General Information
Gene ID | 1956 |
---|---|
Gene Symbol | EGFR |
Gene Name | epidermal growth factor receptor |
Gene Type | protein-coding |
Cytoband | 7p12 |
Ensembl ID | ENSG00000146648 |
#miR regulators | 7 |
Omim ID | 131550 211980 |
Gene ontology |
GO:0000165: MAPK cascade GO:0000186: activation of MAPKK activity GO:0001503: ossification GO:0001892: embryonic placenta development GO:0001934: positive regulation of protein phosphorylation GO:0001942: hair follicle development GO:0007165: signal transduction GO:0006950: response to stress GO:0007166: cell surface receptor signaling pathway GO:0007173: epidermal growth factor receptor signaling pathway GO:0007202: activation of phospholipase C activity GO:0007411: axon guidance GO:0007435: salivary gland morphogenesis GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0016337: cell-cell adhesion GO:0048015: phosphatidylinositol-mediated signaling GO:0021795: cerebral cortex cell migration GO:0030335: positive regulation of cell migration GO:0031659: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0035413: positive regulation of catenin import into nucleus GO:0038095: Fc-epsilon receptor signaling pathway GO:0042059: negative regulation of epidermal growth factor receptor signaling pathway GO:0042177: negative regulation of protein catabolic process GO:0042327: positive regulation of phosphorylation GO:0043006: activation of phospholipase A2 activity by calcium-mediated signaling GO:0043406: positive regulation of MAP kinase activity GO:0045087: innate immune response GO:0045429: positive regulation of nitric oxide biosynthetic process GO:0045739: positive regulation of DNA repair GO:0045740: positive regulation of DNA replication GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0046777: protein autophosphorylation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0048146: positive regulation of fibroblast proliferation GO:0048546: digestive tract morphogenesis GO:0050679: positive regulation of epithelial cell proliferation GO:0050730: regulation of peptidyl-tyrosine phosphorylation GO:0050999: regulation of nitric-oxide synthase activity GO:0051205: protein insertion into membrane GO:0051897: positive regulation of protein kinase B signaling cascade GO:0060571: morphogenesis of an epithelial fold GO:0070141: response to UV-A GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0071392: cellular response to estradiol stimulus GO:0005886: plasma membrane GO:0000139: Golgi membrane GO:0016021: integral to membrane GO:0016020: membrane GO:0005615: extracellular space GO:0005634: nucleus GO:0005737: cytoplasm GO:0005768: endosome GO:0005789: endoplasmic reticulum membrane GO:0030122: AP-2 adaptor complex GO:0010008: endosome membrane GO:0016323: basolateral plasma membrane GO:0031965: nuclear membrane GO:0045121: membrane raft GO:0048471: perinuclear region of cytoplasm GO:0070435: Shc-EGFR complex GO:0005515: protein binding GO:0003682: chromatin binding GO:0003690: double-stranded DNA binding GO:0051015: actin filament binding GO:0004709: MAP kinase kinase kinase activity GO:0004713: protein tyrosine kinase activity GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0004716: receptor signaling protein tyrosine kinase activity GO:0004888: transmembrane signaling receptor activity GO:0005006: epidermal growth factor-activated receptor activity GO:0005524: ATP binding GO:0042802: identical protein binding GO:0019899: enzyme binding GO:0019903: protein phosphatase binding GO:0030235: nitric-oxide synthase regulator activity GO:0046982: protein heterodimerization activity |
KEGG pathways |
4010: MAPK signaling pathway 4012: ErbB signaling pathway 4020: Calcium signaling pathway 4060: Cytokine-cytokine receptor interaction 4144: Endocytosis 4320: Dorso-ventral axis formation 4510: Focal adhesion 4520: Adherens junction 4540: Gap junction 4810: Regulation of actin cytoskeleton 4912: GnRH signaling pathway 5120: Epithelial cell signaling in Helicobacter pylori infection 5160: Hepatitis C 5200: Pathways in cancer 5212: Pancreatic cancer 5213: Endometrial cancer 5214: Glioma 5215: Prostate cancer 5218: Melanoma 5219: Bladder cancer 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
9935160 | Redundancy of autocrine loops in human osteosarcoma cells. | no | no |
12221644 | Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcoma. | yes | no |
15026342 | Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. | yes | no |
16007579 | Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. | no | no |
17505002 | Epidermal growth factor receptor expression in high-grade osteosarcomas is associated with a good clinical outcome. | yes | yes |
17509661 | Epidermal growth factor receptor in osteosarcoma: expression and mutational analysis. | no | no |
18464244 | Biological importance of a polymorphic CA sequence within intron 1 of the epidermal growth factor receptor gene (EGFR) in high grade central osteosarcomas. | yes | yes |
18505923 | Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells. | no | no |
18510171 | Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. | no | no |
18607665 | Specific tyrosine kinase inhibitors regulate human osteosarcoma cells in vitro. | no | no |
18704985 | Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. | yes | no |
19212684 | The expression of epidermal growth factor receptor and its downstream signaling molecules in osteosarcoma. | yes | yes |
19347870 | Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. | no | no |
20881269 | Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. | yes | no |
21236332 | 15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. | no | no |
21240382 | Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. | yes | yes |
22090361 | Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma. | yes | no |
22682017 | Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. | yes | yes |
23168047 | Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. | no | no |
title | all | all |