Results for F2R

General Information

Gene ID 2149
Gene Symbol F2R
Gene Name coagulation factor II (thrombin) receptor
Gene Type protein-coding
Cytoband 5q13
Ensembl ID ENSG00000181104
#miR regulators 13
Omim ID 187930
Gene ontology GO:0000186: activation of MAPKK activity
GO:0002248: connective tissue replacement involved in inflammatory response wound healing
GO:0003105: negative regulation of glomerular filtration
GO:0007596: blood coagulation
GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954: inflammatory response
GO:0007186: G-protein coupled receptor signaling pathway
GO:0007200: phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204: elevation of cytosolic calcium ion concentration
GO:0007205: protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007260: tyrosine phosphorylation of STAT protein
GO:0007262: STAT protein import into nucleus
GO:0009653: anatomical structure morphogenesis
GO:0007529: establishment of synaptic specificity at neuromuscular junction
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0045987: positive regulation of smooth muscle contraction
GO:0009611: response to wounding
GO:0014068: positive regulation of phosphatidylinositol 3-kinase cascade
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0030168: platelet activation
GO:0030193: regulation of blood coagulation
GO:0030194: positive regulation of blood coagulation
GO:0030335: positive regulation of cell migration
GO:0032496: response to lipopolysaccharide
GO:0032651: regulation of interleukin-1 beta production
GO:0032967: positive regulation of collagen biosynthetic process
GO:0035025: positive regulation of Rho protein signal transduction
GO:0043123: positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043280: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410: positive regulation of MAPK cascade
GO:0043524: negative regulation of neuron apoptotic process
GO:0045907: positive regulation of vasoconstriction
GO:0046427: positive regulation of JAK-STAT cascade
GO:0048873: homeostasis of number of cells within a tissue
GO:0051209: release of sequestered calcium ion into cytosol
GO:0051281: positive regulation of release of sequestered calcium ion into cytosol
GO:0051482: elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928: positive regulation of calcium ion transport
GO:0051930: regulation of sensory perception of pain
GO:0060155: platelet dense granule organization
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:1900134: negative regulation of renin secretion into blood stream
GO:2000484: positive regulation of interleukin-8 secretion
GO:2000778: positive regulation of interleukin-6 secretion
GO:0005886: plasma membrane
GO:0005576: extracellular region
GO:0005887: integral to plasma membrane
GO:0005794: Golgi apparatus
GO:0005901: caveola
GO:0031094: platelet dense tubular network
GO:0031594: neuromuscular junction
GO:0045211: postsynaptic membrane
GO:0005515: protein binding
GO:0001965: G-protein alpha-subunit binding
GO:0005102: receptor binding
GO:0004930: G-protein coupled receptor activity
GO:0015057: thrombin receptor activity
GO:0031681: G-protein beta-subunit binding
KEGG pathways 4020: Calcium signaling pathway
4080: Neuroactive ligand-receptor interaction
4144: Endocytosis
4610: Complement and coagulation cascades
4810: Regulation of actin cytoskeleton

PubMed abstracts associated with F2R

PMID Title Tumor Value
20563836 Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. yes no
title all all