Results for FGF2

General Information

Gene ID 2247
Gene Symbol FGF2
Gene Name fibroblast growth factor 2 (basic)
Gene Type protein-coding
Cytoband 4q26
Ensembl ID ENSG00000138685
#miR regulators 7
Omim ID 134920
Gene ontology GO:0000186: activation of MAPKK activity
GO:0000187: activation of MAPK activity
GO:0000189: MAPK import into nucleus
GO:0001658: branching involved in ureteric bud morphogenesis
GO:0001759: organ induction
GO:0001938: positive regulation of endothelial cell proliferation
GO:0002042: cell migration involved in sprouting angiogenesis
GO:0051726: regulation of cell cycle
GO:0006915: apoptotic process
GO:0007165: signal transduction
GO:0006661: phosphatidylinositol biosynthetic process
GO:0006700: C21-steroid hormone biosynthetic process
GO:0006935: chemotaxis
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007265: Ras protein signal transduction
GO:0009887: organ morphogenesis
GO:0007399: nervous system development
GO:0008284: positive regulation of cell proliferation
GO:0008285: negative regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010001: glial cell differentiation
GO:0010764: negative regulation of fibroblast migration
GO:0010863: positive regulation of phospholipase C activity
GO:0045893: positive regulation of transcription, DNA-dependent
GO:0045892: negative regulation of transcription, DNA-dependent
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021762: substantia nigra development
GO:0021940: positive regulation of cerebellar granule cell precursor proliferation
GO:0030198: extracellular matrix organization
GO:0030214: hyaluronan catabolic process
GO:0030308: negative regulation of cell growth
GO:0030324: lung development
GO:0032958: inositol phosphate biosynthetic process
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042060: wound healing
GO:0042660: positive regulation of cell fate specification
GO:0043536: positive regulation of blood vessel endothelial cell migration
GO:0043537: negative regulation of blood vessel endothelial cell migration
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045669: positive regulation of osteoblast differentiation
GO:0045765: regulation of angiogenesis
GO:0045766: positive regulation of angiogenesis
GO:0045944: positive regulation of transcription from RNA polymerase II promoter
GO:0046668: regulation of retinal cell programmed cell death
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048598: embryonic morphogenesis
GO:0048678: response to axon injury
GO:0048864: stem cell development
GO:0050918: positive chemotaxis
GO:0051209: release of sequestered calcium ion into cytosol
GO:0051781: positive regulation of cell division
GO:0060045: positive regulation of cardiac muscle cell proliferation
GO:0060128: corticotropin hormone secreting cell differentiation
GO:0060129: thyroid-stimulating hormone-secreting cell differentiation
GO:0060548: negative regulation of cell death
GO:0060591: chondroblast differentiation
GO:0060644: mammary gland epithelial cell differentiation
GO:0061045: negative regulation of wound healing
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0005576: extracellular region
GO:0005829: cytosol
GO:0005615: extracellular space
GO:0005634: nucleus
GO:0005515: protein binding
GO:0005104: fibroblast growth factor receptor binding
GO:0005125: cytokine activity
GO:0008083: growth factor activity
GO:0008201: heparin binding
GO:0017134: fibroblast growth factor binding
GO:0030374: ligand-dependent nuclear receptor transcription coactivator activity
GO:0042056: chemoattractant activity
KEGG pathways 4010: MAPK signaling pathway
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5218: Melanoma

PubMed abstracts associated with FGF2

PMID Title Tumor Value
1586971 Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. no no
9824653 A possible role for multidrug resistance-associated protein in the secretion of basic fibroblast growth factor by osteogenic sarcoma cell line (MG-63). no no
9858899 Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL. no no
11874241 Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells. no no
12393937 Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. no no
20027339 Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas. yes no
21619704 A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. yes yes
21834878 Parathyroid hormone affects the fibroblast growth factor-proteoglycan signaling axis to regulate osteosarcoma cell migration. no no
23167426 Clinical predictive value of serum angiogenic factor in patients with osteosarcoma. yes yes
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