General Information
| Gene ID | 1576 |
|---|---|
| Gene Symbol | CYP3A4 |
| Gene Name | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Gene Type | protein-coding |
| Cytoband | 7q21.1 |
| Ensembl ID | ENSG00000160868 |
| #miR regulators | 4 |
| Omim ID | 124010 |
| Gene ontology |
GO:0055114: oxidation-reduction process GO:0006629: lipid metabolic process GO:0006706: steroid catabolic process GO:0006805: xenobiotic metabolic process GO:0008202: steroid metabolic process GO:0008209: androgen metabolic process GO:0009822: alkaloid catabolic process GO:0016098: monoterpenoid metabolic process GO:0017144: drug metabolic process GO:0036378: calcitriol biosynthetic process from calciol GO:0042359: vitamin D metabolic process GO:0042737: drug catabolic process GO:0042738: exogenous drug catabolic process GO:0044281: small molecule metabolic process GO:0046483: heterocycle metabolic process GO:0070989: oxidative demethylation GO:0016021: integral to membrane GO:0005737: cytoplasm GO:0005789: endoplasmic reticulum membrane GO:0043231: intracellular membrane-bounded organelle GO:0009986: cell surface GO:0009055: electron carrier activity GO:0004497: monooxygenase activity GO:0005496: steroid binding GO:0005506: iron ion binding GO:0016491: oxidoreductase activity GO:0008395: steroid hydroxylase activity GO:0019825: oxygen binding GO:0016712: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0019899: enzyme binding GO:0020037: heme binding GO:0030343: vitamin D3 25-hydroxylase activity GO:0033780: taurochenodeoxycholate 6alpha-hydroxylase activity GO:0034875: caffeine oxidase activity GO:0047638: albendazole monooxygenase activity GO:0050591: quinine 3-monooxygenase activity GO:0050649: testosterone 6-beta-hydroxylase activity GO:0070576: vitamin D 24-hydroxylase activity |
| KEGG pathways |
140: Steroid hormone biosynthesis 591: Linoleic acid metabolism 830: Retinol metabolism 980: Metabolism of xenobiotics by cytochrome P450 982: Drug metabolism - cytochrome P450 983: Drug metabolism - other enzymes 1100: Metabolic pathways 4976: Bile secretion |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 12829666 | Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. | yes | yes |
| 17279585 | Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. | no | no |
| title | all | all |