Results for EGF

General Information

Gene ID 1950
Gene Symbol EGF
Gene Name epidermal growth factor
Gene Type protein-coding
Cytoband 4q25
Ensembl ID ENSG00000138798
#miR regulators 4
Omim ID 131530 611718
Gene ontology GO:0006260: DNA replication
GO:0000186: activation of MAPKK activity
GO:0001525: angiogenesis
GO:0002576: platelet degranulation
GO:0007596: blood coagulation
GO:0007165: signal transduction
GO:0045741: positive regulation of epidermal growth factor-activated receptor activity
GO:0007171: activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007262: STAT protein import into nucleus
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010800: positive regulation of peptidyl-threonine phosphorylation
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021940: positive regulation of cerebellar granule cell precursor proliferation
GO:0030168: platelet activation
GO:0035413: positive regulation of catenin import into nucleus
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway
GO:0042327: positive regulation of phosphorylation
GO:0043388: positive regulation of DNA binding
GO:0043406: positive regulation of MAP kinase activity
GO:0045087: innate immune response
GO:0045840: positive regulation of mitosis
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048754: branching morphogenesis of an epithelial tube
GO:0051048: negative regulation of secretion
GO:0060749: mammary gland alveolus development
GO:0070371: ERK1 and ERK2 cascade
GO:0090279: regulation of calcium ion import
GO:0090370: negative regulation of cholesterol efflux
GO:1900127: positive regulation of hyaluronan biosynthetic process
GO:2000008: regulation of protein localization to cell surface
GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0031093: platelet alpha granule lumen
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0005154: epidermal growth factor receptor binding
GO:0030297: transmembrane receptor protein tyrosine kinase activator activity
GO:0008083: growth factor activity
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4510: Focal adhesion
4540: Gap junction
4810: Regulation of actin cytoskeleton
5160: Hepatitis C
5200: Pathways in cancer
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with EGF

PMID Title Tumor Value
1586971 Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. no no
20627196 Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation. no no
23168047 Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. no no
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