Results for AKT1

General Information

Gene ID 207
Gene Symbol AKT1
Gene Name v-akt murine thymoma viral oncogene homolog 1
Gene Type protein-coding
Cytoband 14q32.32
Ensembl ID ENSG00000142208
#miR regulators 3
Omim ID 114480 114500 164730 176920 181500 615109
Gene ontology GO:0000060: protein import into nucleus, translocation
GO:0001649: osteoblast differentiation
GO:0001893: maternal placenta development
GO:0001934: positive regulation of protein phosphorylation
GO:0007596: blood coagulation
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0035556: intracellular signal transduction
GO:0016567: protein ubiquitination
GO:0005978: glycogen biosynthetic process
GO:0005979: regulation of glycogen biosynthetic process
GO:0006006: glucose metabolic process
GO:0006412: translation
GO:0006417: regulation of translation
GO:0006464: cellular protein modification process
GO:0006468: protein phosphorylation
GO:0006469: negative regulation of protein kinase activity
GO:0006809: nitric oxide biosynthetic process
GO:0006924: activation-induced cell death of T cells
GO:0006954: inflammatory response
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007186: G-protein coupled receptor signaling pathway
GO:0007281: germ cell development
GO:0007568: aging
GO:0043066: negative regulation of apoptotic process
GO:0008283: cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0008637: apoptotic mitochondrial changes
GO:0009408: response to heat
GO:0010467: gene expression
GO:0010507: negative regulation of autophagy
GO:0010748: negative regulation of plasma membrane long-chain fatty acid transport
GO:0010765: positive regulation of sodium ion transport
GO:0010907: positive regulation of glucose metabolic process
GO:0010951: negative regulation of endopeptidase activity
GO:0010975: regulation of neuron projection development
GO:0015758: glucose transport
GO:0016044: cellular membrane organization
GO:0016070: RNA metabolic process
GO:0016071: mRNA metabolic process
GO:0046326: positive regulation of glucose import
GO:0046889: positive regulation of lipid biosynthetic process
GO:0016310: phosphorylation
GO:0018105: peptidyl-serine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0030030: cell projection organization
GO:0030154: cell differentiation
GO:0030163: protein catabolic process
GO:0030168: platelet activation
GO:0030307: positive regulation of cell growth
GO:0030334: regulation of cell migration
GO:0031018: endocrine pancreas development
GO:0031295: T cell costimulation
GO:0031659: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031999: negative regulation of fatty acid beta-oxidation
GO:0032094: response to food
GO:0032270: positive regulation of cellular protein metabolic process
GO:0032287: peripheral nervous system myelin maintenance
GO:0032436: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869: cellular response to insulin stimulus
GO:0033138: positive regulation of peptidyl-serine phosphorylation
GO:0034405: response to fluid shear stress
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042593: glucose homeostasis
GO:0042640: anagen
GO:0043065: positive regulation of apoptotic process
GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491: protein kinase B signaling cascade
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0044281: small molecule metabolic process
GO:0045087: innate immune response
GO:0045429: positive regulation of nitric oxide biosynthetic process
GO:0045600: positive regulation of fat cell differentiation
GO:0045725: positive regulation of glycogen biosynthetic process
GO:0045792: negative regulation of cell size
GO:0045861: negative regulation of proteolysis
GO:0045907: positive regulation of vasoconstriction
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046209: nitric oxide metabolic process
GO:0046329: negative regulation of JNK cascade
GO:0046777: protein autophosphorylation
GO:0048009: insulin-like growth factor receptor signaling pathway
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0050999: regulation of nitric-oxide synthase activity
GO:0051000: positive regulation of nitric-oxide synthase activity
GO:0051091: positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146: striated muscle cell differentiation
GO:0060644: mammary gland epithelial cell differentiation
GO:0060709: glycogen cell differentiation involved in embryonic placenta development
GO:0060716: labyrinthine layer blood vessel development
GO:0070141: response to UV-A
GO:0071364: cellular response to epidermal growth factor stimulus
GO:0071456: cellular response to hypoxia
GO:0090004: positive regulation of establishment of protein localization to plasma membrane
GO:0090201: negative regulation of release of cytochrome c from mitochondria
GO:0097193: intrinsic apoptotic signaling pathway
GO:1900740: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901976: regulation of cell cycle checkpoint
GO:1902176: negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
GO:2001240: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005654: nucleoplasm
GO:0005819: spindle
GO:0015630: microtubule cytoskeleton
GO:0030027: lamellipodium
GO:0005515: protein binding
GO:0004672: protein kinase activity
GO:0004674: protein serine/threonine kinase activity
GO:0005080: protein kinase C binding
GO:0005524: ATP binding
GO:0005547: phosphatidylinositol-3,4,5-trisphosphate binding
GO:0042802: identical protein binding
GO:0016301: kinase activity
GO:0019899: enzyme binding
GO:0030235: nitric-oxide synthase regulator activity
GO:0043325: phosphatidylinositol-3,4-bisphosphate binding
GO:0071889: 14-3-3 protein binding
KEGG pathways 4010: MAPK signaling pathway
4012: ErbB signaling pathway
4062: Chemokine signaling pathway
4150: mTOR signaling pathway
4210: Apoptosis
4370: VEGF signaling pathway
4380: Osteoclast differentiation
4510: Focal adhesion
4530: Tight junction
4620: Toll-like receptor signaling pathway
4630: Jak-STAT signaling pathway
4660: T cell receptor signaling pathway
4662: B cell receptor signaling pathway
4664: Fc epsilon RI signaling pathway
4666: Fc gamma R-mediated phagocytosis
4722: Neurotrophin signaling pathway
4910: Insulin signaling pathway
4914: Progesterone-mediated oocyte maturation
4920: Adipocytokine signaling pathway
4973: Carbohydrate digestion and absorption
5142: Chagas disease (American trypanosomiasis)
5145: Toxoplasmosis
5160: Hepatitis C
5200: Pathways in cancer
5210: Colorectal cancer
5211: Renal cell carcinoma
5212: Pancreatic cancer
5213: Endometrial cancer
5214: Glioma
5215: Prostate cancer
5218: Melanoma
5220: Chronic myeloid leukemia
5221: Acute myeloid leukemia
5222: Small cell lung cancer
5223: Non-small cell lung cancer

