Results for ERBB4

General Information

Gene ID 2066
Gene Symbol ERBB4
Gene Name v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Gene Type protein-coding
Cytoband 2q33.3-q34
Ensembl ID ENSG00000178568
#miR regulators 10
Omim ID 600543
Gene ontology GO:0001755: neural crest cell migration
GO:0001934: positive regulation of protein phosphorylation
GO:0007165: signal transduction
GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway
GO:0006351: transcription, DNA-dependent
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0009880: embryonic pattern specification
GO:0007399: nervous system development
GO:0007507: heart development
GO:0007595: lactation
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0016477: cell migration
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021551: central nervous system morphogenesis
GO:0021889: olfactory bulb interneuron differentiation
GO:0030334: regulation of cell migration
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0043653: mitochondrial fragmentation involved in apoptotic process
GO:0045087: innate immune response
GO:0045165: cell fate commitment
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0060045: positive regulation of cardiac muscle cell proliferation
GO:0060644: mammary gland epithelial cell differentiation
GO:0060749: mammary gland alveolus development
GO:0061026: cardiac muscle tissue regeneration
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:2000366: positive regulation of STAT protein import into nucleus
GO:0005886: plasma membrane
GO:0016021: integral to membrane
GO:0005739: mitochondrion
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005759: mitochondrial matrix
GO:0016323: basolateral plasma membrane
GO:0005515: protein binding
GO:0004713: protein tyrosine kinase activity
GO:0004714: transmembrane receptor protein tyrosine kinase activity
GO:0004716: receptor signaling protein tyrosine kinase activity
GO:0005154: epidermal growth factor receptor binding
GO:0005524: ATP binding
GO:0044212: transcription regulatory region DNA binding
GO:0042803: protein homodimerization activity
KEGG pathways 4012: ErbB signaling pathway
4020: Calcium signaling pathway
4144: Endocytosis

PubMed abstracts associated with ERBB4

PMID Title Tumor Value
12883746 Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression. yes yes
15026342 Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. yes no
16007579 Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. no no
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