General Information
| Gene ID | 2146 |
|---|---|
| Gene Symbol | EZH2 |
| Gene Name | enhancer of zeste homolog 2 (Drosophila) |
| Gene Type | protein-coding |
| Cytoband | 7q35-q36 |
| Ensembl ID | ENSG00000106462 |
| #miR regulators | 5 |
| Omim ID | 277590 601573 |
| Gene ontology |
GO:0000122: negative regulation of transcription from RNA polymerase II promoter GO:0006325: chromatin organization GO:0006351: transcription, DNA-dependent GO:0006355: regulation of transcription, DNA-dependent GO:0010718: positive regulation of epithelial to mesenchymal transition GO:0014013: regulation of gliogenesis GO:0045892: negative regulation of transcription, DNA-dependent GO:0021695: cerebellar cortex development GO:0032320: positive regulation of Ras GTPase activity GO:0034244: negative regulation of transcription elongation from RNA polymerase II promoter GO:0042127: regulation of cell proliferation GO:0043406: positive regulation of MAP kinase activity GO:0045605: negative regulation of epidermal cell differentiation GO:0045814: negative regulation of gene expression, epigenetic GO:0048387: negative regulation of retinoic acid receptor signaling pathway GO:0051154: negative regulation of striated muscle cell differentiation GO:0070314: G1 to G0 transition GO:0070734: histone H3-K27 methylation GO:0071902: positive regulation of protein serine/threonine kinase activity GO:2000134: negative regulation of G1/S transition of mitotic cell cycle GO:0035098: ESC/E(Z) complex GO:0045120: pronucleus GO:0005515: protein binding GO:0001047: core promoter binding GO:0003677: DNA binding GO:0003682: chromatin binding GO:0003723: RNA binding GO:0018024: histone-lysine N-methyltransferase activity GO:0042054: histone methyltransferase activity GO:0043565: sequence-specific DNA binding |
| KEGG pathways | --- |
| PMID | Title | Tumor | Value |
|---|---|---|---|
| 20127006 | The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth. | yes | no |
| title | all | all |