Results for CYP3A4

General Information

Gene ID 1576
Gene Symbol CYP3A4
Gene Name cytochrome P450, family 3, subfamily A, polypeptide 4
Gene Type protein-coding
Cytoband 7q21.1
Ensembl ID ENSG00000160868
#miR regulators 4
Omim ID 124010
Gene ontology GO:0055114: oxidation-reduction process
GO:0006629: lipid metabolic process
GO:0006706: steroid catabolic process
GO:0006805: xenobiotic metabolic process
GO:0008202: steroid metabolic process
GO:0008209: androgen metabolic process
GO:0009822: alkaloid catabolic process
GO:0016098: monoterpenoid metabolic process
GO:0017144: drug metabolic process
GO:0036378: calcitriol biosynthetic process from calciol
GO:0042359: vitamin D metabolic process
GO:0042737: drug catabolic process
GO:0042738: exogenous drug catabolic process
GO:0044281: small molecule metabolic process
GO:0046483: heterocycle metabolic process
GO:0070989: oxidative demethylation
GO:0016021: integral to membrane
GO:0005737: cytoplasm
GO:0005789: endoplasmic reticulum membrane
GO:0043231: intracellular membrane-bounded organelle
GO:0009986: cell surface
GO:0009055: electron carrier activity
GO:0004497: monooxygenase activity
GO:0005496: steroid binding
GO:0005506: iron ion binding
GO:0016491: oxidoreductase activity
GO:0008395: steroid hydroxylase activity
GO:0019825: oxygen binding
GO:0016712: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019899: enzyme binding
GO:0020037: heme binding
GO:0030343: vitamin D3 25-hydroxylase activity
GO:0033780: taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0034875: caffeine oxidase activity
GO:0047638: albendazole monooxygenase activity
GO:0050591: quinine 3-monooxygenase activity
GO:0050649: testosterone 6-beta-hydroxylase activity
GO:0070576: vitamin D 24-hydroxylase activity
KEGG pathways 140: Steroid hormone biosynthesis
591: Linoleic acid metabolism
830: Retinol metabolism
980: Metabolism of xenobiotics by cytochrome P450
982: Drug metabolism - cytochrome P450
983: Drug metabolism - other enzymes
1100: Metabolic pathways
4976: Bile secretion

PubMed abstracts associated with CYP3A4

PMID Title Tumor Value
12829666 Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. yes yes
17279585 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. no no
title all all