Results for EGFR

General Information

Gene ID 1956
Gene Symbol EGFR
Gene Name epidermal growth factor receptor
Gene Type protein-coding
Cytoband 7p12
Ensembl ID ENSG00000146648
#miR regulators 7
Omim ID 131550 211980
Gene ontology GO:0000165: MAPK cascade
GO:0000186: activation of MAPKK activity
GO:0001503: ossification
GO:0001892: embryonic placenta development
GO:0001934: positive regulation of protein phosphorylation
GO:0001942: hair follicle development
GO:0007165: signal transduction
GO:0006950: response to stress
GO:0007166: cell surface receptor signaling pathway
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007202: activation of phospholipase C activity
GO:0007411: axon guidance
GO:0007435: salivary gland morphogenesis
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0016337: cell-cell adhesion
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021795: cerebral cortex cell migration
GO:0030335: positive regulation of cell migration
GO:0031659: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0035413: positive regulation of catenin import into nucleus
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway
GO:0042177: negative regulation of protein catabolic process
GO:0042327: positive regulation of phosphorylation
GO:0043006: activation of phospholipase A2 activity by calcium-mediated signaling
GO:0043406: positive regulation of MAP kinase activity
GO:0045087: innate immune response
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045739: positive regulation of DNA repair
GO:0045740: positive regulation of DNA replication
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048146: positive regulation of fibroblast proliferation
GO:0048546: digestive tract morphogenesis
GO:0050679: positive regulation of epithelial cell proliferation
GO:0050730: regulation of peptidyl-tyrosine phosphorylation
GO:0050999: regulation of nitric-oxide synthase activity
GO:0051205: protein insertion into membrane
GO:0051897: positive regulation of protein kinase B signaling cascade
GO:0060571: morphogenesis of an epithelial fold
GO:0070141: response to UV-A
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071392: cellular response to estradiol stimulus
GO:0005886: plasma membrane
GO:0000139: Golgi membrane
GO:0016021: integral to membrane
GO:0016020: membrane
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005768: endosome
GO:0005789: endoplasmic reticulum membrane
GO:0030122: AP-2 adaptor complex
GO:0010008: endosome membrane
GO:0016323: basolateral plasma membrane
GO:0031965: nuclear membrane
GO:0045121: membrane raft
GO:0048471: perinuclear region of cytoplasm
GO:0070435: Shc-EGFR complex
GO:0005515: protein binding
GO:0003682: chromatin binding
GO:0003690: double-stranded DNA binding
GO:0051015: actin filament binding
GO:0004709: MAP kinase kinase kinase activity
GO:0004713: protein tyrosine kinase activity
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0004716: receptor signaling protein tyrosine kinase activity
GO:0004888: transmembrane signaling receptor activity
GO:0005006: epidermal growth factor-activated receptor activity
GO:0005524: ATP binding
GO:0042802: identical protein binding
GO:0019899: enzyme binding
GO:0019903: protein phosphatase binding
GO:0030235: nitric-oxide synthase regulator activity
GO:0046982: protein heterodimerization activity
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4020: Calcium signaling pathway
4060: Cytokine-cytokine receptor interaction
4144: Endocytosis
4320: Dorso-ventral axis formation
4510: Focal adhesion
4520: Adherens junction
4540: Gap junction
4810: Regulation of actin cytoskeleton
4912: GnRH signaling pathway
5120: Epithelial cell signaling in Helicobacter pylori infection
5160: Hepatitis C
5200: Pathways in cancer
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5219: Bladder cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with EGFR

PMID Title Tumor Value
9935160 Redundancy of autocrine loops in human osteosarcoma cells. no no
12221644 Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma. yes no
15026342 Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. yes no
16007579 Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. no no
17505002 Epidermal growth factor receptor expression in high-grade osteosarcomas is associated with a good clinical outcome. yes yes
17509661 Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis. no no
18464244 Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas. yes yes
18505923 Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. no no
18510171 Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. no no
18607665 Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. no no
18704985 Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. yes no
19212684 The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. yes yes
19347870 Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. no no
20881269 Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. yes no
21236332 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. no no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
22090361 Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma. yes no
22682017 Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. yes yes
23168047 Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. no no
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