Results for PTK2B

General Information

Gene ID 2185
Gene Symbol PTK2B
Gene Name protein tyrosine kinase 2 beta
Gene Type protein-coding
Cytoband 8p21.1
Ensembl ID ENSG00000120899
#miR regulators 3
Omim ID 601212
Gene ontology GO:0000165: MAPK cascade
GO:0001556: oocyte maturation
GO:0001666: response to hypoxia
GO:0001954: positive regulation of cell-matrix adhesion
GO:0002040: sprouting angiogenesis
GO:0002315: marginal zone B cell differentiation
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0043267: negative regulation of potassium ion transport
GO:0006461: protein complex assembly
GO:0006468: protein phosphorylation
GO:0009612: response to mechanical stimulus
GO:0006950: response to stress
GO:0006970: response to osmotic stress
GO:0007166: cell surface receptor signaling pathway
GO:0007172: signal complex assembly
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007204: elevation of cytosolic calcium ion concentration
GO:0007229: integrin-mediated signaling pathway
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008360: regulation of cell shape
GO:0042493: response to drug
GO:0009725: response to hormone stimulus
GO:0009749: response to glucose stimulus
GO:0010226: response to lithium ion
GO:0010595: positive regulation of endothelial cell migration
GO:2000379: positive regulation of reactive oxygen species metabolic process
GO:0010752: regulation of cGMP-mediated signaling
GO:0010758: regulation of macrophage chemotaxis
GO:0010976: positive regulation of neuron projection development
GO:0014009: glial cell proliferation
GO:0045727: positive regulation of translation
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0030155: regulation of cell adhesion
GO:0030307: positive regulation of cell growth
GO:0030335: positive regulation of cell migration
GO:0030502: negative regulation of bone mineralization
GO:0030826: regulation of cGMP biosynthetic process
GO:0030838: positive regulation of actin filament polymerization
GO:0031175: neuron projection development
GO:0032863: activation of Rac GTPase activity
GO:0032960: regulation of inositol trisphosphate biosynthetic process
GO:0033209: tumor necrosis factor-mediated signaling pathway
GO:0042220: response to cocaine
GO:0042542: response to hydrogen peroxide
GO:0042976: activation of Janus kinase activity
GO:0043149: stress fiber assembly
GO:0043507: positive regulation of JUN kinase activity
GO:0043534: blood vessel endothelial cell migration
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045428: regulation of nitric oxide biosynthetic process
GO:0045453: bone resorption
GO:0045471: response to ethanol
GO:0045638: negative regulation of myeloid cell differentiation
GO:0045766: positive regulation of angiogenesis
GO:0045860: positive regulation of protein kinase activity
GO:0046330: positive regulation of JNK cascade
GO:0046777: protein autophosphorylation
GO:0048010: vascular endothelial growth factor receptor signaling pathway
GO:0048041: focal adhesion assembly
GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848: regulation of calcium-mediated signaling
GO:0051000: positive regulation of nitric-oxide synthase activity
GO:0051279: regulation of release of sequestered calcium ion into cytosol
GO:0051591: response to cAMP
GO:0051592: response to calcium ion
GO:0070098: chemokine-mediated signaling pathway
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0071300: cellular response to retinoic acid
GO:2000058: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000114: regulation of establishment of cell polarity
GO:2000249: regulation of actin cytoskeleton reorganization
GO:2000538: positive regulation of B cell chemotaxis
GO:0005886: plasma membrane
GO:0005829: cytosol
GO:0005634: nucleus
GO:0005737: cytoplasm
GO:0005925: focal adhesion
GO:0005938: cell cortex
GO:0014069: postsynaptic density
GO:0030027: lamellipodium
GO:0030424: axon
GO:0030426: growth cone
GO:0045121: membrane raft
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004713: protein tyrosine kinase activity
GO:0004715: non-membrane spanning protein tyrosine kinase activity
GO:0004871: signal transducer activity
GO:0005524: ATP binding
GO:0032403: protein complex binding
GO:0043423: 3-phosphoinositide-dependent protein kinase binding
KEGG pathways 4020: Calcium signaling pathway
4062: Chemokine signaling pathway
4650: Natural killer cell mediated cytotoxicity
4670: Leukocyte transendothelial migration
4912: GnRH signaling pathway

PubMed abstracts associated with PTK2B

PMID Title Tumor Value
22387266 Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. no no
title all all