General Information
Gene ID | 2185 |
---|---|
Gene Symbol | PTK2B |
Gene Name | protein tyrosine kinase 2 beta |
Gene Type | protein-coding |
Cytoband | 8p21.1 |
Ensembl ID | ENSG00000120899 |
#miR regulators | 3 |
Omim ID | 601212 |
Gene ontology |
GO:0000165: MAPK cascade GO:0001556: oocyte maturation GO:0001666: response to hypoxia GO:0001954: positive regulation of cell-matrix adhesion GO:0002040: sprouting angiogenesis GO:0002315: marginal zone B cell differentiation GO:0006915: apoptotic process GO:0007165: signal transduction GO:0043267: negative regulation of potassium ion transport GO:0006461: protein complex assembly GO:0006468: protein phosphorylation GO:0009612: response to mechanical stimulus GO:0006950: response to stress GO:0006970: response to osmotic stress GO:0007166: cell surface receptor signaling pathway GO:0007172: signal complex assembly GO:0007173: epidermal growth factor receptor signaling pathway GO:0007204: elevation of cytosolic calcium ion concentration GO:0007229: integrin-mediated signaling pathway GO:0043066: negative regulation of apoptotic process GO:0008284: positive regulation of cell proliferation GO:0008285: negative regulation of cell proliferation GO:0008360: regulation of cell shape GO:0042493: response to drug GO:0009725: response to hormone stimulus GO:0009749: response to glucose stimulus GO:0010226: response to lithium ion GO:0010595: positive regulation of endothelial cell migration GO:2000379: positive regulation of reactive oxygen species metabolic process GO:0010752: regulation of cGMP-mediated signaling GO:0010758: regulation of macrophage chemotaxis GO:0010976: positive regulation of neuron projection development GO:0014009: glial cell proliferation GO:0045727: positive regulation of translation GO:0018108: peptidyl-tyrosine phosphorylation GO:0030155: regulation of cell adhesion GO:0030307: positive regulation of cell growth GO:0030335: positive regulation of cell migration GO:0030502: negative regulation of bone mineralization GO:0030826: regulation of cGMP biosynthetic process GO:0030838: positive regulation of actin filament polymerization GO:0031175: neuron projection development GO:0032863: activation of Rac GTPase activity GO:0032960: regulation of inositol trisphosphate biosynthetic process GO:0033209: tumor necrosis factor-mediated signaling pathway GO:0042220: response to cocaine GO:0042542: response to hydrogen peroxide GO:0042976: activation of Janus kinase activity GO:0043149: stress fiber assembly GO:0043507: positive regulation of JUN kinase activity GO:0043534: blood vessel endothelial cell migration GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity GO:0045428: regulation of nitric oxide biosynthetic process GO:0045453: bone resorption GO:0045471: response to ethanol GO:0045638: negative regulation of myeloid cell differentiation GO:0045766: positive regulation of angiogenesis GO:0045860: positive regulation of protein kinase activity GO:0046330: positive regulation of JNK cascade GO:0046777: protein autophosphorylation GO:0048010: vascular endothelial growth factor receptor signaling pathway GO:0048041: focal adhesion assembly GO:0050731: positive regulation of peptidyl-tyrosine phosphorylation GO:0050848: regulation of calcium-mediated signaling GO:0051000: positive regulation of nitric-oxide synthase activity GO:0051279: regulation of release of sequestered calcium ion into cytosol GO:0051591: response to cAMP GO:0051592: response to calcium ion GO:0070098: chemokine-mediated signaling pathway GO:0070374: positive regulation of ERK1 and ERK2 cascade GO:0071300: cellular response to retinoic acid GO:2000058: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060: positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000114: regulation of establishment of cell polarity GO:2000249: regulation of actin cytoskeleton reorganization GO:2000538: positive regulation of B cell chemotaxis GO:0005886: plasma membrane GO:0005829: cytosol GO:0005634: nucleus GO:0005737: cytoplasm GO:0005925: focal adhesion GO:0005938: cell cortex GO:0014069: postsynaptic density GO:0030027: lamellipodium GO:0030424: axon GO:0030426: growth cone GO:0045121: membrane raft GO:0048471: perinuclear region of cytoplasm GO:0005515: protein binding GO:0004713: protein tyrosine kinase activity GO:0004715: non-membrane spanning protein tyrosine kinase activity GO:0004871: signal transducer activity GO:0005524: ATP binding GO:0032403: protein complex binding GO:0043423: 3-phosphoinositide-dependent protein kinase binding |
KEGG pathways |
4020: Calcium signaling pathway 4062: Chemokine signaling pathway 4650: Natural killer cell mediated cytotoxicity 4670: Leukocyte transendothelial migration 4912: GnRH signaling pathway |
PMID | Title | Tumor | Value |
---|---|---|---|
22387266 | Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. | no | no |
title | all | all |