Results for E2F1

General Information

Gene ID 1869
Gene Symbol E2F1
Gene Name E2F transcription factor 1
Gene Type protein-coding
Cytoband 20q11.2
Ensembl ID ENSG00000101412
#miR regulators 7
Omim ID 189971
Gene ontology GO:0000077: DNA damage checkpoint
GO:0000080: G1 phase of mitotic cell cycle
GO:0000082: G1/S transition of mitotic cell cycle
GO:0000085: G2 phase of mitotic cell cycle
GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000278: mitotic cell cycle
GO:0006351: transcription, DNA-dependent
GO:0006355: regulation of transcription, DNA-dependent
GO:0007283: spermatogenesis
GO:0008283: cell proliferation
GO:0008630: intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628: positive regulation of gene expression
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0030900: forebrain development
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048146: positive regulation of fibroblast proliferation
GO:0048255: mRNA stabilization
GO:0071398: cellular response to fatty acid
GO:0071456: cellular response to hypoxia
GO:0071930: negative regulation of transcription involved in G1/S phase of mitotic cell cycle
GO:2000045: regulation of G1/S transition of mitotic cell cycle
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0035189: Rb-E2F complex
GO:0005515: protein binding
GO:0001047: core promoter binding
GO:0003677: DNA binding
GO:0003700: sequence-specific DNA binding transcription factor activity
GO:0003714: transcription corepressor activity
GO:0008134: transcription factor binding
GO:0043565: sequence-specific DNA binding
KEGG pathways 4110: Cell cycle
5200: Pathways in cancer
5212: Pancreatic cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5220: Chronic myeloid leukemia
5222: Small cell lung cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with E2F1

PMID Title Tumor Value
9154817 Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. no no
9187120 Overexpression of p21waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. no no
11393276 Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells. no no
12789260 Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. no no
12813132 mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma. yes yes
14559221 E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. no no
15883045 Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. no no
16849574 E2F-1 overexpression in U2OS cells increases cyclin B1 levels and cdc2 kinase activity and sensitizes cells to antimitotic agents. no no
19541929 Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. no no
21959981 MicroRNA cloning and sequencing in osteosarcoma cell lines: differential role of miR-93. no no
23113351 The microRNA-29 plays a central role in osteosarcoma pathogenesis and progression. no no
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