General Information
| Gene ID | 1719 |
|---|---|
| Gene Symbol | DHFR |
| Gene Name | dihydrofolate reductase |
| Gene Type | protein-coding |
| Cytoband | 5q11.2-q13.2 |
| Ensembl ID | ENSG00000228716 |
| #miR regulators | 6 |
| Omim ID | 126060 613839 |
| Gene ontology | --- |
| KEGG pathways |
670: One carbon pool by folate 790: Folate biosynthesis 1100: Metabolic pathways |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 9187120 | Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. | no | no |
| 10100715 | Mechanisms of methotrexate resistance in osteosarcoma. | yes | no |
| 12802802 | Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. | yes | no |
| 12813132 | mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. | yes | yes |
| 14582536 | Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques. | no | no |
| 14679136 | Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. | yes | yes |
| 18385200 | Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma. | yes | no |
| 19105235 | Mechanisms of gene amplification and evidence of coamplification in drug-resistant human osteosarcoma cell lines. | no | no |
| 19159907 | Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. | yes | no |
| 20433742 | Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells. | no | no |
| title | all | all |