Results for ERCC2

General Information

Gene ID 2068
Gene Symbol ERCC2
Gene Name excision repair cross-complementing rodent repair deficiency, complementation group 2
Gene Type protein-coding
Cytoband 19q13.3
Ensembl ID ENSG00000104884
#miR regulators 6
Omim ID 126340 278730 601675 610756
Gene ontology GO:0007059: chromosome segregation
GO:0000075: cell cycle checkpoint
GO:0000718: nucleotide-excision repair, DNA damage removal
GO:0001666: response to hypoxia
GO:0001701: in utero embryonic development
GO:0006360: transcription from RNA polymerase I promoter
GO:0006366: transcription from RNA polymerase II promoter
GO:0006363: termination of RNA polymerase I transcription
GO:0006915: apoptotic process
GO:0006281: DNA repair
GO:0006283: transcription-coupled nucleotide-excision repair
GO:0006289: nucleotide-excision repair
GO:0006361: transcription initiation from RNA polymerase I promoter
GO:0006362: transcription elongation from RNA polymerase I promoter
GO:0006367: transcription initiation from RNA polymerase II promoter
GO:0006368: transcription elongation from RNA polymerase II promoter
GO:0006370: 7-methylguanosine mRNA capping
GO:0006468: protein phosphorylation
GO:0006979: response to oxidative stress
GO:0007568: aging
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0016032: viral process
GO:0009650: UV protection
GO:0009791: post-embryonic development
GO:0010467: gene expression
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0019048: modulation by virus of host morphology or physiology
GO:0021510: spinal cord development
GO:0030198: extracellular matrix organization
GO:0030282: bone mineralization
GO:0032289: central nervous system myelin formation
GO:0033683: nucleotide-excision repair, DNA incision
GO:0035264: multicellular organism growth
GO:0035315: hair cell differentiation
GO:0040016: embryonic cleavage
GO:0043249: erythrocyte maturation
GO:0043388: positive regulation of DNA binding
GO:0044281: small molecule metabolic process
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0048820: hair follicle maturation
GO:0050434: positive regulation of viral transcription
GO:0060218: hematopoietic stem cell differentiation
GO:0000441: SSL2-core TFIIH complex
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005675: holo TFIIH complex
GO:0005819: spindle
GO:0019907: cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0071817: MMXD complex
GO:0005515: protein binding
GO:0003677: DNA binding
GO:0004003: ATP-dependent DNA helicase activity
GO:0004672: protein kinase activity
GO:0046872: metal ion binding
GO:0005524: ATP binding
GO:0008022: protein C-terminus binding
GO:0008094: DNA-dependent ATPase activity
GO:0008353: RNA polymerase II carboxy-terminal domain kinase activity
GO:0043139: 5'-3' DNA helicase activity
GO:0047485: protein N-terminus binding
GO:0051539: 4 iron, 4 sulfur cluster binding
KEGG pathways 3420: Nucleotide excision repair

PubMed abstracts associated with ERCC2

PMID Title Tumor Value
19434073 Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. yes yes
21826087 Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. yes yes
23098477 Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. yes yes
23317281 Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. yes yes
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