Results for FGFR3

General Information

Gene ID 2261
Gene Symbol FGFR3
Gene Name fibroblast growth factor receptor 3
Gene Type protein-coding
Cytoband 4p16.3
Ensembl ID ENSG00000068078
#miR regulators 8
Omim ID 100800 109800 114500 134934 146000 149730 162900 187600 187601 602849 603956 610474 612247
Gene ontology GO:0000122: negative regulation of transcription from RNA polymerase II promoter
GO:0000165: MAPK cascade
GO:0001501: skeletal system development
GO:0001938: positive regulation of endothelial cell proliferation
GO:0001958: endochondral ossification
GO:0002009: morphogenesis of an epithelium
GO:0002062: chondrocyte differentiation
GO:0002089: lens morphogenesis in camera-type eye
GO:0003416: endochondral bone growth
GO:0007173: epidermal growth factor receptor signaling pathway
GO:0007259: JAK-STAT cascade
GO:0043066: negative regulation of apoptotic process
GO:0008284: positive regulation of cell proliferation
GO:0008286: insulin receptor signaling pathway
GO:0008543: fibroblast growth factor receptor signaling pathway
GO:0010518: positive regulation of phospholipase activity
GO:0018108: peptidyl-tyrosine phosphorylation
GO:0048015: phosphatidylinositol-mediated signaling
GO:0021762: substantia nigra development
GO:0022010: central nervous system myelination
GO:0031398: positive regulation of protein ubiquitination
GO:0035019: somatic stem cell maintenance
GO:0035988: chondrocyte proliferation
GO:0038095: Fc-epsilon receptor signaling pathway
GO:0042511: positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517: positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043065: positive regulation of apoptotic process
GO:0043410: positive regulation of MAPK cascade
GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087: innate immune response
GO:0045597: positive regulation of cell differentiation
GO:0045839: negative regulation of mitosis
GO:0045879: negative regulation of smoothened signaling pathway
GO:0046777: protein autophosphorylation
GO:0048011: neurotrophin TRK receptor signaling pathway
GO:0048546: digestive tract morphogenesis
GO:0048640: negative regulation of developmental growth
GO:0048678: response to axon injury
GO:0048712: negative regulation of astrocyte differentiation
GO:0050680: negative regulation of epithelial cell proliferation
GO:0060113: inner ear receptor cell differentiation
GO:0060349: bone morphogenesis
GO:0060385: axonogenesis involved in innervation
GO:0061144: alveolar secondary septum development
GO:0070307: lens fiber cell development
GO:0070374: positive regulation of ERK1 and ERK2 cascade
GO:0070977: bone maturation
GO:0072148: epithelial cell fate commitment
GO:0090080: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0090102: cochlea development
GO:0090263: positive regulation of canonical Wnt receptor signaling pathway
GO:1902178: fibroblast growth factor receptor signaling pathway involved in apoptotic process
GO:0005886: plasma membrane
GO:0005764: lysosome
GO:0005783: endoplasmic reticulum
GO:0005887: integral to plasma membrane
GO:0005925: focal adhesion
GO:0009898: internal side of plasma membrane
GO:0016023: cytoplasmic membrane-bounded vesicle
GO:0048471: perinuclear region of cytoplasm
GO:0005515: protein binding
GO:0004713: protein tyrosine kinase activity
GO:0005007: fibroblast growth factor-activated receptor activity
GO:0005524: ATP binding
GO:0017134: fibroblast growth factor binding
KEGG pathways 4010: MAPK signaling pathway
4144: Endocytosis
4810: Regulation of actin cytoskeleton
5200: Pathways in cancer
5219: Bladder cancer

PubMed abstracts associated with FGFR3

PMID Title Tumor Value
11906172 Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells. no no
21619704 A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. yes yes
title all all