General Information
Gene ID | 2068 |
---|---|
Gene Symbol | ERCC2 |
Gene Name | excision repair cross-complementing rodent repair deficiency, complementation group 2 |
Gene Type | protein-coding |
Cytoband | 19q13.3 |
Ensembl ID | ENSG00000104884 |
#miR regulators | 6 |
Omim ID | 126340 278730 601675 610756 |
Gene ontology |
GO:0007059: chromosome segregation GO:0000075: cell cycle checkpoint GO:0000718: nucleotide-excision repair, DNA damage removal GO:0001666: response to hypoxia GO:0001701: in utero embryonic development GO:0006360: transcription from RNA polymerase I promoter GO:0006366: transcription from RNA polymerase II promoter GO:0006363: termination of RNA polymerase I transcription GO:0006915: apoptotic process GO:0006281: DNA repair GO:0006283: transcription-coupled nucleotide-excision repair GO:0006289: nucleotide-excision repair GO:0006361: transcription initiation from RNA polymerase I promoter GO:0006362: transcription elongation from RNA polymerase I promoter GO:0006367: transcription initiation from RNA polymerase II promoter GO:0006368: transcription elongation from RNA polymerase II promoter GO:0006370: 7-methylguanosine mRNA capping GO:0006468: protein phosphorylation GO:0006979: response to oxidative stress GO:0007568: aging GO:0043066: negative regulation of apoptotic process GO:0008283: cell proliferation GO:0016032: viral process GO:0009650: UV protection GO:0009791: post-embryonic development GO:0010467: gene expression GO:0045893: positive regulation of transcription, DNA-dependent GO:0019048: modulation by virus of host morphology or physiology GO:0021510: spinal cord development GO:0030198: extracellular matrix organization GO:0030282: bone mineralization GO:0032289: central nervous system myelin formation GO:0033683: nucleotide-excision repair, DNA incision GO:0035264: multicellular organism growth GO:0035315: hair cell differentiation GO:0040016: embryonic cleavage GO:0043249: erythrocyte maturation GO:0043388: positive regulation of DNA binding GO:0044281: small molecule metabolic process GO:0045944: positive regulation of transcription from RNA polymerase II promoter GO:0048820: hair follicle maturation GO:0050434: positive regulation of viral transcription GO:0060218: hematopoietic stem cell differentiation GO:0000441: SSL2-core TFIIH complex GO:0005634: nucleus GO:0005737: cytoplasm GO:0005654: nucleoplasm GO:0005675: holo TFIIH complex GO:0005819: spindle GO:0019907: cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0071817: MMXD complex GO:0005515: protein binding GO:0003677: DNA binding GO:0004003: ATP-dependent DNA helicase activity GO:0004672: protein kinase activity GO:0046872: metal ion binding GO:0005524: ATP binding GO:0008022: protein C-terminus binding GO:0008094: DNA-dependent ATPase activity GO:0008353: RNA polymerase II carboxy-terminal domain kinase activity GO:0043139: 5'-3' DNA helicase activity GO:0047485: protein N-terminus binding GO:0051539: 4 iron, 4 sulfur cluster binding |
KEGG pathways |
3420: Nucleotide excision repair |
PMID | Title | Tumor | Value |
---|---|---|---|
19434073 | Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. | yes | yes |
21826087 | Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy. | yes | yes |
23098477 | Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. | yes | yes |
23317281 | Glutathione S-transferase P1 and DNA polymorphisms influence response to chemotherapy and prognosis of bone tumors. | yes | yes |
title | all | all |