PubMed abstracts associated with AKT1

PMID Title Tumor Value
11920584 Troglitazione affects survival of human osteosarcoma cells. no no
14624456 Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. yes no
14704791 The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. no yes
15144225 Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. no no
15455381 Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. no no
15547696 Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinase. no no
16759849 PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. no no
17116726 Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2. no no
17218775 Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. no no
19148492 Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. no no
19393247 Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells. no no
20038829 Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappaB. no no
20486173 R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts. no no
21056138 Extracellular pressure stimulates adhesion of sarcoma cells via activation of focal adhesion kinase and Akt. no no
21145881 Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways. no no
21246613 Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. no no
21440986 Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. no no
21617855 Caffeine activates tumor suppressor PTEN in sarcoma cells. no no
21617882 Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt. no no
21667022 The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor. no no
22263786 Genistein potentiates the anti-cancer effects of gemcitabine in human osteosarcoma via the downregulation of Akt and nuclear factor-κB pathway. no no
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
22583777 Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro. yes no
22939995 IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. yes no
22948234 Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. no no
22993301 Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways. no no
22994717 LY294002 induces G0/G1 cell cycle arrest and apoptosis of cancer stem-like cells from human osteosarcoma via down-regulation of PI3K activity. no no
23091618 Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research. no no
23208072 Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. no no
23168047 Effects of tick saliva on the migratory and invasive activity of Saos-2 osteosarcoma and MDA-MB-231 breast cancer cells. no no
23201449 Phyllanthus urinaria suppresses human osteosarcoma cell invasion and migration by transcriptionally inhibiting u-PA via ERK and Akt signaling pathways. no no
23527720 Knockdown of AXL receptor tyrosine kinase in osteosarcoma cells leads to decreased proliferation and increased apoptosis. yes no
23740448 Relaxin promotes in vitro tumour growth, invasion and angiogenesis of human Saos-2 osteosarcoma cells by AKT/VEGF pathway. no no
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