|---|
10189891 | Frequent beta-catenin abnormalities in bone and soft-tissue tumors. | yes | no |
10550312 | Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. | yes | yes |
12402302 | Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. | yes | no |
14598886 | Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. | yes | yes |
15087387 | Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. | no | no |
15670817 | Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. | no | no |
19307728 | Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. | no | no |
19730790 | Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells. | no | no |
19882675 | Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. | yes | no |
20530678 | High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. | no | no |
20594821 | Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. | yes | no |
20926002 | Celecoxib inhibits β-catenin-dependent survival of the human osteosarcoma MG-63 cell line. | no | no |
21517265 | SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. | no | no |
21671177 | Influence of β-catenin small interfering RNA on human osteosarcoma cells. | no | no |
21963453 | Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D₃ action in osteosarcoma. | no | no |
22006429 | High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. | yes | no |
22546756 | Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. | no | no |
24009496 | How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation | no | no |
23291185 | Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. | yes | yes |
title | all | all |