General Information
Gene ID | 1649 |
---|---|
Gene Symbol | DDIT3 |
Gene Name | DNA-damage-inducible transcript 3 |
Gene Type | protein-coding |
Cytoband | 12q13.1-q13.2 |
Ensembl ID | ENSG00000175197 |
#miR regulators | 1 |
Omim ID | 126337 613488 |
Gene ontology |
GO:0006986: response to unfolded protein GO:0016055: Wnt receptor signaling pathway GO:0045454: cell redox homeostasis GO:0006355: regulation of transcription, DNA-dependent GO:0006974: response to DNA damage stimulus GO:0006987: activation of signaling protein activity involved in unfolded protein response GO:0007050: cell cycle arrest GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0030968: endoplasmic reticulum unfolded protein response GO:0032757: positive regulation of interleukin-8 production GO:0034976: response to endoplasmic reticulum stress GO:0042789: mRNA transcription from RNA polymerase II promoter GO:0043161: proteasomal ubiquitin-dependent protein catabolic process GO:0043433: negative regulation of sequence-specific DNA binding transcription factor activity GO:0043620: regulation of DNA-dependent transcription in response to stress GO:0044267: cellular protein metabolic process GO:0044324: regulation of transcription involved in anterior/posterior axis specification GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0070059: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0090090: negative regulation of canonical Wnt receptor signaling pathway GO:2000016: negative regulation of determination of dorsal identity GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005515: protein binding GO:0003677: DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003714: transcription corepressor activity GO:0008134: transcription factor binding GO:0043565: sequence-specific DNA binding |
KEGG pathways |
4010: MAPK signaling pathway 4141: Protein processing in endoplasmic reticulum |
PMID | Title | Tumor | Value |
---|---|---|---|
7828148 | The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas. | yes | no |
8117620 | Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. | yes | no |
21573491 | Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways. | no | no |
title | all | all |