General Information
Gene ID | 2066 |
---|---|
Gene Symbol | ERBB4 |
Gene Name | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
Gene Type | protein-coding |
Cytoband | 2q33.3-q34 |
Ensembl ID | ENSG00000178568 |
#miR regulators | 10 |
Omim ID | 600543 |
Gene ontology |
GO:0001755: neural crest cell migration GO:0001934: positive regulation of protein phosphorylation GO:0007165: signal transduction GO:0007169: transmembrane receptor protein tyrosine kinase signaling pathway GO:0006351: transcription, DNA-dependent GO:0007173: epidermal growth factor receptor signaling pathway GO:0009880: embryonic pattern specification GO:0007399: nervous system development GO:0007507: heart development GO:0007595: lactation GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008543: fibroblast growth factor receptor signaling pathway GO:0016477: cell migration GO:0045893: positive regulation of transcription, DNA-dependent GO:0018108: peptidyl-tyrosine phosphorylation GO:0048015: phosphatidylinositol-mediated signaling GO:0021551: central nervous system morphogenesis GO:0021889: olfactory bulb interneuron differentiation GO:0030334: regulation of cell migration GO:0038095: Fc-epsilon receptor signaling pathway GO:0042523: positive regulation of tyrosine phosphorylation of Stat5 protein GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0043653: mitochondrial fragmentation involved in apoptotic process GO:0045087: innate immune response GO:0045165: cell fate commitment GO:0046777: protein autophosphorylation GO:0048011: neurotrophin TRK receptor signaling pathway GO:0060045: positive regulation of cardiac muscle cell proliferation GO:0060644: mammary gland epithelial cell differentiation GO:0060749: mammary gland alveolus development GO:0061026: cardiac muscle tissue regeneration GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:2000366: positive regulation of STAT protein import into nucleus GO:0005886: plasma membrane GO:0016021: integral to membrane GO:0005739: mitochondrion GO:0005576: extracellular region GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005759: mitochondrial matrix GO:0016323: basolateral plasma membrane GO:0005515: protein binding GO:0004713: protein tyrosine kinase activity GO:0004714: transmembrane receptor protein tyrosine kinase activity GO:0004716: receptor signaling protein tyrosine kinase activity GO:0005154: epidermal growth factor receptor binding GO:0005524: ATP binding GO:0044212: transcription regulatory region DNA binding GO:0042803: protein homodimerization activity |
KEGG pathways |
4012: ErbB signaling pathway 4020: Calcium signaling pathway 4144: Endocytosis |
PMID | Title | Tumor | Value |
---|---|---|---|
12883746 | Induction chemotherapy for bone sarcoma in adults: correlation of results with erbB-4 expression. | yes | yes |
15026342 | Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma. | yes | no |
16007579 | Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition. | no | no |
title | all | all |