General Information
Gene ID | 2149 |
---|---|
Gene Symbol | F2R |
Gene Name | coagulation factor II (thrombin) receptor |
Gene Type | protein-coding |
Cytoband | 5q13 |
Ensembl ID | ENSG00000181104 |
#miR regulators | 13 |
Omim ID | 187930 |
Gene ontology |
GO:0000186: activation of MAPKK activity GO:0002248: connective tissue replacement involved in inflammatory response wound healing GO:0003105: negative regulation of glomerular filtration GO:0007596: blood coagulation GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006954: inflammatory response GO:0007186: G-protein coupled receptor signaling pathway GO:0007200: phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204: elevation of cytosolic calcium ion concentration GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007260: tyrosine phosphorylation of STAT protein GO:0007262: STAT protein import into nucleus GO:0009653: anatomical structure morphogenesis GO:0007529: establishment of synaptic specificity at neuromuscular junction GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0045987: positive regulation of smooth muscle contraction GO:0009611: response to wounding GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade GO:0045893: positive regulation of transcription, DNA-dependent GO:0030168: platelet activation GO:0030193: regulation of blood coagulation GO:0030194: positive regulation of blood coagulation GO:0030335: positive regulation of cell migration GO:0032496: response to lipopolysaccharide GO:0032651: regulation of interleukin-1 beta production GO:0032967: positive regulation of collagen biosynthetic process GO:0035025: positive regulation of Rho protein signal transduction GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043410: positive regulation of MAPK cascade GO:0043524: negative regulation of neuron apoptotic process GO:0045907: positive regulation of vasoconstriction GO:0046427: positive regulation of JAK-STAT cascade GO:0048873: homeostasis of number of cells within a tissue GO:0051209: release of sequestered calcium ion into cytosol GO:0051281: positive regulation of release of sequestered calcium ion into cytosol GO:0051482: elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051928: positive regulation of calcium ion transport GO:0051930: regulation of sensory perception of pain GO:0060155: platelet dense granule organization GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:1900134: negative regulation of renin secretion into blood stream GO:2000484: positive regulation of interleukin-8 secretion GO:2000778: positive regulation of interleukin-6 secretion GO:0005886: plasma membrane GO:0005576: extracellular region GO:0005887: integral to plasma membrane GO:0005794: Golgi apparatus GO:0005901: caveola GO:0031094: platelet dense tubular network GO:0031594: neuromuscular junction GO:0045211: postsynaptic membrane GO:0005515: protein binding GO:0001965: G-protein alpha-subunit binding GO:0005102: receptor binding GO:0004930: G-protein coupled receptor activity GO:0015057: thrombin receptor activity GO:0031681: G-protein beta-subunit binding |
KEGG pathways |
4020: Calcium signaling pathway 4080: Neuroactive ligand-receptor interaction 4144: Endocytosis 4610: Complement and coagulation cascades 4810: Regulation of actin cytoskeleton |
PMID | Title | Tumor | Value |
---|---|---|---|
20563836 | Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. | yes | no |
title | all | all |