General Information
Gene ID | 1869 |
---|---|
Gene Symbol | E2F1 |
Gene Name | E2F transcription factor 1 |
Gene Type | protein-coding |
Cytoband | 20q11.2 |
Ensembl ID | ENSG00000101412 |
#miR regulators | 7 |
Omim ID | 189971 |
Gene ontology |
GO:0000077: DNA damage checkpoint GO:0000080: G1 phase of mitotic cell cycle GO:0000082: G1/S transition of mitotic cell cycle GO:0000085: G2 phase of mitotic cell cycle GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0000278: mitotic cell cycle GO:0006351: transcription, DNA-dependent GO:0006355: regulation of transcription, DNA-dependent GO:0007283: spermatogenesis GO:0008283: cell proliferation GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage GO:0010628: positive regulation of gene expression GO:0045893: positive regulation of transcription, DNA-dependent GO:0045892: negative regulation of transcription, DNA-dependent GO:0030900: forebrain development GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048146: positive regulation of fibroblast proliferation GO:0048255: mRNA stabilization GO:0071398: cellular response to fatty acid GO:0071456: cellular response to hypoxia GO:0071930: negative regulation of transcription involved in G1/S phase of mitotic cell cycle GO:2000045: regulation of G1/S transition of mitotic cell cycle GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0035189: Rb-E2F complex GO:0005515: protein binding GO:0001047: core promoter binding GO:0003677: DNA binding GO:0003700: sequence-specific DNA binding transcription factor activity GO:0003714: transcription corepressor activity GO:0008134: transcription factor binding GO:0043565: sequence-specific DNA binding |
KEGG pathways |
4110: Cell cycle 5200: Pathways in cancer 5212: Pancreatic cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5219: Bladder cancer 5220: Chronic myeloid leukemia 5222: Small cell lung cancer 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
9154817 | Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. | no | no |
9187120 | Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. | no | no |
11393276 | Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. | no | no |
12789260 | Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. | no | no |
12813132 | mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. | yes | yes |
14559221 | E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. | no | no |
15883045 | Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. | no | no |
16849574 | E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. | no | no |
19541929 | Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. | no | no |
21959981 | MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93. | no | no |
23113351 | The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. | no | no |
title | all | all |