Results for F2

General Information

Gene ID 2147
Gene Symbol F2
Gene Name coagulation factor II (thrombin)
Gene Type protein-coding
Cytoband 11p11
Ensembl ID ENSG00000180210
#miR regulators ---
Omim ID 176930 188050 601367 613679 614390
Gene ontology GO:0001934: positive regulation of protein phosphorylation
GO:0006953: acute-phase response
GO:0007596: blood coagulation
GO:0006508: proteolysis
GO:0007166: cell surface receptor signaling pathway
GO:0007275: multicellular organismal development
GO:0007597: blood coagulation, intrinsic pathway
GO:0008284: positive regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0009611: response to wounding
GO:0010468: regulation of gene expression
GO:0010544: negative regulation of platelet activation
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0017187: peptidyl-glutamic acid carboxylation
GO:0030168: platelet activation
GO:0030193: regulation of blood coagulation
GO:0030194: positive regulation of blood coagulation
GO:0030307: positive regulation of cell growth
GO:0032967: positive regulation of collagen biosynthetic process
GO:0042730: fibrinolysis
GO:0043687: post-translational protein modification
GO:0044267: cellular protein metabolic process
GO:0045861: negative regulation of proteolysis
GO:0048712: negative regulation of astrocyte differentiation
GO:0050900: leukocyte migration
GO:0051281: positive regulation of release of sequestered calcium ion into cytosol
GO:0051480: cytosolic calcium ion homeostasis
GO:0051918: negative regulation of fibrinolysis
GO:1900738: positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005615: extracellular space
GO:0005788: endoplasmic reticulum lumen
GO:0005796: Golgi lumen
GO:0005515: protein binding
GO:0005509: calcium ion binding
GO:0004252: serine-type endopeptidase activity
GO:0005102: receptor binding
GO:0008083: growth factor activity
GO:0070053: thrombospondin receptor activity
KEGG pathways 4080: Neuroactive ligand-receptor interaction
4610: Complement and coagulation cascades
4810: Regulation of actin cytoskeleton

PubMed abstracts associated with F2

PMID Title Tumor Value
12408470 Thrombin is present in the lungs of patients with primary extremity osteosarcoma and pulmonary metastases. yes no
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