Results for DHFR

General Information

Gene ID 1719
Gene Symbol DHFR
Gene Name dihydrofolate reductase
Gene Type protein-coding
Cytoband 5q11.2-q13.2
Ensembl ID ENSG00000228716
#miR regulators 6
Omim ID 126060 613839
Gene ontology ---
KEGG pathways 670: One carbon pool by folate
790: Folate biosynthesis
1100: Metabolic pathways

PubMed abstracts associated with DHFR

PMID Title Tumor Value
9187120 Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. no no
10100715 Mechanisms of methotrexate resistance in osteosarcoma. yes no
12802802 Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. yes no
12813132 mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. yes yes
14582536 Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. no no
14679136 Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. yes yes
18385200 Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. yes no
19105235 Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. no no
19159907 Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. yes no
20433742 Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. no no
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