Results for CTNNB1

General Information

Gene ID 1499
Gene Symbol CTNNB1
Gene Name catenin (cadherin-associated protein), beta 1, 88kDa
Gene Type protein-coding
Cytoband 3p21
Ensembl ID ENSG00000168036
#miR regulators 4
Omim ID 114500 114550 116806 132600 615075
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000578: embryonic axis specification
GO:0001569: patterning of blood vessels
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001701: in utero embryonic development
GO:0001702: gastrulation with mouth forming second
GO:0001708: cell fate specification
GO:0001711: endodermal cell fate commitment
GO:0001764: neuron migration
GO:0001837: epithelial to mesenchymal transition
GO:0001840: neural plate development
GO:0001889: liver development
GO:0002052: positive regulation of neuroblast proliferation
GO:0002053: positive regulation of mesenchymal cell proliferation
GO:0002089: lens morphogenesis in camera-type eye
GO:0003136: negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003266: regulation of secondary heart field cardioblast proliferation
GO:0003337: mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006915: apoptotic process
GO:0007155: cell adhesion
GO:0016055: Wnt receptor signaling pathway
GO:0006351: transcription, DNA-dependent
GO:0006921: cellular component disassembly involved in execution phase of apoptosis
GO:0007016: cytoskeletal anchoring at plasma membrane
GO:0007160: cell-matrix adhesion
GO:0007398: ectoderm development
GO:0007403: glial cell fate determination
GO:0007494: midgut development
GO:0008285: negative regulation of cell proliferation
GO:0042493: response to drug
GO:0009948: anterior/posterior axis specification
GO:0009950: dorsal/ventral axis specification
GO:0009954: proximal/distal pattern formation
GO:0010909: positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010: Schwann cell proliferation
GO:0016337: cell-cell adhesion
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0046686: response to cadmium ion
GO:0022009: central nervous system vasculogenesis
GO:0030316: osteoclast differentiation
GO:0030326: embryonic limb morphogenesis
GO:0030521: androgen receptor signaling pathway
GO:0030539: male genitalia development
GO:0030900: forebrain development
GO:0030902: hindbrain development
GO:0030997: regulation of centriole-centriole cohesion
GO:0031016: pancreas development
GO:0031069: hair follicle morphogenesis
GO:0031641: regulation of myelination
GO:0032331: negative regulation of chondrocyte differentiation
GO:0032355: response to estradiol stimulus
GO:0032481: positive regulation of type I interferon production
GO:0033077: T cell differentiation in thymus
GO:0033234: negative regulation of protein sumoylation
GO:0034097: response to cytokine stimulus
GO:0034333: adherens junction assembly
GO:0034394: protein localization to cell surface
GO:0035050: embryonic heart tube development
GO:0036023: embryonic skeletal limb joint morphogenesis
GO:0035112: genitalia morphogenesis
GO:0035115: embryonic forelimb morphogenesis
GO:0035116: embryonic hindlimb morphogenesis
GO:0035315: hair cell differentiation
GO:0042129: regulation of T cell proliferation
GO:0042475: odontogenesis of dentin-containing tooth
GO:0042692: muscle cell differentiation
GO:0042733: embryonic digit morphogenesis
GO:0043065: positive regulation of apoptotic process
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043410: positive regulation of MAPK cascade
GO:0043587: tongue morphogenesis
GO:0044334: canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336: canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process
GO:0045087: innate immune response
GO:0045445: myoblast differentiation
GO:0045453: bone resorption
GO:0045603: positive regulation of endothelial cell differentiation
GO:0045669: positive regulation of osteoblast differentiation
GO:0045671: negative regulation of osteoclast differentiation
GO:0045743: positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045765: regulation of angiogenesis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048145: regulation of fibroblast proliferation
GO:0048262: determination of dorsal/ventral asymmetry
GO:0048469: cell maturation
GO:0048489: synaptic vesicle transport
GO:0048538: thymus development
GO:0048599: oocyte development
GO:0048617: embryonic foregut morphogenesis
GO:0048660: regulation of smooth muscle cell proliferation
GO:0048715: negative regulation of oligodendrocyte differentiation
GO:0050808: synapse organization
GO:0051145: smooth muscle cell differentiation
GO:0051149: positive regulation of muscle cell differentiation
GO:0051291: protein heterooligomerization
GO:0060066: oviduct development
GO:0060070: canonical Wnt receptor signaling pathway
GO:0060440: trachea formation
GO:0060441: epithelial tube branching involved in lung morphogenesis
GO:0060479: lung cell differentiation
GO:0060484: lung-associated mesenchyme development
GO:0060492: lung induction
GO:0060742: epithelial cell differentiation involved in prostate gland development
GO:0060769: positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789: hair follicle placode formation
