Results for DDIT3

General Information

Gene ID 1649
Gene Symbol DDIT3
Gene Name DNA-damage-inducible transcript 3
Gene Type protein-coding
Cytoband 12q13.1-q13.2
Ensembl ID ENSG00000175197
#miR regulators 1
Omim ID 126337 613488
Gene ontology GO:0006986: response to unfolded protein
GO:0016055: Wnt receptor signaling pathway
GO:0045454: cell redox homeostasis
GO:0006355: regulation of transcription, DNA-dependent
GO:0006974: response to DNA damage stimulus
GO:0006987: activation of signaling protein activity involved in unfolded protein response
GO:0007050: cell cycle arrest
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030968: endoplasmic reticulum unfolded protein response
GO:0032757: positive regulation of interleukin-8 production
GO:0034976: response to endoplasmic reticulum stress
GO:0042789: mRNA transcription from RNA polymerase II promoter
GO:0043161: proteasomal ubiquitin-dependent protein catabolic process
GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043620: regulation of DNA-dependent transcription in response to stress
GO:0044267: cellular protein metabolic process
GO:0044324: regulation of transcription involved in anterior/posterior axis specification
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0090090: negative regulation of canonical Wnt receptor signaling pathway
GO:2000016: negative regulation of determination of dorsal identity
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003714: transcription corepressor activity
GO:0008134: transcription factor binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4010: MAPK signaling pathway
4141: Protein processing in endoplasmic reticulum

PubMed abstracts associated with DDIT3

PMID Title Tumor Value
7828148 The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. yes no
8117620 Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. yes no
21573491 Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. no no
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