General Information
Gene ID | 2067 |
---|---|
Gene Symbol | ERCC1 |
Gene Name | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
Gene Type | protein-coding |
Cytoband | 19q13.32 |
Ensembl ID | ENSG00000012061 |
#miR regulators | 4 |
Omim ID | 126380 610758 |
Gene ontology |
GO:0051276: chromosome organization GO:0000718: nucleotide-excision repair, DNA damage removal GO:0000720: pyrimidine dimer repair by nucleotide-excision repair GO:0001302: replicative cell aging GO:0006281: DNA repair GO:0006283: transcription-coupled nucleotide-excision repair GO:0006289: nucleotide-excision repair GO:0006295: nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006296: nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006302: double-strand break repair GO:0006310: DNA recombination GO:0006312: mitotic recombination GO:0006949: syncytium formation GO:0006979: response to oxidative stress GO:0007281: germ cell development GO:0007283: spermatogenesis GO:0007584: response to nutrient GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0008584: male gonad development GO:0009650: UV protection GO:0009744: response to sucrose stimulus GO:0010165: response to X-ray GO:0010259: multicellular organismal aging GO:0032205: negative regulation of telomere maintenance GO:0035166: post-embryonic hemopoiesis GO:0035264: multicellular organism growth GO:0045190: isotype switching GO:0048477: oogenesis GO:0048568: embryonic organ development GO:0000109: nucleotide-excision repair complex GO:0000784: nuclear chromosome, telomeric region GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005669: transcription factor TFIID complex GO:0000014: single-stranded DNA endodeoxyribonuclease activity GO:0005515: protein binding GO:0001094: TFIID-class transcription factor binding GO:0003684: damaged DNA binding GO:0003697: single-stranded DNA binding GO:0008022: protein C-terminus binding GO:0017025: TBP-class protein binding GO:0019904: protein domain specific binding GO:0043566: structure-specific DNA binding |
KEGG pathways |
3420: Nucleotide excision repair |
PMID | Title | Tumor | Value |
---|---|---|---|
21826087 | Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. | yes | yes |
23098477 | Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. | yes | yes |
23317281 | Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. | yes | yes |
title | all | all |