GO:0060916: mesenchymal cell proliferation involved in lung development
GO:0061047: positive regulation of branching involved in lung morphogenesis
GO:0061154: endothelial tube morphogenesis
GO:0061198: fungiform papilla formation
GO:0061324: canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0070602: regulation of centromeric sister chromatid cohesion
GO:0071363: cellular response to growth factor stimulus
GO:0071681: cellular response to indole-3-methanol
GO:0072033: renal vesicle formation
GO:0072053: renal inner medulla development
GO:0072054: renal outer medulla development
GO:0072079: nephron tubule formation
GO:0072182: regulation of nephron tubule epithelial cell differentiation
GO:0090279: regulation of calcium ion import
GO:2000008: regulation of protein localization to cell surface
GO:2000017: positive regulation of determination of dorsal identity
GO:0005886: plasma membrane
GO:0000922: spindle pole
GO:0016020: membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005667: transcription factor complex
GO:0005813: centrosome
GO:0005911: cell-cell junction
GO:0005912: adherens junction
GO:0005913: cell-cell adherens junction
GO:0005915: zonula adherens
GO:0005916: fascia adherens
GO:0005924: cell-substrate adherens junction
GO:0005938: cell cortex
GO:0009898: internal side of plasma membrane
GO:0016323: basolateral plasma membrane
GO:0016328: lateral plasma membrane
GO:0016342: catenin complex
GO:0030018: Z disc
GO:0030027: lamellipodium
GO:0030054: cell junction
GO:0030057: desmosome
GO:0030877: beta-catenin destruction complex
GO:0031528: microvillus membrane
GO:0032993: protein-DNA complex
GO:0034750: Scrib-APC-beta-catenin complex
GO:0043198: dendritic shaft
GO:0045177: apical part of cell
GO:0045202: synapse
GO:0048471: perinuclear region of cytoplasm
GO:0070369: beta-catenin-TCF7L2 complex
GO:0071944: cell periphery
GO:0005515: protein binding
GO:0001102: RNA polymerase II activating transcription factor binding
GO:0003682: chromatin binding
GO:0003690: double-stranded DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003713: transcription coactivator activity
GO:0004871: signal transducer activity
GO:0005198: structural molecule activity
GO:0008022: protein C-terminus binding
GO:0008134: transcription factor binding
GO:0044212: transcription regulatory region DNA binding
GO:0019899: enzyme binding
GO:0019900: kinase binding
GO:0019901: protein kinase binding
GO:0019903: protein phosphatase binding
GO:0030331: estrogen receptor binding
GO:0032403: protein complex binding
GO:0035255: ionotropic glutamate receptor binding
GO:0035257: nuclear hormone receptor binding
GO:0044325: ion channel binding
GO:0045294: alpha-catenin binding
GO:0045296: cadherin binding
GO:0046332: SMAD binding
GO:0050681: androgen receptor binding
GO:0070411: I-SMAD binding
GO:0070412: R-SMAD binding
GO:0070491: repressing transcription factor binding
KEGG pathways 4310: Wnt signaling pathway
4510: Focal adhesion
4520: Adherens junction
4530: Tight junction
4670: Leukocyte transendothelial migration
4916: Melanogenesis
5100: Bacterial invasion of epithelial cells
5130: Pathogenic Escherichia coli infection
5200: Pathways in cancer
5210: Colorectal cancer
5213: Endometrial cancer
5215: Prostate cancer
5216: Thyroid cancer
5217: Basal cell carcinoma
5412: Arrhythmogenic right ventricular cardiomyopathy (ARVC)

PubMed abstracts associated with CTNNB1

PMID Title Tumor Value
10189891 Frequent beta-catenin abnormalities in bone and soft-tissue tumors. yes no
10550312 Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. yes yes
12402302 Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. yes no
14598886 Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. yes yes
15087387 Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. no no
15670817 Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells. no no
19307728 Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. no no
19730790 Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/?-catenin antagonists against human osteosarcoma cells. no no
19882675 Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. yes no
20530678 High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells. no no
20594821 Prognostic impact of adenomatous polyposis coli gene expression in osteosarcoma of the extremities. yes no
20926002 Celecoxib inhibits ?-catenin-dependent survival of the human osteosarcoma MG-63 cell line. no no
21517265 SiRNA-mediated silencing of beta-catenin suppresses invasion and chemosensitivity to doxorubicin in MG-63 osteosarcoma cells. no no
21671177 Influence of ?-catenin small interfering RNA on human osteosarcoma cells. no no
21963453 Snail-1 regulates VDR signaling and inhibits 1,25(OH)-D? action in osteosarcoma. no no
22006429 High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. yes no
22546756 Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. no no
24009496 How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation no no
23291185 Inhibition of the Wnt-?-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. yes yes
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