General Information
| Gene ID | 1594 |
|---|---|
| Gene Symbol | CYP27B1 |
| Gene Name | cytochrome P450, family 27, subfamily B, polypeptide 1 |
| Gene Type | protein-coding |
| Cytoband | 12q13.1-q13.3 |
| Ensembl ID | ENSG00000111012 |
| #miR regulators | 10 |
| Omim ID | 264700 609506 |
| Gene ontology |
GO:0006766: vitamin metabolic process GO:0006805: xenobiotic metabolic process GO:0006816: calcium ion transport GO:0008202: steroid metabolic process GO:0008285: negative regulation of cell proliferation GO:0010956: negative regulation of calcidiol 1-monooxygenase activity GO:0010980: positive regulation of vitamin D 24-hydroxylase activity GO:0030282: bone mineralization GO:0030308: negative regulation of cell growth GO:0030500: regulation of bone mineralization GO:0032496: response to lipopolysaccharide GO:0033280: response to vitamin D GO:0034341: response to interferon-gamma GO:0036378: calcitriol biosynthetic process from calciol GO:0042359: vitamin D metabolic process GO:0042369: vitamin D catabolic process GO:0043627: response to estrogen stimulus GO:0044281: small molecule metabolic process GO:0045618: positive regulation of keratinocyte differentiation GO:0046697: decidualization GO:0055074: calcium ion homeostasis GO:0070314: G1 to G0 transition GO:0070564: positive regulation of vitamin D receptor signaling pathway GO:0005739: mitochondrion GO:0005737: cytoplasm GO:0005741: mitochondrial outer membrane GO:0009055: electron carrier activity GO:0004498: calcidiol 1-monooxygenase activity GO:0005506: iron ion binding GO:0020037: heme binding |
| KEGG pathways |
100: Steroid biosynthesis 1100: Metabolic pathways |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 15540165 | Gene amplifications in osteosarcoma-CGH microarray analysis. | yes | no |
| 17254772 | RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells. | no | no |
| title | all | all |