General Information
Gene ID | 2064 |
---|---|
Gene Symbol | ERBB2 |
Gene Name | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
Gene Type | protein-coding |
Cytoband | 17q12 |
Ensembl ID | ENSG00000141736 |
#miR regulators | 1 |
Omim ID | 137800 164870 211980 613659 |
Gene ontology |
GO:0001934: positive regulation of protein phosphorylation GO:0007165: signal transduction GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0006351: transcription, DNA-dependent GO:0006468: protein phosphorylation GO:0007166: cell surface receptor signaling pathway GO:0007167: enzyme linked receptor protein signaling pathway GO:0007173: epidermal growth factor receptor signaling pathway GO:0007399: nervous system development GO:0007411: axon guidance GO:0007422: peripheral nervous system development GO:0007507: heart development GO:0007528: neuromuscular junction development GO:0008045: motor neuron axon guidance GO:0008283: cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0014065: phosphatidylinositol 3-kinase cascade GO:0045727: positive regulation of translation GO:0048015: phosphatidylinositol-mediated signaling GO:0023014: signal transduction by phosphorylation GO:0030307: positive regulation of cell growth GO:0030879: mammary gland development GO:0032321: positive regulation of Rho GTPase activity GO:0032886: regulation of microtubule-based process GO:0033088: negative regulation of immature T cell proliferation in thymus GO:0038095: Fc-epsilon receptor signaling pathway GO:0042060: wound healing GO:0042552: myelination GO:0043406: positive regulation of MAP kinase activity GO:0045087: innate immune response GO:0045765: regulation of angiogenesis GO:0045785: positive regulation of cell adhesion GO:0045943: positive regulation of transcription from RNA polymerase I promoter GO:0045945: positive regulation of transcription from RNA polymerase III promoter GO:0046777: protein autophosphorylation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0050679: positive regulation of epithelial cell proliferation GO:0070372: regulation of ERK1 and ERK2 cascade GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005634: nucleus GO:0010008: endosome membrane GO:0016323: basolateral plasma membrane GO:0016324: apical plasma membrane GO:0043235: receptor complex GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0001042: RNA polymerase I core binding GO:0004713: protein tyrosine kinase activity GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0004716: receptor signaling protein tyrosine kinase activity GO:0004888: transmembrane signaling receptor activity GO:0005006: epidermal growth factor-activated receptor activity GO:0043125: ErbB-3 class receptor binding GO:0019838: growth factor binding GO:0005524: ATP binding GO:0046983: protein dimerization activity GO:0008022: protein C-terminus binding GO:0042802: identical protein binding GO:0019903: protein phosphatase binding GO:0046982: protein heterodimerization activity |
KEGG pathways |
4012: ErbB signaling pathway 4020: Calcium signaling pathway 4510: Focal adhesion 4520: Adherens junction 5200: Pathways in cancer 5212: Pancreatic cancer 5213: Endometrial cancer 5215: Prostate cancer 5219: Bladder cancer 5223: Non-small cell lung cancer |
PMID | Title | Tumor | Value |
---|---|---|---|
1358045 | Overexpression of the c-erbB-2 oncogene in sarcomas and small round-cell tumors of childhood. An immunohistochemical investigation. | yes | no |
8630943 | ErbB-2 expression is correlated with poor prognosis for patients with osteosarcoma. | yes | yes |
10561353 | Expression of HER2/erbB-2 correlates with survival in osteosarcoma. | yes | yes |
11154005 | Human epidermal growth factor receptor 2 as a prognostic indicator in osteogenic sarcoma. | yes | yes |
11408805 | Loss of ErbB2 expression in pulmonary metastatic lesions in osteosarcoma. | yes | yes |
11505415 | Amplification of the HER-2/neu oncogene is uncommon in pediatric osteosarcomas. | yes | no |
11743051 | Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. | yes | no |
11895910 | Absence of HER2/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma. | yes | no |
11920494 | ErbB2 expression is correlated with increased survival of patients with osteosarcoma. | yes | yes |
12544770 | Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. | yes | yes |
12569382 | ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells. | yes | yes |
14631380 | Evaluation of the predictive value of Her-2/neu gene expression on osteosarcoma therapy in laser-microdissected paraffin-embedded tissue. | yes | yes |
15026342 | Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. | yes | no |
15069760 | HER-2/neu and p53 in osteosarcoma: an immunohistochemical and fluorescence in situ hybridization analysis. | yes | no |
15093570 | Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcomas. | yes | no |
15112275 | Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma. | yes | yes |
15201972 | Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma. | yes | no |
15913990 | Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma. | yes | yes |
16007579 | Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. | no | no |
16211448 | HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study. | yes | no |
16596382 | Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma. | yes | no |
16683887 | Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions. | yes | yes |
17998668 | Prognostic and predictive value of c-erbB2 overexpression in osteogenic sarcoma. | no | no |
18421709 | C-erbB-2 expression and prognostic significance in osteosarcoma. | yes | no |
18787415 | scFv-mediated delivery of truncated BID suppresses HER2-positive osteosarcoma growth and metastasis. | no | no |
19346874 | Her-2/neu, p-53, and their coexpression in osteosarcoma. | yes | no |
19488908 | A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma. | no | no |
19709164 | A meta-analysis on the association of HER-2 overexpression with prognosis in human osteosarcoma. | yes | yes |
19719941 | Integrated assessment of potential value of erbB-2 amplification or expression status as novel therapy target in Chinese children and adolescents with osteosarcoma. | yes | no |
21240382 | Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. | yes | yes |
21292304 | Aberrant expression of the human epidermal growth factor receptor 2 oncogene is not a common feature in osteosarcoma. | yes | no |
21751203 | Cell surface receptor expression patterns in osteosarcoma. | yes | no |
22173710 | Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. | no | no |
22665540 | Phase II trial of trastuzumab in combination with cytotoxic chemotherapy for treatment of metastatic osteosarcoma with human epidermal growth factor receptor 2 overexpression: a report from the children's oncology group. | yes | no |
22682017 | Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: a predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas. | yes | yes |
title | all | all |