Results for ERBB2

General Information

Gene ID 2064
Gene Symbol ERBB2
Gene Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Type protein-coding
Cytoband 17q12
Ensembl ID ENSG00000141736
#miR regulators 1
Omim ID 137800 164870 211980 613659
Gene ontology GO:0001934: positive regulation of protein phosphorylation
GO:0007165: signal transduction
GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway
GO:0006351: transcription, DNA-dependent
GO:0006468: protein phosphorylation
GO:0007166: cell surface receptor signaling pathway
GO:0007167: enzyme linked receptor protein signaling pathway
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007399: nervous system development
GO:0007411: axon guidance
GO:0007422: peripheral nervous system development
GO:0007507: heart development
GO:0007528: neuromuscular junction development
GO:0008045: motor neuron axon guidance
GO:0008283: cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0014065: phosphatidylinositol 3-kinase cascade
GO:0045727: positive regulation of translation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0023014: signal transduction by phosphorylation
GO:0030307: positive regulation of cell growth
GO:0030879: mammary gland development
GO:0032321: positive regulation of Rho GTPase activity
GO:0032886: regulation of microtubule-based process
GO:0033088: negative regulation of immature T cell proliferation in thymus
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042060: wound healing
GO:0042552: myelination
GO:0043406: positive regulation of MAP kinase activity
GO:0045087: innate immune response
GO:0045765: regulation of angiogenesis
GO:0045785: positive regulation of cell adhesion
GO:0045943: positive regulation of transcription from RNA polymerase I promoter
GO:0045945: positive regulation of transcription from RNA polymerase III promoter
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050679: positive regulation of epithelial cell proliferation
GO:0070372: regulation of ERK1 and ERK2 cascade
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005634: nucleus
GO:0010008: endosome membrane
GO:0016323: basolateral plasma membrane
GO:0016324: apical plasma membrane
GO:0043235: receptor complex
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0001042: RNA polymerase I core binding
GO:0004713: protein tyrosine kinase activity
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0004716: receptor signaling protein tyrosine kinase activity
GO:0004888: transmembrane signaling receptor activity
GO:0005006: epidermal growth factor-activated receptor activity
GO:0043125: ErbB-3 class receptor binding
GO:0019838: growth factor binding
GO:0005524: ATP binding
GO:0046983: protein dimerization activity
GO:0008022: protein C-terminus binding
GO:0042802: identical protein binding
GO:0019903: protein phosphatase binding
GO:0046982: protein heterodimerization activity
KEGG pathways 4012: ErbB signaling pathway
4020: Calcium signaling pathway
4510: Focal adhesion
4520: Adherens junction
5200: Pathways in cancer
5212: Pancreatic cancer
5213: Endometrial cancer
5215: Prostate cancer
5219: Bladder cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with ERBB2

PMID Title Tumor Value
1358045 Overexpression of the c-erbB-2 oncogene in sarcomas and small round-cell tumors of childhood. An immunohistochemical investigation. yes no
8630943 ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. yes yes
10561353 Expression of HER2/erbB-2 correlates with survival in osteosarcoma. yes yes
11154005 Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma. yes yes
11408805 Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma. yes yes
11505415 Amplification of the HER-2/neu oncogene is uncommon in pediatric osteosarcomas. yes no
11743051 Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. yes no
11895910 Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma. yes no
11920494 ErbB2 expression is correlated with increased survival of patients with osteosarcoma. yes yes
12544770 Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. yes yes
12569382 ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. yes yes
14631380 Evaluation of the predictive value of Her-2/neu gene expression on osteosarcoma therapy in laser-microdissected paraffin-embedded tissue. yes yes
15026342 Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. yes no
15069760 HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. yes no
15093570 Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcomas. yes no
15112275 Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. yes yes
15201972 Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma. yes no
15913990 Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. yes yes
16007579 Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. no no
16211448 HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. yes no
16596382 Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. yes no
16683887 Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions. yes yes
17998668 Prognostic and predictive value of c-erbB2 overexpression in osteogenic sarcoma. no no
18421709 C-erbB-2 expression and prognostic significance in osteosarcoma. yes no
18787415 scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. no no
19346874 Her-2/neu, p-53, and their coexpression in osteosarcoma. yes no
19488908 A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. no no
19709164 A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma. yes yes
19719941 Integrated assessment of potential value of erbB-2 amplification or expression status as novel therapy target in Chinese children and adolescents with osteosarcoma. yes no
21240382 Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. yes yes
21292304 Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma. yes no
21751203 Cell surface receptor expression patterns in osteosarcoma. yes no
22173710 Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. no no
22665540 Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. yes no
22682017 Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. yes yes
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