General Information
| Gene ID | 1647 |
|---|---|
| Gene Symbol | GADD45A |
| Gene Name | growth arrest and DNA-damage-inducible, alpha |
| Gene Type | protein-coding |
| Cytoband | 1p31.2 |
| Ensembl ID | ENSG00000116717 |
| #miR regulators | 5 |
| Omim ID | 126335 |
| Gene ontology |
GO:0000079: regulation of cyclin-dependent protein serine/threonine kinase activity GO:0006915: apoptotic process GO:0006281: DNA repair GO:0006469: negative regulation of protein kinase activity GO:0007050: cell cycle arrest GO:0007098: centrosome cycle GO:2000379: positive regulation of reactive oxygen species metabolic process GO:0071260: cellular response to mechanical stimulus GO:0042770: signal transduction in response to DNA damage GO:0071479: cellular response to ionizing radiation GO:0005634: nucleus GO:0005515: protein binding GO:0001047: core promoter binding |
| KEGG pathways |
4010: MAPK signaling pathway 4110: Cell cycle 4115: p53 signaling pathway |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 18097539 | Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines. | no | no |
| 18472964 | Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. | no | no |
| 19052873 | Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. | no | no |
| title | all | all |